Tuberculist information
Gene namembtD
Protein functionPolyketide synthetase MbtD (polyketide synthase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)2667.25
Molecular mass(da)105592
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1004
	  		  	1    MAPKQLPDGRVAVLLSAHAEELIGPDARAIADYLERFPATTVTEVARQLRKTRRVRRHRA   60
			  	61   VLRAADRLELAEGLRALAAGREHPLIARSSLGSAPRQAFVFPGQGGHWPGMGAVAYRELP  120
			  	121  TYRTATDTCAAAFAAAGVDSPLPYLIAPPGTDERQAFCEIEIEGAQFVHAVALAEVWRSC  180
			  	181  GVLPDLTVGHSLGEVAAAYLAGSITLSDAVAVVAARANVVGRLPGRYAVAALGIGEQDAS  240
			  	241  ALIATTGGWLELSVVNASSTVAVSGERQAVAAIVDTVRSSGHFARGITVGFPVHTSVLES  300
			  	301  LRDELCEQLPDSEFMEAPVQFIGGTTGDVVAPGTTFGDYWYANLRHTVRFDRAVESAIRC  360
			  	361  GARAFIEISAHPALLFAIGQNCEGAANLPDGPAVLVGSARRGERFVDALSANIVSAAVAD  420
			  	421  PGYPWGDLGGDPLDGDVDLSGFPNAPMRAVPMWAHPEPLPPVSGLTIAVERWERMVPSTP  480
			  	481  VAGRHRHLAVLDLGAHRALAQTLCAAIDSHPDTELSAARDAELILVIAPDFEHTDAVRAA  540
			  	541  GALADLVGAGLLDYPMHIGARCQSVCLVTVGAEQVDAADAVPSAGQAALAAMHRSIGFEH  600
			  	601  PEQTFSHLDLPSWDLDPVLGVSVITAVLRGFGETALRGSVNGYTLFERTLADAPAVPNWS  660
			  	661  LDSGVLDDVVVTGGAGAIGMHYARYLAEHGARRIVLLSRRAADQATVAMLRKQHGTVIVS  720
			  	721  PPCDITDPTQLSAIAAEYGGVGASLIVHAAGSVISGTAPGVTSAAVVDNFAAKVLGLAQM  780
			  	781  IELWPLRPDVRTLLCSSVMGVWGGHGVVAYSAANRLLDVMAAQLRAQGRHCVAVKWGLWQ  840
			  	841  APKAGEPARGIADAVTIARVERSGLRQMAPQQAIEASLHEFTVDPLVFAADAARLQMLLD  900
			  	901  SRQFERYEGPTDPNLTIVDAVRTQLAAVLGIPQAGEVNLQESLFDLGVDSMLALDLRNRL  960
			  	961  KRSIGATVSLATLMGDITGDGLVAKLEDADERSHTAQKVDISRD
			  			

Known structures in the PDB
No Known structures
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl_transf_1PF0069898-421
KRPF08659668-842
PP-bindingPF00550919-986
Mtb Structural Proteome models
Model Number1
Model nameRv2381c.5
Template2CG5    BPDBCREDO
Template coverage2131_2187
Template Identity(%)33.3
Model coverage(%)5.7
Normalized DOPE score-1.298

Model Number2
Model nameRv2381c
Template2HG4    APDBCREDO
Template coverage450_899
Template Identity(%)33.3
Model coverage(%)45.1
Normalized DOPE score-0.156

Model Number3
Model nameRv2381c.3
Template2FR1    APDBCREDO
Template coverage1451_1909
Template Identity(%)24.4
Model coverage(%)46.6
Normalized DOPE score0.22

Model Number4
Model nameRv2381c.4
Template2FR1    APDBCREDO
Template coverage1529_1860
Template Identity(%)29.7
Model coverage(%)32.1
Normalized DOPE score0.42

Structure Models from Chopin
Model Number1
Profile3.30.70.250, 3.40.366.10
Click for model details
zscore29.91
Residue begin92
Residue end408
Model Number2
Profile3.40.366.10
Click for model details
zscore29.53
Residue begin86
Residue end339
Model Number3
Profilea.28.1.1 - 1.10.1200.10
Click for model details
zscore14.49
Residue begin908
Residue end1004
Model Number4
Profiled.58.23.1
Click for model details
zscore10.77
Residue begin224
Residue end291
Model Number5
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore9.06
Residue begin668
Residue end842
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2381cGene nameConfidence Score
Rv2382cmbtC0.982
Rv2382cmbtC0.982
Rv2378cmbtG0.973
Rv2383cmbtB0.96
Rv2383cmbtB0.96
Rv2383cmbtB0.96
Rv2383cmbtB0.96
Rv2383cmbtB0.96
Rv2383cmbtB0.96
Rv2384mbtA0.936
Rv2384mbtA0.936
Rv2385mbtJ0.902
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv2381c.531xbb_STI_A_1PDBCREDO0.7460.0500.7100.000
Rv2381c.363v5w_8PR_A_701PDBCREDO0.6810.0960.6810.000
Rv2381c.363oez_STI_B_601PDBCREDO0.6960.0840.6530.001
Rv2381c.362jfa_RAL_A_600PDBCREDO0.6940.0860.6510.001
Rv2381c.361qkn_RAL_A_600PDBCREDO0.6450.1290.6450.001
Rv2381c.361d4s_TPV_A_201PDBCREDO0.6760.1000.6330.001
Rv2381c.362hyy_STI_B_600PDBCREDO0.7340.0570.6280.001
Rv2381c.362fum_MIX_D_3539PDBCREDO0.6910.0880.6250.001
Rv2381c.362pl0_STI_A_200PDBCREDO0.7290.0600.6230.001
Rv2381c.361err_RAL_A_600PDBCREDO0.6820.0960.6200.001
Rv2381c.362jfa_RAL_B_600PDBCREDO0.6810.0960.6190.001
Rv2381c.361err_RAL_B_600PDBCREDO0.6770.1000.6150.002
Rv2381c.364asd_BAX_A_1500PDBCREDO0.7290.0600.6050.002
Rv2381c.362gqg_1N1_B_502PDBCREDO0.6140.1620.5940.002
Rv2381c.363hec_STI_A_1PDBCREDO0.6310.1440.5920.002
Rv2381c.363mss_STI_B_1PDBCREDO0.7540.0450.5900.003
Rv2381c.533ug2_IRE_A_1PDBCREDO0.6190.1570.5890.003
Rv2381c.363mss_STI_A_1PDBCREDO0.7510.0470.5880.003
Rv2381c.363ms9_STI_B_1PDBCREDO0.7510.0470.5880.003
Rv2381c.363pyy_STI_B_4PDBCREDO0.7510.0470.5880.003
Rv2381c.363heg_BAX_A_1PDBCREDO0.6870.0910.5880.003
Rv2381c.362hyy_STI_C_600PDBCREDO0.7500.0480.5870.003
Rv2381c.363mss_STI_D_1PDBCREDO0.7500.0480.5870.003
Rv2381c.362hyy_STI_A_600PDBCREDO0.7490.0480.5870.003
Rv2381c.363k5v_STI_B_2PDBCREDO0.7490.0480.5870.003
Rv2381c.424asd_BAX_A_1500PDBCREDO0.6390.1350.5860.003
Rv2381c.363mss_STI_C_1PDBCREDO0.7470.0490.5850.003
Rv2381c.363oez_STI_A_601PDBCREDO0.7460.0500.5840.003
Rv2381c.362hyy_STI_D_600PDBCREDO0.7450.0510.5830.003
Rv2381c.361iep_STI_A_201PDBCREDO0.7450.0510.5830.003
Rv2381c.423oez_STI_A_601PDBCREDO0.6000.1790.5830.003
Rv2381c.363gvu_STI_A_1001PDBCREDO0.7440.0510.5830.003
Rv2381c.363ms9_STI_A_1PDBCREDO0.7440.0510.5820.003
Rv2381c.363pyy_STI_A_3PDBCREDO0.7440.0510.5820.003
Rv2381c.362oiq_STI_A_1001PDBCREDO0.6800.0970.5810.003
Rv2381c.362y6o_1N1_A_1892PDBCREDO0.6000.1790.5810.003
Rv2381c.363rgf_BAX_A_465PDBCREDO0.7620.0410.5800.003
Rv2381c.361iep_STI_B_202PDBCREDO0.7380.0550.5780.003
Rv2381c.362fum_MIX_A_539PDBCREDO0.7050.0770.5740.003
Rv2381c.421uwj_BAX_A_1723PDBCREDO0.5710.2150.5710.004
Rv2381c.423gvu_STI_A_1001PDBCREDO0.5850.1970.5690.004
Rv2381c.423mss_STI_B_1PDBCREDO0.5850.1970.5690.004
Rv2381c.361s9p_DES_D_600PDBCREDO0.6730.1030.5680.004
Rv2381c.421iep_STI_B_202PDBCREDO0.5840.1980.5680.004
Rv2381c.422hyy_STI_D_600PDBCREDO0.5840.1980.5680.004
Rv2381c.422hyy_STI_A_600PDBCREDO0.5840.1990.5670.004
Rv2381c.423k5v_STI_B_2PDBCREDO0.5840.1990.5670.004
Rv2381c.422hyy_STI_C_600PDBCREDO0.5830.1990.5670.004
Rv2381c.421iep_STI_A_201PDBCREDO0.5830.2000.5670.004
Rv2381c.423ms9_STI_B_1PDBCREDO0.5830.2000.5670.004
Rv2381c.363k5v_STI_A_2PDBCREDO0.7660.0400.5670.004
Rv2381c.363u7s_017_A_202PDBCREDO0.5850.1980.5660.004
Rv2381c.423mss_STI_C_1PDBCREDO0.5820.2010.5650.004
Rv2381c.423mss_STI_D_1PDBCREDO0.5820.2010.5650.004
Rv2381c.363erd_DES_A_600PDBCREDO0.6940.0850.5650.004
Rv2381c.423pyy_STI_A_3PDBCREDO0.5810.2020.5650.004
Rv2381c.363u7s_017_A_201PDBCREDO0.6030.1750.5650.004
Rv2381c.423mss_STI_A_1PDBCREDO0.5810.2030.5640.004
Rv2381c.361opj_STI_A_3PDBCREDO0.7840.0310.5640.004
Rv2381c.421t46_STI_A_3PDBCREDO0.6470.1280.5640.004
Rv2381c.423pyy_STI_B_4PDBCREDO0.5800.2040.5640.004
Rv2381c.423ms9_STI_A_1PDBCREDO0.5800.2040.5630.004
Rv2381c.361opj_STI_B_4PDBCREDO0.7800.0330.5610.004
Rv2381c.423gcs_BAX_A_401PDBCREDO0.6120.1650.5610.004
Rv2381c.423k5v_STI_A_2PDBCREDO0.5760.2090.5600.004
Rv2381c.362gqg_1N1_A_501PDBCREDO0.6860.0920.5590.004
Rv2381c.423oez_STI_B_601PDBCREDO0.6860.0920.5570.004
Rv2381c.423gp0_NIL_A_1PDBCREDO0.6550.1190.5560.005
Rv2381c.361t7j_478_A_200PDBCREDO0.6310.1440.5560.005
Rv2381c.422hyy_STI_B_600PDBCREDO0.6250.1510.5560.005
Rv2381c.421opj_STI_A_3PDBCREDO0.5870.1950.5550.005
Rv2381c.533grv_ADN_A_300PDBCREDO0.6420.1320.5550.005
Rv2381c.361s9p_DES_A_459PDBCREDO0.6570.1170.5550.005
Rv2381c.362o4n_TPV_A_300PDBCREDO0.6260.1490.5520.005
Rv2381c.421opj_STI_B_4PDBCREDO0.5830.2000.5510.005
Rv2381c.363ogp_017_A_200PDBCREDO0.6440.1300.5510.005
Rv2381c.363gcs_BAX_A_401PDBCREDO0.6610.1140.5490.005
Rv2381c.423rgf_BAX_A_465PDBCREDO0.5470.2480.5470.005
Rv2381c.423el9_DR7_A_100PDBCREDO0.6090.1680.5460.005
Rv2381c.423hec_STI_A_1PDBCREDO0.6720.1040.5450.005
Rv2381c.423heg_BAX_A_1PDBCREDO0.6110.1660.5440.006
Rv2381c.531qhy_CLM_A_999PDBCREDO0.5710.2160.5430.006
Rv2381c.361d4y_TPV_A_501PDBCREDO0.6140.1630.5410.006
Rv2381c.363erd_DES_B_800PDBCREDO0.6640.1110.5410.006
Rv2381c.363oht_1N1_B_1000PDBCREDO0.6400.1350.5400.006
Rv2381c.363cs9_NIL_C_600PDBCREDO0.8130.0200.5390.006
Rv2381c.421uwj_BAX_B_1723PDBCREDO0.5870.1940.5380.006
Rv2381c.422oiq_STI_A_1001PDBCREDO0.6040.1740.5370.006
Rv2381c.533jw3_TOP_A_208PDBCREDO0.6650.1100.5370.006
Rv2381c.531uay_ADN_A_1001PDBCREDO0.6510.1230.5370.006
Rv2381c.363cs9_NIL_D_600PDBCREDO0.8080.0220.5360.006
Rv2381c.422pl0_STI_A_200PDBCREDO0.6010.1780.5350.006
Rv2381c.422fxd_DR7_A_102PDBCREDO0.5970.1820.5350.006
Rv2381c.421t7j_478_A_200PDBCREDO0.6190.1570.5340.006
Rv2381c.361kij_NOV_A_400PDBCREDO0.5900.1910.5340.006
Rv2381c.363cs9_NIL_A_600PDBCREDO0.7420.0520.5340.006
Rv2381c.423v5w_8PR_A_701PDBCREDO0.7000.0810.5330.007
Rv2381c.422qxs_RAL_A_600PDBCREDO0.5770.2080.5310.007
Rv2381c.423cs9_NIL_C_600PDBCREDO0.6070.1700.5290.007
Rv2381c.422qxs_RAL_B_600PDBCREDO0.5750.2100.5290.007
Rv2381c.423cs9_NIL_A_600PDBCREDO0.5600.2300.5290.007
Rv2381c.531fb7_ROC_A_100PDBCREDO0.6520.1220.5270.007
Rv2381c.361uwh_BAX_A_1723PDBCREDO0.5970.1830.5260.007
Rv2381c.362rkg_AB1_B_501PDBCREDO0.5960.1840.5250.007
Rv2381c.361uwh_BAX_B_1723PDBCREDO0.5950.1840.5250.007
Rv2381c.423cs9_NIL_D_600PDBCREDO0.6020.1770.5250.007
Rv2381c.421n49_RIT_D_401PDBCREDO0.5400.2590.5240.008
Rv2381c.421uwh_BAX_B_1723PDBCREDO0.6070.1700.5240.008
Rv2381c.363gws_T3_X_500PDBCREDO0.5240.2810.5240.008
Rv2381c.423spk_TPV_B_100PDBCREDO0.5550.2380.5240.008
Rv2381c.363spk_TPV_A_100PDBCREDO0.5590.2310.5240.008
Rv2381c.421uwh_BAX_A_1723PDBCREDO0.6060.1720.5230.008
Rv2381c.362zva_1N1_A_513PDBCREDO0.7750.0350.5220.008
Rv2381c.422y6o_1N1_A_1892PDBCREDO0.6640.1110.5220.008
Rv2381c.363bbt_FMM_D_91PDBCREDO0.5760.2090.5210.008
Rv2381c.363cs9_NIL_B_600PDBCREDO0.7440.0510.5210.008
Rv2381c.532w9s_TOP_A_1160PDBCREDO0.5480.2470.5210.008
Rv2381c.361bsx_T3_A_1PDBCREDO0.5200.2880.5200.008
Rv2381c.361bsx_T3_B_2PDBCREDO0.5200.2880.5200.008
Rv2381c.361mui_AB1_B_100PDBCREDO0.5900.1920.5200.008
Rv2381c.533fl9_TOP_A_200PDBCREDO0.5470.2490.5190.008
Rv2381c.421c6y_MK1_B_524PDBCREDO0.5790.2040.5190.008
Rv2381c.421n49_RIT_B_301PDBCREDO0.5480.2460.5190.008
Rv2381c.421xkk_FMM_A_91PDBCREDO0.6250.1510.5170.008
Rv2381c.531uay_ADN_B_1002PDBCREDO0.6770.0990.5170.008
Rv2381c.532w9s_TOP_C_1160PDBCREDO0.5440.2530.5170.008
Rv2381c.362fxd_DR7_A_102PDBCREDO0.7570.0440.5160.009
Rv2381c.363k54_1N1_A_1PDBCREDO0.6570.1180.5160.009
Rv2381c.533fl9_TOP_G_200PDBCREDO0.5430.2550.5150.009
Rv2381c.361mx1_THA_C_3PDBCREDO0.6080.1690.5130.009
Rv2381c.361mx1_THA_E_5PDBCREDO0.6540.1210.5130.009
Rv2381c.361xzx_T3_X_500PDBCREDO0.5300.2730.5130.009
Rv2381c.363uvv_T3_A_501PDBCREDO0.5300.2730.5130.009
Rv2381c.363tne_RIT_A_401PDBCREDO0.5470.2480.5130.009
Rv2381c.362r5q_1UN_B_900PDBCREDO0.6360.1380.5130.009
Rv2381c.362qxs_RAL_B_600PDBCREDO0.7320.0580.5130.009
Rv2381c.423cs9_NIL_B_600PDBCREDO0.5570.2340.5130.009
Rv2381c.361kij_NOV_B_444PDBCREDO0.7030.0780.5120.009
Rv2381c.532nnj_225_A_501PDBCREDO0.5380.2600.5120.009
Rv2381c.362r5q_1UN_D_900PDBCREDO0.6350.1400.5120.009
Rv2381c.361uwj_BAX_B_1723PDBCREDO0.6170.1600.5120.009
Rv2381c.533fl9_TOP_B_200PDBCREDO0.5380.2600.5120.009
Rv2381c.362j7y_E3O_A_1454PDBCREDO0.7020.0790.5110.009
Rv2381c.422jfa_RAL_A_600PDBCREDO0.6290.1460.5110.009
Rv2381c.362qxs_RAL_A_600PDBCREDO0.7290.0600.5100.009
Rv2381c.423lzv_017_A_200PDBCREDO0.5250.2800.5100.009
Rv2381c.521uay_ADN_B_1002PDBCREDO0.6110.1660.5090.009
Rv2381c.421hsh_MK1_A_401PDBCREDO0.5680.2190.5090.010
Rv2381c.363qlg_1N1_A_601PDBCREDO0.7220.0650.5060.010
Rv2381c.522wd9_IBP_A_1570PDBCREDO0.5060.3090.5060.010
Rv2381c.523s23_CER_A_359PDBCREDO0.5060.3090.5060.010
Rv2381c.421hsh_MK1_C_402PDBCREDO0.5650.2230.5060.010
Rv2381c.423ekq_ROC_A_100PDBCREDO0.5500.2440.5060.010
Rv2381c.533jw3_TOP_B_208PDBCREDO0.7020.0790.5050.010
Rv2381c.423el0_1UN_A_201PDBCREDO0.5200.2880.5050.010
Rv2381c.363qlg_1N1_B_601PDBCREDO0.7200.0660.5050.010
Rv2381c.421hwk_117_B_1PDBCREDO0.5190.2890.5040.010
Rv2381c.363oct_1N1_A_663PDBCREDO0.5760.2090.5030.010
Rv2381c.421sgu_MK1_B_2632PDBCREDO0.5180.2910.5030.010
Rv2381c.361s9p_DES_B_459PDBCREDO0.7450.0510.5020.011
Rv2381c.361zgy_BRL_A_503PDBCREDO0.5370.2630.5020.011
Rv2381c.363g5d_1N1_A_1PDBCREDO0.7160.0690.5020.011
Rv2381c.362x9g_LYA_A_1270PDBCREDO0.5190.2890.5020.011
Rv2381c.363ogp_017_B_200PDBCREDO0.6410.1330.5020.011
Rv2381c.524dta_ADN_B_401PDBCREDO0.6130.1630.5020.011
Rv2381c.533jw5_TOP_B_208PDBCREDO0.5280.2760.5010.011
Rv2381c.361s9p_DES_C_500PDBCREDO0.7430.0520.5010.011
Rv2381c.363g5d_1N1_B_1PDBCREDO0.7140.0700.5010.011
Rv2381c.423tne_RIT_B_401PDBCREDO0.6170.1600.5000.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions