Rv3790

Tuberculist information
Gene namedprE1
Protein functionDecaprenylphosphoryl-beta-D-ribose 2'-oxidase
Functional category(tuberculist)lipid metabolism
Gene location(kb)4235.78
Molecular mass(da)50163.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 461
	  		  	1    MLSVGATTTATRLTGWGRTAPSVANVLRTPDAEMIVKAVARVAESGGGRGAIARGLGRSY   60
			  	61   GDNAQNGGGLVIDMTPLNTIHSIDADTKLVDIDAGVNLDQLMKAALPFGLWVPVLPGTRQ  120
			  	121  VTVGGAIACDIHGKNHHSAGSFGNHVRSMDLLTADGEIRHLTPTGEDAELFWATVGGNGL  180
			  	181  TGIIMRATIEMTPTSTAYFIADGDVTASLDETIALHSDGSEARYTYSSAWFDAISAPPKL  240
			  	241  GRAAVSRGRLATVEQLPAKLRSEPLKFDAPQLLTLPDVFPNGLANKYTFGPIGELWYRKS  300
			  	301  GTYRGKVQNLTQFYHPLDMFGEWNRAYGPAGFLQYQFVIPTEAVDEFKKIIGVIQASGHY  360
			  	361  SFLNVFKLFGPRNQAPLSFPIPGWNICVDFPIKDGLGKFVSELDRRVLEFGGRLYTAKDS  420
			  	421  RTTAETFHAMYPRVDEWISVRRKVDPLRVFASDMARRLELL

Known structures in the PDB
PDB ID4FDN
Total residue count481
Number of chains1
MethodX-RAY
Resolution2.4
PDB ID4FDO
Total residue count481
Number of chains1
MethodX-RAY
Resolution2.4
PDB ID4FDP
Total residue count962
Number of chains2
MethodX-RAY
Resolution2.23
PDB ID4FEH
Total residue count481
Number of chains1
MethodX-RAY
Resolution2.04
PDB ID4FF6
Total residue count962
Number of chains2
MethodX-RAY
Resolution2.6
PDB ID4KW5
Total residue count922
Number of chains2
MethodX-RAY
Resolution2.61
PDB ID4NCR
Total residue count962
Number of chains2
MethodX-RAY
Resolution1.88
1 47 93 139 185 231 277 323 369 415 461 Range: 24 to 162  |  Coverage: 29% FAD_binding_4 Range: 389 to 458  |  Coverage: 14% ALO Range: 2 to 451  |  Coverage: 97% 1 Range: 1 to 460  |  Coverage: 99% 1 Range: 389 to 458  |  Coverage: 14% 2 Range: 24 to 162  |  Coverage: 29% 3 Range: 1 to 211  |  Coverage: 45% 4 Range: 20 to 460  |  Coverage: 95% 5
Number of amino acids : 461
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FAD_binding_4PF0156524-162
ALOPF04030389-458
Mtb Structural Proteome models
Model Number1
Model nameRv3790
Template1W1O    APDBCREDO
Template coverage47_527
Template Identity(%)18.9
Model coverage(%)97.4
Normalized DOPE score0.114

Structure Models from Chopin
Model Number1
Profiled.145.1.1, d.58.32.3 - 1.10.45.10, 3.30.43.10, 3.30.465.10, 3.40.462.10
Click for model details
zscore29.54
Residue begin1
Residue end460
Model Number2
Profiled.58.32.3
Click for model details
zscore16.41
Residue begin389
Residue end458
Model Number3
Profiled.145.1.1
Click for model details
zscore16.11
Residue begin24
Residue end162
Model Number4
Profiled.145.1.2
Click for model details
zscore12.74
Residue begin1
Residue end211
Model Number5
Profiled.58.32.3
Click for model details
zscore9.3
Residue begin20
Residue end460
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3790Gene nameConfidence Score
Rv3791dprE20.999
Rv3806cubiA0.993
Rv3792aftA0.976
Rv3792aftA0.976
Rv3793embC0.976
Rv3793embC0.976
Rv2073cRv2073c0.975
Rv3794embA0.929
Rv3794embA0.929
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
  View results in TIBLE page
NameAffinityAssay descriptionDOI
CDD-930297NoneNoneNone
Off-target activity - ligand based from TIBLE
  View results in TIBLE page
Predicted off-targetMethodSummaryFull results
Protein-glutamine gamma-glutamyltransferase E 1L9NPharmMapper3 hydroph + 5 HB + 0 pos/neg + 0 aromLink
GTPase HRas 5P21PharmMapper0 hydroph + 13 HB + 2 pos/neg + 0 aromLink
Macrophage metalloelastase 1UTZPharmMapper4 hydroph + 3 HB + 0 pos/neg + 0 aromLink
Angiotensin-converting enzyme 1UZFPharmMapper2 hydroph + 3 HB + 2 pos/neg + 0 aromLink
Cellular retinoic acid-binding protein 2 1CBSPharmMapper7 hydroph + 2 HB + 1 pos/neg + 0 aromLink
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions