Rv3791

Tuberculist information
Gene namedprE2
Protein functionDecaprenylphosphoryl-D-2-keto erythro pentose reductase
Functional category(tuberculist)lipid metabolism
Gene location(kb)4237.17
Molecular mass(da)27468.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 254
	  		  	1    MVLDAVGNPQTVLLLGGTSEIGLAICERYLHNSAARIVLACLPDDPRREDAAAAMKQAGA   60
			  	61   RSVELIDFDALDTDSHPKMIEAAFSGGDVDVAIVAFGLLGDAEELWQNQRKAVQIAEINY  120
			  	121  TAAVSVGVLLAEKMRAQGFGQIIAMSSAAGERVRRANFVYGSTKAGLDGFYLGLSEALRE  180
			  	181  YGVRVLVIRPGQVRTRMSAHLKEAPLTVDKEYVANLAVTASAKGKELVWAPAAFRYVMMV  240
			  	241  LRHIPRSIFRKLPI

Known structures in the PDB
No Known structures
1 26 51 76 101 126 151 176 201 226 251 Range: 10 to 208  |  Coverage: 77% adh_short Range: 6 to 250  |  Coverage: 96% 1 Range: 1 to 254  |  Coverage: 99% 1
Number of amino acids : 254
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
adh_shortPF0010610-208
Mtb Structural Proteome models
Model Number1
Model nameRv3791
Template1ULS    APDBCREDO
Template coverage2_235
Template Identity(%)21.8
Model coverage(%)96.1
Normalized DOPE score-0.27

Structure Models from Chopin
Model Number1
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore17.66
Residue begin1
Residue end254
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3791Gene nameConfidence Score
Rv3790dprE10.999
Rv3790dprE10.999
Rv3806cubiA0.985
Rv3793embC0.983
Rv3793embC0.983
Rv3792aftA0.976
Rv3792aftA0.976
Rv3794embA0.938
Rv3794embA0.938
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
  View results in TIBLE page
NameAffinityAssay descriptionDOI
CDD-930297NoneNoneNone
Off-target activity - ligand based from TIBLE
  View results in TIBLE page
Predicted off-targetMethodSummaryFull results
Protein-glutamine gamma-glutamyltransferase E 1L9NPharmMapper3 hydroph + 5 HB + 0 pos/neg + 0 aromLink
GTPase HRas 5P21PharmMapper0 hydroph + 13 HB + 2 pos/neg + 0 aromLink
Macrophage metalloelastase 1UTZPharmMapper4 hydroph + 3 HB + 0 pos/neg + 0 aromLink
Angiotensin-converting enzyme 1UZFPharmMapper2 hydroph + 3 HB + 2 pos/neg + 0 aromLink
Cellular retinoic acid-binding protein 2 1CBSPharmMapper7 hydroph + 2 HB + 1 pos/neg + 0 aromLink
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions