Rv3794

Tuberculist information
Gene nameembA
Protein functionIntegral membrane indolylacetylinositol arabinosyltransferase EmbA (arabinosylindolylacetylinositol synthase)
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)4243.23
Molecular mass(da)115692
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1094
	  		  	1    VPHDGNERSHRIARLAAVVSGIAGLLLCGIVPLLPVNQTTATIFWPQGSTADGNITQITA   60
			  	61   PLVSGAPRALDISIPCSAIATLPANGGLVLSTLPAGGVDTGKAGLFVRANQDTVVVAFRD  120
			  	121  SVAAVAARSTIAAGGCSALHIWADTGGAGADFMGIPGGAGTLPPEKKPQVGGIFTDLKVG  180
			  	181  AQPGLSARVDIDTRFITTPGALKKAVMLLGVLAVLVAMVGLAALDRLSRGRTLRDWLTRY  240
			  	241  RPRVRVGFASRLADAAVIATLLLWHVIGATSSDDGYLLTVARVAPKAGYVANYYRYFGTT  300
			  	301  EAPFDWYTSVLAQLAAVSTAGVWMRLPATLAGIACWLIVSRFVLRRLGPGPGGLASNRVA  360
			  	361  VFTAGAVFLSAWLPFNNGLRPEPLIALGVLVTWVLVERSIALGRLAPAAVAIIVATLTAT  420
			  	421  LAPQGLIALAPLLTGARAIAQRIRRRRATDGLLAPLAVLAAALSLITVVVFRDQTLATVA  480
			  	481  ESARIKYKVGPTIAWYQDFLRYYFLTVESNVEGSMSRRFAVLVLLFCLFGVLFVLLRRGR  540
			  	541  VAGLASGPAWRLIGTTAVGLLLLTFTPTKWAVQFGAFAGLAGVLGAVTAFTFARIGLHSR  600
			  	601  RNLTLYVTALLFVLAWATSGINGWFYVGNYGVPWYDIQPVIASHPVTSMFLTLSILTGLL  660
			  	661  AAWYHFRMDYAGHTEVKDNRRNRILASTPLLVVAVIMVAGEVGSMAKAAVFRYPLYTTAK  720
			  	721  ANLTALSTGLSSCAMADDVLAEPDPNAGMLQPVPGQAFGPDGPLGGISPVGFKPEGVGED  780
			  	781  LKSDPVVSKPGLVNSDASPNKPNAAITDSAGTAGGKGPVGINGSHAALPFGLDPARTPVM  840
			  	841  GSYGENNLAATATSAWYQLPPRSPDRPLVVVSAAGAIWSYKEDGDFIYGQSLKLQWGVTG  900
			  	901  PDGRIQPLGQVFPIDIGPQPAWRNLRFPLAWAPPEADVARIVAYDPNLSPEQWFAFTPPR  960
			  	961  VPVLESLQRLIGSATPVLMDIATAANFPCQRPFSEHLGIAELPQYRILPDHKQTAASSNL 1020
			  	1021 WQSSSTGGPFLFTQALLRTSTIATYLRGDWYRDWGSVEQYHRLVPADQAPDAVVEEGVIT 1080
			  	1081 VPGWGRPGPIRALP

Known structures in the PDB
No Known structures
1 110 219 328 437 546 655 764 873 982 1091 Range: 4 to 668  |  Coverage: 60% Arabinose_trans Range: 701 to 1093  |  Coverage: 35% Arabino_trans_C Range: 428 to 653  |  Coverage: 20% 1 Range: 39 to 193  |  Coverage: 14% 1 Range: 311 to 593  |  Coverage: 25% 2
Number of amino acids : 1094
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Arabinose_transPF046024-668
Arabino_trans_CPF14896701-1093
Mtb Structural Proteome models
Model Number1
Model nameRv3794
Template1L7V    APDBCREDO
Template coverage50_260
Template Identity(%)9.0
Model coverage(%)20.6
Normalized DOPE score0.978

Structure Models from Chopin
Model Number1
Profile2.60.120.610
Click for model details
zscore23.93
Residue begin39
Residue end193
Model Number2
Profilea.209.1.1
Click for model details
zscore8.43
Residue begin311
Residue end593
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3794Gene nameConfidence Score
Rv3792aftA0.979
Rv3792aftA0.979
Rv3791dprE20.938
Rv3790dprE10.929
Rv3790dprE10.929
Rv3808cglfT20.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
  View results in TIBLE page
NameAffinityAssay descriptionDOI
CDD-1761NoneNoneNone
CDD-1765NoneNoneNone
Off-target activity - ligand based from TIBLE
  View results in TIBLE page
Predicted off-targetMethodSummaryFull results
Tyrosine-protein phosphatase non-receptor type 1 1Q6JPharmMapper5 hydroph + 1 HB + 2 pos/neg + 0 aromLink
Tyrosine-protein phosphatase non-receptor type 1 1KAKPharmMapper3 hydroph + 1 HB + 2 pos/neg + 0 aromLink
Tyrosine-protein phosphatase non-receptor type 1 1KAVPharmMapper4 hydroph + 3 HB + 1 pos/neg + 0 aromLink
Aldo-keto reductase family 1 member C2 1IHIPharmMapper3 hydroph + 3 HB + 1 pos/neg + 0 aromLink
Retinoic acid receptor RXR-beta 1H9UPharmMapper8 hydroph + 1 HB + 1 pos/neg + 0 aromLink
Superoxide dismutase  PASSPa = 0.807 & SM = CDD-1761Link
Thrombocytopoiesis  PASSPa = 0.762 & SM = CDD-1761Link
lysophosphatidic acid receptor 1 [-] SEAE_value = 1.01e-21 & MaxTC = 0.46Link
lysophosphatidic acid receptor Edg-4; LPA receptor 2 [-] SEAE_value = 4.44e-21 & MaxTC = 0.46Link
lysophosphatidic acid receptor 1 SEAE_value = 4.44e-21 & MaxTC = 0.46Link
lysophosphatidic acid receptor Edg-7; LPA receptor 3 [-] SEAE_value = 4.44e-21 & MaxTC = 0.46Link
lysophosphatidic acid receptor Edg-4; LPA receptor 2 SEAE_value = 4.44e-21 & MaxTC = 0.46Link
lysophosphatidic acid receptor [-] SEAE_value = 4.36e-19 & MaxTC = 0.46Link
lysophosphatidic acid receptor SEAE_value = 1.22e-16 & MaxTC = 0.46Link
glycogen phosphorylase b [-] SEAE_value = 3.82e-16 & MaxTC = 0.37Link
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ethambutolPubChem0.824204.31