SInCRe - Rv2073c

Tuberculist information

Gene name	Rv2073c
Protein function	Probable shortchain dehydrogenase
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	2330.21
Molecular mass(da)	25890
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 249

	  		  	1    VDDTGAAPVVIFGGRSQIGGELARRLAAGATMVLAARNADQLADQAAALRAAGAIAVHTR   60
			  	61   EFDADDLAAHGPLVASLVAEHGPIGTAVLAFGILGDQARAETDAAHAVAIVHTDYVAQVS  120
			  	121  LLTHLAAAMRTAGRGSLVVFSSVAGIRVRRANYVYGSAKAGLDGFASGLADALHGTGVRL  180
			  	181  LIARPGFVIGRMTEGMTPAPLSVTPERVAAATARALVNGKRVVWIPWALRPMFVALRLLP  240
			  	241  RFVWRRMPR

Known structures in the PDB

No Known structures

Number of amino acids : 249

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
adh_short	PF00106	7-174

Mtb Structural Proteome models

Model Number	1
Model name	Rv2073c
Template	1YB1 APDB CREDO
Template coverage	27_268
Template Identity(%)	22.7
Model coverage(%)	94.8
Normalized DOPE score	-0.34

Structure Models from Chopin

Model Number	1
Profile	c.2.1.2 - 3.40.50.720 Click for model details
zscore	19.23
Residue begin	1
Residue end	249

Binding pockets

STRING

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Protein interacting with Rv2073c	Gene name	Confidence Score
Rv3790	dprE1	0.975
Rv3790	dprE1	0.975
Rv3806c	ubiA	0.916

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

No high confidence interactions