Rv3731

Tuberculist information
Gene nameligC
Protein functionPossible ATP-dependent DNA ligase LigC (polydeoxyribonucleotide synthase [ATP]) (polynucleotide ligase [ATP]) (sealase) (DNA repair protein) (DNA joinase)
Functional category(tuberculist)information pathways
Gene location(kb)4181.76
Molecular mass(da)40159.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 358
	  		  	1    MQLPVMPPVSPMLAKSVTAIPPDASYEPKWDGFRSICFRDGDQVELGSRNERPMTRYFPE   60
			  	61   LVAAIRAELPHRCVIDGEIIIATDHGLDFEALQQRIHPAESRVRMLADRTPASFIAFDLL  120
			  	121  ALGDDDYTGRPFSERRAALVDAVTGSGADADLSIHVTPATTDMATAQRWFSEFEGAGLDG  180
			  	181  VIAKPPHITYQPDKRVMFKIKHLRTADCVVAGYRVHKSGSDAIGSLLLGLYQEDGQLASV  240
			  	241  GVIGAFPMAERRRLLTELQPLVTSFDDHPWNWAAHVAGQRTPRKNEFSRWNVGKDLSFVP  300
			  	301  LRPERVVEVRYDRMEGARFRHTAQFNRWRPDRDPRSCSYAQLERPLTVSLSDIVPGLR

Known structures in the PDB
No Known structures
1 36 71 106 141 176 211 246 281 316 351 Range: 11 to 201  |  Coverage: 53% DNA_ligase_A_M Range: 219 to 332  |  Coverage: 31% DNA_ligase_A_C Range: 1 to 356  |  Coverage: 99% 1 Range: 11 to 201  |  Coverage: 53% 1 Range: 1 to 309  |  Coverage: 86% 2
Number of amino acids : 358
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DNA_ligase_A_MPF0106811-201
DNA_ligase_A_CPF04679219-332
Mtb Structural Proteome models
Model Number1
Model nameRv3731
Template2CFM    APDBCREDO
Template coverage214_557
Template Identity(%)23.3
Model coverage(%)99.2
Normalized DOPE score-0.031

Structure Models from Chopin
Model Number1
Profiled.142.2.1
Click for model details
zscore20.26
Residue begin11
Residue end201
Model Number2
Profiled.142.2.1
Click for model details
zscore14.29
Residue begin1
Residue end309
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3731Gene nameConfidence Score
Rv3730cRv3730c0.993
Rv0269cRv0269c0.945
Rv0937cmku0.929
Rv3014cligA0.91
Rv3014cligA0.91
Rv3014cligA0.91
Rv3014cligA0.91
Rv3014cligA0.91
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.928663.425
nicotinamide nucleotidePubChem0.9335.227
alpha-NMNPubChem0.9335.227
adenosine monophosphatePubChem0.9347.221