SInCRe - Rv3730c

Tuberculist information

Gene name	Rv3730c
Protein function	Conserved hypothetical protein
Functional category(tuberculist)	conserved hypotheticals
Gene location(kb)	4180.68
Molecular mass(da)	38543.7
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 346

	  		  	1    MAAAAEELDVDGIAVRLTSPDRMYFPKLGSHGTKRRLVEYYFAVAGGPMLTALRDRPTHL   60
			  	61   QRFPDGVDGEQIYQKRIPRHRPDYLQTCRVTFPSGRMADALKVTHPAAIVWAAQMGTITL  120
			  	121  HPWQVRCPDTEHPDELRIDLDPQPGTGFVEARTVAVDVLRSVLDDLGLVGYPKTSGGRGI  180
			  	181  HVFLRIATDWDFVEVRRAGIALAREVERRAPDAVTTSWWKEERGARIFIDFNQNARDRTM  240
			  	241  ASAYSVRPTPIATVSMPLTWEELAGADPDDYTMTTVPELVKIRDDPWAGMDDVAQSIAPL  300
			  	301  LDLAAADEERGLGDMPYPPNYPKMPGEPKRVQPSRDTDLKGGNTSK

Known structures in the PDB

No Known structures

Number of amino acids : 346

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
DNA_primase_S	PF01896	138-260

Mtb Structural Proteome models

Model Number	1
Model name	Rv3730c
Template	2FAO APDB CREDO
Template coverage	543_834
Template Identity(%)	29.1
Model coverage(%)	84.7
Normalized DOPE score	-0.51

Structure Models from Chopin

CHOPIN models not available for this query

Binding pockets

STRING

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Protein interacting with Rv3730c	Gene name	Confidence Score
Rv3731	ligC	0.993
Rv3731	ligC	0.993
Rv0937c	mku	0.959

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

No high confidence interactions