Rv2200c

Tuberculist information
Gene namectaC
Protein functionProbable transmembrane cytochrome C oxidase (subunit II) CtaC
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2463.66
Molecular mass(da)40447.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 363
	  		  	1    VTPRGPGRLQRLSQCRPQRGSGGPARGLRQLALAAMLGALAVTVSGCSWSEALGIGWPEG   60
			  	61   ITPEAHLNRELWIGAVIASLAVGVIVWGLIFWSAVFHRKKNTDTELPRQFGYNMPLELVL  120
			  	121  TVIPFLIISVLFYFTVVVQEKMLQIAKDPEVVIDITSFQWNWKFGYQRVNFKDGTLTYDG  180
			  	181  ADPERKRAMVSKPEGKDKYGEELVGPVRGLNTEDRTYLNFDKVETLGTSTEIPVLVLPSG  240
			  	241  KRIEFQMASADVIHAFWVPEFLFKRDVMPNPVANNSVNVFQIEEITKTGAFVGHCAEMCG  300
			  	301  TYHSMMNFEVRVVTPNDFKAYLQQRIDGKTNAEALRAINQPPLAVTTHPFDTRRGELAPQ  360
			  	361  PVG

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 54 to 136  |  Coverage: 22% COX2_TM Range: 212 to 313  |  Coverage: 27% COX2 Range: 149 to 363  |  Coverage: 58% 1 Range: 177 to 363  |  Coverage: 51% 1
Number of amino acids : 363
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
COX2_TMPF0279054-136
COX2PF00116212-313
Mtb Structural Proteome models
Model Number1
Model nameRv2200c
Template1CYX    APDBCREDO
Template coverage125_279
Template Identity(%)20.0
Model coverage(%)59.0
Normalized DOPE score0.369

Structure Models from Chopin
Model Number1
Profileb.6.1.2 - 2.60.40.420
Click for model details
zscore22.07
Residue begin177
Residue end363
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2200cGene nameConfidence Score
Rv3043cctaD0.999
Rv2193ctaE0.999
Rv1451ctaB0.982
Rv2196qcrB0.981
Rv2196qcrB0.981
Rv1456cRv1456c0.962
Rv2199cRv2199c0.953
Rv2194qcrC0.919
Rv2194qcrC0.919
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions