Rv2196

Tuberculist information
Gene nameqcrB
Protein functionProbable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2459.68
Molecular mass(da)61014.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 549
	  		  	1    MSPKLSPPNIGEVLARQAEDIDTRYHPSAALRRQLNKVFPTHWSFLLGEIALYSFVVLLI   60
			  	61   TGVYLTLFFDPSMVDVTYNGVYQPLRGVEMSRAYQSALDISFEVRGGLFVRQIHHWAALM  120
			  	121  FAAAIMVHLARIFFTGAFRRPRETNWVIGSLLLILAMFEGYFGYSLPDDLLSGLGLRAAL  180
			  	181  SSITLGMPVIGTWLHWALFGGDFPGTILIPRLYALHILLLPGIILALIGLHLALVWFQKH  240
			  	241  TQFPGPGRTEHNVVGVRVMPVFAFKSGAFFAAIVGVLGLMGGLLQINPIWNLGPYKPSQV  300
			  	301  SAGSQPDFYMMWTEGLARIWPPWEFYFWHHTIPAPVWVAVIMGLVFVLLPAYPFLEKRFT  360
			  	361  GDYAHHNLLQRPRDVPVRTAIGAMAIAFYMVLTLAAMNDIIALKFHISLNATTWIGRIGM  420
			  	421  VILPPFVYFITYRWCIGLQRSDRSVLEHGVETGIIKRLPHGAYIELHQPLGPVDEHGHPI  480
			  	481  PLQYQGAPLPKRMNKLGSAGSPGSGSFLFADSAAEDAALREAGHAAEQRALAALREHQDS  540
			  	541  IMGSPDGEH

Known structures in the PDB
No Known structures
1 55 109 163 217 271 325 379 433 487 541 Range: 41 to 234  |  Coverage: 35% Cytochrom_B_N Range: 119 to 294  |  Coverage: 31% Cytochrom_B_N_2 Range: 38 to 424  |  Coverage: 70% 1 Range: 40 to 243  |  Coverage: 36% 1 Range: 4 to 445  |  Coverage: 80% 2
Number of amino acids : 549
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Cytochrom_B_NPF0003341-234
Cytochrom_B_N_2PF13631119-294
Mtb Structural Proteome models
Model Number1
Model nameRv2196
Template2A06    CPDBCREDO
Template coverage24_367
Template Identity(%)20.9
Model coverage(%)70.3
Normalized DOPE score0.952

Structure Models from Chopin
Model Number1
Profilef.21.1.2 - 1.20.810.10
Click for model details
zscore30.58
Residue begin40
Residue end243
Model Number2
Profilef.21.1.2 - 1.20.810.10
Click for model details
zscore23.47
Residue begin4
Residue end445
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2196Gene nameConfidence Score
Rv2195qcrA0.999
Rv2194qcrC0.998
Rv2194qcrC0.998
Rv2199cRv2199c0.981
Rv2200cctaC0.981
Rv2200cctaC0.981
Rv3043cctaD0.98
Rv2193ctaE0.978
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions