Rv2194

Tuberculist information
Gene nameqcrC
Protein functionProbable ubiquinol-cytochrome C reductase QcrC (cytochrome C subunit)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2457.55
Molecular mass(da)29120.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 280
	  		  	1    LTKLGFTRSGGSKSGRTRRRLRRRLSGGVLLLIALTIAGGLAAVLTPTPQVAVADESSSA   60
			  	61   LLRTGKQLFDTSCVSCHGANLQGVPDHGPSLIGVGEAAVYFQVSTGRMPAMRGEAQAPRK  120
			  	121  DPIFDEAQIDAIGAYVQANGGGPTVVRNPDGSIATQSLRGNDLGRGGDLFRLNCASCHNF  180
			  	181  TGKGGALSSGKYAPDLAPANEQQILTAMLTGPQNMPKFSNRQLSFEAKKDIIAYVKVATE  240
			  	241  ARQPGGYLLGGFGPAPEGMAMWIIGMVAAIGLALWIGARS

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 62 to 140  |  Coverage: 27% Cytochrom_C Range: 161 to 235  |  Coverage: 26% Cytochrome_CBB3 Range: 168 to 241  |  Coverage: 26% 1 Range: 118 to 243  |  Coverage: 44% 1
Number of amino acids : 280
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Cytochrom_CPF0003462-140
Cytochrome_CBB3PF13442161-235
Mtb Structural Proteome models
Model Number1
Model nameRv2194
Template1C6R    APDBCREDO
Template coverage9_86
Template Identity(%)24.3
Model coverage(%)26.1
Normalized DOPE score-0.674

Structure Models from Chopin
Model Number1
Profilea.3.1.2
Click for model details
zscore10.47
Residue begin118
Residue end243
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2194Gene nameConfidence Score
Rv2196qcrB0.998
Rv2196qcrB0.998
Rv2195qcrA0.992
Rv2199cRv2199c0.978
Rv2193ctaE0.954
Rv3043cctaD0.919
Rv2200cctaC0.919
Rv2200cctaC0.919
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions