SInCRe - Rv3882c

Tuberculist information

Gene name	eccE1
Protein function	ESX conserved component EccE1. ESX-1 type VII secretion system protein. Possible membrane protein.
Functional category(tuberculist)	cell wall and cell processes
Gene location(kb)	4362.03
Molecular mass(da)	50396.7
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 462

	  		  	1    MRNPLGLRFSTGHALLASALAPPCIIAFLETRYWWAGIALASLGVIVATVTFYGRRITGW   60
			  	61   VAAVYAWLRRRRRPPDSSSEPVVGATVKPGDHVAVRWQGEFLVAVIELIPRPFTPTVIVD  120
			  	121  GQAHTDDMLDTGLVEELLSVHCPDLEADIVSAGYRVGNTAAPDVVSLYQQVIGTDPAPAN  180
			  	181  RRTWIVLRADPERTRKSAQRRDEGVAGLARYLVASATRIADRLASHGVDAVCGRSFDDYD  240
			  	241  HATDIGFVREKWSMIKGRDAYTAAYAAPGGPDVWWSARADHTITRVRVAPGMAPQSTVLL  300
			  	301  TTADKPKTPRGFARLFGGQRPALQGQHLVANRHCQLPIGSAGVLVGETVNRCPVYMPFDD  360
			  	361  VDIALNLGDAQTFTQFVVRAAAAGAMVTVGPQFEEFARLIGAHIGQEVKVAWPNATTYLG  420
			  	421  PHPGIDRVILRHNVIGTPRHRQLPIRRVSPPEESRYQMALPK

Known structures in the PDB

No Known structures

Number of amino acids : 462

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
DUF2984	PF11203	176-268

Mtb Structural Proteome models

Model Number	1
Model name	Rv3882c
Template	1WP9 APDB CREDO
Template coverage	22_166
Template Identity(%)	11.5
Model coverage(%)	29.9
Normalized DOPE score	0.509

Structure Models from Chopin

CHOPIN models not available for this query

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3882c	Gene name	Confidence Score
Rv3883c	mycP1	0.958
Rv3870	eccCa1	0.913
Rv3877	eccD1	0.913
Rv0177	Rv0177	0.909

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

No high confidence interactions