Rv3877

Tuberculist information
Gene nameeccD1
Protein functionESX conserved component EccD1. ESX-1 type VII secretion system protein. Probable transmembrane protein.
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)4355.01
Molecular mass(da)53981.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 511
	  		  	1    LSAPAVAAGPTAAGATAARPATTRVTILTGRRMTDLVLPAAVPMETYIDDTVAVLSEVLE   60
			  	61   DTPADVLGGFDFTAQGVWAFARPGSPPLKLDQSLDDAGVVDGSLLTLVSVSRTERYRPLV  120
			  	121  EDVIDAIAVLDESPEFDRTALNRFVGAAIPLLTAPVIGMAMRAWWETGRSLWWPLAIGIL  180
			  	181  GIAVLVGSFVANRFYQSGHLAECLLVTTYLLIATAAALAVPLPRGVNSLGAPQVAGAATA  240
			  	241  VLFLTLMTRGGPRKRHELASFAVITAIAVIAAAAAFGYGYQDWVPAGGIAFGLFIVTNAA  300
			  	301  KLTVAVARIALPPIPVPGETVDNEELLDPVATPEATSEETPTWQAIIASVPASAVRLTER  360
			  	361  SKLAKQLLIGYVTSGTLILAAGAIAVVVRGHFFVHSLVVAGLITTVCGFRSRLYAERWCA  420
			  	421  WALLAATVAIPTGLTAKLIIWYPHYAWLLLSVYLTVALVALVVVGSMAHVRRVSPVVKRT  480
			  	481  LELIDGAMIAAIIPMLLWITGVYDTVRNIRF

Known structures in the PDB
PDB ID4KV2
Total residue count184
Number of chains2
MethodX-RAY
Resolution1.88
1 52 103 154 205 256 307 358 409 460 511 Range: 21 to 108  |  Coverage: 17% YukD Range: 1 to 511  |  Coverage: 99% 1
Number of amino acids : 511
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
YukDPF0881721-108
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
Model Number1
Profiled.258.1.1 - 3.60.150.10
Click for model details
zscore4.54
Residue begin1
Residue end511
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3877Gene nameConfidence Score
Rv3876espI0.994
Rv3875esxA0.981
Rv3878espJ0.979
Rv3874esxB0.978
Rv3871eccCb10.974
Rv3866espG10.961
Rv3870eccCa10.959
Rv3873PPE680.953
Rv3879cespK0.932
Rv3869eccB10.931
Rv3882ceccE10.913
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions