Rv3870

Tuberculist information
Gene nameeccCa1
Protein functionESX conserved component EccCa1. ESX-1 type VII secretion system protein. Possible transmembrane protein.
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)4346.48
Molecular mass(da)80913
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 747
	  		  	1    MTTKKFTPTITRGPRLTPGEISLTPPDDLGIDIPPSGVQKILPYVMGGAMLGMIAIMVAG   60
			  	61   GTRQLSPYMLMMPLMMIVMMVGGLAGSTGGGGKKVPEINADRKEYLRYLAGLRTRVTSSA  120
			  	121  TSQVAFFSYHAPHPEDLLSIVGTQRQWSRPANADFYAATRIGIGDQPAVDRLLKPAVGGE  180
			  	181  LAAASAAPQPFLEPVSHMWVVKFLRTHGLIHDCPKLLQLRTFPTIAIGGDLAGAAGLMTA  240
			  	241  MICHLAVFHPPDLLQIRVLTEEPDDPDWSWLKWLPHVQHQTETDAAGSTRLIFTRQEGLS  300
			  	301  DLAARGPHAPDSLPGGPYVVVVDLTGGKAGFPPDGRAGVTVITLGNHRGSAYRIRVHEDG  360
			  	361  TADDRLPNQSFRQVTSVTDRMSPQQASRIARKLAGWSITGTILDKTSRVQKKVATDWHQL  420
			  	421  VGAQSVEEITPSRWRMYTDTDRDRLKIPFGHELKTGNVMYLDIKEGAEFGAGPHGMLIGT  480
			  	481  TGSGKSEFLRTLILSLVAMTHPDQVNLLLTDFKGGSTFLGMEKLPHTAAVVTNMAEEAEL  540
			  	541  VSRMGEVLTGELDRRQSILRQAGMKVGAAGALSGVAEYEKYRERGADLPPLPTLFVVVDE  600
			  	601  FAELLQSHPDFIGLFDRICRVGRSLRVHLLLATQSLQTGGVRIDKLEPNLTYRIALRTTS  660
			  	661  SHESKAVIGTPEAQYITNKESGVGFLRVGMEDPVKFSTFYISGPYMPPAAGVETNGEAGG  720
			  	721  PGQQTTRQAARIHRFTAAPVLEEAPTP

Known structures in the PDB
No Known structures
1 75 149 223 297 371 445 519 593 667 741 Range: 428 to 638  |  Coverage: 28% FtsK_SpoIIIE Range: 450 to 672  |  Coverage: 29% 1 Range: 442 to 667  |  Coverage: 30% 1
Number of amino acids : 747
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FtsK_SpoIIIEPF01580428-638
Mtb Structural Proteome models
Model Number1
Model nameRv3870
Template1G6H    APDBCREDO
Template coverage12_249
Template Identity(%)15.2
Model coverage(%)29.7
Normalized DOPE score0.121

Structure Models from Chopin
Model Number1
Profileb.2.5.3
Click for model details
zscore8.2
Residue begin442
Residue end667
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3870Gene nameConfidence Score
Rv3869eccB10.994
Rv3868eccA10.986
Rv3866espG10.976
Rv3877eccD10.959
Rv3874esxB0.953
Rv3616cespA0.952
Rv3864espE0.947
Rv3867espH0.939
Rv3871eccCb10.921
Rv3882ceccE10.913
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions