Rv3393

Tuberculist information
Gene nameiunH
Protein functionProbable nucleoside hydrolase IunH (purine nucleosidase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3808.46
Molecular mass(da)32937.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 308
	  		  	1    VSVVFADVDTGIDDALAVIYLLASPDADLVGIASTGGNIAVGQVCANNLSLLELCGAADI   60
			  	61   PVSKGADEPLGGRWPDHPKFHGPKGIGYAELPASNRRLTDYDATTAWIAAAHSHAGDLIG  120
			  	121  LVTGPLTNLALALRAEPALPRLLRRLVIMGGMFDGQPITEWNIRVDPEAASEVFTAWAGQ  180
			  	181  RQLPIVCGLDLTRRVAMTPDILARLASVCGSSPVMRVIEDALRFYFESHEARGHGYLAYM  240
			  	241  HDPLAAAVAMDPELLTTRTATVDVDPTGATVTDWSGKRNPNARIGMSVDPAVFFDRFVER  300
			  	301  IGRFARRT

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 1 to 305  |  Coverage: 98% IU_nuc_hydro Range: 2 to 305  |  Coverage: 98% 1 Range: 1 to 308  |  Coverage: 99% 1
Number of amino acids : 308
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
IU_nuc_hydroPF011561-305
Mtb Structural Proteome models
Model Number1
Model nameRv3393
Template1YOE    APDBCREDO
Template coverage3_311
Template Identity(%)31.8
Model coverage(%)98.4
Normalized DOPE score-0.822

Structure Models from Chopin
Model Number1
Profilec.70.1.1 - 3.90.245.10
Click for model details
zscore50.45
Residue begin1
Residue end308
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3393Gene nameConfidence Score
Rv2436rbsK0.98
Rv3307deoD0.964
Rv2584capt0.956
Rv3313cadd0.953
Rv2043cpncA0.934
Rv3624chpt0.927
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ribosePubChem0.957150.13
inosinePubChem0.955268.226
nicotinamide ribosidePubChem0.948255.247
D-ribosePubChem0.941150.13
adenosinePubChem0.937267.241
nicotinic acidPubChem0.928122.101
hydroxyl radicalsPubChem0.90917.0073
hypoxanthinePubChem0.905136.111
H(+)PubChem0.9022.01588
deuteriumPubChem0.9022.01588
SODIUM XANTHINEPubChem0.9152.111
nicotinamide ribosePubChem0.9255.247
adeninePubChem0.9135.127
vitamin BPubChem0.9122.125
ammoniaPubChem0.917.0305
guaninePubChem0.9151.126
protiumPubChem0.92.01576
calciumPubChem0.81640.078