Rv1647

Tuberculist information
Gene nameRv1647
Protein functionAdenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1856.77
Molecular mass(da)33938.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 316
	  		  	1    LAGSARTTYPCHVEVGPQDSESGAPDETATAMASPVPRQRSALRWLRTVNRSPGLVSFIH   60
			  	61   RARRLLPGDPEFGDPLSTAGEGGPRAAARAADRLLRDRDAASREVGLSVLQVWQALTEAV  120
			  	121  SRRPANPEVTLVFTDLVGFSTWSLHAGDDATLTLLRQVARAVESPLLDAGGHIVKRLGDG  180
			  	181  IMAVFRNPTVALRAVLVAQDAVKSLEVQGYTPRMRIGIHTGRPQRLAADWLGVDVNIAAR  240
			  	241  VMERATKGGIMISQPTLDLIPQSELDALGVVARRVRKPVFASKPTGIPPDLAIYRIKTVS  300
			  	301  ESTAADNFDEMSPDAQ

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 122 to 282  |  Coverage: 50% Guanylate_cyc Range: 28 to 298  |  Coverage: 85% 1 Range: 114 to 315  |  Coverage: 63% 1
Number of amino acids : 316
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Guanylate_cycPF00211122-282
Mtb Structural Proteome models
Model Number1
Model nameRv1647
Template1Y10    APDBCREDO
Template coverage130_376
Template Identity(%)20.5
Model coverage(%)85.4
Normalized DOPE score0.436

Structure Models from Chopin
Model Number1
Profiled.58.29.1 - 3.30.70.1230
Click for model details
zscore20.36
Residue begin114
Residue end315
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1647Gene nameConfidence Score
Rv1625ccya0.961
Rv1359Rv13590.941
Rv1319cRv1319c0.924
Rv1319cRv1319c0.924
Rv1318cRv1318c0.923
Rv1318cRv1318c0.923
Rv1320cRv1320c0.913
Rv1320cRv1320c0.913
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions