Rv1319c

Tuberculist information
Gene nameRv1319c
Protein functionPossible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1480.89
Molecular mass(da)58097.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 535
	  		  	1    MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMT   60
			  	61   ANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIR  120
			  	121  WAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTIC  180
			  	181  GVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTA  240
			  	241  LYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLR  300
			  	301  GDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRH  360
			  	361  AAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAP  420
			  	421  NRLDRPEDAALAAARAIADRLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVN  480
			  	481  QAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT

Known structures in the PDB
No Known structures
1 54 107 160 213 266 319 372 425 478 531 Range: 258 to 327  |  Coverage: 12% HAMP Range: 356 to 533  |  Coverage: 33% Guanylate_cyc Range: 361 to 533  |  Coverage: 32% 1 Range: 356 to 533  |  Coverage: 33% 1
Number of amino acids : 535
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HAMPPF00672258-327
Guanylate_cycPF00211356-533
Mtb Structural Proteome models
Model Number1
Model nameRv1319c
Template1YBT    APDBCREDO
Template coverage296_452
Template Identity(%)35.7
Model coverage(%)32.1
Normalized DOPE score-0.059

Structure Models from Chopin
Model Number1
Profiled.58.29.1 - 3.30.70.1230
Click for model details
zscore32.18
Residue begin356
Residue end533
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1319cGene nameConfidence Score
Rv1647Rv16470.924
Rv1264Rv12640.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Target nameCHEMBL IDSMILES
Adenylyl CyclaseC[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)COS(=O)(=O)c5ccc(Br)cc5
Adenylyl CyclaseOC(=O)c1cc2C3C(C4C(c2cc1S(=O)(=O)O)C5(Cl)C(=C(Cl)C4(Cl)C5(Cl)Cl)Cl)C6(Cl)C(=C(Cl)C3(Cl)C6(Cl)Cl)Cl
Adenylyl CyclaseCC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]2(O)C(=O)C[C@@](C)(O[C@]12C)C=C
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
guanosine triphosphatePubChem0.9523.18
adenosine triphosphatePubChem0.9507.181