SInCRe - Rv1264

Tuberculist information

Gene name	Rv1264
Protein function	Adenylyl cyclase (ATP pyrophosphate-lyase) (adenylate cyclase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	1411.89
Molecular mass(da)	42200
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 397

	  		  	1    VTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLV   60
			  	61   GDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVEL  120
			  	121  GLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGP  180
			  	181  MIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGH  240
			  	241  LAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAG  300
			  	301  VASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPR  360
			  	361  RLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP

Known structures in the PDB

	PDB ID	1Y10
	Total residue count	1628
	Number of chains	4
	Method	X-RAY
	Resolution	2.3

	PDB ID	1Y11
	Total residue count	407
	Number of chains	1
	Method	X-RAY
	Resolution	3.3

	PDB ID	2EV1
	Total residue count	444
	Number of chains	2
	Method	X-RAY
	Resolution	1.6

	PDB ID	2EV2
	Total residue count	444
	Number of chains	2
	Method	X-RAY
	Resolution	2.35

	PDB ID	2EV3
	Total residue count	444
	Number of chains	2
	Method	X-RAY
	Resolution	2.68

	PDB ID	2EV4
	Total residue count	444
	Number of chains	2
	Method	X-RAY
	Resolution	2.28

Number of amino acids : 397

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Guanylate_cyc	PF00211	209-376

Mtb Structural Proteome models

Model Number	1
Model name	Rv1264_2ev1_A
Template	2EV1 APDB CREDO
Template coverage	11_195
Template Identity(%)	100.0
Model coverage(%)	46.3
Normalized DOPE score	-0.722

Model Number	2
Model name	Rv1264_1y10_A
Template	1Y10 APDB CREDO
Template coverage	14_376
Template Identity(%)	100.0
Model coverage(%)	91.2
Normalized DOPE score	-0.63

Model Number	3
Model name	Rv1264
Template	1Y10 APDB CREDO
Template coverage	14_376
Template Identity(%)	100.0
Model coverage(%)	91.2
Normalized DOPE score	-0.385

Structure Models from Chopin

Model Number	1
Profile	d.58.29.1 - 3.30.70.1230 Click for model details
zscore	9.93
Residue begin	201
Residue end	393

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1264	Gene name	Confidence Score
Rv0891c	Rv0891c	0.959
Rv1359	Rv1359	0.92
Rv1318c	Rv1318c	0.918
Rv1318c	Rv1318c	0.918
Rv1265	Rv1265	0.916
Rv1319c	Rv1319c	0.905
Rv1319c	Rv1319c	0.905

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
oleic acidPubChem	0.919	282.461
PEG400PubChem	0.9	238.278
adenosine triphosphatePubChem	0.9	507.181
chloridePubChem	0.9	35.453
guanosine triphosphatePubChem	0.9	523.18
sulfatePubChem	0.9	96.0626
hydron sulfatePubChem	0.9	196.157
calciumPubChem	0.9	40.078
glycerolPubChem	0.9	92.0938