Rv1320c

Tuberculist information
Gene nameRv1320c
Protein functionPossible adenylate cyclase (ATP pyrophosphate-lyase) (adenylyl cyclase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1482.51
Molecular mass(da)61964.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 567
	  		  	1    MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILV   60
			  	61   TNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRW  120
			  	121  AIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIG  180
			  	181  VVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAI  240
			  	241  FDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSG  300
			  	301  DLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHV  360
			  	361  AVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPN  420
			  	421  RLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNE  480
			  	481  AARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLTSPVQQLQMP  540
			  	541  AQSADIVGGALGDHQTHTIYRGAHPTD

Known structures in the PDB
No Known structures
1 57 113 169 225 281 337 393 449 505 561 Range: 257 to 326  |  Coverage: 12% HAMP Range: 355 to 533  |  Coverage: 31% Guanylate_cyc Range: 356 to 528  |  Coverage: 30% 1 Range: 355 to 533  |  Coverage: 31% 1
Number of amino acids : 567
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HAMPPF00672257-326
Guanylate_cycPF00211355-533
Mtb Structural Proteome models
Model Number1
Model nameRv1320c
Template1WC3    APDBCREDO
Template coverage1007_1190
Template Identity(%)34.1
Model coverage(%)30.3
Normalized DOPE score-0.309

Structure Models from Chopin
Model Number1
Profiled.58.29.1 - 3.30.70.1230
Click for model details
zscore27.5
Residue begin355
Residue end533
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1320cGene nameConfidence Score
Rv1647Rv16470.913
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Target nameCHEMBL IDSMILES
Adenylyl CyclaseC[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)COS(=O)(=O)c5ccc(Br)cc5
Adenylyl CyclaseOC(=O)c1cc2C3C(C4C(c2cc1S(=O)(=O)O)C5(Cl)C(=C(Cl)C4(Cl)C5(Cl)Cl)Cl)C6(Cl)C(=C(Cl)C3(Cl)C6(Cl)Cl)Cl
Adenylyl CyclaseCC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]2(O)C(=O)C[C@@](C)(O[C@]12C)C=C
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
guanosine triphosphatePubChem0.9523.18
adenosine triphosphatePubChem0.9507.181