Rv1423

Tuberculist information
Gene namewhiA
Protein functionProbable transcriptional regulatory protein WhiA
Functional category(tuberculist)regulatory proteins
Gene location(kb)1597.91
Molecular mass(da)34933
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 325
	  		  	1    MTTDVKDELSRLVVKSVSARRAEVTSLLRFAGGLHIVGGRVVVEAELDLGSIARRLRKEI   60
			  	61   FELYGYTAVVHVLSASGIRKSTRYVLRVANDGEALARQTGLLDMRGRPVRGLPAQVVGGS  120
			  	121  IDDAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALALVGAARRLGVGAKAREVRGAD  180
			  	181  RVVVRDGEAIGALLTRMGAQDTRLVWEERRLRREVRATANRLANFDDANLRRSARAAVAA  240
			  	241  AARVERALEILGDTVPEHLASAGKLRVEHRQASLEELGRLADPPMTKDAVAGRIRRLLSM  300
			  	301  ADRKAKVDGIPDTESVVTPDLLEDA

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 17 to 102  |  Coverage: 26% WhiA_N Range: 124 to 216  |  Coverage: 28% LAGLIDADG_WhiA Range: 219 to 302  |  Coverage: 25% HTH_WhiA Range: 24 to 320  |  Coverage: 91% 1 Range: 253 to 318  |  Coverage: 20% 1 Range: 17 to 102  |  Coverage: 26% 2
Number of amino acids : 325
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
WhiA_NPF1029817-102
LAGLIDADG_WhiAPF14527124-216
HTH_WhiAPF02650219-302
Mtb Structural Proteome models
Model Number1
Model nameRv1423
Template1DQ3    APDBCREDO
Template coverage142_446
Template Identity(%)12.1
Model coverage(%)91.1
Normalized DOPE score1.121

Structure Models from Chopin
Model Number1
Profilea.4.5.32
Click for model details
zscore4.48
Residue begin253
Residue end318
Model Number2
Profiled.95.2.2
Click for model details
zscore4.29
Residue begin17
Residue end102
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1423Gene nameConfidence Score
Rv1422Rv14220.989
Rv1421Rv14210.979
Rv1420uvrC0.939
Rv1420uvrC0.939
Rv1420uvrC0.939
Rv1420uvrC0.939
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions