Rv1421

Tuberculist information
Gene nameRv1421
Protein functionConserved protein
Functional category(tuberculist)conserved hypotheticals
Gene location(kb)1595.98
Molecular mass(da)32912.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 301
	  		  	1    MMNHARGVENRSEGGGIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNLPPQLITRMVDFG   60
			  	61   LAAGSRITQLAVVMDVRSRGFTGDLDSVRNELATRAITPRVVFMEASDDTLVRRYEQNRR  120
			  	121  SHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSTLSVGGLRDSIERAFGGDGGATTSV  180
			  	181  TVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTGQHPAVRDYVLHRPGAAEFLESY  240
			  	241  HRLLSLVVDGYRREGKRYMTIAIGCTGGKHRSVAIAEALMGLLRSDQQLSVRALHRDLGR  300
			  	301  E

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 17 to 301  |  Coverage: 94% ATP_bind_2 Range: 18 to 171  |  Coverage: 50% 1 Range: 14 to 179  |  Coverage: 54% 1
Number of amino acids : 301
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ATP_bind_2PF0366817-301
Mtb Structural Proteome models
Model Number1
Model nameRv1421
Template2G1K    APDBCREDO
Template coverage3_167
Template Identity(%)24.0
Model coverage(%)50.8
Normalized DOPE score-0.19

Structure Models from Chopin
Model Number1
Profilec.37.1.25 - 3.40.50.300
Click for model details
zscore10.47
Residue begin14
Residue end179
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1421Gene nameConfidence Score
Rv1422Rv14220.989
Rv1423whiA0.979
Rv1423whiA0.979
Rv1423whiA0.979
Rv1420uvrC0.962
Rv1420uvrC0.962
Rv1420uvrC0.962
Rv1420uvrC0.962
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions