Rv0445c

Tuberculist information
Gene namesigK
Protein functionAlternative RNA polymerase sigma factor SigK
Functional category(tuberculist)information pathways
Gene location(kb)533.833
Molecular mass(da)21034.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 187
	  		  	1    MTGPPRLSSDLDALLRRVAGHDQAAFAEFYDHTKSRVYGLVMRVLRDTGYSEETTQEIYL   60
			  	61   EVWRNASEFDSAKGSALAWLLTMAHRRAVDRVRCEQAGNQREVRYGAANVDPASDVVADL  120
			  	121  AIAGDERRRVTECLKALTDTQRQCIELAYYGGLTYVEVSRRLAANLSTIKSRMRDALRSL  180
			  	181  RNCLDVS

Known structures in the PDB
PDB ID4NQW
Total residue count284
Number of chains2
MethodX-RAY
Resolution2.4
1 19 37 55 73 91 109 127 145 163 181 Range: 29 to 98  |  Coverage: 36% Sigma70_r2 Range: 133 to 182  |  Coverage: 26% Sigma70_r4 Range: 6 to 185  |  Coverage: 95% 1 Range: 3 to 117  |  Coverage: 60% 1
Number of amino acids : 187
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Sigma70_r2PF0454229-98
Sigma70_r4PF04545133-182
Mtb Structural Proteome models
Model Number1
Model nameRv0445c
Template1OR7    APDBCREDO
Template coverage0_186
Template Identity(%)21.8
Model coverage(%)95.7
Normalized DOPE score-0.372

Structure Models from Chopin
Model Number1
Profilea.177.1.1
Click for model details
zscore13.82
Residue begin3
Residue end117
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0445cGene nameConfidence Score
Rv0444crskA0.997
Rv2876Rv28760.964
Rv0449cRv0449c0.936
Rv2875mpt700.934
Rv3911sigM0.924
Rv3911sigM0.924
Rv0448cRv0448c0.91
Rv0446cRv0446c0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions