Rv3911

Tuberculist information
Gene namesigM
Protein functionPossible alternative RNA polymerase sigma factor SigM
Functional category(tuberculist)information pathways
Gene location(kb)4400.19
Molecular mass(da)24404.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 222
	  		  	1    MPPPIGYCPAVGFGGRHERSDAELLAAHVAGDRYAFDQLFRRHHRQLHRLARLTSRTSED   60
			  	61   ADDALQDAMLSAHRGAGSFRYDAAVSSWLHRIVVNACLDRLRRAKAHPTAPLEDVYPVAD  120
			  	121  RTAQVETAIAVQRALMRLPVEQRAAVVAVDMQGYSIADTRPDAGRGRGHRQEPLRPGAGP  180
			  	181  PSAAAGLSQHRGEHPALTPLPVRRSIDPRARRYPTSGYCHRA

Known structures in the PDB
No Known structures
1 23 45 67 89 111 133 155 177 199 221 Range: 39 to 107  |  Coverage: 30% Sigma70_r2 Range: 138 to 185  |  Coverage: 21% HTH_27 Range: 17 to 181  |  Coverage: 73% 1 Range: 13 to 192  |  Coverage: 80% 1 Range: 28 to 102  |  Coverage: 33% 2 Range: 13 to 126  |  Coverage: 50% 3
Number of amino acids : 222
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Sigma70_r2PF0454239-107
HTH_27PF13463138-185
Mtb Structural Proteome models
Model Number1
Model nameRv3911
Template1OR7    APDBCREDO
Template coverage3_181
Template Identity(%)23.6
Model coverage(%)73.9
Normalized DOPE score-0.433

Structure Models from Chopin
Model Number1
Profilea.177.1.1, a.4.13.2 - 1.10.10.10, 1.10.1740.10
Click for model details
zscore30.05
Residue begin13
Residue end192
Model Number2
Profilea.177.1.1 - 1.10.1740.10
Click for model details
zscore24.24
Residue begin28
Residue end102
Model Number3
Profilea.177.1.1
Click for model details
zscore21.54
Residue begin13
Residue end126
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3911Gene nameConfidence Score
Rv2069sigC0.933
Rv2069sigC0.933
Rv0445csigK0.924
Rv0445csigK0.924
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions