Rv0084

Tuberculist information
Gene namehycD
Protein functionPossible formate hydrogenlyase HycD (FHL)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)92.328
Molecular mass(da)32153.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 316
	  		  	1    MSYLAGAAQIGGVMVGAPLVIGMTRQVRARWEGRAGAGLLQPWRDLLKQLGKQQITPAGT   60
			  	61   TIVFAAAPVIVAGTTLLIAAIAPLVATGSPLDPSADLFAVVGLLFLGTVALTLAGIDTGT  120
			  	121  SFGGMGASREITIAALVEPTILLAVFALSIPAGSANLGALVASTIDHPGHVVSLAGVLAF  180
			  	181  VALVIVIVAETGRLPVDNPATHLELTMVHEAMVLEYAGPRLALVEWAAGMRLTVLLALLA  240
			  	241  NLFLPWGIAGAAPTALDVLTGVVAVAAKVAILAVLLATFEVFLAKLRLFRVPELLAGSFL  300
			  	301  LALLAVTAANFFTVGA

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 4 to 314  |  Coverage: 98% NADHdh
Number of amino acids : 316
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NADHdhPF001464-314
Mtb Structural Proteome models
Structure models not available for this query
Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
Structure models not available for this query
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0084Gene nameConfidence Score
Rv0087hycE0.999
Rv0087hycE0.999
Rv0087hycE0.999
Rv0082Rv00820.996
Rv0083Rv00830.996
Rv0085hycP0.995
Rv0086hycQ0.995
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
formatePubChem0.92445.0174
pyruvic acidPubChem0.988.0621
Co-APubChem0.9767.534
acetyl-CoAPubChem0.9809.571
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
protiumPubChem0.92.01576
carbon dioxidePubChem0.944.0095
coenzyme APubChem0.9767.534
acetyl coenzyme-APubChem0.9809.571