Indian Institute of Science, Bangalore
Maintained by Richa Mudgal
Copyright (c) 2013 IISc. All rights reserved. | Design by FreeCSSTemplates.org
For each of 3087 protein family with unknown function (DUFs/UPFs) and no known structures, family profile (hidden Markov model) or a
representative sequence were queried against SCOP-NrichD database, SUPFAM+ database , SUPERFAMILY database, pDomTHREADER and
HHsearch against SCOP-profile database (1.75v).
For 614 DUF families, a SCOP superfamily could be associated at various stringent cut-offs using 5 different
sensitive computational methods.
15 DUF families were predicted to have same SCOP superfamily by all 5 methods.
39 DUF families were predicted to have same SCOP superfamily by any 4 methods.
50 DUF families were predicted to have same SCOP superfamily by any of the 3 methods.
89 DUF families were predicted to have same SCOP superfamily by any of the 2 methods.
421 DUF families were predicted to have SCOP superfamily by any 1 method.
| S. No. | Pfam Accession | Description | Pfam Clan | Number of sequences (Full and Seed) | Profile Length | Query Sequence length | SCOP-superfamily prediction (domain boundry) | SCOP-Fold | SCOP-NrichD Predictions | SUPFAM+ Predictions | SUPERFAMILY database Predictions | pDomTHREADER Predictions | HHsearch Predictions | Confidence Score | Essential DUF | Phylogenetic Kingdoms | Associated EC numbers | GO (Cellular component) | GO (Molecular function) | GO (Biological process) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | PF04311 | Protein of unknown function (DUF459) | SGNH_hydrolase (CL0264) | 172 (2) | 327 | 327 | (1) SGNH hydrolase [c.23.10] (80-324) |
(1) Flavodoxin-like [c.23] |
c.23.10(7-241) | c.23.10(110-325) | c.23.10(113-321) | c.23.10(80-324) | c.23.10(114-321) | 5 | No information | Eukaryota|Bacteria | 3.1.1.2| 3.1.1.47| 3.1.1.5| 3.1.1.53| 3.1.1.72| 3.2.1.4 | No information | carboxylic ester hydrolase activity | sexual reproduction| spermatogenesis |
| 2 | PF04601 | Protein of unknown function (DUF569) | Trefoil (CL0066) | 184 (7) | 142 | 144 | (1) Actin-crosslinking proteins [b.42.5] (2-144) |
(1) beta-Trefoil [b.42] |
b.42.5(10-142) | b.42.5(7-129) | b.42.5(5-134) | b.42.5(2-144) | b.42.5(9-120) | 5 | No information | Eukaryota | No information | No information | actin binding| actin filament binding | actin cytoskeleton organization| actin filament organization |
| 3 | PF06866 | Protein of unknown function (DUF1256) | Peptidase_ML (CL0095) | 439 (13) | 164 | 165 | (1) HybD-like [c.56.1] (1-165) |
(1) Phosphorylase/hydrolase-like [c.56] |
c.56.1(6-125) | c.56.1(1-163) | c.56.1(2-164) | c.56.1(1-165) | c.56.1(4-123) | 5 | No information | Bacteria|Viruses | 3.4.23.51| 3.4.24.78 | No information | No information | No information |
| 4 | PF07588 | Protein of unknown function (DUF1554) | No Pfam Clan | 119 (15) | 142 | 144 | (1) C-type lectin-like [d.169.1] (1-144) |
(1) C-type lectin-like [d.169] |
d.169.1(2-141) | d.169.1(6-133) | d.169.1(4-135) | d.169.1(1-144) | d.169.1(4-137) | 5 | No information | Bacteria | No information | extracellular matrix| extracellular matrix part| proteinaceous extracellular matrix | carbohydrate binding| galactose binding| receptor activity | biological adhesion| cell adhesion| negative regulation of epidermal cell differentiation| negative regulation of epidermis development| negative regulation of epithelial cell differentiation| negative regulation of keratinocyte differentiation| ossification| positive regulation of keratinocyte proliferation| positive regulation of wound healing| regulation of epidermal cell differentiation| regulation of epidermis development| regulation of keratinocyte differentiation| regulation of keratinocyte proliferation |
| 5 | PF11813 | Protein of unknown function (DUF3334) | CheC-like (CL0355) | 187 (19) | 229 | 233 | (1) CheC-like [d.252.1] (7-228) |
(1) CheC-like [d.252] |
d.252.1(10-173) | d.252.1(7-228) | d.252.1(11-173) | d.252.1(3-177) | d.252.1(11-173) | 5 | No information | Bacteria | No information | No information | No information | No information |
| 6 | PF07602 | Protein of unknown function (DUF1565) | Pec_lyase-like (CL0268) | 240 (8) | 246 | 273 | (1) Pectin lyase-like [b.80.1] (1-273) |
(1) Single-stranded right-handed beta-helix [b.80] |
b.80.1(1-241) | b.80.1(1-245) | b.80.1(2-253) | b.80.1(1-273) | b.80.1(2-219) | 5 | No information | Eukaryota|Bacteria|Archaea | 3.1.1.11| 3.2.1.11| 3.2.1.15| 3.2.1.157| 3.2.1.57| 3.2.1.58| 3.4.21.72| 4.2.2.10| 4.2.2.18| 4.2.2.19| 4.2.2.2| 4.2.2.7 | anchored to membrane| plant-type cell wall | carbon-oxygen lyase activity, acting on polysaccharides| carboxylic ester hydrolase activity| galacturan 1,4-alpha-galacturonidase activity| pectinesterase activity| polygalacturonase activity | cell growth| cell wall organization or biogenesis| developmental cell growth| developmental growth| developmental growth involved in morphogenesis| external encapsulating structure organization| galacturonan metabolic process| pectin catabolic process| plant-type cell wall organization| plant-type cell wall organization or biogenesis| pollen tube development| pollen tube growth| pollination| polysaccharide catabolic process| polysaccharide metabolic process| unidimensional cell growth |
| 7 | PF07609 | Protein of unknown function (DUF1572) | DinB (CL0310) | 202 (15) | 163 | 163 | (1) DinB/YfiT-like putative metalloenzymes [a.213.1] (1-155) |
(1) DinB/YfiT-like putative metalloenzymes [a.213] |
a.213.1(2-152) | a.213.1(3-151) | a.213.1(7-150) | a.213.1(1-155) | a.213.1(3-149) | 5 | No information | Bacteria | 5.2.1.4 | No information | No information | No information |
| 8 | PF07894 | Protein of unknown function (DUF1669) | PLD (CL0479) | 379 (23) | 284 | 284 | (1) Phospholipase D/nuclease [d.136.1] (84-283) |
(1) Phospholipase D/nuclease [d.136] |
d.136.1(84-283) | d.136.1(90-283) | d.136.1(120-283) | d.136.1(118-282) | d.136.1(118-284) | 5 | No information | Eukaryota | 2.7.4.1| 2.7.8.8| 3.1.21.4| 3.1.4.4 | mitochondrial outer membrane| organelle outer membrane| outer membrane | cardiolipin hydrolase activity| lipase activity| phospholipase activity| phosphoric diester hydrolase activity| protein homodimerization activity | DNA alkylation| DNA methylation| DNA methylation involved in gamete generation| DNA methylation or demethylation| DNA modification| P granule organization| anterior/posterior axis specification| anterior/posterior axis specification, embryo| anterior/posterior pattern specification| axis specification| blastoderm segmentation| cell maturation| cellular membrane fusion| cellular membrane organization| cellular process involved in reproduction in multicellular organism| cytoplasm organization| developmental maturation| embryonic axis specification| embryonic pattern specification| epithelial cell development| female gamete generation| germ cell development| macromolecule methylation| maternal determination of anterior/posterior axis, embryo| meiosis| meiotic cell cycle| membrane fusion| mitochondrial fusion| mitochondrion organization| oocyte anterior/posterior axis specification| oocyte axis specification| oocyte construction| oocyte development| oocyte differentiation| oogenesis| organelle fusion| piRNA metabolic process| pole plasm assembly| regulation of gene expression, epigenetic| ribonucleoprotein complex subunit organization| segmentation| spermatid development| spermatid differentiation| spermatogenesis| tripartite regional subdivision |
| 9 | PF04862 | Protein of unknown function (DUF642) | GBD (CL0202) | 419 (56) | 159 | 157 | (1) Galactose-binding domain-like [b.18.1] (2-158) |
(1) Galactose-binding domain-like [b.18] |
b.18.1(3-158) | b.18.1(2-158) | b.18.1(2-156) | b.18.1(2-157) | b.18.1(2-156) | 5 | No information | Eukaryota|Bacteria | 3.2.1.165| 3.2.1.31| 3.2.1.40| 3.2.1.50| 3.2.1.97| 3.5.3.4| 4.2.2.10 | cullin-RING ubiquitin ligase complex| nuclear ubiquitin ligase complex| ubiquitin ligase complex | carbohydrate binding| fucose binding| hydrolase activity, hydrolyzing O-glycosyl compounds| ubiquitin-protein ligase activity | branching involved in mammary gland duct morphogenesis| branching morphogenesis of an epithelial tube| embryo implantation| gland morphogenesis| mammary gland alveolus development| mammary gland development| mammary gland duct morphogenesis| mammary gland epithelium development| mammary gland lobule development| mammary gland morphogenesis| morphogenesis of a branching structure| morphogenesis of an epithelium| multi-multicellular organism process| peptidyl-tyrosine modification| peptidyl-tyrosine phosphorylation| proteasomal ubiquitin-dependent protein catabolic process| regulation of acute inflammatory response| regulation of cell adhesion| regulation of cell growth| regulation of cell-matrix adhesion| regulation of cell-substrate adhesion| regulation of cellular defense response| regulation of complement activation| regulation of complement activation, lectin pathway| regulation of humoral immune response| regulation of protein activation cascade| regulation of protein processing |
| 10 | PF05705 | Eukaryotic protein of unknown function (DUF829) | AB_hydrolase (CL0028) | 555 (43) | 240 | 264 | (1) alpha/beta-Hydrolases [c.69.1] (1-264) |
(1) alpha/beta-Hydrolases [c.69] |
c.69.1(52-239) | c.69.1(1-239) | c.69.1(2-115)| c.69.1(191-264) | c.69.1(1-264) | c.69.1(1-264) | 5 | No information | Eukaryota | 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 | trans-Golgi network transport vesicle | CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity | acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process |
| 11 | PF04007 | Protein of unknown function (DUF354) | GT-B (CL0113) | 167 (4) | 335 | 338 | (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (1-334) |
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87] |
c.87.1(1-333) | c.87.1(1-334) | c.87.1(4-313) | c.87.1(2-180) | c.87.1(10-336) | 5 | No information | Bacteria|Archaea | 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 | alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) | UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups | L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process |
| 12 | PF09865 | Predicted periplasmic protein (DUF2092) | No Pfam Clan | 95 (17) | 215 | 218 | (1) Prokaryotic lipoproteins and lipoprotein localization factors [b.125.1] (4-215) |
(1) LolA-like prokaryotic lipoproteins and lipoprotein localization factors [b.125] |
b.125.1(5-212) | b.125.1(4-213) | b.125.1(4-207) | b.125.1(4-215) | b.125.1(6-213) | 5 | No information | Bacteria | No information | No information | No information | No information |
| 13 | PF07944 | Putative glycosyl hydrolase of unknown function (DUF1680) | 6_Hairpin (CL0059) | 1388 (20) | 520 | 521 | (1) Six-hairpin glycosidases [a.102.1] (1-417) |
(1) alpha/alpha toroid [a.102] |
a.102.1(19-331) | a.102.1(59-391) | a.102.1(73-327) | a.102.1(1-417) | a.102.1(87-345) | 5 | No information | Eukaryota|Bacteria|Archaea | 2.4.1.20| 2.4.1.8| 3.2.1.132| 3.2.1.156| 3.2.1.28| 3.2.1.3| 3.2.1.4| 3.2.1.40| 3.2.1.63| 3.2.1.70| 3.2.1.8| 3.2.1.91| 5.1.3.8| 5.3.1.8 | brush border | N-acylglucosamine 2-epimerase activity| cellulase activity| hydrolase activity, hydrolyzing O-glycosyl compounds| racemase and epimerase activity| racemase and epimerase activity, acting on carbohydrates and derivatives | cell wall organization or biogenesis| cellular carbohydrate catabolic process| cellular polysaccharide metabolic process| oligosaccharide catabolic process| oligosaccharide metabolic process| polysaccharide metabolic process |
| 14 | PF11230 | Protein of unknown function (DUF3029) | PFL-like (CL0339) | 631 (19) | 487 | 484 | (1) PFL-like glycyl radical enzymes [c.7.1] (1-486) |
(1) PFL-like glycyl radical enzymes [c.7] |
c.7.1(1-468) | c.7.1(1-486) | c.7.1(5-450) | c.7.1(1-468) | c.7.1(6-447) | 5 | No information | Bacteria | 1.17.4.1| 1.17.4.2| 2.3.1.54 | No information | No information | No information |
| 15 | PF06080 | Protein of unknown function (DUF938) | NADP_Rossmann (CL0063) | 529 (6) | 204 | 204 | (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (1-204) |
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66] |
c.66.1(22-189) | c.66.1(1-197) | c.66.1(10-202) | c.66.1(1-204) | c.66.1(4-201) | 5 | No information | Eukaryota|Bacteria|Viruses | 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 | nuclear matrix | glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups | Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process |
| 16 | PF10007 | Uncharacterized protein conserved in archaea (DUF2250) | HTH (CL0123) | 100 (18) | 93 | 93 | (1) "Winged helix" DNA-binding domain [a.4.5] (3-92) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
a.4.5(6-88) | a.4.5(3-92) | a.4.5(2-61) | NO PREDICTION | a.4.5(3-92) | 4 | No information | Bacteria|Archaea | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 17 | PF06162 | Caenorhabditis elegans protein of unknown function (DUF976) | PgaPase (CL0379) | 29 (6) | 166 | 157 | (1) Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) [c.56.4] (22-166) |
(1) Phosphorylase/hydrolase-like [c.56] |
c.56.4(22-166) | c.56.4(24-160) | NO PREDICTION | c.56.4(23-157) | c.56.4(25-139) | 4 | No information | Eukaryota | 3.4.19.3 | No information | No information | No information |
| 18 | PF06779 | Protein of unknown function (DUF1228) | MFS (CL0015) | 952 (12) | 85 | 85 | (1) MFS general substrate transporter [f.38.1] (3-84) |
(1) MFS general substrate transporter [f.38] |
f.38.1(7-85) | f.38.1(1-79) | f.38.1(3-84) | NO PREDICTION | f.38.1(4-83) | 4 | No information | Eukaryota|Bacteria|Viruses | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 19 | PF09970 | Nucleotidyl transferase of unknown function (DUF2204) | NTP_transf (CL0260) | 161 (15) | 181 | 179 | (1) Nucleotidyltransferase [d.218.1] (3-152) |
(1) Nucleotidyltransferase [d.218] |
d.218.1(3-152) | d.218.1(1-148) | d.218.1(10-146) | NO PREDICTION | d.218.1(2-142) | 4 | No information | Eukaryota|Bacteria|Archaea | 2.7.6.5| 2.7.7.19| 2.7.7.31| 2.7.7.42| 2.7.7.52| 2.7.7.7| 2.7.7.72 | No information | adenylyltransferase activity| double-stranded RNA binding | No information |
| 20 | PF10184 | Uncharacterized conserved protein (DUF2358) | NTF2 (CL0051) | 393 (29) | 113 | 107 | (1) NTF2-like [d.17.4] (1-112) |
(1) Cystatin-like [d.17] |
d.17.4(2-113) | d.17.4(1-112) | d.17.4(3-107) | NO PREDICTION | d.17.4(17-107) | 4 | No information | Eukaryota|Bacteria | 3.3.2.8| 4.2.1.94| 5.3.3.1 | T-tubule| axon initial segment| axon part| cell-cell contact zone| main axon| neuromuscular junction| nuclear envelope| pore complex| sarcolemma | Ran GTPase binding | G1/S transition of mitotic cell cycle| RNA export from nucleus| RNA localization| antibiotic biosynthetic process| antibiotic metabolic process| blood circulation| calcium ion transport| cardiac muscle contraction| cell cycle phase| cell cycle phase transition| drug metabolic process| establishment of RNA localization| heart contraction| heart process| interphase| interphase of mitotic cell cycle| mitotic cell cycle phase transition| muscle contraction| muscle system process| nuclear transport| nucleobase-containing compound transport| nucleocytoplasmic transport| peptidyl-serine phosphorylation| poly(A)+ mRNA export from nucleus| positive regulation of antimicrobial peptide biosynthetic process| positive regulation of cellular amide metabolic process| protein autophosphorylation| regulation of antimicrobial humoral response| regulation of antimicrobial peptide biosynthetic process| regulation of antimicrobial peptide production| regulation of cellular amide metabolic process| regulation of humoral immune response| regulation of production of molecular mediator of immune response| regulation of sodium ion transport| striated muscle contraction |
| 21 | PF04305 | Protein of unknown function (DUF455) | No Pfam Clan | 772 (81) | 253 | 249 | (1) Ferritin-like [a.25.1] (10-227) |
(1) Ferritin-like [a.25] |
a.25.1(69-225) | a.25.1(10-227) | a.25.1(64-215) | NO PREDICTION | a.25.1(64-204) | 4 | YES | Eukaryota|Bacteria | 1.11.1.6| 1.14.13.25| 1.14.19.2| 1.16.3.1| 1.17.4.1| 4.2.1.52 | ferritin complex| intracellular ferritin complex| ribonucleoside-diphosphate reductase complex | iron ion binding| oxidoreductase activity, acting on CH or CH2 groups| oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor| ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | DNA replication| cellular ketone metabolic process| cellular transition metal ion homeostasis| deoxyribonucleoside triphosphate metabolic process| deoxyribonucleotide biosynthetic process| deoxyribonucleotide metabolic process| immune response| intracellular sequestering of iron ion| iron ion homeostasis| ketone biosynthetic process| kidney development| maintenance of location| maintenance of location in cell| metal ion homeostasis| mitochondrial DNA metabolic process| mitochondrial DNA replication| mitochondrial genome maintenance| mitochondrion organization| negative regulation of apoptotic signaling pathway| negative regulation of cell proliferation| negative regulation of intrinsic apoptotic signaling pathway| negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator| negative regulation of signal transduction by p53 class mediator| oxidoreduction coenzyme metabolic process| photosynthesis| quinone biosynthetic process| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of apoptotic signaling pathway| regulation of intrinsic apoptotic signaling pathway| regulation of intrinsic apoptotic signaling pathway by p53 class mediator| regulation of signal transduction by p53 class mediator| renal system process| response to iron ion| sequestering of metal ion| transition metal ion homeostasis| ubiquinone biosynthetic process| ubiquinone metabolic process |
| 22 | PF11350 | Protein of unknown function (DUF3152) | Peptidase_MA (CL0126) | 313 (17) | 204 | 206 | (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (28-203) |
(1) Zincin-like [d.92] |
d.92.1(32-158) | d.92.1(28-203) | d.92.1(30-191) | NO PREDICTION | d.92.1(31-185) | 4 | No information | Bacteria | 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 | cortical granule | glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity | biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing |
| 23 | PF08551 | Eukaryotic integral membrane protein (DUF1751) | Rhomboid-like (CL0207) | 355 (23) | 99 | 96 | (1) Rhomboid-like [f.51.1] (1-99) |
(1) Rhomboid-like [f.51] |
f.51.1(1-99) | f.51.1(5-96) | f.51.1(5-94) | NO PREDICTION | f.51.1(5-63) | 4 | No information | Eukaryota|Bacteria | 3.4.21.105 | No information | No information | No information |
| 24 | PF14125 | Domain of unknown function (DUF4292) | No Pfam Clan | 228 (73) | 210 | 205 | (1) Prokaryotic lipoproteins and lipoprotein localization factors [b.125.1] (2-210) |
(1) LolA-like prokaryotic lipoproteins and lipoprotein localization factors [b.125] |
b.125.1(2-210) | b.125.1(1-193) | b.125.1(7-104) | NO PREDICTION | b.125.1(5-185) | 4 | YES | Bacteria | No information | No information | No information | No information |
| 25 | PF03754 | Domain of unknown function (DUF313) | DNA_b-psBarrel (CL0405) | 95 (14) | 114 | 113 | (1) DNA-binding pseudobarrel domain [b.142.1] (17-113) |
(1) DNA-binding pseudobarrel domain [b.142] |
b.142.1(19-113) | NO PREDICTION | b.142.1(20-113) | b.142.1(17-113) | b.142.1(19-113) | 4 | No information | Eukaryota | No information | No information | No information | No information |
| 26 | PF04301 | Protein of unknown function (DUF452) | AB_hydrolase (CL0028) | 358 (2) | 213 | 212 | (1) alpha/beta-Hydrolases [c.69.1] (3-212) |
(1) alpha/beta-Hydrolases [c.69] |
NO PREDICTION | c.69.1(3-212) | c.69.1(52-203) | c.69.1(8-212) | c.69.1(13-114) | 4 | YES | Bacteria | 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 | trans-Golgi network transport vesicle | CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity | acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process |
| 27 | PF05631 | Protein of unknown function (DUF791) | MFS (CL0015) | 263 (3) | 354 | 377 | (1) MFS general substrate transporter [f.38.1] (29-374) |
(1) MFS general substrate transporter [f.38] |
f.38.1(29-374) | f.38.1(27-333) | f.38.1(40-147)| f.38.1(198-352) | NO PREDICTION | f.38.1(54-327) | 4 | No information | Eukaryota|Bacteria | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 28 | PF10230 | Uncharacterised conserved protein (DUF2305) | AB_hydrolase (CL0028) | 346 (27) | 266 | 258 | (1) alpha/beta-Hydrolases [c.69.1] (1-265) |
(1) alpha/beta-Hydrolases [c.69] |
c.69.1(2-265) | c.69.1(1-265) | c.69.1(4-166) | NO PREDICTION | c.69.1(2-140) | 4 | No information | Eukaryota|Bacteria | 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 | trans-Golgi network transport vesicle | CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity | acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process |
| 29 | PF07082 | Protein of unknown function (DUF1350) | AB_hydrolase (CL0028) | 176 (3) | 250 | 248 | (1) alpha/beta-Hydrolases [c.69.1] (14-249) |
(1) alpha/beta-Hydrolases [c.69] |
c.69.1(4-236) | c.69.1(14-249) | c.69.1(8-126)| c.69.1(153-206) | NO PREDICTION | c.69.1(23-207) | 4 | No information | Eukaryota|Bacteria | 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 | trans-Golgi network transport vesicle | CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity | acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process |
| 30 | PF11010 | Protein of unknown function (DUF2848) | FAH (CL0377) | 154 (37) | 194 | 193 | (1) FAH [d.177.1] (10-183) |
(1) FAH [d.177] |
d.177.1(12-182) | d.177.1(10-183) | d.177.1(17-182) | NO PREDICTION | d.177.1(12-181) | 4 | No information | Bacteria|Archaea | 3.7.1.2| 4.2.1.80| 5.3.3.10 | No information | hydrolase activity, acting on acid carbon-carbon bonds | No information |
| 31 | PF14372 | Domain of unknown function (DUF4413) | No Pfam Clan | 377 (79) | 101 | 103 | (1) Ribonuclease H-like [c.55.3] (2-102) |
(1) Ribonuclease H-like motif [c.55] |
c.55.3(1-101) | c.55.3(1-100) | c.55.3(2-102) | NO PREDICTION | c.55.3(1-64) | 4 | No information | Eukaryota|Bacteria | 2.7.7.7| 3.1.11.1| 3.1.13.1| 3.1.13.4| 3.1.13.5| 3.1.22.4| 3.1.26.4| 3.6.4.12 | CCR4-NOT complex| DNA polymerase complex| cytoplasmic mRNA processing body| micro-ribonucleoprotein complex| nucleolus| ribonuclease H2 complex| ribonucleoprotein granule | DNA polymerase activity| DNA-directed DNA polymerase activity| endoribonuclease activity, producing 5'-phosphomonoesters| exonuclease activity| nuclease activity| ribonuclease H activity| transposase activity | DNA catabolic process| DNA replication| DNA replication, removal of RNA primer| DNA strand elongation| RNA 3'-end processing| RNA catabolic process| RNA phosphodiester bond hydrolysis| cytoplasmic mRNA processing body assembly| gene silencing| gene silencing by RNA| lagging strand elongation| mRNA 3'-end processing| mitochondrial genome maintenance| mitotic DNA integrity checkpoint| mitotic G2 DNA damage checkpoint| ncRNA 3'-end processing| negative regulation of DNA metabolic process| negative regulation of DNA recombination| negative regulation of mitotic recombination| negative regulation of translation| nuclear-transcribed mRNA poly(A) tail shortening| nucleic acid phosphodiester bond hydrolysis| positive regulation of catabolic process| positive regulation of cellular catabolic process| positive regulation of mRNA catabolic process| positive regulation of mRNA processing| regulation of DNA metabolic process| regulation of DNA recombination| regulation of mRNA 3'-end processing| regulation of mRNA catabolic process| regulation of mRNA processing| regulation of mitotic recombination| response to ionizing radiation| ribonucleoprotein complex biogenesis| ribonucleoprotein complex subunit organization| transposition| transposition, DNA-mediated |
| 32 | PF05677 | Chlamydia CHLPS protein (DUF818) | AB_hydrolase (CL0028) | 50 (5) | 365 | 361 | (1) alpha/beta-Hydrolases [c.69.1] (105-361) |
(1) alpha/beta-Hydrolases [c.69] |
NO PREDICTION | c.69.1(108-364) | c.69.1(157-297) | c.69.1(105-361) | c.69.1(102-232) | 4 | No information | Eukaryota|Bacteria | 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 | trans-Golgi network transport vesicle | CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity | acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process |
| 33 | PF08937 | MTH538 TIR-like domain (DUF1863) | STIR (CL0173) | 389 (55) | 130 | 188 | (1) Hypothetical protein MTH538 [c.23.3] (66-168) (2) Toll/Interleukin receptor TIR domain [c.23.2] (3-120) |
(1) Flavodoxin-like [c.23] |
c.23.2(3-120) | c.23.2(1-111) | c.23.2(1-102) | NO PREDICTION | c.23.3(66-168)| c.23.2(1-113) | 4 | No information | Bacteria|Viruses|Archaea | No information | No information | No information | No information |
| 34 | PF11251 | Protein of unknown function (DUF3050) | HO (CL0230) | 145 (32) | 232 | 230 | (1) Heme oxygenase-like [a.132.1] (1-232) |
(1) Heme oxygenase-like [a.132] |
a.132.1(1-232) | a.132.1(1-231) | a.132.1(3-229) | NO PREDICTION | a.132.1(2-230) | 4 | No information | Eukaryota|Bacteria | 1.14.99.3| 1.3.3.11| 2.5.1.2| 3.5.99.2 | No information | No information | heme metabolic process| pigment metabolic process| porphyrin-containing compound metabolic process| tetrapyrrole metabolic process |
| 35 | PF11695 | Domain of unknown function (DUF3291) | Dim_A_B_barrel (CL0032) | 150 (34) | 140 | 138 | (1) Dimeric alpha+beta barrel [d.58.4] (2-107) |
(1) Ferredoxin-like [d.58] |
d.58.4(12-99) | d.58.4(2-107) | d.58.4(18-111) | NO PREDICTION | d.58.4(18-94) | 4 | No information | Bacteria | 1.13.11.49| 1.13.11.55| 1.14.99.3| 5.3.3.4| 5.4.99.14 | No information | No information | No information |
| 36 | PF11274 | Protein of unknown function (DUF3074) | Bet_V_1_like (CL0209) | 152 (28) | 184 | 194 | (1) Bet v1-like [d.129.3] (1-183) |
(1) TBP-like [d.129] |
d.129.3(38-172) | d.129.3(1-183) | d.129.3(14-193) | NO PREDICTION | d.129.3(18-185) | 4 | No information | Eukaryota | 1.14.12.12| 1.14.12.18| 3.1.3.16| 4.2.1.78 | intercellular canaliculus| microvillus | abscisic acid binding| alcohol binding| alcohol transmembrane transporter activity| anion transmembrane transporter activity| carboxylic acid binding| hormone binding| isoprenoid binding| lipid transporter activity| monocarboxylic acid binding| organic anion transmembrane transporter activity| organic cation transmembrane transporter activity| organic hydroxy compound transmembrane transporter activity| phosphate transmembrane transporter activity| phosphatidylcholine transporter activity| phospholipid transporter activity| protein homodimerization activity| quaternary ammonium group transmembrane transporter activity | abscisic acid mediated signaling pathway| acid secretion| bile acid secretion| cellular response to abscisic acid stimulus| cellular response to alcohol| cellular response to hormone stimulus| cellular response to lipid| hormone-mediated signaling pathway| lipid localization| lipid transport| monocarboxylic acid transport| organic anion transport| organophosphate ester transport| phospholipid transport| positive regulation of peroxisome proliferator activated receptor signaling pathway| quaternary ammonium group transport| regulation of peroxisome proliferator activated receptor signaling pathway| regulation of post-embryonic development| response to abscisic acid stimulus| response to alcohol| response to hormone stimulus| response to lipid |
| 37 | PF07845 | Protein of unknown function (DUF1636) | No Pfam Clan | 189 (52) | 116 | 114 | (1) Thioredoxin-like [c.47.1] (1-105) |
(1) Thioredoxin fold [c.47] |
c.47.1(1-84) | c.47.1(1-105) | c.47.1(2-102) | NO PREDICTION | c.47.1(1-82) | 4 | No information | Bacteria | 1.1.4.2| 1.11.1.12| 1.11.1.15| 1.11.1.7| 1.11.1.9| 1.20.4.1| 1.8.1.7| 1.8.1.8| 1.8.1.9| 1.8.4.2| 1.8.4.7| 1.8.4.8| 1.8.5.1| 2.5.1.18| 5.2.1.2| 5.3.4.1| 5.3.99.3 | NADH dehydrogenase complex| chloroplast stroma| ferredoxin hydrogenase complex| formate dehydrogenase complex| myelin sheath| plastid stroma| respiratory chain complex I | antioxidant activity| arsenate reductase activity| disulfide oxidoreductase activity| electron carrier activity| formate dehydrogenase (NAD+) activity| glutathione binding| glutathione transferase activity| intramolecular oxidoreductase activity| intramolecular oxidoreductase activity, interconverting keto- and enol-groups| intramolecular oxidoreductase activity, transposing S-S bonds| oxidoreductase activity, acting on a sulfur group of donors| oxidoreductase activity, acting on hydrogen as donor| oxidoreductase activity, acting on peroxide as acceptor| oxidoreductase activity, acting on phosphorus or arsenic in donors| oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor| peroxidase activity| peroxiredoxin activity| phospholipid-hydroperoxide glutathione peroxidase activity| prostaglandin-F synthase activity| protein disulfide isomerase activity| thioredoxin peroxidase activity | androecium development| anther development| cell redox homeostasis| cellular response to hydrogen peroxide| cellular response to oxidative stress| cellular response to reactive oxygen species| fatty acid derivative biosynthetic process| fatty acid derivative metabolic process| floral organ development| floral whorl development| flower development| formate metabolic process| hydrogen peroxide catabolic process| icosanoid biosynthetic process| nucleolus organization| phyllome development| positive regulation of DNA binding| positive regulation of binding| prostanoid biosynthetic process| protein deglutathionylation| protein folding| reactive oxygen species metabolic process| regulation of DNA binding| regulation of binding| regulation of intracellular transport| regulation of protein import into nucleus| regulation of protein import into nucleus, translocation| regulation of protein localization to nucleus| removal of superoxide radicals| response to hydrogen peroxide| response to hydroperoxide| response to reactive oxygen species| response to selenium ion| shoot system development| stamen development| toxin catabolic process| unsaturated fatty acid biosynthetic process| unsaturated fatty acid metabolic process |
| 38 | PF11854 | Protein of unknown function (DUF3374) | MBB (CL0193) | 127 (30) | 637 | 599 | (1) Porins [f.4.3] (14-636) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.3(14-636) | f.4.3(343-564)| f.4.3(164-376) | f.4.3(51-599) | f.4.3(156-567) | 4 | No information | Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 39 | PF12048 | Protein of unknown function (DUF3530) | AB_hydrolase (CL0028) | 175 (36) | 310 | 303 | (1) alpha/beta-Hydrolases [c.69.1] (61-309) |
(1) alpha/beta-Hydrolases [c.69] |
NO PREDICTION | c.69.1(61-309) | c.69.1(101-244) | c.69.1(64-302) | c.69.1(78-302) | 4 | No information | Bacteria | 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 | trans-Golgi network transport vesicle | CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity | acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process |
| 40 | PF09314 | Domain of unknown function (DUF1972) | GT-B (CL0113) | 494 (12) | 185 | 185 | (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (3-184) |
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87] |
c.87.1(3-183) | c.87.1(3-184) | c.87.1(6-171) | NO PREDICTION | c.87.1(3-184) | 4 | No information | Bacteria|Archaea | 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 | alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) | UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups | L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process |
| 41 | PF14358 | Domain of unknown function (DUF4405) | 2heme_cytochrom (CL0328) | 320 (112) | 64 | 63 | (1) Transmembrane di-heme cytochromes [f.21.1] (1-63) |
(1) Heme-binding four-helical bundle [f.21] |
f.21.1(7-64) | f.21.1(1-63) | f.21.1(8-61) | NO PREDICTION | f.21.1(4-61) | 4 | No information | Bacteria|Archaea | 1.10.2.2 | No information | electron carrier activity | cellular respiration |
| 42 | PF04937 | Protein of unknown function (DUF 659) | No Pfam Clan | 467 (15) | 153 | 164 | (1) Ribonuclease H-like [c.55.3] (5-153) |
(1) Ribonuclease H-like motif [c.55] |
c.55.3(5-153) | c.55.3(22-152) | c.55.3(26-138) | NO PREDICTION | c.55.3(23-163) | 4 | No information | Eukaryota | 2.7.7.7| 3.1.11.1| 3.1.13.1| 3.1.13.4| 3.1.13.5| 3.1.22.4| 3.1.26.4| 3.6.4.12 | CCR4-NOT complex| DNA polymerase complex| cytoplasmic mRNA processing body| micro-ribonucleoprotein complex| nucleolus| ribonuclease H2 complex| ribonucleoprotein granule | DNA polymerase activity| DNA-directed DNA polymerase activity| endoribonuclease activity, producing 5'-phosphomonoesters| exonuclease activity| nuclease activity| ribonuclease H activity| transposase activity | DNA catabolic process| DNA replication| DNA replication, removal of RNA primer| DNA strand elongation| RNA 3'-end processing| RNA catabolic process| RNA phosphodiester bond hydrolysis| cytoplasmic mRNA processing body assembly| gene silencing| gene silencing by RNA| lagging strand elongation| mRNA 3'-end processing| mitochondrial genome maintenance| mitotic DNA integrity checkpoint| mitotic G2 DNA damage checkpoint| ncRNA 3'-end processing| negative regulation of DNA metabolic process| negative regulation of DNA recombination| negative regulation of mitotic recombination| negative regulation of translation| nuclear-transcribed mRNA poly(A) tail shortening| nucleic acid phosphodiester bond hydrolysis| positive regulation of catabolic process| positive regulation of cellular catabolic process| positive regulation of mRNA catabolic process| positive regulation of mRNA processing| regulation of DNA metabolic process| regulation of DNA recombination| regulation of mRNA 3'-end processing| regulation of mRNA catabolic process| regulation of mRNA processing| regulation of mitotic recombination| response to ionizing radiation| ribonucleoprotein complex biogenesis| ribonucleoprotein complex subunit organization| transposition| transposition, DNA-mediated |
| 43 | PF05872 | Bacterial protein of unknown function (DUF853) | P-loop_NTPase (CL0023) | 1311 (9) | 504 | 499 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (7-422) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
c.37.1(7-422) | c.37.1(17-376) | c.37.1(9-379) | NO PREDICTION | c.37.1(12-321) | 4 | YES | Eukaryota|Bacteria|Archaea | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 44 | PF14237 | Domain of unknown function (DUF4339) | No Pfam Clan | 701 (59) | 45 | 45 | (1) GYF domain [d.76.1] (3-44) |
(1) GYF/BRK domain-like [d.76] |
d.76.1(2-38) | d.76.1(1-41) | d.76.1(3-44) | NO PREDICTION | d.76.1(2-40) | 4 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 45 | PF11997 | Domain of unknown function (DUF3492) | GT-B (CL0113) | 322 (39) | 268 | 281 | (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (INDIRECT) |
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87] |
c.87.1(1-268) | c.87.1(INDIRECT) | c.87.1(3-89)| c.87.1(173-209)| c.87.1(237-280) | NO PREDICTION | c.87.1(1-43) | 4 | No information | Eukaryota|Bacteria|Viruses|Archaea | 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 | alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) | UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups | L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process |
| 46 | PF10698 | Protein of unknown function (DUF2505) | Bet_V_1_like (CL0209) | 427 (34) | 159 | 163 | (1) Bet v1-like [d.129.3] (1-162) |
(1) TBP-like [d.129] |
d.129.3(5-149) | d.129.3(1-158) | NO PREDICTION | d.129.3(1-162) | d.129.3(2-156) | 4 | No information | Eukaryota|Bacteria|Viruses | 1.14.12.12| 1.14.12.18| 3.1.3.16| 4.2.1.78 | intercellular canaliculus| microvillus | abscisic acid binding| alcohol binding| alcohol transmembrane transporter activity| anion transmembrane transporter activity| carboxylic acid binding| hormone binding| isoprenoid binding| lipid transporter activity| monocarboxylic acid binding| organic anion transmembrane transporter activity| organic cation transmembrane transporter activity| organic hydroxy compound transmembrane transporter activity| phosphate transmembrane transporter activity| phosphatidylcholine transporter activity| phospholipid transporter activity| protein homodimerization activity| quaternary ammonium group transmembrane transporter activity | abscisic acid mediated signaling pathway| acid secretion| bile acid secretion| cellular response to abscisic acid stimulus| cellular response to alcohol| cellular response to hormone stimulus| cellular response to lipid| hormone-mediated signaling pathway| lipid localization| lipid transport| monocarboxylic acid transport| organic anion transport| organophosphate ester transport| phospholipid transport| positive regulation of peroxisome proliferator activated receptor signaling pathway| quaternary ammonium group transport| regulation of peroxisome proliferator activated receptor signaling pathway| regulation of post-embryonic development| response to abscisic acid stimulus| response to alcohol| response to hormone stimulus| response to lipid |
| 47 | PF13200 | Putative glycosyl hydrolase domain | Glyco_hydro_tim (CL0058) | 311 (62) | 316 | 321 | (1) (Trans)glycosidases [c.1.8] (1-321) |
(1) TIM beta/alpha-barrel [c.1] |
NO PREDICTION | c.1.8(14-314) | c.1.8(15-319) | c.1.8(1-321) | c.1.8(12-315) | 4 | No information | Eukaryota|Bacteria|Archaea | 2.4.1.18| 2.4.1.19| 2.4.1.25| 2.4.1.4| 2.4.1.5| 2.4.1.7| 2.7.1.31| 2.7.7.43| 3.1.3.16| 3.1.3.18| 3.1.3.2| 3.1.3.23| 3.1.3.24| 3.1.3.29| 3.1.3.3| 3.1.3.41| 3.1.3.45| 3.1.3.48| 3.1.3.5| 3.1.3.70| 3.1.3.71| 3.1.3.74| 3.1.8.2| 3.11.1.1| 3.2.1.1| 3.2.1.10| 3.2.1.105| 3.2.1.123| 3.2.1.133| 3.2.1.135| 3.2.1.136| 3.2.1.139| 3.2.1.14| 3.2.1.141| 3.2.1.147| 3.2.1.151| 3.2.1.165| 3.2.1.17| 3.2.1.2| 3.2.1.20| 3.2.1.21| 3.2.1.22| 3.2.1.23| 3.2.1.25| 3.2.1.31| 3.2.1.32| 3.2.1.35| 3.2.1.37| 3.2.1.39| 3.2.1.4| 3.2.1.41| 3.2.1.45| 3.2.1.48| 3.2.1.49| 3.2.1.51| 3.2.1.52| 3.2.1.54| 3.2.1.55| 3.2.1.58| 3.2.1.60| 3.2.1.68| 3.2.1.70| 3.2.1.73| 3.2.1.78| 3.2.1.8| 3.2.1.85| 3.2.1.86| 3.2.1.89| 3.2.1.96| 3.2.1.98| 3.6.1.1| 3.6.3.10| 3.6.3.4| 3.6.3.6| 3.6.3.8| 3.6.3.9| 3.8.1.2| 4.2.2.13| 5.4.2.6| 5.4.2.8| 5.4.99.11| 5.4.99.15 | anchored to membrane| anchored to plasma membrane| cell wall| fungal-type cell wall| hyaluranon cable| lysosome | beta-mannosidase activity| galactosidase activity| glucanosyltransferase activity| hyaluronan synthase activity| hydrolase activity, hydrolyzing O-glycosyl compounds| transferase activity, transferring glycosyl groups| virus receptor activity | aminoglycan biosynthetic process| aminoglycan catabolic process| aminoglycan metabolic process| autolysis| cartilage development| cell wall beta-glucan metabolic process| cell wall macromolecule catabolic process| cell wall macromolecule metabolic process| cell wall organization or biogenesis| cellular carbohydrate catabolic process| cellular polysaccharide catabolic process| cellular polysaccharide metabolic process| cellular response to UV| cellular response to UV-B| cellular response to abiotic stimulus| cellular response to cytokine stimulus| cellular response to growth factor stimulus| cellular response to interleukin-1| cellular response to light stimulus| cellular response to pH| cellular response to platelet-derived growth factor stimulus| cellular response to radiation| ceramide catabolic process| ceramide metabolic process| connective tissue development| cytolysis| diaphragm contraction| external encapsulating structure organization| glucosamine-containing compound catabolic process| glucosamine-containing compound metabolic process| glycosaminoglycan catabolic process| glycosphingolipid catabolic process| glycosylceramide catabolic process| glycosylceramide metabolic process| hyaluronan biosynthetic process| hyaluronan catabolic process| hyaluronan metabolic process| inflammatory response| involuntary skeletal muscle contraction| lysosome organization| mannan metabolic process| membrane lipid catabolic process| multicellular organismal movement| negative regulation of cell growth| negative regulation of growth| neuromuscular process controlling balance| neuromuscular process controlling posture| peptidoglycan turnover| polysaccharide catabolic process| polysaccharide metabolic process| positive regulation of angiogenesis| positive regulation of cell adhesion| positive regulation of cell growth| positive regulation of epithelial cell migration| positive regulation of epithelial cell proliferation| positive regulation of hyaluranon cable assembly| regulation of angiogenesis| regulation of cell growth| regulation of cell migration| regulation of cell motility| regulation of cellular component movement| regulation of epithelial cell migration| regulation of hyaluranon cable assembly| regulation of locomotion| regulation of vasculature development| respiratory gaseous exchange| respiratory system process| response to UV| response to UV-B| response to antibiotic| response to cytokine stimulus| response to growth factor stimulus| response to interleukin-1| response to pH| response to platelet-derived growth factor stimulus| response to reactive oxygen species| response to toxic substance| response to virus| single-species biofilm formation| skeletal muscle contraction| skeletal system development| sphingolipid catabolic process| vacuole organization |
| 48 | PF09967 | VWA-like domain (DUF2201) | vWA-like (CL0128) | 512 (16) | 126 | 126 | (1) vWA-like [c.62.1] (1-125) |
(1) vWA-like [c.62] |
c.62.1(1-118) | c.62.1(1-125) | c.62.1(1-101) | NO PREDICTION | c.62.1(1-94) | 4 | No information | Eukaryota|Bacteria|Viruses|Archaea | No information | extracellular matrix | No information | DNA repair| double-strand break repair| double-strand break repair via nonhomologous end joining| non-recombinational repair| response to ionizing radiation |
| 49 | PF11968 | Putative methyltransferase (DUF3321) | NADP_Rossmann (CL0063) | 219 (25) | 220 | 221 | (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (4-216) |
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66] |
c.66.1(4-216) | c.66.1(1-197) | c.66.1(45-183) | NO PREDICTION | c.66.1(28-187) | 4 | No information | Eukaryota | 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 | nuclear matrix | glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups | Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process |
| 50 | PF11288 | Protein of unknown function (DUF3089) | AB_hydrolase (CL0028) | 100 (25) | 208 | 199 | (1) alpha/beta-Hydrolases [c.69.1] (2-197) |
(1) alpha/beta-Hydrolases [c.69] |
c.69.1(2-197) | c.69.1(1-139) | c.69.1(77-132) | NO PREDICTION | c.69.1(77-138) | 4 | No information | Eukaryota|Bacteria|Archaea | 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 | trans-Golgi network transport vesicle | CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity | acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process |
| 51 | PF10890 | Protein of unknown function (DUF2741) | UcrQ-like (CL0429) | 42 (4) | 72 | 72 | (1) Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [f.23.13] (5-71) |
(1) Single transmembrane helix [f.23] |
f.23.13(7-71) | f.23.13(5-71) | f.23.13(10-66) | NO PREDICTION | f.23.13(10-62) | 4 | No information | Eukaryota | No information | No information | No information | No information |
| 52 | PF11865 | Domain of unknown function (DUF3385) | TPR (CL0020) | 388 (32) | 160 | 161 | (1) ARM repeat [a.118.1] (1-160) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(1-160) | a.118.1(6-159) | a.118.1(4-46)| a.118.1(80-159) | NO PREDICTION | a.118.1(2-160) | 4 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 53 | PF05988 | Bacterial protein of unknown function (DUF899) | Thioredoxin (CL0172) | 520 (51) | 211 | 233 | (1) Thioredoxin-like [c.47.1] (48-213) |
(1) Thioredoxin fold [c.47] |
c.47.1(42-174) | c.47.1(38-193) | c.47.1(58-152) | NO PREDICTION | c.47.1(48-213) | 4 | No information | Eukaryota|Bacteria | 1.1.4.2| 1.11.1.12| 1.11.1.15| 1.11.1.7| 1.11.1.9| 1.20.4.1| 1.8.1.7| 1.8.1.8| 1.8.1.9| 1.8.4.2| 1.8.4.7| 1.8.4.8| 1.8.5.1| 2.5.1.18| 5.2.1.2| 5.3.4.1| 5.3.99.3 | NADH dehydrogenase complex| chloroplast stroma| ferredoxin hydrogenase complex| formate dehydrogenase complex| myelin sheath| plastid stroma| respiratory chain complex I | antioxidant activity| arsenate reductase activity| disulfide oxidoreductase activity| electron carrier activity| formate dehydrogenase (NAD+) activity| glutathione binding| glutathione transferase activity| intramolecular oxidoreductase activity| intramolecular oxidoreductase activity, interconverting keto- and enol-groups| intramolecular oxidoreductase activity, transposing S-S bonds| oxidoreductase activity, acting on a sulfur group of donors| oxidoreductase activity, acting on hydrogen as donor| oxidoreductase activity, acting on peroxide as acceptor| oxidoreductase activity, acting on phosphorus or arsenic in donors| oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor| peroxidase activity| peroxiredoxin activity| phospholipid-hydroperoxide glutathione peroxidase activity| prostaglandin-F synthase activity| protein disulfide isomerase activity| thioredoxin peroxidase activity | androecium development| anther development| cell redox homeostasis| cellular response to hydrogen peroxide| cellular response to oxidative stress| cellular response to reactive oxygen species| fatty acid derivative biosynthetic process| fatty acid derivative metabolic process| floral organ development| floral whorl development| flower development| formate metabolic process| hydrogen peroxide catabolic process| icosanoid biosynthetic process| nucleolus organization| phyllome development| positive regulation of DNA binding| positive regulation of binding| prostanoid biosynthetic process| protein deglutathionylation| protein folding| reactive oxygen species metabolic process| regulation of DNA binding| regulation of binding| regulation of intracellular transport| regulation of protein import into nucleus| regulation of protein import into nucleus, translocation| regulation of protein localization to nucleus| removal of superoxide radicals| response to hydrogen peroxide| response to hydroperoxide| response to reactive oxygen species| response to selenium ion| shoot system development| stamen development| toxin catabolic process| unsaturated fatty acid biosynthetic process| unsaturated fatty acid metabolic process |
| 54 | PF05951 | Bacterial protein of unknown function (DUF882) | Peptidase_MD (CL0170) | 1137 (10) | 153 | 151 | (1) Hedgehog/DD-peptidase [d.65.1] (22-152) |
(1) Hedgehog/DD-peptidase [d.65] |
d.65.1(23-153) | d.65.1(22-152) | d.65.1(24-151) | NO PREDICTION | d.65.1(35-151) | 4 | YES | Eukaryota|Bacteria | 3.4.13.22| 3.4.17.14 | No information | No information | No information |
| 55 | PF10356 | Protein of unknown function (DUF2034) | PDDEXK (CL0236) | 178 (11) | 185 | 185 | (1) Restriction endonuclease-like [c.52.1] (INDIRECT) |
(1) Restriction endonuclease-like [c.52] |
c.52.1(9-154) | c.52.1(INDIRECT) | NO PREDICTION | NO PREDICTION | c.52.1(9-153) | 3 | No information | Eukaryota | 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 | No information | endonuclease activity| nuclease activity | DNA repair| nucleotide-excision repair |
| 56 | PF12010 | Domain of unknown function (DUF3502) | No Pfam Clan | 679 (18) | 134 | 140 | (1) Periplasmic binding protein-like II [c.94.1] (1-135) |
(1) Periplasmic binding protein-like II [c.94] |
c.94.1(1-132) | NO PREDICTION | c.94.1(4-135) | NO PREDICTION | c.94.1(1-135) | 3 | No information | Eukaryota|Bacteria | 1.16.1.2| 2.4.2.17| 2.5.1.2| 2.5.1.61| 3.13.1.3| 3.6.3.24 | ATP-binding cassette (ABC) transporter complex| cell envelope| coated pit| early endosome| external encapsulating structure part| periplasmic space| recycling endosome | ATPase activity| ATPase activity, coupled| ATPase activity, coupled to movement of substances| P-P-bond-hydrolysis-driven transmembrane transporter activity| amino acid transmembrane transporter activity| amino acid-transporting ATPase activity| anion transmembrane-transporting ATPase activity| hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances| iron ion binding| primary active transmembrane transporter activity | SMAD protein signal transduction| iron ion transport| phosphate ion transport| polyamine transmembrane transport| polyamine transport| thiamine biosynthetic process| thiamine-containing compound biosynthetic process| thiamine-containing compound metabolic process| water-soluble vitamin biosynthetic process |
| 57 | PF05973 | Phage derived protein Gp49-like (DUF891) | Plasmid_toxin (CL0136) | 2071 (226) | 91 | 83 | (1) RelE-like [d.298.1] (2-75) |
(1) RelE-like [d.298] |
d.298.1(2-75) | d.298.1(1-71) | NO PREDICTION | NO PREDICTION | d.298.1(3-66) | 3 | No information | Eukaryota|Bacteria|Viruses | No information | No information | endonuclease activity| nuclease activity | RNA catabolic process| nucleic acid phosphodiester bond hydrolysis |
| 58 | PF11841 | Domain of unknown function (DUF3361) | No Pfam Clan | 228 (9) | 160 | 156 | (1) ARM repeat [a.118.1] (2-159) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(7-145) | a.118.1(2-159) | a.118.1(8-140) | NO PREDICTION | NO PREDICTION | 3 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 59 | PF07394 | Protein of unknown function (DUF1501) | Alk_phosphatase (CL0088) | 1229 (51) | 392 | 419 | (1) Alkaline phosphatase-like [c.76.1] (1-391) |
(1) Alkaline phosphatase-like [c.76] |
NO PREDICTION | c.76.1(1-391) | c.76.1(243-405) | NO PREDICTION | c.76.1(259-394) | 3 | No information | Eukaryota|Bacteria | 3.1.3.1| 3.1.6.1| 3.1.6.12| 3.1.6.2| 3.1.6.8| 3.11.1.2| 3.6.1.9| 5.4.2.1 | endoplasmic reticulum lumen| extracellular membrane-bounded organelle| extracellular organelle| lysosomal lumen| vacuolar lumen| vacuolar part | alkaline phosphatase activity| glycerophosphocholine cholinephosphodiesterase activity| phospholipase activity| phosphoric diester hydrolase activity| sulfuric ester hydrolase activity| zinc ion binding | aminoglycan catabolic process| aminoglycan metabolic process| bone development| bone morphogenesis| choline metabolic process| dephosphorylation| endochondral bone morphogenesis| endochondral ossification| ethanolamine-containing compound metabolic process| glycolipid metabolic process| glycoprotein metabolic process| glycosaminoglycan catabolic process| glycosaminoglycan metabolic process| heparan sulfate proteoglycan metabolic process| membrane lipid metabolic process| organ morphogenesis| ossification| post-translational protein modification| proteoglycan metabolic process| replacement ossification| response to antibiotic| response to organic cyclic compound| response to toxic substance| skeletal system development| skeletal system morphogenesis| sphingolipid metabolic process| sulfur compound catabolic process |
| 60 | PF11019 | Protein of unknown function (DUF2608) | No Pfam Clan | 271 (27) | 253 | 272 | (1) HAD-like [c.108.1] (17-240) |
(1) HAD-like [c.108] |
c.108.1(36-191) | c.108.1(17-240) | NO PREDICTION | NO PREDICTION | c.108.1(83-226) | 3 | No information | Bacteria | 2.7.7.43| 3.1.3.16| 3.1.3.18| 3.1.3.2| 3.1.3.23| 3.1.3.24| 3.1.3.29| 3.1.3.3| 3.1.3.41| 3.1.3.45| 3.1.3.48| 3.1.3.5| 3.1.3.70| 3.1.3.74| 3.1.8.2| 3.11.1.1| 3.6.1.1| 3.6.3.10| 3.6.3.4| 3.6.3.6| 3.6.3.8| 3.6.3.9| 3.8.1.2| 5.4.2.6| 5.4.2.8 | Nem1-Spo7 phosphatase complex| nuclear envelope| nuclear membrane| protein serine/threonine phosphatase complex | D,D-heptose 1,7-bisphosphate phosphatase activity| acireductone synthase activity| inorganic diphosphatase activity| intramolecular transferase activity| intramolecular transferase activity, phosphotransferases| magnesium ion binding| phosphatase activity | L-methionine biosynthetic process| L-methionine salvage| L-methionine salvage from methylthioadenosine| L-serine metabolic process| amino acid salvage| cellular carbohydrate biosynthetic process| cellular membrane organization| cellular metabolic compound salvage| cofactor catabolic process| deoxyribonucleotide catabolic process| dephosphorylation| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| methionine metabolic process| nuclear envelope organization| nucleus organization| organophosphate catabolic process| positive regulation of lipid biosynthetic process| positive regulation of lipid metabolic process| positive regulation of triglyceride biosynthetic process| positive regulation of triglyceride metabolic process| regulation of lipid biosynthetic process| regulation of lipid metabolic process| regulation of triglyceride biosynthetic process| regulation of triglyceride metabolic process |
| 61 | PF06862 | Protein of unknown function (DUF1253) | P-loop_NTPase (CL0023) | 368 (36) | 442 | 459 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (103-386) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
c.37.1(103-386) | NO PREDICTION | NO PREDICTION | c.37.1(255-459) | c.37.1(135-241) | 3 | No information | Eukaryota | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 62 | PF14371 | Domain of unknown function (DUF4412) | No Pfam Clan | 199 (91) | 89 | 81 | (1) Prokaryotic lipoproteins and lipoprotein localization factors [b.125.1] (2-89) |
(1) LolA-like prokaryotic lipoproteins and lipoprotein localization factors [b.125] |
b.125.1(2-89) | NO PREDICTION | b.125.1(8-81) | NO PREDICTION | b.125.1(2-50) | 3 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 63 | PF07642 | Outer membrane protein family (DUF1597) | MBB (CL0193) | 396 (89) | 344 | 469 | (1) Porins [f.4.3] (1-343) |
(1) Transmembrane beta-barrels [f.4] |
f.4.3(76-314) | f.4.3(1-343) | f.4.3(2-22)| f.4.3(50-298)| f.4.3(344-381)| f.4.3(414-469) | NO PREDICTION | NO PREDICTION | 3 | No information | Eukaryota|Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 64 | PF12030 | Domain of unknown function (DUF3517) | No Pfam Clan | 66 (7) | 337 | 337 | (1) ARM repeat [a.118.1] (1-323) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(10-322) | a.118.1(1-323) | a.118.1(124-272) | NO PREDICTION | NO PREDICTION | 3 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 65 | PF10302 | DUF2407 ubiquitin-like domain | Ubiquitin (CL0072) | 152 (46) | 97 | 90 | (1) Ubiquitin-like [d.15.1] (5-80) |
(1) beta-Grasp (ubiquitin-like) [d.15] |
d.15.1(5-80) | d.15.1(1-64) | NO PREDICTION | NO PREDICTION | d.15.1(3-68) | 3 | No information | Eukaryota | 3.1.2.15| 3.1.4.11 | autophagic vacuole| nuclear body | SUMO ligase activity| non-membrane spanning protein tyrosine phosphatase activity| phosphoprotein phosphatase activity| protein tag| protein tyrosine phosphatase activity| small conjugating protein ligase activity| small conjugating protein ligase binding | autophagy| catechol-containing compound metabolic process| catecholamine metabolic process| catecholamine transport| catecholamine uptake| catecholamine uptake involved in synaptic transmission| dopamine metabolic process| dopamine transport| dopamine uptake| dopamine uptake involved in synaptic transmission| monoamine transport| neurotransmitter uptake| norepinephrine metabolic process| peptidyl-tyrosine dephosphorylation| positive regulation of protein ubiquitination| positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc| protein modification by small protein conjugation or removal| protein sumoylation| proteolysis involved in cellular protein catabolic process| regulation of neurotransmitter secretion| regulation of neurotransmitter transport| regulation of protein catabolic process| regulation of protein ubiquitination| regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process| regulation of proteolysis| response to transforming growth factor beta stimulus| startle response| synaptic transmission, dopaminergic| synaptic transmission, glutamatergic |
| 66 | PF10006 | Uncharacterized conserved protein (DUF2249) | TusA-like (CL0397) | 821 (163) | 69 | 70 | (1) SirA-like [d.68.3] (1-70) |
(1) IF3-like [d.68] |
d.68.3(1-69) | d.68.3(1-68) | NO PREDICTION | NO PREDICTION | d.68.3(1-70) | 3 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 67 | PF08843 | Nucleotidyl transferase of unknown function (DUF1814) | NTP_transf (CL0260) | 2210 (177) | 233 | 250 | (1) Nucleotidyltransferase [d.218.1] (1-170) |
(1) Nucleotidyltransferase [d.218] |
d.218.1(2-166) | d.218.1(1-170) | NO PREDICTION | NO PREDICTION | d.218.1(10-61) | 3 | No information | Eukaryota|Bacteria|Viruses|Archaea | 2.7.6.5| 2.7.7.19| 2.7.7.31| 2.7.7.42| 2.7.7.52| 2.7.7.7| 2.7.7.72 | No information | adenylyltransferase activity| double-stranded RNA binding | No information |
| 68 | PF12965 | Domain of unknown function (DUF3854) | Toprim-like (CL0413) | 235 (54) | 130 | 115 | (1) DNA primase core [e.13.1] (1-130) |
(1) DNA primase core [e.13] |
e.13.1(1-130) | e.13.1(10-125) | NO PREDICTION | NO PREDICTION | e.13.1(9-115) | 3 | No information | Eukaryota|Bacteria|Viruses | No information | No information | No information | No information |
| 69 | PF14868 | Domain of unknown function (DUF4487) | No Pfam Clan | 134 (12) | 559 | 548 | (1) ARM repeat [a.118.1] (3-555) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(3-555) | a.118.1(142-210)| a.118.1(279-334)| a.118.1(397-541) | a.118.1(1-548) | NO PREDICTION | 3 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 70 | PF02721 | Domain of unknown function DUF223 | OB (CL0021) | 441 (15) | 95 | 95 | (1) Nucleic acid-binding proteins [b.40.4] (2-83) |
(1) OB-fold [b.40] |
b.40.4(2-83) | NO PREDICTION | b.40.4(2-74) | NO PREDICTION | b.40.4(1-73) | 3 | No information | Eukaryota | 3.1.13.1| 3.1.26.12| 6.5.1.1 | DNA replication factor A complex| DNA-directed RNA polymerase II, core complex| DNA-directed RNA polymerase II, holoenzyme| DNA-directed RNA polymerase complex| RNA polymerase complex| cytoplasmic exosome (RNase complex)| cytosolic small ribosomal subunit| exosome (RNase complex)| mitochondrial nucleoid| nuclear DNA-directed RNA polymerase complex| nucleoid| organellar ribosome| replisome | RNA polymerase activity| chromatin binding| ribonucleoprotein complex binding| single-stranded DNA binding| structure-specific DNA binding | regulation of DNA-dependent transcription, termination| regulation of RNA stability| regulation of mRNA stability| response to cold| ribonucleoprotein complex biogenesis| telomere maintenance| telomere organization| transcriptional attenuation| translational initiation |
| 71 | PF12530 | Protein of unknown function (DUF3730) | No Pfam Clan | 180 (25) | 234 | 196 | (1) ARM repeat [a.118.1] (1-233) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(1-161) | a.118.1(1-233) | a.118.1(3-192) | NO PREDICTION | NO PREDICTION | 3 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 72 | PF03445 | Putative nucleotidyltransferase DUF294 | NTP_transf (CL0260) | 1219 (86) | 138 | 142 | (1) Nucleotidyltransferase [d.218.1] (5-140) |
(1) Nucleotidyltransferase [d.218] |
d.218.1(5-99) | d.218.1(1-103) | NO PREDICTION | NO PREDICTION | d.218.1(5-140) | 3 | No information | Eukaryota|Bacteria|Viruses|Archaea | 2.7.6.5| 2.7.7.19| 2.7.7.31| 2.7.7.42| 2.7.7.52| 2.7.7.7| 2.7.7.72 | No information | adenylyltransferase activity| double-stranded RNA binding | No information |
| 73 | PF12043 | Domain of unknown function (DUF3527) | No Pfam Clan | 128 (12) | 346 | 264 | (1) Tubby C-terminal domain-like [d.23.1] (1-261) |
(1) Tubby C-terminal domain-like [d.23] |
NO PREDICTION | NO PREDICTION | d.23.1(214-259) | d.23.1(1-261) | d.23.1(103-261) | 3 | No information | Eukaryota | No information | No information | G-protein coupled photoreceptor activity| G-protein coupled receptor activity| molecular transducer activity| photoreceptor activity| receptor activity| signaling receptor activity| transmembrane signaling receptor activity | detection of abiotic stimulus| detection of external stimulus| detection of light stimulus| detection of stimulus| detection of visible light| eye development| phototransduction| retina development in camera-type eye| sensory organ development |
| 74 | PF09960 | Uncharacterized protein conserved in bacteria (DUF2194) | No Pfam Clan | 111 (8) | 585 | 718 | (1) Class I glutamine amidotransferase-like [c.23.16] (52-261) (2) Glycoside hydrolase/deacetylase [c.6.2] (251-534) |
(1) Flavodoxin-like [c.23] (2) 7-stranded beta/alpha barrel [c.6] |
NO PREDICTION | c.23.16(52-261)| c.6.2(251-534) | c.6.2(428-561) | NO PREDICTION | c.6.2(415-664) | 3 | No information | Bacteria|Archaea | 2.3.1.46| 2.4.1.18| 2.4.1.211| 2.4.1.25| 3.1.1.72| 3.2.1.1| 3.2.1.114| 3.2.1.24| 3.4.13.21| 3.4.15.6| 3.4.17.13| 3.4.19.9| 3.5.1.33| 3.5.1.41| 3.5.2.5| 4.2.1.103| 6.3.5.2| 6.3.5.5 | No information | 4-amino-4-deoxychorismate synthase activity| anthranilate synthase activity| antioxidant activity| carbon-carbon lyase activity| carbon-nitrogen ligase activity, with glutamine as amido-N-donor| deacetylase activity| glyoxalase III activity| oxidoreductase activity, acting on peroxide as acceptor| oxo-acid-lyase activity| peptidase activity| peroxidase activity| peroxiredoxin activity| transaminase activity| transferase activity, transferring nitrogenous groups | adult behavior| adult locomotory behavior| amine biosynthetic process| aromatic amino acid family biosynthetic process| aromatic amino acid family metabolic process| catecholamine transport| catecholamine uptake| catecholamine uptake involved in synaptic transmission| cellular biogenic amine biosynthetic process| cellular response to oxidative stress| cellular response to reactive oxygen species| dopamine transport| dopamine uptake| dopamine uptake involved in synaptic transmission| folic acid-containing compound biosynthetic process| folic acid-containing compound metabolic process| hydrogen peroxide metabolic process| indolalkylamine biosynthetic process| indole-containing compound biosynthetic process| indole-containing compound metabolic process| lactate biosynthetic process| lactate metabolic process| membrane depolarization| membrane hyperpolarization| monoamine transport| negative regulation of binding| negative regulation of protein binding| neuron-neuron synaptic transmission| neurotransmitter transport| neurotransmitter uptake| organic hydroxy compound transport| positive regulation of oxidative phosphorylation uncoupler activity| positive regulation of transporter activity| protein stabilization| pteridine-containing compound biosynthetic process| pteridine-containing compound metabolic process| reactive oxygen species metabolic process| regulation of binding| regulation of neuron apoptotic process| regulation of neuron death| regulation of neurotransmitter levels| regulation of oxidative phosphorylation uncoupler activity| regulation of protein binding| regulation of protein stability| regulation of proton transport| regulation of transmembrane transport| regulation of transmembrane transporter activity| regulation of transporter activity| response to hydrogen peroxide| response to reactive oxygen species| synaptic transmission, dopaminergic| thiamine biosynthetic process| thiamine-containing compound biosynthetic process| thiamine-containing compound metabolic process| tryptophan biosynthetic process| tryptophan metabolic process| water-soluble vitamin biosynthetic process |
| 75 | PF10096 | Uncharacterized protein conserved in bacteria (DUF2334) | GH_CE (CL0158) | 444 (40) | 243 | 256 | (1) Glycoside hydrolase/deacetylase [c.6.2] (1-242) |
(1) 7-stranded beta/alpha barrel [c.6] |
NO PREDICTION | c.6.2(1-242) | c.6.2(24-154) | NO PREDICTION | c.6.2(18-191) | 3 | No information | Bacteria|Archaea | 2.4.1.18| 2.4.1.25| 3.1.1.72| 3.2.1.1| 3.2.1.114| 3.2.1.24| 3.5.1.33| 3.5.1.41| 3.5.2.5 | No information | deacetylase activity | No information |
| 76 | PF10923 | P-loop Domain of unknown function (DUF2791) | P-loop_NTPase (CL0023) | 286 (28) | 417 | 408 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (25-397) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
NO PREDICTION | c.37.1(25-397) | c.37.1(28-116)| c.37.1(233-357) | NO PREDICTION | c.37.1(26-362) | 3 | No information | Bacteria|Archaea | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 77 | PF12074 | Domain of unknown function (DUF3554) | No Pfam Clan | 248 (30) | 339 | 351 | (1) ARM repeat [a.118.1] (1-338) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(11-338) | a.118.1(1-338) | a.118.1(8-248)| a.118.1(276-320) | NO PREDICTION | NO PREDICTION | 3 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 78 | PF12340 | Protein of unknown function (DUF3638) | No Pfam Clan | 218 (26) | 229 | 229 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (1-226) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
NO PREDICTION | c.37.1(1-226) | c.37.1(18-189) | NO PREDICTION | c.37.1(3-187) | 3 | No information | Eukaryota|Bacteria | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 79 | PF05152 | Protein of unknown function (DUF705) | HAD (CL0137) | 75 (27) | 297 | 313 | (1) HAD-like [c.108.1] (114-296) |
(1) HAD-like [c.108] |
NO PREDICTION | c.108.1(114-296) | c.108.1(125-200) | NO PREDICTION | c.108.1(121-200) | 3 | No information | Eukaryota|Bacteria|Viruses | 2.7.7.43| 3.1.3.16| 3.1.3.18| 3.1.3.2| 3.1.3.23| 3.1.3.24| 3.1.3.29| 3.1.3.3| 3.1.3.41| 3.1.3.45| 3.1.3.48| 3.1.3.5| 3.1.3.70| 3.1.3.74| 3.1.8.2| 3.11.1.1| 3.6.1.1| 3.6.3.10| 3.6.3.4| 3.6.3.6| 3.6.3.8| 3.6.3.9| 3.8.1.2| 5.4.2.6| 5.4.2.8 | Nem1-Spo7 phosphatase complex| nuclear envelope| nuclear membrane| protein serine/threonine phosphatase complex | D,D-heptose 1,7-bisphosphate phosphatase activity| acireductone synthase activity| inorganic diphosphatase activity| intramolecular transferase activity| intramolecular transferase activity, phosphotransferases| magnesium ion binding| phosphatase activity | L-methionine biosynthetic process| L-methionine salvage| L-methionine salvage from methylthioadenosine| L-serine metabolic process| amino acid salvage| cellular carbohydrate biosynthetic process| cellular membrane organization| cellular metabolic compound salvage| cofactor catabolic process| deoxyribonucleotide catabolic process| dephosphorylation| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| methionine metabolic process| nuclear envelope organization| nucleus organization| organophosphate catabolic process| positive regulation of lipid biosynthetic process| positive regulation of lipid metabolic process| positive regulation of triglyceride biosynthetic process| positive regulation of triglyceride metabolic process| regulation of lipid biosynthetic process| regulation of lipid metabolic process| regulation of triglyceride biosynthetic process| regulation of triglyceride metabolic process |
| 80 | PF14908 | Domain of unknown function (DUF4496) | No Pfam Clan | 151 (29) | 140 | 154 | (1) IHF-like DNA-binding proteins [a.55.1] (3-134) |
(1) IHF-like DNA-binding proteins [a.55] |
a.55.1(3-134) | NO PREDICTION | a.55.1(4-67) | NO PREDICTION | a.55.1(2-70) | 3 | No information | Eukaryota | No information | No information | No information | DNA packaging |
| 81 | PF11229 | Protein of unknown function (DUF3028) | No Pfam Clan | 60 (3) | 589 | 589 | (1) ARM repeat [a.118.1] (1-589) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(2-580) | a.118.1(10-358) | a.118.1(1-589) | NO PREDICTION | 3 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 82 | PF11918 | Domain of unknown function (DUF3436) | No Pfam Clan | 2173 (47) | 55 | 55 | (1) ClpP/crotonase [c.14.1] (1-55) |
(1) ClpP/crotonase [c.14] |
c.14.1(1-55) | NO PREDICTION | c.14.1(2-54) | NO PREDICTION | c.14.1(1-55) | 3 | No information | Eukaryota | 2.1.3.1| 3.1.2.4| 3.4.21.92| 3.7.1.7| 3.8.1.7| 4.1.1.41| 4.1.1.70| 4.1.3.36| 4.2.1.101| 4.2.1.17| 4.2.1.18| 4.2.1.55| 5.3.3.8| 6.4.1.2| 6.4.1.3 | acetyl-CoA carboxylase complex| chloroplastic endopeptidase Clp complex| endopeptidase Clp complex| microbody| organelle subcompartment| plastid envelope | 1,4-dihydroxy-2-naphthoyl-CoA synthase activity| enoyl-CoA hydratase activity| hydro-lyase activity| intramolecular oxidoreductase activity| intramolecular oxidoreductase activity, transposing C=C bonds| ligase activity, forming carbon-carbon bonds | RNA catabolic process| cellular lipid catabolic process| fatty acid catabolic process| fatty acid oxidation| ketone biosynthetic process| lipid modification| lipid oxidation| mRNA catabolic process| monocarboxylic acid catabolic process| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay| quinone biosynthetic process| quinone metabolic process |
| 83 | PF10826 | Protein of unknown function (DUF2551) | No Pfam Clan | 39 (12) | 83 | 81 | (1) "Winged helix" DNA-binding domain [a.4.5] (6-82) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
a.4.5(22-75) | a.4.5(6-82) | NO PREDICTION | NO PREDICTION | a.4.5(11-75) | 3 | No information | Bacteria|Archaea | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 84 | PF05277 | Protein of unknown function (DUF726) | AB_hydrolase (CL0028) | 559 (9) | 345 | 339 | (1) alpha/beta-Hydrolases [c.69.1] (12-343) |
(1) alpha/beta-Hydrolases [c.69] |
c.69.1(79-323) | c.69.1(12-343) | c.69.1(198-284) | NO PREDICTION | NO PREDICTION | 3 | No information | Eukaryota|Bacteria|Archaea | 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 | trans-Golgi network transport vesicle | CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity | acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process |
| 85 | PF14134 | Domain of unknown function (DUF4301) | No Pfam Clan | 177 (43) | 513 | 508 | (1) Nucleotide-diphospho-sugar transferases [c.68.1] (4-511) |
(1) Nucleotide-diphospho-sugar transferases [c.68] |
NO PREDICTION | c.68.1(4-511) | c.68.1(163-334)| c.68.1(384-504) | NO PREDICTION | c.68.1(157-504) | 3 | No information | Bacteria | 2.4.1.101| 2.4.1.131| 2.4.1.135| 2.4.1.186| 2.4.1.217| 2.4.1.222| 2.4.1.223| 2.4.1.37| 2.4.1.41| 2.4.1.44| 2.4.1.87| 2.7.7.13| 2.7.7.23| 2.7.7.24| 2.7.7.27| 2.7.7.33| 2.7.7.38| 2.7.7.43| 2.7.7.60| 2.7.7.64| 2.7.7.9 | Golgi apparatus| Golgi apparatus part| Golgi membrane| cis-Golgi network| mannosyltransferase complex | UDP-glycosyltransferase activity| acetylgalactosaminyltransferase activity| ceramide glucosyltransferase activity| cytidylyltransferase activity| galactosyltransferase activity| glucose-1-phosphate thymidylyltransferase activity| guanylyltransferase activity| magnesium ion binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups | aminoglycan biosynthetic process| aminoglycan metabolic process| cell wall biogenesis| cell wall mannoprotein biosynthetic process| cell wall organization or biogenesis| cellular carbohydrate biosynthetic process| cellular component macromolecule biosynthetic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| chondroitin sulfate biosynthetic process| chondroitin sulfate metabolic process| chondroitin sulfate proteoglycan biosynthetic process| chondroitin sulfate proteoglycan metabolic process| dolichol metabolic process| extracellular fibril organization| extracellular matrix organization| extracellular structure organization| fibril organization| galactose metabolic process| gametophyte development| glycolipid metabolic process| glycoprotein biosynthetic process| glycoprotein metabolic process| glycosaminoglycan biosynthetic process| glycosphingolipid biosynthetic process| glycosylation| heparan sulfate proteoglycan biosynthetic process| heparan sulfate proteoglycan metabolic process| lipopolysaccharide metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| negative regulation of fibroblast proliferation| nucleotide-sugar metabolic process| peptidyl-asparagine modification| phosphatidylinositol biosynthetic process| phosphatidylinositol metabolic process| pollen development| polyprenol metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein O-linked glycosylation| protein glycosylation| regulation of Notch signaling pathway| regulation of fibroblast proliferation| sphingolipid biosynthetic process| sphingolipid metabolic process |
| 86 | PF09844 | Uncharacterized conserved protein (COG2071) | ADC-like (CL0403) | 298 (36) | 217 | 213 | (1) Acetoacetate decarboxylase-like [d.347.1] (1-214) |
(1) Acetoacetate decarboxylase-like [d.347] |
d.347.1(1-214) | NO PREDICTION | d.347.1(5-207) | NO PREDICTION | d.347.1(7-125) | 3 | No information | Bacteria|Archaea | 4.1.1.4 | No information | No information | No information |
| 87 | PF11751 | Protein of unknown function (DUF3308) | MBB (CL0193) | 599 (103) | 274 | 286 | (1) Porins [f.4.3] (1-286) |
(1) Transmembrane beta-barrels [f.4] |
f.4.3(17-191) | f.4.3(14-273) | NO PREDICTION | f.4.3(1-286) | NO PREDICTION | 3 | No information | Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 88 | PF11144 | Protein of unknown function (DUF2920) | AB_hydrolase (CL0028) | 738 (20) | 403 | 409 | (1) alpha/beta-Hydrolases [c.69.1] (10-367) |
(1) alpha/beta-Hydrolases [c.69] |
NO PREDICTION | c.69.1(10-367) | c.69.1(32-82)| c.69.1(151-229)| c.69.1(260-337) | NO PREDICTION | c.69.1(10-337) | 3 | No information | Bacteria | 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 | trans-Golgi network transport vesicle | CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity | acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process |
| 89 | PF04391 | Protein of unknown function (DUF533) | TerB (CL0414) | 974 (61) | 189 | 210 | (1) TerB-like [a.287.1] (64-207) |
(1) TerB-like [a.287] |
a.287.1(62-189) | NO PREDICTION | a.287.1(64-207) | NO PREDICTION | a.287.1(99-209) | 3 | YES | Bacteria|Viruses | No information | No information | No information | No information |
| 90 | PF13251 | Domain of unknown function (DUF4042) | No Pfam Clan | 156 (19) | 182 | 184 | (1) ARM repeat [a.118.1] (1-182) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(1-182) | a.118.1(1-177) | a.118.1(1-175) | NO PREDICTION | NO PREDICTION | 3 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 91 | PF07381 | Winged helix DNA-binding domain (DUF1495) | HTH (CL0123) | 58 (11) | 90 | 90 | (1) "Winged helix" DNA-binding domain [a.4.5] (1-89) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
a.4.5(3-82) | a.4.5(1-89) | NO PREDICTION | NO PREDICTION | a.4.5(1-88) | 3 | No information | Archaea | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 92 | PF11152 | Protein of unknown function (DUF2930) | GAF (CL0161) | 160 (30) | 195 | 194 | (1) GAF domain-like [d.110.2] (71-192) |
(1) Profilin-like [d.110] |
d.110.2(74-194) | d.110.2(74-194) | NO PREDICTION | NO PREDICTION | d.110.2(71-192) | 3 | No information | Eukaryota|Bacteria | 1.8.4.14| 4.6.1.1 | No information | No information | No information |
| 93 | PF11313 | Protein of unknown function (DUF3116) | HTH (CL0123) | 124 (6) | 85 | 86 | (1) "Winged helix" DNA-binding domain [a.4.5] (3-84) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
a.4.5(7-83) | a.4.5(3-84) | NO PREDICTION | NO PREDICTION | a.4.5(5-84) | 3 | No information | Bacteria | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 94 | PF12541 | Protein of unknown function (DUF3737) | Pec_lyase-like (CL0268) | 223 (36) | 278 | 278 | (1) Pectin lyase-like [b.80.1] (12-277) |
(1) Single-stranded right-handed beta-helix [b.80] |
NO PREDICTION | b.80.1(12-277) | b.80.1(87-258) | NO PREDICTION | b.80.1(49-229) | 3 | No information | Eukaryota|Bacteria|Archaea | 3.1.1.11| 3.2.1.11| 3.2.1.15| 3.2.1.157| 3.2.1.57| 3.2.1.58| 3.4.21.72| 4.2.2.10| 4.2.2.18| 4.2.2.19| 4.2.2.2| 4.2.2.7 | anchored to membrane| plant-type cell wall | carbon-oxygen lyase activity, acting on polysaccharides| carboxylic ester hydrolase activity| galacturan 1,4-alpha-galacturonidase activity| pectinesterase activity| polygalacturonase activity | cell growth| cell wall organization or biogenesis| developmental cell growth| developmental growth| developmental growth involved in morphogenesis| external encapsulating structure organization| galacturonan metabolic process| pectin catabolic process| plant-type cell wall organization| plant-type cell wall organization or biogenesis| pollen tube development| pollen tube growth| pollination| polysaccharide catabolic process| polysaccharide metabolic process| unidimensional cell growth |
| 95 | PF14367 | Domain of unknown function (DUF4411) | PIN (CL0280) | 237 (58) | 162 | 162 | (1) PIN domain-like [c.120.1] (2-159) |
(1) PIN domain-like [c.120] |
c.120.1(1-138) | c.120.1(1-152) | NO PREDICTION | NO PREDICTION | c.120.1(2-159) | 3 | No information | Bacteria|Archaea | 3.1.11.3| 3.1.26.4 | No information | nuclease activity | RNA phosphodiester bond hydrolysis| interspecies interaction between organisms| negative regulation of growth| nucleic acid phosphodiester bond hydrolysis| posttranscriptional regulation of gene expression |
| 96 | PF10711 | Hypothetical protein (DUF2513) | No Pfam Clan | 250 (27) | 102 | 98 | (1) "Winged helix" DNA-binding domain [a.4.5] (1-101) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
a.4.5(4-82) | a.4.5(1-101) | NO PREDICTION | NO PREDICTION | a.4.5(20-84) | 3 | No information | Eukaryota|Bacteria|Viruses | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 97 | PF12128 | Protein of unknown function (DUF3584) | P-loop_NTPase (CL0023) | 142 (10) | 1201 | 1195 | (1) Ribonuclease domain of colicin E3 [b.101.1] (595-769) (2) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (9-154) |
(1) Ribonuclease domain of colicin E3 [b.101] (2) P-loop containing nucleoside triphosphate hydrolases [c.37] |
NO PREDICTION | NO PREDICTION | c.37.1(9-81) | b.101.1(595-769) | c.37.1(9-154) | 3 | No information | Eukaryota|Bacteria|Viruses|Archaea | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 98 | PF11339 | Protein of unknown function (DUF3141) | AB_hydrolase (CL0028) | 171 (28) | 581 | 579 | (1) alpha/beta-Hydrolases [c.69.1] (4-373) |
(1) alpha/beta-Hydrolases [c.69] |
NO PREDICTION | c.69.1(4-373) | c.69.1(30-352) | NO PREDICTION | c.69.1(59-173) | 3 | No information | Eukaryota|Bacteria|Archaea | 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 | trans-Golgi network transport vesicle | CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity | acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process |
| 99 | PF01796 | DUF35 OB-fold domain | OB (CL0021) | 1861 (157) | 68 | 66 | (1) Nucleic acid-binding proteins [b.40.4] (1-68) |
(1) OB-fold [b.40] |
b.40.4(1-68) | NO PREDICTION | b.40.4(1-65) | NO PREDICTION | b.40.4(1-65) | 3 | No information | Eukaryota|Bacteria|Archaea | 3.1.13.1| 3.1.26.12| 6.5.1.1 | DNA replication factor A complex| DNA-directed RNA polymerase II, core complex| DNA-directed RNA polymerase II, holoenzyme| DNA-directed RNA polymerase complex| RNA polymerase complex| cytoplasmic exosome (RNase complex)| cytosolic small ribosomal subunit| exosome (RNase complex)| mitochondrial nucleoid| nuclear DNA-directed RNA polymerase complex| nucleoid| organellar ribosome| replisome | RNA polymerase activity| chromatin binding| ribonucleoprotein complex binding| single-stranded DNA binding| structure-specific DNA binding | regulation of DNA-dependent transcription, termination| regulation of RNA stability| regulation of mRNA stability| response to cold| ribonucleoprotein complex biogenesis| telomere maintenance| telomere organization| transcriptional attenuation| translational initiation |
| 100 | PF11379 | Protein of unknown function (DUF3182) | No Pfam Clan | 90 (15) | 355 | 353 | (1) Glutathione synthetase ATP-binding domain-like [d.142.1] (17-312) |
(1) ATP-grasp [d.142] |
NO PREDICTION | d.142.1(17-312) | d.142.1(110-219) | NO PREDICTION | d.142.1(115-303) | 3 | No information | Eukaryota|Bacteria | 4.1.1.21| 6.3.1.9| 6.3.2.23| 6.3.2.3| 6.3.2.4| 6.3.4.13| 6.3.4.14| 6.3.4.18 | No information | glutathione synthase activity | microtubule-based process| response to cadmium ion |
| 101 | PF09986 | Uncharacterized protein conserved in bacteria (DUF2225) | TPR (CL0020) | 252 (23) | 214 | 212 | (1) TPR-like [a.118.8] (37-196) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(37-196) | NO PREDICTION | a.118.8(94-192) | NO PREDICTION | a.118.8(87-194) | 3 | No information | Bacteria|Archaea | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 102 | PF06537 | Protein of unknown function (DUF1111) | Cytochrome-c (CL0318) | 817 (6) | 499 | 499 | (1) Cytochrome c [a.3.1] (335-499) |
(1) Cytochrome c [a.3] |
NO PREDICTION | NO PREDICTION | a.3.1(350-499) | a.3.1(335-499) | a.3.1(359-499) | 3 | No information | Bacteria|Viruses | 1.11.1.5| 1.4.99.3| 1.7.99.7 | periplasmic space | electron carrier activity| electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrom| heme binding| tetrapyrrole binding | DNA catabolic process| DNA catabolic process, endonucleolytic| apoptotic DNA fragmentation| apoptotic nuclear changes| apoptotic process| cellular component disassembly| cellular component disassembly involved in execution phase of apoptosis| cellular respiration| electron transport chain| execution phase of apoptosis| mitochondrial ATP synthesis coupled electron transport| mitochondrial electron transport, cytochrome c to oxygen| nucleic acid phosphodiester bond hydrolysis| oxidative phosphorylation |
| 103 | PF10335 | Putative nucleotidyltransferase substrate binding domain | KNTase_C (CL0291) | 1001 (86) | 145 | 145 | (1) Nucleotidyltransferase substrate binding subunit/domain [a.24.16] (2-144) |
(1) Four-helical up-and-down bundle [a.24] |
a.24.16(36-124) | a.24.16(2-144) | NO PREDICTION | NO PREDICTION | a.24.16(36-102) | 3 | No information | Eukaryota|Bacteria|Archaea | 2.7.7.42 | No information | No information | No information |
| 104 | PF14121 | Domain of unknown function (DUF4289) | MBB (CL0193) | 213 (62) | 614 | 621 | (1) Porins [f.4.3] (90-619) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.3(83-611) | NO PREDICTION | f.4.3(90-619) | f.4.3(102-619) | 3 | YES | Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 105 | PF10521 | Protein of unknown function (DUF2454) | No Pfam Clan | 199 (29) | 282 | 249 | (1) ARM repeat [a.118.1] (1-277) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(36-243) | a.118.1(1-277) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 106 | PF11340 | Protein of unknown function (DUF3142) | No Pfam Clan | 151 (16) | 181 | 166 | (1) (Trans)glycosidases [c.1.8] (29-121) |
(1) TIM beta/alpha-barrel [c.1] |
NO PREDICTION | NO PREDICTION | c.1.8(29-121) | NO PREDICTION | c.1.8(22-110) | 2 | No information | Bacteria | 2.4.1.18| 2.4.1.19| 2.4.1.25| 2.4.1.4| 2.4.1.5| 2.4.1.7| 2.7.1.31| 2.7.7.43| 3.1.3.16| 3.1.3.18| 3.1.3.2| 3.1.3.23| 3.1.3.24| 3.1.3.29| 3.1.3.3| 3.1.3.41| 3.1.3.45| 3.1.3.48| 3.1.3.5| 3.1.3.70| 3.1.3.71| 3.1.3.74| 3.1.8.2| 3.11.1.1| 3.2.1.1| 3.2.1.10| 3.2.1.105| 3.2.1.123| 3.2.1.133| 3.2.1.135| 3.2.1.136| 3.2.1.139| 3.2.1.14| 3.2.1.141| 3.2.1.147| 3.2.1.151| 3.2.1.165| 3.2.1.17| 3.2.1.2| 3.2.1.20| 3.2.1.21| 3.2.1.22| 3.2.1.23| 3.2.1.25| 3.2.1.31| 3.2.1.32| 3.2.1.35| 3.2.1.37| 3.2.1.39| 3.2.1.4| 3.2.1.41| 3.2.1.45| 3.2.1.48| 3.2.1.49| 3.2.1.51| 3.2.1.52| 3.2.1.54| 3.2.1.55| 3.2.1.58| 3.2.1.60| 3.2.1.68| 3.2.1.70| 3.2.1.73| 3.2.1.78| 3.2.1.8| 3.2.1.85| 3.2.1.86| 3.2.1.89| 3.2.1.96| 3.2.1.98| 3.6.1.1| 3.6.3.10| 3.6.3.4| 3.6.3.6| 3.6.3.8| 3.6.3.9| 3.8.1.2| 4.2.2.13| 5.4.2.6| 5.4.2.8| 5.4.99.11| 5.4.99.15 | anchored to membrane| anchored to plasma membrane| cell wall| fungal-type cell wall| hyaluranon cable| lysosome | beta-mannosidase activity| galactosidase activity| glucanosyltransferase activity| hyaluronan synthase activity| hydrolase activity, hydrolyzing O-glycosyl compounds| transferase activity, transferring glycosyl groups| virus receptor activity | aminoglycan biosynthetic process| aminoglycan catabolic process| aminoglycan metabolic process| autolysis| cartilage development| cell wall beta-glucan metabolic process| cell wall macromolecule catabolic process| cell wall macromolecule metabolic process| cell wall organization or biogenesis| cellular carbohydrate catabolic process| cellular polysaccharide catabolic process| cellular polysaccharide metabolic process| cellular response to UV| cellular response to UV-B| cellular response to abiotic stimulus| cellular response to cytokine stimulus| cellular response to growth factor stimulus| cellular response to interleukin-1| cellular response to light stimulus| cellular response to pH| cellular response to platelet-derived growth factor stimulus| cellular response to radiation| ceramide catabolic process| ceramide metabolic process| connective tissue development| cytolysis| diaphragm contraction| external encapsulating structure organization| glucosamine-containing compound catabolic process| glucosamine-containing compound metabolic process| glycosaminoglycan catabolic process| glycosphingolipid catabolic process| glycosylceramide catabolic process| glycosylceramide metabolic process| hyaluronan biosynthetic process| hyaluronan catabolic process| hyaluronan metabolic process| inflammatory response| involuntary skeletal muscle contraction| lysosome organization| mannan metabolic process| membrane lipid catabolic process| multicellular organismal movement| negative regulation of cell growth| negative regulation of growth| neuromuscular process controlling balance| neuromuscular process controlling posture| peptidoglycan turnover| polysaccharide catabolic process| polysaccharide metabolic process| positive regulation of angiogenesis| positive regulation of cell adhesion| positive regulation of cell growth| positive regulation of epithelial cell migration| positive regulation of epithelial cell proliferation| positive regulation of hyaluranon cable assembly| regulation of angiogenesis| regulation of cell growth| regulation of cell migration| regulation of cell motility| regulation of cellular component movement| regulation of epithelial cell migration| regulation of hyaluranon cable assembly| regulation of locomotion| regulation of vasculature development| respiratory gaseous exchange| respiratory system process| response to UV| response to UV-B| response to antibiotic| response to cytokine stimulus| response to growth factor stimulus| response to interleukin-1| response to pH| response to platelet-derived growth factor stimulus| response to reactive oxygen species| response to toxic substance| response to virus| single-species biofilm formation| skeletal muscle contraction| skeletal system development| sphingolipid catabolic process| vacuole organization |
| 107 | PF05331 | Protein of unknown function (DUF742) | HTH (CL0123) | 710 (14) | 114 | 129 | (1) "Winged helix" DNA-binding domain [a.4.5] (63-110) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
NO PREDICTION | NO PREDICTION | a.4.5(63-110) | NO PREDICTION | a.4.5(60-106) | 2 | No information | Bacteria|Archaea | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 108 | PF11864 | Domain of unknown function (DUF3384) | No Pfam Clan | 254 (26) | 464 | 714 | (1) ARM repeat [a.118.1] (1-463) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(11-464) | a.118.1(1-463) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 109 | PF04510 | Family of unknown function (DUF577) | No Pfam Clan | 53 (17) | 174 | 177 | (1) ARM repeat [a.118.1] (3-156) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(3-156) | NO PREDICTION | a.118.1(14-140) | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota|Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 110 | PF13258 | Domain of unknown function (DUF4049) | No Pfam Clan | 501 (3) | 318 | 310 | (1) Metallo-dependent phosphatases [d.159.1] (16-225) |
(1) Metallo-dependent phosphatases [d.159] |
NO PREDICTION | d.159.1(16-225) | d.159.1(97-193) | NO PREDICTION | NO PREDICTION | 2 | No information | Bacteria | 3.1.3.16| 3.1.3.2| 3.1.3.3| 3.1.3.48| 3.1.3.5| 3.1.3.53| 3.1.4.17| 3.1.4.46| 3.6.1.41 | cis-Golgi network| endoplasmic reticulum exit site| endoplasmic reticulum-Golgi intermediate compartment| protein serine/threonine phosphatase complex | GPI anchor binding| RNA lariat debranching enzyme activity| acid phosphatase activity| endonuclease activity| endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomo| endoribonuclease activity| endoribonuclease activity, producing 5'-phosphomonoesters| ferric iron binding| glycolipid binding| manganese ion binding| phosphatidylinositol binding| phospholipid binding | ER to Golgi vesicle-mediated transport| GPI anchor biosynthetic process| GPI anchor metabolic process| Golgi vesicle transport| RNA phosphodiester bond hydrolysis, endonucleolytic| dephosphorylation| glycerolipid biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| lipoprotein biosynthetic process| lipoprotein metabolic process| membrane lipid biosynthetic process| membrane lipid metabolic process| phosphatidylinositol biosynthetic process| phosphatidylinositol metabolic process| phospholipid biosynthetic process| protein lipidation |
| 111 | PF06382 | Protein of unknown function (DUF1074) | HMG-box (CL0114) | 76 (3) | 183 | 125 | (1) HMG-box [a.21.1] (24-69) |
(1) HMG-box [a.21] |
NO PREDICTION | NO PREDICTION | a.21.1(24-69) | NO PREDICTION | a.21.1(25-69) | 2 | No information | Eukaryota | No information | chromosomal part | DNA binding, bending| chromatin binding| nucleic acid binding transcription factor activity| sequence-specific DNA binding transcription factor activity| structural constituent of chromatin | chromatin organization| chromosome organization |
| 112 | PF11287 | Protein of unknown function (DUF3088) | No Pfam Clan | 111 (19) | 112 | 111 | (1) Thioredoxin-like [c.47.1] (20-111) |
(1) Thioredoxin fold [c.47] |
NO PREDICTION | c.47.1(20-111) | NO PREDICTION | NO PREDICTION | c.47.1(20-107) | 2 | No information | Eukaryota|Bacteria | 1.1.4.2| 1.11.1.12| 1.11.1.15| 1.11.1.7| 1.11.1.9| 1.20.4.1| 1.8.1.7| 1.8.1.8| 1.8.1.9| 1.8.4.2| 1.8.4.7| 1.8.4.8| 1.8.5.1| 2.5.1.18| 5.2.1.2| 5.3.4.1| 5.3.99.3 | NADH dehydrogenase complex| chloroplast stroma| ferredoxin hydrogenase complex| formate dehydrogenase complex| myelin sheath| plastid stroma| respiratory chain complex I | antioxidant activity| arsenate reductase activity| disulfide oxidoreductase activity| electron carrier activity| formate dehydrogenase (NAD+) activity| glutathione binding| glutathione transferase activity| intramolecular oxidoreductase activity| intramolecular oxidoreductase activity, interconverting keto- and enol-groups| intramolecular oxidoreductase activity, transposing S-S bonds| oxidoreductase activity, acting on a sulfur group of donors| oxidoreductase activity, acting on hydrogen as donor| oxidoreductase activity, acting on peroxide as acceptor| oxidoreductase activity, acting on phosphorus or arsenic in donors| oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor| peroxidase activity| peroxiredoxin activity| phospholipid-hydroperoxide glutathione peroxidase activity| prostaglandin-F synthase activity| protein disulfide isomerase activity| thioredoxin peroxidase activity | androecium development| anther development| cell redox homeostasis| cellular response to hydrogen peroxide| cellular response to oxidative stress| cellular response to reactive oxygen species| fatty acid derivative biosynthetic process| fatty acid derivative metabolic process| floral organ development| floral whorl development| flower development| formate metabolic process| hydrogen peroxide catabolic process| icosanoid biosynthetic process| nucleolus organization| phyllome development| positive regulation of DNA binding| positive regulation of binding| prostanoid biosynthetic process| protein deglutathionylation| protein folding| reactive oxygen species metabolic process| regulation of DNA binding| regulation of binding| regulation of intracellular transport| regulation of protein import into nucleus| regulation of protein import into nucleus, translocation| regulation of protein localization to nucleus| removal of superoxide radicals| response to hydrogen peroxide| response to hydroperoxide| response to reactive oxygen species| response to selenium ion| shoot system development| stamen development| toxin catabolic process| unsaturated fatty acid biosynthetic process| unsaturated fatty acid metabolic process |
| 113 | PF12955 | Domain of unknown function (DUF3844) | No Pfam Clan | 106 (32) | 103 | 91 | (1) EGF/Laminin [g.3.11] (4-50) |
(1) Knottins (small inhibitors, toxins, lectins) [g.3] |
NO PREDICTION | NO PREDICTION | g.3.11(6-52) | NO PREDICTION | g.3.11(4-50) | 2 | No information | Eukaryota | No information | No information | No information | No information |
| 114 | PF04063 | Domain of unknown function (DUF383) | No Pfam Clan | 308 (31) | 192 | 261 | (1) ARM repeat [a.118.1] (11-191) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(4-153) | a.118.1(11-191) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 115 | PF14262 | Domain of unknown function (DUF4353) | No Pfam Clan | 568 (51) | 264 | 266 | (1) Pectin lyase-like [b.80.1] (2-263) |
(1) Single-stranded right-handed beta-helix [b.80] |
NO PREDICTION | b.80.1(2-263) | NO PREDICTION | b.80.1(6-266) | NO PREDICTION | 2 | No information | Bacteria|Archaea | 3.1.1.11| 3.2.1.11| 3.2.1.15| 3.2.1.157| 3.2.1.57| 3.2.1.58| 3.4.21.72| 4.2.2.10| 4.2.2.18| 4.2.2.19| 4.2.2.2| 4.2.2.7 | anchored to membrane| plant-type cell wall | carbon-oxygen lyase activity, acting on polysaccharides| carboxylic ester hydrolase activity| galacturan 1,4-alpha-galacturonidase activity| pectinesterase activity| polygalacturonase activity | cell growth| cell wall organization or biogenesis| developmental cell growth| developmental growth| developmental growth involved in morphogenesis| external encapsulating structure organization| galacturonan metabolic process| pectin catabolic process| plant-type cell wall organization| plant-type cell wall organization or biogenesis| pollen tube development| pollen tube growth| pollination| polysaccharide catabolic process| polysaccharide metabolic process| unidimensional cell growth |
| 116 | PF11849 | Domain of unknown function (DUF3369) | GAF (CL0161) | 346 (63) | 174 | 172 | (1) GAF domain-like [d.110.2] (15-170) |
(1) Profilin-like [d.110] |
d.110.2(34-173) | d.110.2(15-170) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota|Bacteria | 1.8.4.14| 4.6.1.1 | No information | No information | No information |
| 117 | PF12416 | Cep120 protein | No Pfam Clan | 109 (16) | 340 | 333 | (1) C2 domain (Calcium/lipid-binding domain, CaLB) [b.7.1] (2-134) |
(1) C2 domain-like [b.7] |
NO PREDICTION | NO PREDICTION | b.7.1(2-134) | NO PREDICTION | b.7.1(2-125) | 2 | No information | Eukaryota | No information | No information | No information | No information |
| 118 | PF15008 | Domain of unknown function (DUF4518) | No Pfam Clan | 96 (14) | 262 | 274 | (1) NTF2-like [d.17.4] (133-271) |
(1) Cystatin-like [d.17] |
NO PREDICTION | NO PREDICTION | d.17.4(135-270) | NO PREDICTION | d.17.4(133-271) | 2 | No information | Eukaryota | 3.3.2.8| 4.2.1.94| 5.3.3.1 | T-tubule| axon initial segment| axon part| cell-cell contact zone| main axon| neuromuscular junction| nuclear envelope| pore complex| sarcolemma | Ran GTPase binding | G1/S transition of mitotic cell cycle| RNA export from nucleus| RNA localization| antibiotic biosynthetic process| antibiotic metabolic process| blood circulation| calcium ion transport| cardiac muscle contraction| cell cycle phase| cell cycle phase transition| drug metabolic process| establishment of RNA localization| heart contraction| heart process| interphase| interphase of mitotic cell cycle| mitotic cell cycle phase transition| muscle contraction| muscle system process| nuclear transport| nucleobase-containing compound transport| nucleocytoplasmic transport| peptidyl-serine phosphorylation| poly(A)+ mRNA export from nucleus| positive regulation of antimicrobial peptide biosynthetic process| positive regulation of cellular amide metabolic process| protein autophosphorylation| regulation of antimicrobial humoral response| regulation of antimicrobial peptide biosynthetic process| regulation of antimicrobial peptide production| regulation of cellular amide metabolic process| regulation of humoral immune response| regulation of production of molecular mediator of immune response| regulation of sodium ion transport| striated muscle contraction |
| 119 | PF11946 | Domain of unknown function (DUF3463) | No Pfam Clan | 326 (67) | 138 | 143 | (1) Radical SAM enzymes [c.1.28] (4-118) |
(1) TIM beta/alpha-barrel [c.1] |
c.1.28(1-114) | NO PREDICTION | c.1.28(4-118) | NO PREDICTION | NO PREDICTION | 2 | No information | Bacteria|Archaea | 1.3.99.22| 1.97.1.4| 2.8.1.6| 5.4.3.2 | lipid particle | 4 iron, 4 sulfur cluster binding| biotin synthase activity| intramolecular transferase activity| lipoate synthase activity| lipoate-protein ligase activity| metal cluster binding| oxidoreductase activity, acting on the CH-CH group of donors| protein self-association| radical SAM enzyme activity| sulfurtransferase activity| transferase activity, transferring sulfur-containing groups | CD4-positive, alpha-beta T cell activation| CD4-positive, alpha-beta T cell differentiation| T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| defense response to virus| lipoate biosynthetic process| lipoate metabolic process| lymphocyte differentiation| molybdopterin cofactor biosynthetic process| molybdopterin cofactor metabolic process| monocarboxylic acid biosynthetic process| negative regulation of protein secretion| negative regulation of protein transport| negative regulation of secretion| positive regulation of T cell cytokine production| positive regulation of T cell mediated immunity| positive regulation of T-helper 2 cell cytokine production| positive regulation of adaptive immune response| positive regulation of adaptive immune response based on somatic recombination of immune receptors b| positive regulation of cytokine production| positive regulation of cytokine production involved in immune response| positive regulation of immune effector process| positive regulation of leukocyte mediated immunity| positive regulation of lymphocyte mediated immunity| positive regulation of production of molecular mediator of immune response| positive regulation of toll-like receptor 9 signaling pathway| positive regulation of toll-like receptor signaling pathway| prosthetic group metabolic process| regulation of T cell cytokine production| regulation of T cell mediated immunity| regulation of T-helper 2 cell cytokine production| regulation of adaptive immune response| regulation of cytokine production involved in immune response| regulation of leukocyte mediated immunity| regulation of lymphocyte mediated immunity| regulation of production of molecular mediator of immune response| regulation of protein secretion| regulation of toll-like receptor 7 signaling pathway| regulation of toll-like receptor 9 signaling pathway| regulation of toll-like receptor signaling pathway| regulation of type 2 immune response| response to virus| vitamin biosynthetic process |
| 120 | PF07611 | Protein of unknown function (DUF1574) | No Pfam Clan | 48 (4) | 345 | 350 | (1) SGNH hydrolase [c.23.10] (38-344) |
(1) Flavodoxin-like [c.23] |
NO PREDICTION | c.23.10(38-344) | NO PREDICTION | NO PREDICTION | c.23.10(256-348) | 2 | No information | Bacteria | 3.1.1.2| 3.1.1.47| 3.1.1.5| 3.1.1.53| 3.1.1.72| 3.2.1.4 | No information | carboxylic ester hydrolase activity | sexual reproduction| spermatogenesis |
| 121 | PF06972 | Protein of unknown function (DUF1296) | UBA (CL0214) | 106 (7) | 60 | 60 | (1) UBA-like [a.5.2] (3-60) |
(1) RuvA C-terminal domain-like [a.5] |
NO PREDICTION | NO PREDICTION | a.5.2(3-60) | NO PREDICTION | a.5.2(4-55) | 2 | No information | Eukaryota | No information | No information | No information | No information |
| 122 | PF12094 | Protein of unknown function (DUF3570) | No Pfam Clan | 141 (41) | 420 | 406 | (1) Porins [f.4.3] (1-406) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.3(24-419) | NO PREDICTION | f.4.3(1-406) | NO PREDICTION | 2 | No information | Bacteria|Viruses | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 123 | PF10649 | Protein of unknown function (DUF2478) | P-loop_NTPase (CL0023) | 205 (57) | 159 | 150 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (INDIRECT) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
c.37.1(4-140) | c.37.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota|Bacteria | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 124 | PF08873 | Domain of unknown function (DUF1834) | No Pfam Clan | 142 (15) | 188 | 202 | (1) Phage tail protein-like [d.323.1] (1-150) |
(1) Phage tail protein-like [d.323] |
NO PREDICTION | d.323.1(1-150) | NO PREDICTION | NO PREDICTION | d.323.1(4-150) | 2 | No information | Bacteria|Viruses | No information | No information | No information | No information |
| 125 | PF11687 | Domain of unknown function (DUF3284) | Bet_V_1_like (CL0209) | 343 (15) | 120 | 120 | (1) Bet v1-like [d.129.3] (1-109) |
(1) TBP-like [d.129] |
NO PREDICTION | NO PREDICTION | d.129.3(6-110) | NO PREDICTION | d.129.3(1-109) | 2 | No information | Bacteria | 1.14.12.12| 1.14.12.18| 3.1.3.16| 4.2.1.78 | intercellular canaliculus| microvillus | abscisic acid binding| alcohol binding| alcohol transmembrane transporter activity| anion transmembrane transporter activity| carboxylic acid binding| hormone binding| isoprenoid binding| lipid transporter activity| monocarboxylic acid binding| organic anion transmembrane transporter activity| organic cation transmembrane transporter activity| organic hydroxy compound transmembrane transporter activity| phosphate transmembrane transporter activity| phosphatidylcholine transporter activity| phospholipid transporter activity| protein homodimerization activity| quaternary ammonium group transmembrane transporter activity | abscisic acid mediated signaling pathway| acid secretion| bile acid secretion| cellular response to abscisic acid stimulus| cellular response to alcohol| cellular response to hormone stimulus| cellular response to lipid| hormone-mediated signaling pathway| lipid localization| lipid transport| monocarboxylic acid transport| organic anion transport| organophosphate ester transport| phospholipid transport| positive regulation of peroxisome proliferator activated receptor signaling pathway| quaternary ammonium group transport| regulation of peroxisome proliferator activated receptor signaling pathway| regulation of post-embryonic development| response to abscisic acid stimulus| response to alcohol| response to hormone stimulus| response to lipid |
| 126 | PF14247 | Domain of unknown function (DUF4344) | No Pfam Clan | 149 (33) | 220 | 230 | (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (9-149) |
(1) Zincin-like [d.92] |
NO PREDICTION | d.92.1(9-149) | d.92.1(12-68)| d.92.1(99-179) | NO PREDICTION | NO PREDICTION | 2 | No information | Bacteria|Archaea | 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 | cortical granule | glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity | biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing |
| 127 | PF11443 | Domain of unknown function (DUF2828) | No Pfam Clan | 303 (19) | 534 | 510 | (1) vWA-like [c.62.1] (299-503) |
(1) vWA-like [c.62] |
NO PREDICTION | NO PREDICTION | c.62.1(301-408) | NO PREDICTION | c.62.1(299-503) | 2 | No information | Eukaryota|Bacteria|Viruses | No information | extracellular matrix | No information | DNA repair| double-strand break repair| double-strand break repair via nonhomologous end joining| non-recombinational repair| response to ionizing radiation |
| 128 | PF07607 | Protein of unknown function (DUF1570) | Peptidase_MA (CL0126) | 34 (9) | 128 | 125 | (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (1-127) |
(1) Zincin-like [d.92] |
NO PREDICTION | d.92.1(1-127) | NO PREDICTION | NO PREDICTION | d.92.1(2-41) | 2 | No information | Bacteria | 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 | cortical granule | glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity | biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing |
| 129 | PF09894 | Uncharacterized protein conserved in archaea (DUF2121) | No Pfam Clan | 34 (13) | 194 | 193 | (1) N-terminal nucleophile aminohydrolases (Ntn hydrolases) [d.153.1] (2-180) |
(1) Ntn hydrolase-like [d.153] |
NO PREDICTION | d.153.1(INDIRECT) | NO PREDICTION | NO PREDICTION | d.153.1(2-180) | 2 | No information | Archaea | 2.3.2.2| 2.4.2.14| 2.6.1.16| 3.4.19.5| 3.4.25.1| 3.4.25.2| 3.5.1.11| 3.5.1.24| 3.5.1.26| 3.5.1.93| 3.5.1.97 | cytoplasmic mRNA processing body| cytosolic proteasome complex| proteasome complex| proteasome core complex| proteasome core complex, alpha-subunit complex| proteasome core complex, beta-subunit complex| ribonucleoprotein granule | N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity| asparaginase activity| gamma-glutamyltransferase activity| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides| omega peptidase activity| peptidase activity| threonine-type endopeptidase activity| threonine-type peptidase activity| transferase activity, transferring amino-acyl groups | DNA damage checkpoint| DNA damage response, signal transduction by p53 class mediator| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest| DNA integrity checkpoint| G1 DNA damage checkpoint| G1/S transition of mitotic cell cycle| antigen processing and presentation| antigen processing and presentation of exogenous peptide antigen| antigen processing and presentation of exogenous peptide antigen via MHC class I| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent| antigen processing and presentation of peptide antigen via MHC class I| asparagine catabolic process| asparagine catabolic process via L-aspartate| asparagine metabolic process| aspartate family amino acid catabolic process| aspartate family amino acid metabolic process| cell cycle checkpoint| cell cycle phase| cell cycle phase transition| cellular amino acid catabolic process| cellular protein catabolic process| cellular protein complex assembly| fat cell differentiation| fatty acid beta-oxidation| gluconeogenesis| glucose catabolic process| glutamine family amino acid metabolic process| glutathione metabolic process| glycolysis| hexose biosynthetic process| hexose catabolic process| interphase| interphase of mitotic cell cycle| interspecies interaction between organisms| lipid modification| lipid oxidation| mitotic DNA damage checkpoint| mitotic DNA integrity checkpoint| mitotic G1 DNA damage checkpoint| mitotic cell cycle| mitotic cell cycle checkpoint| mitotic cell cycle phase transition| mitotic spindle elongation| modification-dependent macromolecule catabolic process| monosaccharide biosynthetic process| monosaccharide catabolic process| multi-organism cellular process| negative regulation of G1/S transition of mitotic cell cycle| negative regulation of apoptotic process| negative regulation of cell cycle phase transition| negative regulation of cell cycle process| negative regulation of ligase activity| negative regulation of mitotic cell cycle phase transition| negative regulation of protein modification process| negative regulation of protein ubiquitination| photorespiration| positive regulation of cell cycle arrest| positive regulation of cell cycle process| positive regulation of ligase activity| positive regulation of protein modification process| positive regulation of protein ubiquitination| positive regulation of ubiquitin-protein ligase activity| positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle| proteasomal protein catabolic process| proteasome assembly| protein catabolic process| protein deglycosylation| protein polyubiquitination| protein ubiquitination| proteolysis| proteolysis involved in cellular protein catabolic process| regulation of G1/S transition of mitotic cell cycle| regulation of cell cycle arrest| regulation of cell cycle phase transition| regulation of cellular amine metabolic process| regulation of cellular amino acid metabolic process| regulation of cellular ketone metabolic process| regulation of ligase activity| regulation of mitotic cell cycle| regulation of protein ubiquitination| regulation of ubiquitin-protein ligase activity| regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle| response to misfolded protein| response to salt stress| response to topologically incorrect protein| signal transduction by p53 class mediator| signal transduction in response to DNA damage| signal transduction involved in DNA damage checkpoint| signal transduction involved in DNA integrity checkpoint| signal transduction involved in cell cycle checkpoint| signal transduction involved in mitotic G1 DNA damage checkpoint| signal transduction involved in mitotic cell cycle checkpoint| spindle elongation| symbiosis, encompassing mutualism through parasitism| viral process |
| 130 | PF09983 | Uncharacterized protein conserved in bacteria C-term(DUF2220) | Toprim-like (CL0413) | 376 (31) | 181 | 178 | (1) DNA topoisomerase IV, alpha subunit [e.12.1] (2-172) |
(1) DNA topoisomerase IV, alpha subunit [e.12] |
e.12.1(2-172) | NO PREDICTION | NO PREDICTION | NO PREDICTION | e.12.1(29-170) | 2 | No information | Eukaryota|Bacteria|Viruses | No information | No information | No information | DNA recombination| cellular process involved in reproduction| chromosome organization| chromosome organization involved in meiosis| meiosis| meiosis I| meiotic cell cycle| reciprocal meiotic recombination |
| 131 | PF11001 | Protein of unknown function (DUF2841) | No Pfam Clan | 181 (34) | 126 | 157 | (1) DNA-binding domain of EIN3-like [a.140.5] (13-124) |
(1) LEM/SAP HeH motif [a.140] |
NO PREDICTION | a.140.5(13-124) | NO PREDICTION | NO PREDICTION | a.140.5(28-120) | 2 | No information | Eukaryota | No information | No information | No information | No information |
| 132 | PF07510 | Protein of unknown function (DUF1524) | His-Me_finger (CL0263) | 2469 (240) | 142 | 168 | (1) His-Me finger endonucleases [d.4.1] (1-141) |
(1) His-Me finger endonucleases [d.4] |
d.4.1(17-103) | d.4.1(1-141) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota|Bacteria|Viruses|Archaea | 3.1.21.1| 3.1.22.4| 3.1.30.2 | No information | No information | No information |
| 133 | PF10288 | Protein of unknown function (DUF2392) | No Pfam Clan | 268 (35) | 107 | 113 | (1) Adenine nucleotide alpha hydrolases-like [c.26.2] (2-113) |
(1) Adenine nucleotide alpha hydrolase-like [c.26] |
c.26.2(2-105) | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.26.2(2-113) | 2 | No information | Eukaryota | 1.8.4.8| 2.1.1.61| 2.7.7.2| 6.3.1.5| 6.3.4.5| 6.3.5.1| 6.3.5.2| 6.3.5.4 | No information | electron carrier activity| oxidoreductase activity, acting on a sulfur group of donors| phosphoadenylyl-sulfate reductase (thioredoxin) activity | response to fungus| response to molecule of fungal origin| sulfate assimilation |
| 134 | PF03314 | Protein of unknown function, DUF273 | GT-A (CL0110) | 87 (12) | 222 | 222 | (1) Nucleotide-diphospho-sugar transferases [c.68.1] (2-201) |
(1) Nucleotide-diphospho-sugar transferases [c.68] |
NO PREDICTION | c.68.1(2-201) | c.68.1(6-128) | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota | 2.4.1.101| 2.4.1.131| 2.4.1.135| 2.4.1.186| 2.4.1.217| 2.4.1.222| 2.4.1.223| 2.4.1.37| 2.4.1.41| 2.4.1.44| 2.4.1.87| 2.7.7.13| 2.7.7.23| 2.7.7.24| 2.7.7.27| 2.7.7.33| 2.7.7.38| 2.7.7.43| 2.7.7.60| 2.7.7.64| 2.7.7.9 | Golgi apparatus| Golgi apparatus part| Golgi membrane| cis-Golgi network| mannosyltransferase complex | UDP-glycosyltransferase activity| acetylgalactosaminyltransferase activity| ceramide glucosyltransferase activity| cytidylyltransferase activity| galactosyltransferase activity| glucose-1-phosphate thymidylyltransferase activity| guanylyltransferase activity| magnesium ion binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups | aminoglycan biosynthetic process| aminoglycan metabolic process| cell wall biogenesis| cell wall mannoprotein biosynthetic process| cell wall organization or biogenesis| cellular carbohydrate biosynthetic process| cellular component macromolecule biosynthetic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| chondroitin sulfate biosynthetic process| chondroitin sulfate metabolic process| chondroitin sulfate proteoglycan biosynthetic process| chondroitin sulfate proteoglycan metabolic process| dolichol metabolic process| extracellular fibril organization| extracellular matrix organization| extracellular structure organization| fibril organization| galactose metabolic process| gametophyte development| glycolipid metabolic process| glycoprotein biosynthetic process| glycoprotein metabolic process| glycosaminoglycan biosynthetic process| glycosphingolipid biosynthetic process| glycosylation| heparan sulfate proteoglycan biosynthetic process| heparan sulfate proteoglycan metabolic process| lipopolysaccharide metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| negative regulation of fibroblast proliferation| nucleotide-sugar metabolic process| peptidyl-asparagine modification| phosphatidylinositol biosynthetic process| phosphatidylinositol metabolic process| pollen development| polyprenol metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein O-linked glycosylation| protein glycosylation| regulation of Notch signaling pathway| regulation of fibroblast proliferation| sphingolipid biosynthetic process| sphingolipid metabolic process |
| 135 | PF04317 | YcjX-like family, DUF463 | P-loop_NTPase (CL0023) | 1031 (51) | 443 | 442 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (2-134) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
NO PREDICTION | NO PREDICTION | c.37.1(2-134) | NO PREDICTION | c.37.1(1-27) | 2 | YES | Bacteria | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 136 | PF14243 | Domain of unknown function (DUF4343) | No Pfam Clan | 270 (33) | 130 | 131 | (1) Glutathione synthetase ATP-binding domain-like [d.142.1] (1-122) |
(1) ATP-grasp [d.142] |
NO PREDICTION | d.142.1(1-122) | NO PREDICTION | NO PREDICTION | d.142.1(2-117) | 2 | No information | Eukaryota|Bacteria|Viruses | 4.1.1.21| 6.3.1.9| 6.3.2.23| 6.3.2.3| 6.3.2.4| 6.3.4.13| 6.3.4.14| 6.3.4.18 | No information | glutathione synthase activity | microtubule-based process| response to cadmium ion |
| 137 | PF14213 | Domain of unknown function (DUF4325) | No Pfam Clan | 205 (60) | 74 | 76 | (1) SpoIIaa-like [c.13.2] (1-71) |
(1) SpoIIaa-like [c.13] |
NO PREDICTION | c.13.2(1-71) | c.13.2(6-65) | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota|Bacteria|Viruses|Archaea | No information | No information | No information | No information |
| 138 | PF10354 | Domain of unknown function (DUF2431) | NADP_Rossmann (CL0063) | 435 (47) | 166 | 204 | (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (1-165) |
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66] |
c.66.1(1-130) | c.66.1(1-165) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota|Bacteria | 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 | nuclear matrix | glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups | Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process |
| 139 | PF09994 | Uncharacterized alpha/beta hydrolase domain (DUF2235) | AB_hydrolase (CL0028) | 1245 (90) | 277 | 265 | (1) alpha/beta-Hydrolases [c.69.1] (1-276) |
(1) alpha/beta-Hydrolases [c.69] |
NO PREDICTION | c.69.1(1-276) | c.69.1(32-189) | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota|Bacteria|Viruses | 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 | trans-Golgi network transport vesicle | CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity | acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process |
| 140 | PF11959 | Domain of unknown function (DUF3473) | No Pfam Clan | 224 (51) | 134 | 133 | (1) Glycoside hydrolase/deacetylase [c.6.2] (1-132) |
(1) 7-stranded beta/alpha barrel [c.6] |
c.6.2(1-132) | NO PREDICTION | c.6.2(16-108) | NO PREDICTION | NO PREDICTION | 2 | No information | Bacteria|Viruses|Archaea | 2.4.1.18| 2.4.1.25| 3.1.1.72| 3.2.1.1| 3.2.1.114| 3.2.1.24| 3.5.1.33| 3.5.1.41| 3.5.2.5 | No information | deacetylase activity | No information |
| 141 | PF12054 | Domain of unknown function (DUF3535) | No Pfam Clan | 289 (32) | 441 | 467 | (1) ARM repeat [a.118.1] (1-441) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(1-441) | a.118.1(1-440) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 142 | PF10962 | Protein of unknown function (DUF2764) | No Pfam Clan | 168 (10) | 271 | 299 | (1) V-type ATP synthase subunit C [f.40.1] (8-266) |
(1) V-type ATP synthase subunit C [f.40] |
NO PREDICTION | f.40.1(8-266) | NO PREDICTION | NO PREDICTION | f.40.1(31-276) | 2 | No information | Bacteria | No information | apical part of cell| apical plasma membrane| vacuolar membrane| vacuolar part | No information | No information |
| 143 | PF07223 | Protein of unknown function (DUF1421) | No Pfam Clan | 104 (9) | 358 | 299 | (1) ssDNA viruses [b.121.5] (1-262) (2) UBA-like [a.5.2] (259-285) |
(1) RuvA C-terminal domain-like [a.5] (2) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | b.121.5(1-262) | a.5.2(259-285) | 2 | No information | Eukaryota | No information | No information | No information | No information |
| 144 | PF11059 | Protein of unknown function (DUF2860) | MBB (CL0193) | 262 (29) | 297 | 301 | (1) Porins [f.4.3] (1-296) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.3(1-296) | f.4.3(2-80)| f.4.3(111-149)| f.4.3(191-261) | NO PREDICTION | NO PREDICTION | 2 | No information | Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 145 | PF15390 | Domain of unknown function (DUF4613) | No Pfam Clan | 69 (23) | 671 | 675 | (1) 3-carboxy-cis,cis-mucoante lactonizing enzyme [b.69.10] (315-400) (2) WD40 repeat-like [b.69.4] (26-221) |
(1) 7-bladed beta-propeller [b.69] |
NO PREDICTION | NO PREDICTION | b.69.4(26-221)| b.69.10(315-400) | NO PREDICTION | b.69.4(20-185) | 2 | No information | Eukaryota | 5.5.1.5 | Arp2/3 protein complex| CIA complex| Cdc73/Paf1 complex| Cul4-RING ubiquitin ligase complex| ER to Golgi transport vesicle| SMN complex| SMN-Sm protein complex| Ski complex| THO complex| TORC1 complex| chromosome, centromeric region| cullin-RING ubiquitin ligase complex| eukaryotic translation initiation factor 3 complex| extrinsic to internal side of plasma membrane| extrinsic to membrane| extrinsic to plasma membrane| female germ cell nucleus| germ cell nucleus| heterotrimeric G-protein complex| histone methyltransferase complex| immunological synapse| internal side of plasma membrane| kinetochore| methylosome| methyltransferase complex| nuclear envelope| nuclear pore| nuclear pore outer ring| pore complex| transcription export complex| transcriptionally active chromatin| ubiquitin ligase complex | G-protein gamma-subunit binding| histone binding| peroxisome targeting sequence binding| phosphatidylinositol binding| phosphatidylinositol-3,5-bisphosphate binding| phosphatidylinositol-3-phosphate binding| phosphatidylinositol-5-phosphate binding| signal sequence binding| translation initiation factor activity | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile| T cell homeostasis| TOR signaling cascade| attachment of spindle microtubules to kinetochore| attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation| autophagy| cellular response to starvation| chromosome segregation| embryonic digit morphogenesis| establishment of RNA localization| establishment of chromosome localization| establishment of organelle localization| fruiting body development| histone H3-K4 methylation| histone methylation| histone modification| iron-sulfur cluster assembly| mRNA export from nucleus| membrane disassembly| metallo-sulfur cluster assembly| metaphase plate congression| methylation| microtubule-based process| mitotic metaphase plate congression| mitotic spindle assembly checkpoint| negative regulation of calcium ion transmembrane transporter activity| negative regulation of cation channel activity| negative regulation of cell cycle process| negative regulation of ion transmembrane transporter activity| negative regulation of transporter activity| negative regulation of voltage-gated calcium channel activity| nuclear envelope disassembly| nuclear pore organization| nucleic acid transport| nucleobase-containing compound transport| peptidyl-lysine modification| peptidyl-lysine trimethylation| peroxisomal transport| positive regulation of DNA-dependent transcription, elongation| positive regulation of histone H3-K79 methylation| positive regulation of histone methylation| positive regulation of histone modification| positive regulation of organelle organization| positive regulation of transcription elongation from RNA polymerase II promoter| protein alkylation| protein import| protein targeting| regulation of cell cycle process| regulation of histone H3-K79 methylation| regulation of histone methylation| regulation of histone modification| regulation of metaphase/anaphase transition of cell cycle| regulation of mitotic metaphase/anaphase transition| regulation of reproductive process| regulation of transcription elongation from RNA polymerase II promoter| regulation of voltage-gated calcium channel activity| response to starvation| spindle assembly checkpoint| spindle checkpoint| uropod organization |
| 146 | PF06727 | Protein of unknown function (DUF1207) | No Pfam Clan | 77 (8) | 338 | 350 | (1) OMPA-like [f.4.1] (138-297) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.1(138-297) | f.4.1(155-262)| f.4.1(292-350) | NO PREDICTION | NO PREDICTION | 2 | No information | Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | O-acyltransferase activity| O-palmitoyltransferase activity| palmitoyltransferase activity| transferase activity, transferring acyl groups other than amino-acyl groups | glycolipid biosynthetic process| glycolipid metabolic process| lipid A biosynthetic process| lipid A metabolic process| lipooligosaccharide biosynthetic process| lipooligosaccharide metabolic process| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| phospholipid biosynthetic process| phospholipid metabolic process |
| 147 | PF13154 | Protein of unknown function (DUF3991) | No Pfam Clan | 763 (113) | 77 | 76 | (1) DNA primase core [e.13.1] (1-77) |
(1) DNA primase core [e.13] |
e.13.1(1-77) | NO PREDICTION | NO PREDICTION | NO PREDICTION | e.13.1(1-70) | 2 | No information | Bacteria | No information | No information | No information | No information |
| 148 | PF13635 | Domain of unknown function (DUF4143) | PDDEXK (CL0236) | 2818 (579) | 90 | 141 | (1) Restriction endonuclease-like [c.52.1] (1-89) |
(1) Restriction endonuclease-like [c.52] |
c.52.1(36-90) | c.52.1(1-89) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota|Bacteria|Viruses|Archaea | 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 | No information | endonuclease activity| nuclease activity | DNA repair| nucleotide-excision repair |
| 149 | PF06852 | Protein of unknown function (DUF1248) | Acetyltrans (CL0257) | 63 (10) | 181 | 181 | (1) Acyl-CoA N-acyltransferases (Nat) [d.108.1] (28-181) |
(1) Acyl-CoA N-acyltransferases (Nat) [d.108] |
d.108.1(28-181) | NO PREDICTION | NO PREDICTION | NO PREDICTION | d.108.1(29-137) | 2 | No information | Eukaryota | 2.3.1.1| 2.3.1.128| 2.3.1.178| 2.3.1.4| 2.3.1.48| 2.3.1.57| 2.3.1.82| 2.3.1.87| 2.3.1.88| 2.3.1.97| 2.3.2.10| 2.3.2.6 | N-terminal protein acetyltransferase complex| perinuclear region of cytoplasm| protein acetyltransferase complex | N-acetyltransferase activity| N-acyltransferase activity| acetyltransferase activity| ornithine decarboxylase inhibitor activity| ornithine decarboxylase regulator activity| transferase activity, transferring acyl groups other than amino-acyl groups | DNA packaging| N-terminal protein amino acid acetylation| N-terminal protein amino acid modification| UDP-N-acetylglucosamine biosynthetic process| UDP-N-acetylglucosamine metabolic process| amide biosynthetic process| amino sugar biosynthetic process| amino sugar metabolic process| cellular hormone metabolic process| cellular response to cAMP| cellular response to nitrogen compound| cellular response to organic cyclic compound| cellular response to organonitrogen compound| chromatin assembly| chromatin organization| chromosome organization| chromosome segregation| circadian rhythm| covalent chromatin modification| gastrulation with mouth forming second| histone acetylation| histone modification| hormone biosynthetic process| hormone metabolic process| indole-containing compound biosynthetic process| indole-containing compound metabolic process| melatonin biosynthetic process| melatonin metabolic process| mitotic sister chromatid cohesion| mitotic sister chromatid segregation| nucleotide-sugar biosynthetic process| nucleotide-sugar metabolic process| peptidyl-lysine modification| peptidyl-methionine modification| polyamine metabolic process| protein acetylation| protein acylation| protein-DNA complex assembly| protein-DNA complex subunit organization| regulation of hormone levels| response to cAMP| response to organophosphorus| response to purine-containing compound| response to toxic substance| rhythmic process |
| 150 | PF10105 | Uncharacterized protein conserved in bacteria (DUF2344) | No Pfam Clan | 639 (74) | 187 | 176 | (1) Pseudouridine synthase [d.265.1] (19-141) |
(1) Pseudouridine synthase [d.265] |
d.265.1(54-169) | NO PREDICTION | NO PREDICTION | NO PREDICTION | d.265.1(19-141) | 2 | No information | Eukaryota|Bacteria | 4.2.1.70| 5.4.99.12 | nucleolus | hydro-lyase activity| intramolecular transferase activity| pseudouridine synthase activity| pseudouridylate synthase activity| ribonucleoprotein complex binding| snoRNP binding | RNA modification| ncRNA processing| rRNA modification| ribonucleoprotein complex biogenesis| ribosome biogenesis| tRNA pseudouridine synthesis |
| 151 | PF09366 | Protein of unknown function (DUF1997) | No Pfam Clan | 280 (34) | 159 | 161 | (1) Bet v1-like [d.129.3] (3-149) |
(1) TBP-like [d.129] |
NO PREDICTION | d.129.3(1-147) | NO PREDICTION | NO PREDICTION | d.129.3(3-149) | 2 | No information | Eukaryota|Bacteria | 1.14.12.12| 1.14.12.18| 3.1.3.16| 4.2.1.78 | intercellular canaliculus| microvillus | abscisic acid binding| alcohol binding| alcohol transmembrane transporter activity| anion transmembrane transporter activity| carboxylic acid binding| hormone binding| isoprenoid binding| lipid transporter activity| monocarboxylic acid binding| organic anion transmembrane transporter activity| organic cation transmembrane transporter activity| organic hydroxy compound transmembrane transporter activity| phosphate transmembrane transporter activity| phosphatidylcholine transporter activity| phospholipid transporter activity| protein homodimerization activity| quaternary ammonium group transmembrane transporter activity | abscisic acid mediated signaling pathway| acid secretion| bile acid secretion| cellular response to abscisic acid stimulus| cellular response to alcohol| cellular response to hormone stimulus| cellular response to lipid| hormone-mediated signaling pathway| lipid localization| lipid transport| monocarboxylic acid transport| organic anion transport| organophosphate ester transport| phospholipid transport| positive regulation of peroxisome proliferator activated receptor signaling pathway| quaternary ammonium group transport| regulation of peroxisome proliferator activated receptor signaling pathway| regulation of post-embryonic development| response to abscisic acid stimulus| response to alcohol| response to hormone stimulus| response to lipid |
| 152 | PF10013 | Uncharacterized protein conserved in bacteria (DUF2256) | TRASH (CL0175) | 341 (71) | 42 | 42 | (1) Glucocorticoid receptor-like (DNA-binding domain) [g.39.1] (7-41) |
(1) Glucocorticoid receptor-like (DNA-binding domain) [g.39] |
NO PREDICTION | g.39.1(7-41) | NO PREDICTION | NO PREDICTION | g.39.1(7-40) | 2 | YES | Eukaryota|Bacteria|Viruses | 2.7.1.21| 4.2.99.18 | No information | No information | No information |
| 153 | PF07855 | Protein of unknown function (DUF1649) | No Pfam Clan | 256 (11) | 163 | 153 | (1) The spindle assembly checkpoint protein mad2 [d.135.1] (6-150) |
(1) The spindle assembly checkpoint protein mad2 [d.135] |
NO PREDICTION | d.135.1(6-150) | NO PREDICTION | NO PREDICTION | d.135.1(8-149) | 2 | No information | Eukaryota | No information | DNA polymerase complex| anaphase-promoting complex| chromosomal part| chromosome, centromeric region| cullin-RING ubiquitin ligase complex| kinetochore| nuclear ubiquitin ligase complex| spindle| ubiquitin ligase complex| zeta DNA polymerase complex | No information | DNA damage response, signal transduction resulting in transcription| chromosome organization| chromosome segregation| mitotic sister chromatid segregation| mitotic spindle assembly checkpoint| mitotic spindle checkpoint| negative regulation of catabolic process| negative regulation of cell cycle| negative regulation of cell cycle phase transition| negative regulation of cell cycle process| negative regulation of cellular catabolic process| negative regulation of cellular component organization| negative regulation of cellular protein metabolic process| negative regulation of ligase activity| negative regulation of metaphase/anaphase transition of cell cycle| negative regulation of mitosis| negative regulation of mitotic anaphase-promoting complex activity| negative regulation of mitotic metaphase/anaphase transition| negative regulation of nuclear division| negative regulation of organelle organization| negative regulation of proteasomal protein catabolic process| negative regulation of proteasomal ubiquitin-dependent protein catabolic process| negative regulation of protein catabolic process| negative regulation of protein modification process| negative regulation of protein ubiquitination| negative regulation of proteolysis| negative regulation of ubiquitin-protein ligase activity| negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle| nuclear division| positive regulation of cellular protein metabolic process| positive regulation of peptidyl-serine phosphorylation| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of phosphorylation| positive regulation of protein phosphorylation| positive regulation of transcription, DNA-dependent| regulation of cell cycle phase transition| regulation of cell cycle process| regulation of ligase activity| regulation of metaphase/anaphase transition of cell cycle| regulation of mitosis| regulation of mitotic metaphase/anaphase transition| regulation of nuclear division| regulation of peptidyl-serine phosphorylation| regulation of proteasomal protein catabolic process| regulation of proteasomal ubiquitin-dependent protein catabolic process| regulation of protein catabolic process| regulation of protein ubiquitination| regulation of proteolysis| regulation of ubiquitin-protein ligase activity| regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle| signal transduction in response to DNA damage| spindle assembly checkpoint| spindle checkpoint |
| 154 | PF03269 | Caenorhabditis protein of unknown function, DUF268 | NADP_Rossmann (CL0063) | 72 (6) | 177 | 164 | (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (1-146) |
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66] |
NO PREDICTION | c.66.1(1-146) | c.66.1(41-108) | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota|Bacteria|Archaea | 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 | nuclear matrix | glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups | Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process |
| 155 | PF12345 | Protein of unknown function (DUF3641) | No Pfam Clan | 232 (83) | 134 | 135 | (1) Radical SAM enzymes [c.1.28] (1-127) |
(1) TIM beta/alpha-barrel [c.1] |
c.1.28(1-127) | NO PREDICTION | c.1.28(11-132) | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota|Bacteria | 1.3.99.22| 1.97.1.4| 2.8.1.6| 5.4.3.2 | lipid particle | 4 iron, 4 sulfur cluster binding| biotin synthase activity| intramolecular transferase activity| lipoate synthase activity| lipoate-protein ligase activity| metal cluster binding| oxidoreductase activity, acting on the CH-CH group of donors| protein self-association| radical SAM enzyme activity| sulfurtransferase activity| transferase activity, transferring sulfur-containing groups | CD4-positive, alpha-beta T cell activation| CD4-positive, alpha-beta T cell differentiation| T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| defense response to virus| lipoate biosynthetic process| lipoate metabolic process| lymphocyte differentiation| molybdopterin cofactor biosynthetic process| molybdopterin cofactor metabolic process| monocarboxylic acid biosynthetic process| negative regulation of protein secretion| negative regulation of protein transport| negative regulation of secretion| positive regulation of T cell cytokine production| positive regulation of T cell mediated immunity| positive regulation of T-helper 2 cell cytokine production| positive regulation of adaptive immune response| positive regulation of adaptive immune response based on somatic recombination of immune receptors b| positive regulation of cytokine production| positive regulation of cytokine production involved in immune response| positive regulation of immune effector process| positive regulation of leukocyte mediated immunity| positive regulation of lymphocyte mediated immunity| positive regulation of production of molecular mediator of immune response| positive regulation of toll-like receptor 9 signaling pathway| positive regulation of toll-like receptor signaling pathway| prosthetic group metabolic process| regulation of T cell cytokine production| regulation of T cell mediated immunity| regulation of T-helper 2 cell cytokine production| regulation of adaptive immune response| regulation of cytokine production involved in immune response| regulation of leukocyte mediated immunity| regulation of lymphocyte mediated immunity| regulation of production of molecular mediator of immune response| regulation of protein secretion| regulation of toll-like receptor 7 signaling pathway| regulation of toll-like receptor 9 signaling pathway| regulation of toll-like receptor signaling pathway| regulation of type 2 immune response| response to virus| vitamin biosynthetic process |
| 156 | PF12916 | Protein of unknown function (DUF3834) | PBP (CL0177) | 19 (10) | 201 | 204 | (1) Periplasmic binding protein-like II [c.94.1] (7-198) |
(1) Periplasmic binding protein-like II [c.94] |
NO PREDICTION | NO PREDICTION | c.94.1(74-140) | NO PREDICTION | c.94.1(7-198) | 2 | No information | Eukaryota|Bacteria|Archaea | 1.16.1.2| 2.4.2.17| 2.5.1.2| 2.5.1.61| 3.13.1.3| 3.6.3.24 | ATP-binding cassette (ABC) transporter complex| cell envelope| coated pit| early endosome| external encapsulating structure part| periplasmic space| recycling endosome | ATPase activity| ATPase activity, coupled| ATPase activity, coupled to movement of substances| P-P-bond-hydrolysis-driven transmembrane transporter activity| amino acid transmembrane transporter activity| amino acid-transporting ATPase activity| anion transmembrane-transporting ATPase activity| hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances| iron ion binding| primary active transmembrane transporter activity | SMAD protein signal transduction| iron ion transport| phosphate ion transport| polyamine transmembrane transport| polyamine transport| thiamine biosynthetic process| thiamine-containing compound biosynthetic process| thiamine-containing compound metabolic process| water-soluble vitamin biosynthetic process |
| 157 | PF07318 | Protein of unknown function (DUF1464) | Actin_ATPase (CL0108) | 65 (11) | 343 | 318 | (1) Actin-like ATPase domain [c.55.1] (1-320) |
(1) Ribonuclease H-like motif [c.55] |
NO PREDICTION | c.55.1(1-320) | NO PREDICTION | NO PREDICTION | c.55.1(150-288) | 2 | No information | Bacteria|Archaea | 2.7.1.1| 2.7.1.12| 2.7.1.16| 2.7.1.17| 2.7.1.2| 2.7.1.30| 2.7.1.33| 2.7.1.4| 2.7.1.5| 2.7.1.55| 2.7.1.59| 2.7.1.60| 2.7.1.63| 2.7.2.1| 2.7.2.15| 2.7.2.7| 3.4.24.57| 3.6.1.11| 3.6.1.3 | cell cortex| cell cortex part| cilium part| contractile fiber part| cortical cytoskeleton| motile cilium| sperm flagellum| sperm part| sperm principal piece | carbohydrate kinase activity| hexokinase activity| phosphotransferase activity, alcohol group as acceptor| unfolded protein binding | 'de novo' protein folding| ATP catabolic process| actomyosin structure organization| carbohydrate phosphorylation| chaperone mediated protein folding requiring cofactor| glucose 6-phosphate metabolic process| glycolysis| myofibril assembly| nucleoside monophosphate catabolic process| protein folding| purine nucleoside monophosphate catabolic process| purine nucleoside monophosphate metabolic process| purine ribonucleoside monophosphate catabolic process| purine ribonucleoside monophosphate metabolic process| ribonucleoside monophosphate catabolic process| ribonucleoside monophosphate metabolic process |
| 158 | PF09892 | Uncharacterized protein conserved in archaea (DUF2119) | No Pfam Clan | 27 (10) | 193 | 194 | (1) Zn-dependent exopeptidases [c.56.5] (2-192) |
(1) Phosphorylase/hydrolase-like [c.56] |
NO PREDICTION | c.56.5(2-192) | NO PREDICTION | NO PREDICTION | c.56.5(8-93) | 2 | No information | Archaea | 2.3.2.5| 3.4.11.1| 3.4.11.10| 3.4.11.21| 3.4.11.24| 3.4.11.4| 3.4.11.7| 3.4.13.18| 3.4.13.20| 3.4.13.3| 3.4.17.1| 3.4.17.11| 3.4.17.12| 3.4.17.15| 3.4.17.18| 3.4.17.2| 3.4.17.20| 3.4.17.21| 3.4.17.3| 3.5.1.14| 3.5.1.15| 3.5.1.16| 3.5.1.18| 3.5.1.28| 3.5.1.6| 3.5.1.96 | No information | aminoacylase activity| exopeptidase activity| glutaminyl-peptide cyclotransferase activity| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides| transferase activity, transferring amino-acyl groups | arginine metabolic process| peptidyl-glutamine modification |
| 159 | PF09324 | Domain of unknown function (DUF1981) | No Pfam Clan | 681 (41) | 86 | 87 | (1) ARM repeat [a.118.1] (13-87) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(23-84) | NO PREDICTION | a.118.1(13-87) | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 160 | PF11684 | Protein of unknown function (DUF2380) | No Pfam Clan | 121 (26) | 140 | 146 | (1) TolB, N-terminal domain [c.51.2] (2-145) |
(1) Anticodon-binding domain-like [c.51] |
NO PREDICTION | c.51.2(1-139) | NO PREDICTION | NO PREDICTION | c.51.2(2-145) | 2 | No information | Bacteria | No information | No information | No information | No information |
| 161 | PF08961 | Domain of unknown function (DUF1875) | No Pfam Clan | 73 (3) | 243 | 243 | (1) MIT domain-like [a.7.16] (1-42) |
(1) Spectrin repeat-like [a.7] |
NO PREDICTION | NO PREDICTION | a.7.16(1-40) | NO PREDICTION | a.7.16(1-42) | 2 | No information | Eukaryota|Bacteria | No information | No information | No information | No information |
| 162 | PF10677 | Protein of unknown function (DUF2490) | MBB (CL0193) | 262 (62) | 194 | 233 | (1) Porins [f.4.3] (1-193) |
(1) Transmembrane beta-barrels [f.4] |
f.4.3(40-181) | f.4.3(1-193) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | YES | Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 163 | PF07632 | Protein of unknown function (DUF1593) | No Pfam Clan | 158 (29) | 260 | 329 | (1) Nucleoside hydrolase [c.70.1] (1-260) |
(1) Nucleoside hydrolase [c.70] |
c.70.1(1-260) | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.70.1(1-189) | 2 | No information | Eukaryota|Bacteria | 3.2.2.1| 3.2.2.8 | No information | hydrolase activity, hydrolyzing N-glycosyl compounds| ribosylpyrimidine nucleosidase activity | cellular metabolic compound salvage| glycosyl compound catabolic process| pyrimidine nucleoside catabolic process| pyrimidine nucleoside metabolic process| pyrimidine ribonucleoside catabolic process| pyrimidine ribonucleoside metabolic process| pyrimidine-containing compound catabolic process| pyrimidine-containing compound metabolic process |
| 164 | PF07279 | Protein of unknown function (DUF1442) | NADP_Rossmann (CL0063) | 79 (4) | 218 | 215 | (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (27-187) |
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66] |
c.66.1(26-185) | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.66.1(27-187) | 2 | No information | Eukaryota|Bacteria | 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 | nuclear matrix | glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups | Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process |
| 165 | PF06672 | Protein of unknown function (DUF1175) | Peptidase_CA (CL0125) | 358 (13) | 217 | 205 | (1) Cysteine proteinases [d.3.1] (27-215) |
(1) Cysteine proteinases [d.3] |
NO PREDICTION | d.3.1(27-215) | NO PREDICTION | NO PREDICTION | d.3.1(21-201) | 2 | No information | Bacteria | 2.3.1.118| 2.3.1.5| 2.3.2.13| 2.3.2.15| 3.1.1.4| 3.4.14.1| 3.4.18.1| 3.4.19.12| 3.4.22.1| 3.4.22.10| 3.4.22.14| 3.4.22.15| 3.4.22.16| 3.4.22.2| 3.4.22.25| 3.4.22.27| 3.4.22.30| 3.4.22.38| 3.4.22.39| 3.4.22.40| 3.4.22.41| 3.4.22.43| 3.4.22.48| 3.4.22.51| 3.4.22.52| 3.4.22.53| 3.4.22.6| 3.4.22.65| 3.4.22.68| 3.5.1.52| 6.3.1.9 | alveolar lamellar body| endosome lumen| lamellar body| lytic vacuole| vacuolar lumen | MHC class I receptor activity| N-acyltransferase activity| acetyltransferase activity| arylamine N-acetyltransferase activity| cysteine-type carboxypeptidase activity| cysteine-type endopeptidase activity| cysteine-type endopeptidase regulator activity involved in apoptotic process| cysteine-type peptidase activity| hormone binding| peptidase activator activity| peptidase activator activity involved in apoptotic process| peptidase activity| peptidase regulator activity| small conjugating protein binding| thiolester hydrolase activity| thyroid hormone binding| ubiquitin thiolesterase activity | ERK1 and ERK2 cascade| T cell mediated cytotoxicity| T cell mediated immunity| adaptive immune response| anatomical structure maturation| bradykinin catabolic process| catagen| cell killing| cellular response to thyroid hormone stimulus| chemical homeostasis within a tissue| collagen metabolic process| decidualization| dichotomous subdivision of an epithelial terminal unit| dichotomous subdivision of terminal units involved in lung branching| epidermis morphogenesis| epithelial tube branching involved in lung morphogenesis| extracellular matrix disassembly| female pregnancy| hair cycle| hair cycle process| hair follicle development| hair follicle maturation| hair follicle morphogenesis| immune response-regulating signaling pathway| leukocyte mediated cytotoxicity| leukocyte mediated immunity| lung development| lung morphogenesis| lymphocyte mediated immunity| maternal placenta development| maternal process involved in female pregnancy| metanephros development| molting cycle process| multicellular organismal catabolic process| multicellular organismal homeostasis| negative regulation of epithelial cell proliferation| negative regulation of keratinocyte proliferation| neuropeptide catabolic process| peptide catabolic process| peptide metabolic process| placenta development| positive regulation of angiogenesis| positive regulation of apoptotic signaling pathway| positive regulation of developmental process| positive regulation of epithelial cell migration| positive regulation of peptidase activity| posttranscriptional regulation of gene expression| protein destabilization| protein maturation| protein modification by small protein conjugation or removal| protein modification by small protein removal| protein processing| proteolysis| regulation of actin cytoskeleton reorganization| regulation of epithelial cell migration| regulation of keratinocyte proliferation| regulation of peptidase activity| regulation of protein stability| respiratory tube development| response to retinoic acid| response to thyroid hormone stimulus| skin morphogenesis| surfactant homeostasis| tissue homeostasis |
| 166 | PF10934 | Protein of unknown function (DUF2634) | No Pfam Clan | 250 (26) | 112 | 103 | (1) gpW/gp25-like [d.373.1] (19-107) |
(1) gpW/gp25-like [d.373] |
d.373.1(19-107) | NO PREDICTION | NO PREDICTION | NO PREDICTION | d.373.1(10-96) | 2 | No information | Bacteria|Viruses | No information | No information | No information | No information |
| 167 | PF13826 | Domain of unknown function (DUF4188) | Dim_A_B_barrel (CL0032) | 173 (48) | 117 | 126 | (1) Dimeric alpha+beta barrel [d.58.4] (1-102) |
(1) Ferredoxin-like [d.58] |
NO PREDICTION | d.58.4(1-102) | NO PREDICTION | NO PREDICTION | d.58.4(22-117) | 2 | No information | Eukaryota|Bacteria|Archaea | 1.13.11.49| 1.13.11.55| 1.14.99.3| 5.3.3.4| 5.4.99.14 | No information | No information | No information |
| 168 | PF04412 | Protein of unknown function (DUF521) | No Pfam Clan | 289 (42) | 400 | 420 | (1) Aconitase iron-sulfur domain [c.83.1] (280-379) |
(1) Aconitase iron-sulfur domain [c.83] |
NO PREDICTION | c.83.1(INDIRECT) | NO PREDICTION | NO PREDICTION | c.83.1(280-379) | 2 | No information | Eukaryota|Bacteria|Archaea | 4.2.1.3 | No information | hydro-lyase activity | No information |
| 169 | PF11903 | Protein of unknown function (DUF3423) | Met_repress (CL0057) | 485 (57) | 73 | 73 | (1) Ribbon-helix-helix [a.43.1] (1-59) |
(1) Ribbon-helix-helix [a.43] |
NO PREDICTION | a.43.1(1-59) | NO PREDICTION | NO PREDICTION | a.43.1(3-52) | 2 | No information | Eukaryota|Bacteria | No information | No information | No information | positive regulation of growth |
| 170 | PF10908 | Protein of unknown function (DUF2778) | No Pfam Clan | 375 (28) | 120 | 107 | (1) L,D-transpeptidase catalytic domain-like [b.160.1] (22-118) |
(1) L,D-transpeptidase catalytic domain-like [b.160] |
NO PREDICTION | b.160.1(22-118) | NO PREDICTION | NO PREDICTION | b.160.1(26-104) | 2 | No information | Eukaryota|Bacteria | No information | No information | No information | No information |
| 171 | PF11925 | Protein of unknown function (DUF3443) | No Pfam Clan | 153 (24) | 371 | 381 | (1) Acid proteases [b.50.1] (23-370) |
(1) Acid proteases [b.50] |
NO PREDICTION | b.50.1(23-370) | NO PREDICTION | NO PREDICTION | b.50.1(29-370) | 2 | No information | Bacteria | 3.4.23.1| 3.4.23.15| 3.4.23.16| 3.4.23.18| 3.4.23.20| 3.4.23.21| 3.4.23.22| 3.4.23.23| 3.4.23.24| 3.4.23.25| 3.4.23.29| 3.4.23.3| 3.4.23.34| 3.4.23.39| 3.4.23.4| 3.4.23.40| 3.4.23.45| 3.4.23.46| 3.4.23.5 | alveolar lamellar body| lamellar body| lytic vacuole | aspartic-type endopeptidase activity| aspartic-type peptidase activity| endopeptidase activity| peptidase activity | anatomical structure homeostasis| antigen processing and presentation| antigen processing and presentation of exogenous antigen| antigen processing and presentation of exogenous peptide antigen| antigen processing and presentation of exogenous peptide antigen via MHC class II| antigen processing and presentation of peptide antigen| antigen processing and presentation of peptide antigen via MHC class II| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II| autophagic vacuole assembly| autophagy| cellular response to external stimulus| cellular response to extracellular stimulus| cellular response to nutrient levels| cellular response to starvation| chemical homeostasis within a tissue| macroautophagy| membrane protein proteolysis| multicellular organismal homeostasis| organelle assembly| protein processing| proteolysis| response to extracellular stimulus| response to nutrient levels| response to starvation| surfactant homeostasis| tissue homeostasis| vacuole organization |
| 172 | PF06940 | Domain of unknown function (DUF1287) | Peptidase_CA (CL0125) | 504 (25) | 164 | 165 | (1) Cysteine proteinases [d.3.1] (35-155) |
(1) Cysteine proteinases [d.3] |
NO PREDICTION | d.3.1(INDIRECT) | NO PREDICTION | NO PREDICTION | d.3.1(35-155) | 2 | No information | Bacteria | 2.3.1.118| 2.3.1.5| 2.3.2.13| 2.3.2.15| 3.1.1.4| 3.4.14.1| 3.4.18.1| 3.4.19.12| 3.4.22.1| 3.4.22.10| 3.4.22.14| 3.4.22.15| 3.4.22.16| 3.4.22.2| 3.4.22.25| 3.4.22.27| 3.4.22.30| 3.4.22.38| 3.4.22.39| 3.4.22.40| 3.4.22.41| 3.4.22.43| 3.4.22.48| 3.4.22.51| 3.4.22.52| 3.4.22.53| 3.4.22.6| 3.4.22.65| 3.4.22.68| 3.5.1.52| 6.3.1.9 | alveolar lamellar body| endosome lumen| lamellar body| lytic vacuole| vacuolar lumen | MHC class I receptor activity| N-acyltransferase activity| acetyltransferase activity| arylamine N-acetyltransferase activity| cysteine-type carboxypeptidase activity| cysteine-type endopeptidase activity| cysteine-type endopeptidase regulator activity involved in apoptotic process| cysteine-type peptidase activity| hormone binding| peptidase activator activity| peptidase activator activity involved in apoptotic process| peptidase activity| peptidase regulator activity| small conjugating protein binding| thiolester hydrolase activity| thyroid hormone binding| ubiquitin thiolesterase activity | ERK1 and ERK2 cascade| T cell mediated cytotoxicity| T cell mediated immunity| adaptive immune response| anatomical structure maturation| bradykinin catabolic process| catagen| cell killing| cellular response to thyroid hormone stimulus| chemical homeostasis within a tissue| collagen metabolic process| decidualization| dichotomous subdivision of an epithelial terminal unit| dichotomous subdivision of terminal units involved in lung branching| epidermis morphogenesis| epithelial tube branching involved in lung morphogenesis| extracellular matrix disassembly| female pregnancy| hair cycle| hair cycle process| hair follicle development| hair follicle maturation| hair follicle morphogenesis| immune response-regulating signaling pathway| leukocyte mediated cytotoxicity| leukocyte mediated immunity| lung development| lung morphogenesis| lymphocyte mediated immunity| maternal placenta development| maternal process involved in female pregnancy| metanephros development| molting cycle process| multicellular organismal catabolic process| multicellular organismal homeostasis| negative regulation of epithelial cell proliferation| negative regulation of keratinocyte proliferation| neuropeptide catabolic process| peptide catabolic process| peptide metabolic process| placenta development| positive regulation of angiogenesis| positive regulation of apoptotic signaling pathway| positive regulation of developmental process| positive regulation of epithelial cell migration| positive regulation of peptidase activity| posttranscriptional regulation of gene expression| protein destabilization| protein maturation| protein modification by small protein conjugation or removal| protein modification by small protein removal| protein processing| proteolysis| regulation of actin cytoskeleton reorganization| regulation of epithelial cell migration| regulation of keratinocyte proliferation| regulation of peptidase activity| regulation of protein stability| respiratory tube development| response to retinoic acid| response to thyroid hormone stimulus| skin morphogenesis| surfactant homeostasis| tissue homeostasis |
| 173 | PF10026 | Predicted Zn-dependent protease (DUF2268) | Peptidase_MA (CL0126) | 528 (29) | 195 | 183 | (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (1-194) |
(1) Zincin-like [d.92] |
d.92.1(7-146) | d.92.1(1-194) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | No information | Bacteria|Archaea | 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 | cortical granule | glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity | biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing |
| 174 | PF09807 | Uncharacterized conserved protein (DUF2348) | No Pfam Clan | 176 (5) | 249 | 251 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (1-213) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
NO PREDICTION | c.37.1(1-213) | NO PREDICTION | NO PREDICTION | c.37.1(2-211) | 2 | No information | Eukaryota | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 175 | PF06245 | Protein of unknown function (DUF1015) | No Pfam Clan | 830 (97) | 416 | 438 | (1) ParB/Sulfiredoxin [d.268.1] (102-404) |
(1) ParB/Sulfiredoxin [d.268] |
NO PREDICTION | d.268.1(102-404) | NO PREDICTION | NO PREDICTION | d.268.1(199-435) | 2 | YES | Eukaryota|Bacteria|Archaea | 1.8.98.2 | No information | No information | No information |
| 176 | PF04781 | Protein of unknown function (DUF627) | No Pfam Clan | 70 (17) | 112 | 122 | (1) TPR-like [a.118.8] (2-109) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(2-107) | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.118.8(2-109) | 2 | No information | Eukaryota | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 177 | PF12099 | Protein of unknown function (DUF3575) | MBB (CL0193) | 605 (39) | 189 | 193 | (1) Autotransporter [f.4.5] (23-188) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.5(23-188) | f.4.5(88-181) | NO PREDICTION | NO PREDICTION | 2 | YES | Bacteria | No information | No information | No information | No information |
| 178 | PF13020 | Domain of unknown function (DUF3883) | PDDEXK (CL0236) | 729 (140) | 91 | 102 | (1) Restriction endonuclease-like [c.52.1] (1-90) |
(1) Restriction endonuclease-like [c.52] |
NO PREDICTION | c.52.1(1-90) | NO PREDICTION | NO PREDICTION | c.52.1(36-80) | 2 | No information | Eukaryota|Bacteria|Archaea | 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 | No information | endonuclease activity| nuclease activity | DNA repair| nucleotide-excision repair |
| 179 | PF11929 | Domain of unknown function (DUF3447) | Ank (CL0465) | 1243 (607) | 76 | 82 | (1) Ankyrin repeat [d.211.1] (1-76) |
(1) beta-hairpin-alpha-hairpin repeat [d.211] |
d.211.1(1-76) | NO PREDICTION | d.211.1(3-62) | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota | No information | intercellular bridge | NF-kappaB binding| cyclin-dependent protein serine/threonine kinase inhibitor activity| cyclin-dependent protein serine/threonine kinase regulator activity| enzyme binding| histone deacetylase binding| kinase inhibitor activity| kinase regulator activity| protein kinase inhibitor activity| protein kinase regulator activity| protein serine/threonine kinase inhibitor activity | cell cycle arrest| cytoplasmic sequestering of protein| cytoplasmic sequestering of transcription factor| interphase| maintenance of location| maintenance of location in cell| maintenance of protein location| maintenance of protein location in cell| mitotic cell cycle phase transition| negative regulation of NF-kappaB transcription factor activity| negative regulation of cell cycle| negative regulation of intracellular protein transport| negative regulation of intracellular transport| negative regulation of kinase activity| negative regulation of phosphorylation| negative regulation of protein import into nucleus| negative regulation of protein kinase activity| negative regulation of protein serine/threonine kinase activity| negative regulation of protein transport| negative regulation of transcription factor import into nucleus| positive regulation of NF-kappaB transcription factor activity| positive regulation of transforming growth factor beta receptor signaling pathway| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway| regulation of I-kappaB kinase/NF-kappaB cascade| regulation of NF-kappaB import into nucleus| regulation of cyclin-dependent protein serine/threonine kinase activity| regulation of protein localization to nucleus| regulation of transcription factor import into nucleus| spleen development |
| 180 | PF11897 | Protein of unknown function (DUF3417) | No Pfam Clan | 640 (79) | 119 | 119 | (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (3-119) |
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87] |
c.87.1(3-119) | NO PREDICTION | c.87.1(21-119) | NO PREDICTION | NO PREDICTION | 2 | No information | Bacteria|Viruses|Archaea | 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 | alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) | UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups | L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process |
| 181 | PF04285 | Protein of unknown function (DUF444) | vWA-like (CL0128) | 1564 (8) | 421 | 423 | (1) vWA-like [c.62.1] (252-418) |
(1) vWA-like [c.62] |
NO PREDICTION | NO PREDICTION | c.62.1(252-418) | NO PREDICTION | c.62.1(246-352) | 2 | No information | Bacteria|Viruses|Archaea | No information | extracellular matrix | No information | DNA repair| double-strand break repair| double-strand break repair via nonhomologous end joining| non-recombinational repair| response to ionizing radiation |
| 182 | PF04789 | Protein of unknown function (DUF621) | GPCR_A (CL0192) | 52 (14) | 306 | 308 | (1) Family A G protein-coupled receptor-like [f.13.1] (12-296) |
(1) Family A G protein-coupled receptor-like [f.13] |
NO PREDICTION | f.13.1(12-296) | NO PREDICTION | NO PREDICTION | f.13.1(49-297) | 2 | No information | Eukaryota | No information | cilium| cilium membrane| cilium part| early endosome| integral to plasma membrane| intrinsic to plasma membrane| photoreceptor inner segment| photoreceptor inner segment membrane| photoreceptor outer segment| photoreceptor outer segment membrane| primary cilium | G-protein coupled receptor activity| amide binding| catecholamine binding| chemokine receptor activity| molecular transducer activity| neuropeptide binding| odorant binding| peptide binding| pheromone binding| receptor activity| retinal binding| signaling receptor activity | G-protein coupled receptor signaling pathway| calcium ion homeostasis| cellular calcium ion homeostasis| cellular divalent inorganic cation homeostasis| cellular response to cytokine stimulus| cellular response to disaccharide stimulus| cellular response to sucrose stimulus| chemokine-mediated signaling pathway| complement receptor mediated signaling pathway| detection of chemical stimulus| detection of chemical stimulus involved in sensory perception| detection of light stimulus| detection of stimulus| detection of stimulus involved in sensory perception| diet induced thermogenesis| divalent inorganic cation homeostasis| germ cell migration| histamine secretion| histamine transport| hormone secretion| inflammatory response| mRNA transcription| mRNA transcription from RNA polymerase II promoter| negative regulation of nucleotide biosynthetic process| negative regulation of nucleotide metabolic process| negative regulation of purine nucleotide metabolic process| nonassociative learning| platelet activation| positive regulation of MAPK cascade| positive regulation of cyclase activity| positive regulation of cyclic nucleotide biosynthetic process| positive regulation of cytokinesis| positive regulation of intracellular protein kinase cascade| positive regulation of leukocyte degranulation| positive regulation of lyase activity| positive regulation of mast cell activation| positive regulation of mast cell activation involved in immune response| positive regulation of mucus secretion| positive regulation of multicellular organismal metabolic process| positive regulation of nucleotide biosynthetic process| positive regulation of nucleotide metabolic process| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of purine nucleotide metabolic process| purinergic receptor signaling pathway| regulation of ERK1 and ERK2 cascade| regulation of MAPK cascade| regulation of cAMP biosynthetic process| regulation of cAMP metabolic process| regulation of cyclase activity| regulation of cyclic nucleotide biosynthetic process| regulation of cyclic nucleotide metabolic process| regulation of interleukin-8 secretion| regulation of intracellular protein kinase cascade| regulation of leukocyte degranulation| regulation of lyase activity| regulation of mast cell activation| regulation of mast cell activation involved in immune response| regulation of mucus secretion| regulation of multicellular organismal metabolic process| regulation of myeloid leukocyte mediated immunity| regulation of nucleotide biosynthetic process| regulation of nucleotide metabolic process| regulation of purine nucleotide biosynthetic process| regulation of purine nucleotide metabolic process| regulation of systemic arterial blood pressure by norepinephrine-epinephrine| regulation of vasoconstriction| response to pheromone| sensory perception| sensory perception of chemical stimulus |
| 183 | PF14394 | Domain of unknown function (DUF4423) | No Pfam Clan | 72 (52) | 171 | 175 | (1) "Winged helix" DNA-binding domain [a.4.5] (20-146) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
NO PREDICTION | a.4.5(20-146) | NO PREDICTION | NO PREDICTION | a.4.5(22-87) | 2 | No information | Bacteria | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 184 | PF10082 | Uncharacterized protein conserved in bacteria (DUF2320) | MBB (CL0193) | 519 (39) | 381 | 373 | (1) Porins [f.4.3] (6-380) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.3(6-380) | NO PREDICTION | f.4.3(1-373) | NO PREDICTION | 2 | No information | Eukaryota|Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 185 | PF11312 | Protein of unknown function (DUF3115) | No Pfam Clan | 129 (20) | 315 | 318 | (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (22-307) |
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66] |
NO PREDICTION | c.66.1(22-307) | NO PREDICTION | NO PREDICTION | c.66.1(107-253) | 2 | No information | Eukaryota | 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 | nuclear matrix | glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups | Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process |
| 186 | PF05911 | Plant protein of unknown function (DUF869) | No Pfam Clan | 276 (12) | 769 | 821 | (1) C-terminal domain of PLC-beta [h.4.10] (66-333) (2) Tropomyosin [h.1.5] (648-815) |
(1) Parallel coiled-coil [h.1] (2) Antiparallel coiled-coil [h.4] |
NO PREDICTION | NO PREDICTION | h.1.5(648-815) | h.4.10(66-333) | NO PREDICTION | 2 | No information | Eukaryota | 3.1.4.11 | actin filament| cell cortex| cell cortex part| cell division site| cell division site part| contractile fiber| contractile fiber part| contractile ring| dendritic spine head| filamentous actin| growth cone| muscle thin filament tropomyosin| myofilament| neuronal postsynaptic density| podosome| site of polarized growth| striated muscle thin filament| synapse part | structural constituent of cytoskeleton | G-protein coupled glutamate receptor signaling pathway| actin filament-based movement| actin-myosin filament sliding| behavioral response to cocaine| chemical homeostasis within a tissue| chordate embryonic development| glutamate receptor signaling pathway| in utero embryonic development| multicellular organismal movement| muscle cell development| muscle cell differentiation| muscle contraction| muscle organ development| muscle system process| muscle tissue development| positive regulation of ion transport| regulation of calcium ion transport| regulation of metal ion transport| response to alkaloid| response to ammonium ion| response to cocaine| striated muscle cell differentiation| striated muscle tissue development| tissue homeostasis |
| 187 | PF10023 | Predicted aminopeptidase (DUF2265) | No Pfam Clan | 162 (26) | 338 | 339 | (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (49-337) |
(1) Zincin-like [d.92] |
NO PREDICTION | d.92.1(49-337) | NO PREDICTION | NO PREDICTION | d.92.1(163-202) | 2 | No information | Bacteria|Viruses | 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 | cortical granule | glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity | biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing |
| 188 | PF09664 | Protein of unknown function C-terminus (DUF2399) | Toprim-like (CL0413) | 184 (17) | 152 | 155 | (1) DNA topoisomerase IV, alpha subunit [e.12.1] (5-144) |
(1) DNA topoisomerase IV, alpha subunit [e.12] |
e.12.1(5-144) | NO PREDICTION | NO PREDICTION | NO PREDICTION | e.12.1(24-148) | 2 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | DNA recombination| cellular process involved in reproduction| chromosome organization| chromosome organization involved in meiosis| meiosis| meiosis I| meiotic cell cycle| reciprocal meiotic recombination |
| 189 | PF02694 | Uncharacterised BCR, YnfA/UPF0060 family | DMT (CL0184) | 1396 (4) | 107 | 108 | (1) Multidrug resistance efflux transporter EmrE [f.39.1] (6-106) |
(1) Multidrug resistance efflux transporter EmrE [f.39] |
NO PREDICTION | f.39.1(6-106) | f.39.1(7-106) | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 190 | PF04570 | Protein of unknown function (DUF581) | TRASH (CL0175) | 427 (42) | 59 | 59 | (1) Glucocorticoid receptor-like (DNA-binding domain) [g.39.1] (16-53) |
(1) Glucocorticoid receptor-like (DNA-binding domain) [g.39] |
g.39.1(19-55) | g.39.1(16-53) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota | 2.7.1.21| 4.2.99.18 | No information | No information | No information |
| 191 | PF11142 | Protein of unknown function (DUF2917) | No Pfam Clan | 253 (40) | 63 | 64 | (1) RmlC-like cupins [b.82.1] (1-61) |
(1) Double-stranded beta-helix [b.82] |
b.82.1(2-53) | b.82.1(1-61) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 2 | No information | Bacteria | 1.13.11.20| 1.13.11.24| 1.13.11.4| 1.13.11.5| 1.13.11.50| 1.13.11.53| 1.13.11.6| 1.2.3.4| 3.5.3.19| 4.1.1.2| 5.1.3.13| 5.3.1.15| 5.3.1.17| 5.3.1.8| 5.3.1.9 | No information | 3-hydroxyanthranilate 3,4-dioxygenase activity| auxin binding| dTDP-4-dehydrorhamnose 3,5-epimerase activity| dioxygenase activity| hormone binding| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporati| racemase and epimerase activity, acting on carbohydrates and derivatives | L-methionine salvage| L-methionine salvage from methylthioadenosine| amino acid salvage| aspartate family amino acid biosynthetic process| cellular carbohydrate biosynthetic process| cellular metabolic compound salvage| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| extracellular polysaccharide biosynthetic process| extracellular polysaccharide metabolic process| lipopolysaccharide metabolic process| methionine biosynthetic process| methionine metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| sulfur amino acid biosynthetic process| sulfur amino acid metabolic process |
| 192 | PF07800 | Protein of unknown function (DUF1644) | No Pfam Clan | 198 (18) | 162 | 140 | (1) RING/U-box [g.44.1] (1-103) (2) beta-beta-alpha zinc fingers [g.37.1] (87-110) |
(1) beta-beta-alpha zinc fingers [g.37] (2) RING/U-box [g.44] |
NO PREDICTION | g.44.1(1-103) | NO PREDICTION | NO PREDICTION | g.44.1(1-82)| g.37.1(87-110) | 2 | No information | Eukaryota | No information | nuclear body| nuclear ubiquitin ligase complex| ubiquitin ligase complex | acid-amino acid ligase activity| chromatin binding| small conjugating protein ligase activity | activation of cysteine-type endopeptidase activity| anatomical structure homeostasis| inflammatory response to antigenic stimulus| intrinsic apoptotic signaling pathway in response to oxidative stress| mesenchyme development| modification-dependent macromolecule catabolic process| modification-dependent protein catabolic process| negative regulation of T-helper 2 cell differentiation| negative regulation of T-helper cell differentiation| negative regulation of type 2 immune response| palate development| positive regulation of gene expression| positive regulation of nucleobase-containing compound metabolic process| protein catabolic process| protein modification by small protein conjugation| protein modification by small protein conjugation or removal| regulation of T cell differentiation| regulation of T-helper 2 cell differentiation| regulation of T-helper cell differentiation| regulation of alpha-beta T cell activation| regulation of cell cycle phase transition| regulation of cysteine-type endopeptidase activity| regulation of endopeptidase activity| regulation of leukocyte activation| regulation of leukocyte differentiation| regulation of lymphocyte activation| regulation of lymphocyte differentiation| regulation of peptidase activity| regulation of type 2 immune response| tongue development |
| 193 | PF12031 | Domain of unknown function (DUF3518) | No Pfam Clan | 191 (6) | 257 | 257 | (1) ARM repeat [a.118.1] (3-244) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(3-244) | a.118.1(13-49)| a.118.1(82-231) | NO PREDICTION | NO PREDICTION | 2 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 194 | PF04842 | Plant protein of unknown function (DUF639) | No Pfam Clan | 126 (4) | 683 | 692 | (1) ARM repeat [a.118.1] (18-670) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(18-670) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 195 | PF06250 | Protein of unknown function (DUF1016) | PDDEXK (CL0236) | 1895 (7) | 320 | 324 | (1) Restriction endonuclease-like [c.52.1] (1-319) |
(1) Restriction endonuclease-like [c.52] |
NO PREDICTION | c.52.1(1-319) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 | No information | endonuclease activity| nuclease activity | DNA repair| nucleotide-excision repair |
| 196 | PF11460 | Protein of unknown function (DUF3007) | No Pfam Clan | 109 (30) | 104 | 97 | (1) MFS general substrate transporter [f.38.1] (7-84) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | NO PREDICTION | f.38.1(7-84) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 197 | PF09895 | RecB-family nuclease (DUF2122) | SPOUT (CL0098) | 59 (18) | 106 | 104 | (1) alpha/beta knot [c.116.1] (9-104) |
(1) alpha/beta knot [c.116] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.116.1(9-104) | 1 | No information | Archaea | 2.1.1.31| 2.1.1.34| 2.1.1.66 | No information | RNA methyltransferase activity| methyltransferase activity| rRNA (pseudouridine) methyltransferase activity| rRNA methyltransferase activity| transferase activity, transferring one-carbon groups | RNA methylation| RNA modification| macromolecule methylation| methylation| ncRNA processing| rRNA modification| ribonucleoprotein complex biogenesis| ribosome biogenesis |
| 198 | PF02720 | Domain of unknown function (DUF222) | No Pfam Clan | 2037 (29) | 301 | 326 | (1) Bacterial muramidases [a.118.5] (67-198) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | NO PREDICTION | a.118.5(67-198) | NO PREDICTION | NO PREDICTION | 1 | YES | Bacteria | No information | No information | No information | No information |
| 199 | PF11271 | Protein of unknown function (DUF3068) | No Pfam Clan | 301 (22) | 301 | 311 | (1) C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase [b.70.2] (INDIRECT) |
(1) 8-bladed beta-propeller [b.70] |
NO PREDICTION | b.70.2(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Bacteria|Archaea | No information | No information | No information | No information |
| 200 | PF05689 | Salmonella repeat of unknown function (DUF823) | No Pfam Clan | 1826 (30) | 184 | 181 | (1) Fibronectin type III [b.1.2] (10-176) |
(1) Immunoglobulin-like beta-sandwich [b.1] |
b.1.2(10-176) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 2.1.1.191| 2.1.1.43| 2.7.7.4| 3.5.1.23 | No information | cytokine receptor activity| molecular transducer activity| receptor activity| signaling receptor activity| transmembrane signaling receptor activity | JAK-STAT cascade| cellular response to cytokine stimulus| cytokine-mediated signaling pathway| developmental growth| growth| intracellular protein kinase cascade| lactation| mammary gland alveolus development| mammary gland epithelial cell differentiation| mammary gland epithelium development| mammary gland lobule development| prolactin signaling pathway| prostate gland development| regulation of body fluid levels| regulation of cell adhesion| response to cytokine stimulus |
| 201 | PF08578 | Protein of unknown function (DUF1765) | No Pfam Clan | 180 (31) | 126 | 138 | (1) Hypothetical protein ST1625 [a.118.20] (4-100) |
(1) alpha-alpha superhelix [a.118] |
a.118.20(4-100) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 202 | PF11259 | Protein of unknown function (DUF3060) | No Pfam Clan | 317 (29) | 61 | 62 | (1) beta-Roll [b.80.7] (16-61) |
(1) Single-stranded right-handed beta-helix [b.80] |
b.80.7(16-61) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 203 | PF07374 | Protein of unknown function (DUF1492) | HTH (CL0123) | 341 (6) | 100 | 104 | (1) Homeodomain-like [a.4.1] (66-100) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.4.1(66-100) | 1 | No information | Bacteria|Viruses | No information | transcription factor complex | chromatin binding| nucleic acid binding transcription factor activity| transposase activity | activin receptor signaling pathway| cell fate commitment| cell fate specification| chordate embryonic development| diencephalon development| embryonic morphogenesis| endoderm development| eye photoreceptor cell differentiation| negative regulation of developmental process| neural tube development| neuron fate commitment| nodal signaling pathway| pancreas development| pattern specification process| positive regulation of neuron differentiation| regulation of cell fate commitment| regulation of epithelial cell differentiation| regulation of gastrulation| retina development in camera-type eye| sensory organ development| somitogenesis| transmembrane receptor protein serine/threonine kinase signaling pathway| transposition| transposition, DNA-mediated| trophectodermal cell differentiation |
| 204 | PF06197 | Protein of unknown function (DUF998) | Frag1-like (CL0412) | 925 (111) | 184 | 183 | (1) MFS general substrate transporter [f.38.1] (1-183) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(1-183) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 205 | PF11847 | Domain of unknown function (DUF3367) | No Pfam Clan | 220 (14) | 680 | 667 | (1) MFS general substrate transporter [f.38.1] (INDIRECT) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 206 | PF13904 | Domain of unknown function (DUF4207) | No Pfam Clan | 192 (19) | 264 | 243 | (1) MW0975(SA0943)-like [a.24.27] (68-237) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(68-237) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | No information | No information | No information |
| 207 | PF03690 | Uncharacterised protein family (UPF0160) | No Pfam Clan | 570 (69) | 318 | 324 | (1) DHH phosphoesterases [c.107.1] (1-317) |
(1) DHH phosphoesterases [c.107] |
NO PREDICTION | c.107.1(1-317) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 3.6.1.1| 3.6.1.11 | No information | No information | No information |
| 208 | PF04028 | Domain of unknown function (DUF374) | Acyltransferase (CL0228) | 649 (79) | 74 | 90 | (1) YVTN repeat-like/Quinoprotein amine dehydrogenase [b.69.2] (21-70) |
(1) 7-bladed beta-propeller [b.69] |
b.69.2(21-70) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Eukaryota|Bacteria | 2.3.2.5 | No information | No information | No information |
| 209 | PF05212 | Protein of unknown function (DUF707) | No Pfam Clan | 266 (9) | 294 | 267 | (1) Nucleotide-diphospho-sugar transferases [c.68.1] (40-290) |
(1) Nucleotide-diphospho-sugar transferases [c.68] |
NO PREDICTION | c.68.1(40-290) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 2.4.1.101| 2.4.1.131| 2.4.1.135| 2.4.1.186| 2.4.1.217| 2.4.1.222| 2.4.1.223| 2.4.1.37| 2.4.1.41| 2.4.1.44| 2.4.1.87| 2.7.7.13| 2.7.7.23| 2.7.7.24| 2.7.7.27| 2.7.7.33| 2.7.7.38| 2.7.7.43| 2.7.7.60| 2.7.7.64| 2.7.7.9 | Golgi apparatus| Golgi apparatus part| Golgi membrane| cis-Golgi network| mannosyltransferase complex | UDP-glycosyltransferase activity| acetylgalactosaminyltransferase activity| ceramide glucosyltransferase activity| cytidylyltransferase activity| galactosyltransferase activity| glucose-1-phosphate thymidylyltransferase activity| guanylyltransferase activity| magnesium ion binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups | aminoglycan biosynthetic process| aminoglycan metabolic process| cell wall biogenesis| cell wall mannoprotein biosynthetic process| cell wall organization or biogenesis| cellular carbohydrate biosynthetic process| cellular component macromolecule biosynthetic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| chondroitin sulfate biosynthetic process| chondroitin sulfate metabolic process| chondroitin sulfate proteoglycan biosynthetic process| chondroitin sulfate proteoglycan metabolic process| dolichol metabolic process| extracellular fibril organization| extracellular matrix organization| extracellular structure organization| fibril organization| galactose metabolic process| gametophyte development| glycolipid metabolic process| glycoprotein biosynthetic process| glycoprotein metabolic process| glycosaminoglycan biosynthetic process| glycosphingolipid biosynthetic process| glycosylation| heparan sulfate proteoglycan biosynthetic process| heparan sulfate proteoglycan metabolic process| lipopolysaccharide metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| negative regulation of fibroblast proliferation| nucleotide-sugar metabolic process| peptidyl-asparagine modification| phosphatidylinositol biosynthetic process| phosphatidylinositol metabolic process| pollen development| polyprenol metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein O-linked glycosylation| protein glycosylation| regulation of Notch signaling pathway| regulation of fibroblast proliferation| sphingolipid biosynthetic process| sphingolipid metabolic process |
| 210 | PF09980 | Predicted membrane protein (DUF2214) | No Pfam Clan | 200 (26) | 150 | 150 | (1) Transmembrane di-heme cytochromes [f.21.1] (3-149) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | f.21.1(3-149) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 1.10.2.2 | No information | electron carrier activity | cellular respiration |
| 211 | PF07878 | Protein of unknown function (DUF1662) | Met_repress (CL0057) | 70 (27) | 55 | 50 | (1) Ribbon-helix-helix [a.43.1] (5-45) |
(1) Ribbon-helix-helix [a.43] |
NO PREDICTION | NO PREDICTION | a.43.1(5-45) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | positive regulation of growth |
| 212 | PF11145 | Protein of unknown function (DUF2921) | No Pfam Clan | 137 (7) | 909 | 955 | (1) Anthrax protective antigen [f.11.1] (INDIRECT) (2) Soluble quinoprotein glucose dehydrogenase [b.68.2] (INDIRECT) |
(1) 6-bladed beta-propeller [b.68] (2) Anthrax protective antigen [f.11] |
NO PREDICTION | f.11.1(INDIRECT)| b.68.2(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 1.1.5.2 | No information | No information | No information |
| 213 | PF14265 | Domain of unknown function (DUF4355) | No Pfam Clan | 633 (85) | 125 | 131 | (1) MW0975(SA0943)-like [a.24.27] (1-124) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(1-124) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | No information | No information | No information | No information |
| 214 | PF10060 | Uncharacterized membrane protein (DUF2298) | No Pfam Clan | 117 (18) | 473 | 553 | (1) Respiratory nitrate reductase 1 gamma chain [f.21.3] (131-338) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | f.21.3(131-338) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | No information | No information | No information |
| 215 | PF12072 | Domain of unknown function (DUF3552) | No Pfam Clan | 2218 (58) | 201 | 194 | (1) MW0975(SA0943)-like [a.24.27] (23-200) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(23-200) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 216 | PF10086 | Putative membrane peptidase family (DUF2324) | Peptidase_U (CL0472) | 607 (28) | 223 | 220 | (1) MFS general substrate transporter [f.38.1] (1-222) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(1-222) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 217 | PF10909 | Protein of unknown function (DUF2682) | No Pfam Clan | 13 (7) | 77 | 79 | (1) BAG domain [a.7.7] (3-70) |
(1) Spectrin repeat-like [a.7] |
a.7.7(3-70) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Viruses | No information | No information | No information | No information |
| 218 | PF10030 | Uncharacterized protein conserved in bacteria (DUF2272) | Peptidase_CA (CL0125) | 136 (13) | 183 | 188 | (1) Cysteine proteinases [d.3.1] (5-170) |
(1) Cysteine proteinases [d.3] |
NO PREDICTION | d.3.1(5-170) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | 2.3.1.118| 2.3.1.5| 2.3.2.13| 2.3.2.15| 3.1.1.4| 3.4.14.1| 3.4.18.1| 3.4.19.12| 3.4.22.1| 3.4.22.10| 3.4.22.14| 3.4.22.15| 3.4.22.16| 3.4.22.2| 3.4.22.25| 3.4.22.27| 3.4.22.30| 3.4.22.38| 3.4.22.39| 3.4.22.40| 3.4.22.41| 3.4.22.43| 3.4.22.48| 3.4.22.51| 3.4.22.52| 3.4.22.53| 3.4.22.6| 3.4.22.65| 3.4.22.68| 3.5.1.52| 6.3.1.9 | alveolar lamellar body| endosome lumen| lamellar body| lytic vacuole| vacuolar lumen | MHC class I receptor activity| N-acyltransferase activity| acetyltransferase activity| arylamine N-acetyltransferase activity| cysteine-type carboxypeptidase activity| cysteine-type endopeptidase activity| cysteine-type endopeptidase regulator activity involved in apoptotic process| cysteine-type peptidase activity| hormone binding| peptidase activator activity| peptidase activator activity involved in apoptotic process| peptidase activity| peptidase regulator activity| small conjugating protein binding| thiolester hydrolase activity| thyroid hormone binding| ubiquitin thiolesterase activity | ERK1 and ERK2 cascade| T cell mediated cytotoxicity| T cell mediated immunity| adaptive immune response| anatomical structure maturation| bradykinin catabolic process| catagen| cell killing| cellular response to thyroid hormone stimulus| chemical homeostasis within a tissue| collagen metabolic process| decidualization| dichotomous subdivision of an epithelial terminal unit| dichotomous subdivision of terminal units involved in lung branching| epidermis morphogenesis| epithelial tube branching involved in lung morphogenesis| extracellular matrix disassembly| female pregnancy| hair cycle| hair cycle process| hair follicle development| hair follicle maturation| hair follicle morphogenesis| immune response-regulating signaling pathway| leukocyte mediated cytotoxicity| leukocyte mediated immunity| lung development| lung morphogenesis| lymphocyte mediated immunity| maternal placenta development| maternal process involved in female pregnancy| metanephros development| molting cycle process| multicellular organismal catabolic process| multicellular organismal homeostasis| negative regulation of epithelial cell proliferation| negative regulation of keratinocyte proliferation| neuropeptide catabolic process| peptide catabolic process| peptide metabolic process| placenta development| positive regulation of angiogenesis| positive regulation of apoptotic signaling pathway| positive regulation of developmental process| positive regulation of epithelial cell migration| positive regulation of peptidase activity| posttranscriptional regulation of gene expression| protein destabilization| protein maturation| protein modification by small protein conjugation or removal| protein modification by small protein removal| protein processing| proteolysis| regulation of actin cytoskeleton reorganization| regulation of epithelial cell migration| regulation of keratinocyte proliferation| regulation of peptidase activity| regulation of protein stability| respiratory tube development| response to retinoic acid| response to thyroid hormone stimulus| skin morphogenesis| surfactant homeostasis| tissue homeostasis |
| 219 | PF14988 | Domain of unknown function (DUF4515) | No Pfam Clan | 151 (11) | 206 | 206 | (1) MW0975(SA0943)-like [a.24.27] (2-189) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(2-189) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | No information | No information | No information |
| 220 | PF04465 | Protein of unknown function (DUF499) | No Pfam Clan | 220 (5) | 1036 | 1016 | (1) ARM repeat [a.118.1] (1-989) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(1-989) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 221 | PF06532 | Protein of unknown function (DUF1109) | No Pfam Clan | 293 (54) | 204 | 204 | (1) Acid phosphatase/Vanadium-dependent haloperoxidase [a.111.1] (9-170) |
(1) Acid phosphatase/Vanadium-dependent haloperoxidase [a.111] |
NO PREDICTION | a.111.1(9-170) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 1.11.1.10| 1.11.1.18| 3.1.3.2 | intrinsic to organelle membrane | inositol phosphoceramide synthase activity| lipid phosphatase activity| phosphatase activity| phosphatidate phosphatase activity| sphingosine-1-phosphate phosphatase activity| sugar-phosphatase activity| sugar-terminal-phosphatase activity | dephosphorylation| germ cell migration| membrane lipid biosynthetic process| membrane lipid metabolic process| phospholipid metabolic process| sphingolipid biosynthetic process| sphingolipid metabolic process |
| 222 | PF04240 | Protein of unknown function (DUF422) | No Pfam Clan | 245 (13) | 215 | 214 | (1) Family A G protein-coupled receptor-like [f.13.1] (INDIRECT) |
(1) Family A G protein-coupled receptor-like [f.13] |
NO PREDICTION | f.13.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | cilium| cilium membrane| cilium part| early endosome| integral to plasma membrane| intrinsic to plasma membrane| photoreceptor inner segment| photoreceptor inner segment membrane| photoreceptor outer segment| photoreceptor outer segment membrane| primary cilium | G-protein coupled receptor activity| amide binding| catecholamine binding| chemokine receptor activity| molecular transducer activity| neuropeptide binding| odorant binding| peptide binding| pheromone binding| receptor activity| retinal binding| signaling receptor activity | G-protein coupled receptor signaling pathway| calcium ion homeostasis| cellular calcium ion homeostasis| cellular divalent inorganic cation homeostasis| cellular response to cytokine stimulus| cellular response to disaccharide stimulus| cellular response to sucrose stimulus| chemokine-mediated signaling pathway| complement receptor mediated signaling pathway| detection of chemical stimulus| detection of chemical stimulus involved in sensory perception| detection of light stimulus| detection of stimulus| detection of stimulus involved in sensory perception| diet induced thermogenesis| divalent inorganic cation homeostasis| germ cell migration| histamine secretion| histamine transport| hormone secretion| inflammatory response| mRNA transcription| mRNA transcription from RNA polymerase II promoter| negative regulation of nucleotide biosynthetic process| negative regulation of nucleotide metabolic process| negative regulation of purine nucleotide metabolic process| nonassociative learning| platelet activation| positive regulation of MAPK cascade| positive regulation of cyclase activity| positive regulation of cyclic nucleotide biosynthetic process| positive regulation of cytokinesis| positive regulation of intracellular protein kinase cascade| positive regulation of leukocyte degranulation| positive regulation of lyase activity| positive regulation of mast cell activation| positive regulation of mast cell activation involved in immune response| positive regulation of mucus secretion| positive regulation of multicellular organismal metabolic process| positive regulation of nucleotide biosynthetic process| positive regulation of nucleotide metabolic process| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of purine nucleotide metabolic process| purinergic receptor signaling pathway| regulation of ERK1 and ERK2 cascade| regulation of MAPK cascade| regulation of cAMP biosynthetic process| regulation of cAMP metabolic process| regulation of cyclase activity| regulation of cyclic nucleotide biosynthetic process| regulation of cyclic nucleotide metabolic process| regulation of interleukin-8 secretion| regulation of intracellular protein kinase cascade| regulation of leukocyte degranulation| regulation of lyase activity| regulation of mast cell activation| regulation of mast cell activation involved in immune response| regulation of mucus secretion| regulation of multicellular organismal metabolic process| regulation of myeloid leukocyte mediated immunity| regulation of nucleotide biosynthetic process| regulation of nucleotide metabolic process| regulation of purine nucleotide biosynthetic process| regulation of purine nucleotide metabolic process| regulation of systemic arterial blood pressure by norepinephrine-epinephrine| regulation of vasoconstriction| response to pheromone| sensory perception| sensory perception of chemical stimulus |
| 223 | PF13252 | Protein of unknown function (DUF4043) | No Pfam Clan | 188 (33) | 341 | 332 | (1) Major capsid protein gp5 [d.183.1] (INDIRECT) |
(1) Major capsid protein gp5 [d.183] |
NO PREDICTION | d.183.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | No information | No information | No information | No information |
| 224 | PF10097 | Predicted membrane protein (DUF2335) | No Pfam Clan | 168 (15) | 50 | 50 | (1) TPR-like [a.118.8] (19-50) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(19-50) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 225 | PF07037 | Putative transcription regulator (DUF1323) | HTH (CL0123) | 925 (10) | 122 | 113 | (1) Putative DNA-binding domain [a.6.1] (1-45) |
(1) Putative DNA-binding domain [a.6] |
NO PREDICTION | NO PREDICTION | a.6.1(1-45) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | nucleic acid binding transcription factor activity| sequence-specific DNA binding transcription factor activity | No information |
| 226 | PF13312 | Domain of unknown function (DUF4081) | No Pfam Clan | 307 (49) | 107 | 107 | (1) Acyl-CoA N-acyltransferases (Nat) [d.108.1] (1-107) |
(1) Acyl-CoA N-acyltransferases (Nat) [d.108] |
d.108.1(1-107) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 2.3.1.1| 2.3.1.128| 2.3.1.178| 2.3.1.4| 2.3.1.48| 2.3.1.57| 2.3.1.82| 2.3.1.87| 2.3.1.88| 2.3.1.97| 2.3.2.10| 2.3.2.6 | N-terminal protein acetyltransferase complex| perinuclear region of cytoplasm| protein acetyltransferase complex | N-acetyltransferase activity| N-acyltransferase activity| acetyltransferase activity| ornithine decarboxylase inhibitor activity| ornithine decarboxylase regulator activity| transferase activity, transferring acyl groups other than amino-acyl groups | DNA packaging| N-terminal protein amino acid acetylation| N-terminal protein amino acid modification| UDP-N-acetylglucosamine biosynthetic process| UDP-N-acetylglucosamine metabolic process| amide biosynthetic process| amino sugar biosynthetic process| amino sugar metabolic process| cellular hormone metabolic process| cellular response to cAMP| cellular response to nitrogen compound| cellular response to organic cyclic compound| cellular response to organonitrogen compound| chromatin assembly| chromatin organization| chromosome organization| chromosome segregation| circadian rhythm| covalent chromatin modification| gastrulation with mouth forming second| histone acetylation| histone modification| hormone biosynthetic process| hormone metabolic process| indole-containing compound biosynthetic process| indole-containing compound metabolic process| melatonin biosynthetic process| melatonin metabolic process| mitotic sister chromatid cohesion| mitotic sister chromatid segregation| nucleotide-sugar biosynthetic process| nucleotide-sugar metabolic process| peptidyl-lysine modification| peptidyl-methionine modification| polyamine metabolic process| protein acetylation| protein acylation| protein-DNA complex assembly| protein-DNA complex subunit organization| regulation of hormone levels| response to cAMP| response to organophosphorus| response to purine-containing compound| response to toxic substance| rhythmic process |
| 227 | PF05284 | Protein of unknown function (DUF736) | No Pfam Clan | 445 (66) | 107 | 105 | (1) TPR-like [a.118.8] (2-101) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(2-101) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 228 | PF10884 | Protein of unknown function (DUF2683) | No Pfam Clan | 17 (7) | 80 | 81 | (1) TPR-like [a.118.8] (3-57) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(3-57) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 229 | PF10022 | Uncharacterized protein conserved in bacteria (DUF2264) | No Pfam Clan | 781 (52) | 361 | 368 | (1) Chondroitin AC/alginate lyase [a.102.3] (41-304) |
(1) alpha/alpha toroid [a.102] |
NO PREDICTION | a.102.3(41-304) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 4.2.2.1| 4.2.2.12| 4.2.2.20| 4.2.2.21| 4.2.2.3| 4.2.2.5 | No information | No information | No information |
| 230 | PF15090 | Domain of unknown function (DUF4553) | No Pfam Clan | 61 (7) | 463 | 459 | (1) Rap30/74 interaction domains [b.65.1] (INDIRECT) (2) "Winged helix" DNA-binding domain [a.4.5] (INDIRECT) |
(1) DNA/RNA-binding 3-helical bundle [a.4] (2) triple barrel [b.65] |
NO PREDICTION | b.65.1(INDIRECT)| a.4.5(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 231 | PF06786 | Uncharacterised protein family (UPF0253) | No Pfam Clan | 619 (8) | 66 | 68 | (1) ARM repeat [a.118.1] (4-66) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(4-66) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 232 | PF14133 | Domain of unknown function (DUF4300) | No Pfam Clan | 333 (36) | 250 | 250 | (1) Cysteine proteinases [d.3.1] (1-248) |
(1) Cysteine proteinases [d.3] |
NO PREDICTION | d.3.1(1-248) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 2.3.1.118| 2.3.1.5| 2.3.2.13| 2.3.2.15| 3.1.1.4| 3.4.14.1| 3.4.18.1| 3.4.19.12| 3.4.22.1| 3.4.22.10| 3.4.22.14| 3.4.22.15| 3.4.22.16| 3.4.22.2| 3.4.22.25| 3.4.22.27| 3.4.22.30| 3.4.22.38| 3.4.22.39| 3.4.22.40| 3.4.22.41| 3.4.22.43| 3.4.22.48| 3.4.22.51| 3.4.22.52| 3.4.22.53| 3.4.22.6| 3.4.22.65| 3.4.22.68| 3.5.1.52| 6.3.1.9 | alveolar lamellar body| endosome lumen| lamellar body| lytic vacuole| vacuolar lumen | MHC class I receptor activity| N-acyltransferase activity| acetyltransferase activity| arylamine N-acetyltransferase activity| cysteine-type carboxypeptidase activity| cysteine-type endopeptidase activity| cysteine-type endopeptidase regulator activity involved in apoptotic process| cysteine-type peptidase activity| hormone binding| peptidase activator activity| peptidase activator activity involved in apoptotic process| peptidase activity| peptidase regulator activity| small conjugating protein binding| thiolester hydrolase activity| thyroid hormone binding| ubiquitin thiolesterase activity | ERK1 and ERK2 cascade| T cell mediated cytotoxicity| T cell mediated immunity| adaptive immune response| anatomical structure maturation| bradykinin catabolic process| catagen| cell killing| cellular response to thyroid hormone stimulus| chemical homeostasis within a tissue| collagen metabolic process| decidualization| dichotomous subdivision of an epithelial terminal unit| dichotomous subdivision of terminal units involved in lung branching| epidermis morphogenesis| epithelial tube branching involved in lung morphogenesis| extracellular matrix disassembly| female pregnancy| hair cycle| hair cycle process| hair follicle development| hair follicle maturation| hair follicle morphogenesis| immune response-regulating signaling pathway| leukocyte mediated cytotoxicity| leukocyte mediated immunity| lung development| lung morphogenesis| lymphocyte mediated immunity| maternal placenta development| maternal process involved in female pregnancy| metanephros development| molting cycle process| multicellular organismal catabolic process| multicellular organismal homeostasis| negative regulation of epithelial cell proliferation| negative regulation of keratinocyte proliferation| neuropeptide catabolic process| peptide catabolic process| peptide metabolic process| placenta development| positive regulation of angiogenesis| positive regulation of apoptotic signaling pathway| positive regulation of developmental process| positive regulation of epithelial cell migration| positive regulation of peptidase activity| posttranscriptional regulation of gene expression| protein destabilization| protein maturation| protein modification by small protein conjugation or removal| protein modification by small protein removal| protein processing| proteolysis| regulation of actin cytoskeleton reorganization| regulation of epithelial cell migration| regulation of keratinocyte proliferation| regulation of peptidase activity| regulation of protein stability| respiratory tube development| response to retinoic acid| response to thyroid hormone stimulus| skin morphogenesis| surfactant homeostasis| tissue homeostasis |
| 233 | PF05895 | Siphovirus protein of unknown function (DUF859) | No Pfam Clan | 110 (11) | 624 | 657 | (1) Porins [f.4.3] (30-628) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | f.4.3(30-628) | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Viruses | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 234 | PF06181 | Protein of unknown function (DUF989) | No Pfam Clan | 485 (60) | 301 | 299 | (1) MFS general substrate transporter [f.38.1] (1-282) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(1-282) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 235 | PF09878 | Predicted membrane protein (DUF2105) | No Pfam Clan | 32 (10) | 212 | 228 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (3-192) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(3-192) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Archaea | No information | No information | No information | No information |
| 236 | PF11154 | Protein of unknown function (DUF2934) | No Pfam Clan | 414 (64) | 40 | 40 | (1) HSP20-like chaperones [b.15.1] (1-38) |
(1) HSP20-like chaperones [b.15] |
b.15.1(1-38) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Viruses | No information | contractile fiber| contractile fiber part | unfolded protein binding | protein folding| response to endoplasmic reticulum stress| response to heat| response to high light intensity| response to hydrogen peroxide| response to light intensity| response to reactive oxygen species| response to temperature stimulus |
| 237 | PF10100 | Uncharacterized protein conserved in bacteria (DUF2338) | No Pfam Clan | 271 (6) | 429 | 430 | (1) NAD(P)-binding Rossmann-fold domains [c.2.1] (1-199) (2) 6-phosphogluconate dehydrogenase C-terminal domain-like [a.100.1] (207-395) |
(1) 6-phosphogluconate dehydrogenase C-terminal domain-like [a.100] (2) NAD(P)-binding Rossmann-fold domains [c.2] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.2.1(1-199)| a.100.1(207-395) | 1 | No information | Bacteria | 1.1.1.1| 1.1.1.10| 1.1.1.100| 1.1.1.103| 1.1.1.118| 1.1.1.12| 1.1.1.125| 1.1.1.126| 1.1.1.132| 1.1.1.133| 1.1.1.138| 1.1.1.14| 1.1.1.141| 1.1.1.146| 1.1.1.153| 1.1.1.157| 1.1.1.159| 1.1.1.16| 1.1.1.169| 1.1.1.17| 1.1.1.18| 1.1.1.184| 1.1.1.195| 1.1.1.2| 1.1.1.206| 1.1.1.219| 1.1.1.22| 1.1.1.234| 1.1.1.236| 1.1.1.237| 1.1.1.24| 1.1.1.248| 1.1.1.25| 1.1.1.252| 1.1.1.26| 1.1.1.268| 1.1.1.27| 1.1.1.271| 1.1.1.275| 1.1.1.276| 1.1.1.28| 1.1.1.282| 1.1.1.289| 1.1.1.29| 1.1.1.290| 1.1.1.291| 1.1.1.292| 1.1.1.30| 1.1.1.304| 1.1.1.31| 1.1.1.35| 1.1.1.36| 1.1.1.37| 1.1.1.38| 1.1.1.40| 1.1.1.44| 1.1.1.45| 1.1.1.47| 1.1.1.50| 1.1.1.51| 1.1.1.53| 1.1.1.60| 1.1.1.62| 1.1.1.67| 1.1.1.69| 1.1.1.79| 1.1.1.8| 1.1.1.82| 1.1.1.86| 1.1.1.9| 1.1.1.90| 1.1.1.94| 1.1.1.95| 1.1.99.28| 1.12.98.2| 1.16.1.2| 1.17.1.3| 1.2.1.10| 1.2.1.12| 1.2.1.13| 1.2.1.2| 1.2.1.38| 1.2.1.43| 1.2.1.46| 1.2.1.5| 1.2.1.59| 1.2.1.72| 1.2.99.4| 1.3.1.10| 1.3.1.12| 1.3.1.24| 1.3.1.26| 1.3.1.28| 1.3.1.34| 1.3.1.38| 1.3.1.43| 1.3.1.48| 1.3.1.74| 1.3.1.76| 1.3.1.77| 1.3.1.9| 1.4.1.1| 1.4.1.18| 1.4.1.20| 1.4.1.21| 1.4.1.3| 1.5.1.10| 1.5.1.11| 1.5.1.15| 1.5.1.2| 1.5.1.33| 1.5.1.34| 1.5.1.5| 1.5.1.7| 1.6.1.2| 1.6.5.2| 1.6.5.5| 2.3.1.85| 2.3.1.94| 3.2.1.122| 3.2.1.139| 3.2.1.20| 3.2.1.49| 3.2.1.86| 3.3.1.1| 4.1.1.35| 4.2.1.119| 4.2.1.45| 4.2.1.46| 4.2.1.47| 4.3.1.12| 5.1.3.10| 5.1.3.18| 5.1.3.2| 5.1.3.20| 5.1.3.7| 5.5.1.4 | microbody | NAD binding| NAD+ binding| NADH binding| NADP binding| NADPH binding| UDP-glucose 4-epimerase activity| coenzyme binding| cofactor binding| dTDP-glucose 4,6-dehydratase activity| fatty acid synthase activity| icosanoid receptor activity| long-chain-fatty-acyl-CoA reductase activity| oxidoreductase activity, acting on CH-OH group of donors| oxidoreductase activity, acting on the CH-CH group of donors| oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor| oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor| prostaglandin E receptor activity| prostaglandin receptor activity| prostanoid receptor activity| racemase and epimerase activity| steroid dehydrogenase activity | amide biosynthetic process| cellular hormone metabolic process| cellular ketone metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| diterpenoid metabolic process| drug metabolic process| ductus arteriosus closure| estrogen biosynthetic process| extracellular polysaccharide biosynthetic process| extracellular polysaccharide metabolic process| fatty acid biosynthetic process| fatty acid elongation| hormone metabolic process| nucleotide-sugar biosynthetic process| nucleotide-sugar metabolic process| organic heteropentacyclic compound metabolic process| ovulation| parturition| pentose metabolic process| phenol-containing compound biosynthetic process| phenol-containing compound metabolic process| polysaccharide biosynthetic process| protein oligomerization| protein tetramerization| pteridine-containing compound biosynthetic process| pteridine-containing compound metabolic process| regulation of hormone levels| retinal metabolic process| retinoic acid biosynthetic process| retinoid metabolic process| secondary metabolic process| steroid metabolic process| terpenoid metabolic process| tetrahydrobiopterin biosynthetic process| tetrahydrobiopterin metabolic process| thrombin receptor signaling pathway| vitamin K metabolic process| xanthone-containing compound biosynthetic process| xanthone-containing compound metabolic process |
| 238 | PF10871 | Protein of unknown function (DUF2748) | No Pfam Clan | 44 (2) | 447 | 440 | (1) ARM repeat [a.118.1] (1-443) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(1-443) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 239 | PF06533 | Protein of unknown function (DUF1110) | No Pfam Clan | 38 (6) | 188 | 156 | (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (4-100) |
(1) 8-bladed beta-propeller [b.70] |
b.70.1(4-100) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 1.1.2.7| 1.1.98.1 | No information | endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity | ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein |
| 240 | PF10670 | Domain of unknown function (DUF4198) | No Pfam Clan | 1021 (108) | 215 | 215 | (1) Cna protein B-type domain [b.3.5] (152-213) |
(1) Prealbumin-like [b.3] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | b.3.5(152-213) | 1 | YES | Bacteria|Archaea | No information | No information | No information | No information |
| 241 | PF11899 | Protein of unknown function (DUF3419) | No Pfam Clan | 261 (42) | 380 | 387 | (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (274-352) |
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66] |
NO PREDICTION | NO PREDICTION | c.66.1(274-352) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 | nuclear matrix | glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups | Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process |
| 242 | PF14220 | Domain of unknown function (DUF4329) | No Pfam Clan | 415 (20) | 123 | 121 | (1) JAB1/MPN domain [c.97.3] (3-115) |
(1) Cytidine deaminase-like [c.97] |
NO PREDICTION | c.97.3(3-115) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 3.1.2.15 | No information | No information | No information |
| 243 | PF12059 | Protein of unknown function (DUF3540) | No Pfam Clan | 188 (14) | 202 | 204 | (1) Nucleic acid-binding proteins [b.40.4] (3-61) |
(1) OB-fold [b.40] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | b.40.4(3-61) | 1 | No information | Bacteria | 3.1.13.1| 3.1.26.12| 6.5.1.1 | DNA replication factor A complex| DNA-directed RNA polymerase II, core complex| DNA-directed RNA polymerase II, holoenzyme| DNA-directed RNA polymerase complex| RNA polymerase complex| cytoplasmic exosome (RNase complex)| cytosolic small ribosomal subunit| exosome (RNase complex)| mitochondrial nucleoid| nuclear DNA-directed RNA polymerase complex| nucleoid| organellar ribosome| replisome | RNA polymerase activity| chromatin binding| ribonucleoprotein complex binding| single-stranded DNA binding| structure-specific DNA binding | regulation of DNA-dependent transcription, termination| regulation of RNA stability| regulation of mRNA stability| response to cold| ribonucleoprotein complex biogenesis| telomere maintenance| telomere organization| transcriptional attenuation| translational initiation |
| 244 | PF10222 | Uncharacterized conserved protein (DUF2152) | No Pfam Clan | 150 (6) | 604 | 508 | (1) Putative isomerase YbhE [b.69.11] (87-569) |
(1) 7-bladed beta-propeller [b.69] |
NO PREDICTION | b.69.11(87-569) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 245 | PF06279 | Protein of unknown function (DUF1033) | No Pfam Clan | 683 (16) | 120 | 120 | (1) TPR-like [a.118.8] (11-115) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(11-115) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 246 | PF10179 | Uncharacterised conserved protein (DUF2369) | No Pfam Clan | 148 (5) | 300 | 297 | (1) Fibronectin type III [b.1.2] (171-287) |
(1) Immunoglobulin-like beta-sandwich [b.1] |
NO PREDICTION | NO PREDICTION | b.1.2(171-287) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 2.1.1.191| 2.1.1.43| 2.7.7.4| 3.5.1.23 | No information | cytokine receptor activity| molecular transducer activity| receptor activity| signaling receptor activity| transmembrane signaling receptor activity | JAK-STAT cascade| cellular response to cytokine stimulus| cytokine-mediated signaling pathway| developmental growth| growth| intracellular protein kinase cascade| lactation| mammary gland alveolus development| mammary gland epithelial cell differentiation| mammary gland epithelium development| mammary gland lobule development| prolactin signaling pathway| prostate gland development| regulation of body fluid levels| regulation of cell adhesion| response to cytokine stimulus |
| 247 | PF04474 | Protein of unknown function (DUF554) | No Pfam Clan | 1327 (64) | 226 | 224 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-220) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(1-220) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | No information | No information | No information |
| 248 | PF04238 | Protein of unknown function (DUF420) | No Pfam Clan | 636 (60) | 133 | 135 | (1) Cytochrome c oxidase subunit III-like [f.25.1] (4-135) |
(1) Cytochrome c oxidase subunit III-like [f.25] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | f.25.1(4-135) | 1 | No information | Bacteria|Archaea | No information | respiratory chain| respiratory chain complex IV | No information | cellular protein complex assembly| cellular respiration| electron transport chain| energy derivation by oxidation of organic compounds| respiratory chain complex IV assembly| respiratory electron transport chain |
| 249 | PF08101 | Domain of unknown function (DUF1708) | GAP (CL0409) | 144 (19) | 420 | 393 | (1) GTPase activation domain, GAP [a.116.1] (4-154) |
(1) GTPase activation domain, GAP [a.116] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.116.1(4-154) | 1 | No information | Eukaryota | 3.1.3.36 | No information | GTPase regulator activity| Rho GTPase activator activity| nucleoside-triphosphatase regulator activity| small GTPase regulator activity | positive regulation of GTPase activity| positive regulation of Ras GTPase activity| positive regulation of Rho GTPase activity| positive regulation of hydrolase activity| regulation of GTP catabolic process| regulation of GTPase activity| regulation of Ras GTPase activity| regulation of Rho GTPase activity| regulation of Rho protein signal transduction| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| regulation of small GTPase mediated signal transduction |
| 250 | PF11856 | Protein of unknown function (DUF3376) | No Pfam Clan | 113 (23) | 488 | 515 | (1) ARM repeat [a.118.1] (5-455) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(5-455) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 251 | PF12449 | Protein of unknown function (DUF3684) | No Pfam Clan | 109 (22) | 1093 | 1078 | (1) ARM repeat [a.118.1] (13-1062) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(13-1062) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 252 | PF12257 | Protein of unknown function (DUF3608) | No Pfam Clan | 344 (9) | 281 | 279 | (1) vWA-like [c.62.1] (69-274) |
(1) vWA-like [c.62] |
NO PREDICTION | c.62.1(69-274) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | extracellular matrix | No information | DNA repair| double-strand break repair| double-strand break repair via nonhomologous end joining| non-recombinational repair| response to ionizing radiation |
| 253 | PF09949 | Uncharacterized conserved protein (DUF2183) | No Pfam Clan | 563 (76) | 100 | 98 | (1) HAD-like [c.108.1] (2-92) |
(1) HAD-like [c.108] |
c.108.1(2-92) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 2.7.7.43| 3.1.3.16| 3.1.3.18| 3.1.3.2| 3.1.3.23| 3.1.3.24| 3.1.3.29| 3.1.3.3| 3.1.3.41| 3.1.3.45| 3.1.3.48| 3.1.3.5| 3.1.3.70| 3.1.3.74| 3.1.8.2| 3.11.1.1| 3.6.1.1| 3.6.3.10| 3.6.3.4| 3.6.3.6| 3.6.3.8| 3.6.3.9| 3.8.1.2| 5.4.2.6| 5.4.2.8 | Nem1-Spo7 phosphatase complex| nuclear envelope| nuclear membrane| protein serine/threonine phosphatase complex | D,D-heptose 1,7-bisphosphate phosphatase activity| acireductone synthase activity| inorganic diphosphatase activity| intramolecular transferase activity| intramolecular transferase activity, phosphotransferases| magnesium ion binding| phosphatase activity | L-methionine biosynthetic process| L-methionine salvage| L-methionine salvage from methylthioadenosine| L-serine metabolic process| amino acid salvage| cellular carbohydrate biosynthetic process| cellular membrane organization| cellular metabolic compound salvage| cofactor catabolic process| deoxyribonucleotide catabolic process| dephosphorylation| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| methionine metabolic process| nuclear envelope organization| nucleus organization| organophosphate catabolic process| positive regulation of lipid biosynthetic process| positive regulation of lipid metabolic process| positive regulation of triglyceride biosynthetic process| positive regulation of triglyceride metabolic process| regulation of lipid biosynthetic process| regulation of lipid metabolic process| regulation of triglyceride biosynthetic process| regulation of triglyceride metabolic process |
| 254 | PF13575 | Domain of unknown function (DUF4135) | No Pfam Clan | 396 (79) | 370 | 375 | (1) Protein kinase-like (PK-like) [d.144.1] (2-353) |
(1) Protein kinase-like (PK-like) [d.144] |
NO PREDICTION | d.144.1(2-353) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 2.7.1.100| 2.7.1.137| 2.7.1.153| 2.7.1.163| 2.7.1.17| 2.7.1.32| 2.7.1.39| 2.7.1.95| 2.7.10.1| 2.7.10.2| 2.7.11.1| 2.7.11.11| 2.7.11.13| 2.7.11.14| 2.7.11.15| 2.7.11.16| 2.7.11.17| 2.7.11.19| 2.7.11.21| 2.7.11.22| 2.7.11.24| 2.7.11.25| 2.7.11.26| 2.7.11.30| 2.7.11.7| 2.7.12.1| 2.7.12.2 | cAMP-dependent protein kinase complex| calcium- and calmodulin-dependent protein kinase complex| cell-substrate adherens junction| cyclin-dependent protein kinase holoenzyme complex| neuromuscular junction| protein kinase CK2 complex| spindle| spindle pole | ATP binding| adenyl nucleotide binding| adenyl ribonucleotide binding| calmodulin binding| cyclin binding| kinase activator activity| kinase regulator activity| magnesium ion binding| molecular transducer activity| nucleoside binding| phosphoprotein binding| phosphotransferase activity, alcohol group as acceptor| phosphotyrosine binding| protein kinase activator activity| protein kinase activity| protein kinase regulator activity| purine nucleoside binding| purine nucleotide binding| purine ribonucleoside binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| receptor signaling protein activity| ribonucleoside binding| ribonucleotide binding | CDP-choline pathway| DNA damage checkpoint| activation of innate immune response| cell cycle phase transition| cell division| cell morphogenesis| cellular component morphogenesis| cellular process involved in reproduction| cellular response to biotic stimulus| cellular response to unfolded protein| embryonic placenta development| enzyme linked receptor protein signaling pathway| ethanolamine-containing compound metabolic process| fruiting body development| germ cell development| glycerolipid biosynthetic process| glycerolipid metabolic process| glycerophospholipid biosynthetic process| heart contraction| heart process| hemostasis| innate immune response| innate immune response-activating signal transduction| intracellular protein kinase cascade| labyrinthine layer development| lens development in camera-type eye| lipopolysaccharide-mediated signaling pathway| microtubule cytoskeleton organization| mitotic cell cycle phase transition| negative regulation of cell cycle process| neurotrophin signaling pathway| oogenesis| organelle fission| organic hydroxy compound biosynthetic process| peptidyl-serine modification| peptidyl-threonine modification| phosphatidylcholine biosynthetic process| phosphatidylcholine metabolic process| phosphatidylinositol-3-phosphate biosynthetic process| phospholipid biosynthetic process| positive regulation of MAP kinase activity| positive regulation of cellular protein metabolic process| positive regulation of determination of dorsal identity| positive regulation of developmental growth| positive regulation of innate immune response| positive regulation of intracellular protein transport| positive regulation of myoblast fusion| positive regulation of myotube differentiation| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of phosphorylation| positive regulation of protein kinase activity| positive regulation of protein phosphorylation| positive regulation of skeletal muscle cell differentiation| positive regulation of syncytium formation by plasma membrane fusion| positive regulation of transferase activity| positive regulation of unidimensional cell growth| programmed necrotic cell death| protein phosphorylation| regulation of Golgi inheritance| regulation of MAPK cascade| regulation of Wnt receptor signaling pathway| regulation of adult chitin-containing cuticle pigmentation| regulation of cell size| regulation of cellular response to stress| regulation of chitin-based cuticle tanning| regulation of early endosome to late endosome transport| regulation of fibroblast apoptotic process| regulation of innate immune response| regulation of intracellular protein kinase cascade| regulation of kinase activity| regulation of muscle cell differentiation| regulation of muscle organ development| regulation of muscle tissue development| regulation of protein kinase activity| regulation of reproductive process| regulation of skeletal muscle fiber development| regulation of sodium ion transport| regulation of transferase activity| response to cadmium ion| response to exogenous dsRNA| response to growth factor stimulus| response to molecule of bacterial origin| response to osmotic stress| salicylic acid biosynthetic process| salicylic acid metabolic process| spindle assembly| spindle midzone assembly| stomatal complex development| stress-activated protein kinase signaling cascade| striated muscle contraction| toll-like receptor signaling pathway |
| 255 | PF12586 | Protein of unknown function (DUF3760) | No Pfam Clan | 44 (15) | 46 | 46 | (1) L domain-like [c.10.2] (3-46) |
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10] |
c.10.2(3-46) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | U2 snRNP | 3'-5' exonuclease activity| 3'-5'-exoribonuclease activity| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomon| exoribonuclease activity| exoribonuclease activity, producing 5'-phosphomonoesters| phosphatase inhibitor activity| phosphatase regulator activity| poly(A)-specific ribonuclease activity | B cell activation| B cell proliferation| B cell proliferation involved in immune response| RNA phosphodiester bond hydrolysis, exonucleolytic| biological adhesion| nuclear transport| nuclear-transcribed mRNA catabolic process| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay| nucleocytoplasmic transport| post-embryonic morphogenesis| post-embryonic organ development| regulation of JNK cascade| regulation of axonogenesis| regulation of cell size| regulation of extent of cell growth |
| 256 | PF06097 | Bacterial protein of unknown function (DUF945) | No Pfam Clan | 1334 (50) | 460 | 446 | (1) Porins [f.4.3] (INDIRECT) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.3(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Bacteria|Viruses | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 257 | PF12119 | Protein of unknown function (DUF3581) | No Pfam Clan | 187 (22) | 218 | 215 | (1) Thioesterase/thiol ester dehydrase-isomerase [d.38.1] (12-82) |
(1) Thioesterase/thiol ester dehydrase-isomerase [d.38] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | d.38.1(12-82) | 1 | No information | Bacteria|Viruses | 3.1.2.1| 3.1.2.14| 3.1.2.20| 3.1.2.23| 4.2.1.119| 4.2.1.17| 4.2.1.60 | No information | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity| CoA hydrolase activity| hydro-lyase activity| thiolester hydrolase activity | fatty acid biosynthetic process| ketone biosynthetic process| quinone biosynthetic process| quinone cofactor biosynthetic process| quinone metabolic process |
| 258 | PF10925 | Protein of unknown function (DUF2680) | No Pfam Clan | 166 (14) | 59 | 61 | (1) TPR-like [a.118.8] (2-60) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(2-60) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 259 | PF10070 | Uncharacterized protein conserved in bacteria (DUF2309) | No Pfam Clan | 634 (67) | 788 | 749 | (1) ARM repeat [a.118.1] (1-784) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(1-784) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses|Archaea | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 260 | PF11681 | Protein of unknown function (DUF3277) | No Pfam Clan | 159 (7) | 146 | 146 | (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (11-141) |
(1) 8-bladed beta-propeller [b.70] |
b.70.1(11-141) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | 1.1.2.7| 1.1.98.1 | No information | endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity | ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein |
| 261 | PF04535 | Domain of unknown function (DUF588) | Marvel-like (CL0396) | 771 (84) | 150 | 151 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (4-149) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(4-149) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 262 | PF15112 | Domain of unknown function (DUF4559) | No Pfam Clan | 62 (8) | 307 | 292 | (1) Cullin repeat-like [a.118.17] (1-306) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.17(1-306) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | protein heterodimerization activity | cellular protein catabolic process| modification-dependent macromolecule catabolic process| modification-dependent protein catabolic process| negative regulation of granulocyte differentiation| negative regulation of leukocyte differentiation| negative regulation of myeloid cell differentiation| negative regulation of myeloid leukocyte differentiation| positive regulation of G1/S transition of mitotic cell cycle| positive regulation of cell cycle phase transition| positive regulation of cell cycle process| positive regulation of mitotic cell cycle phase transition| protein catabolic process| proteolysis| proteolysis involved in cellular protein catabolic process| regulation of DNA damage checkpoint| regulation of DNA metabolic process| regulation of DNA repair| regulation of cell cycle checkpoint| regulation of granulocyte differentiation| regulation of leukocyte differentiation| regulation of myeloid cell differentiation| regulation of myeloid leukocyte differentiation| regulation of nucleotide-excision repair| regulation of response to DNA damage stimulus| somatic stem cell maintenance| stem cell maintenance| ubiquitin-dependent protein catabolic process |
| 263 | PF15483 | Domain of unknown function (DUF4641) | No Pfam Clan | 39 (16) | 445 | 461 | (1) ssDNA viruses [b.121.5] (1-407) |
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | b.121.5(1-407) | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 264 | PF13595 | Domain of unknown function (DUF4138) | No Pfam Clan | 514 (30) | 246 | 254 | (1) TPR-like [a.118.8] (9-167) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(9-167) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 265 | PF04250 | Protein of unknown function (DUF429) | No Pfam Clan | 405 (41) | 209 | 224 | (1) Ribonuclease H-like [c.55.3] (1-185) |
(1) Ribonuclease H-like motif [c.55] |
NO PREDICTION | c.55.3(1-185) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 2.7.7.7| 3.1.11.1| 3.1.13.1| 3.1.13.4| 3.1.13.5| 3.1.22.4| 3.1.26.4| 3.6.4.12 | CCR4-NOT complex| DNA polymerase complex| cytoplasmic mRNA processing body| micro-ribonucleoprotein complex| nucleolus| ribonuclease H2 complex| ribonucleoprotein granule | DNA polymerase activity| DNA-directed DNA polymerase activity| endoribonuclease activity, producing 5'-phosphomonoesters| exonuclease activity| nuclease activity| ribonuclease H activity| transposase activity | DNA catabolic process| DNA replication| DNA replication, removal of RNA primer| DNA strand elongation| RNA 3'-end processing| RNA catabolic process| RNA phosphodiester bond hydrolysis| cytoplasmic mRNA processing body assembly| gene silencing| gene silencing by RNA| lagging strand elongation| mRNA 3'-end processing| mitochondrial genome maintenance| mitotic DNA integrity checkpoint| mitotic G2 DNA damage checkpoint| ncRNA 3'-end processing| negative regulation of DNA metabolic process| negative regulation of DNA recombination| negative regulation of mitotic recombination| negative regulation of translation| nuclear-transcribed mRNA poly(A) tail shortening| nucleic acid phosphodiester bond hydrolysis| positive regulation of catabolic process| positive regulation of cellular catabolic process| positive regulation of mRNA catabolic process| positive regulation of mRNA processing| regulation of DNA metabolic process| regulation of DNA recombination| regulation of mRNA 3'-end processing| regulation of mRNA catabolic process| regulation of mRNA processing| regulation of mitotic recombination| response to ionizing radiation| ribonucleoprotein complex biogenesis| ribonucleoprotein complex subunit organization| transposition| transposition, DNA-mediated |
| 266 | PF05957 | Bacterial protein of unknown function (DUF883) | YjbJ-CsbD-like (CL0406) | 2283 (59) | 94 | 94 | (1) ARM repeat [a.118.1] (3-85) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(3-85) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 267 | PF06023 | Archaeal protein of unknown function (DUF911) | PDDEXK (CL0236) | 70 (8) | 290 | 281 | (1) Restriction endonuclease-like [c.52.1] (INDIRECT) |
(1) Restriction endonuclease-like [c.52] |
NO PREDICTION | c.52.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 | No information | endonuclease activity| nuclease activity | DNA repair| nucleotide-excision repair |
| 268 | PF07028 | Protein of unknown function (DUF1319) | No Pfam Clan | 50 (11) | 126 | 145 | (1) L domain-like [c.10.2] (2-107) |
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10] |
c.10.2(2-107) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Viruses | No information | U2 snRNP | 3'-5' exonuclease activity| 3'-5'-exoribonuclease activity| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomon| exoribonuclease activity| exoribonuclease activity, producing 5'-phosphomonoesters| phosphatase inhibitor activity| phosphatase regulator activity| poly(A)-specific ribonuclease activity | B cell activation| B cell proliferation| B cell proliferation involved in immune response| RNA phosphodiester bond hydrolysis, exonucleolytic| biological adhesion| nuclear transport| nuclear-transcribed mRNA catabolic process| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay| nucleocytoplasmic transport| post-embryonic morphogenesis| post-embryonic organ development| regulation of JNK cascade| regulation of axonogenesis| regulation of cell size| regulation of extent of cell growth |
| 269 | PF07617 | Protein of unknown function (DUF1579) | No Pfam Clan | 94 (17) | 159 | 165 | (1) Lipocalins [b.60.1] (5-157) |
(1) Lipocalins [b.60] |
NO PREDICTION | b.60.1(5-157) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 1.10.99.3| 5.3.99.2 | cell body| dendrite| neuron projection| neuronal cell body| perinuclear region of cytoplasm| rough endoplasmic reticulum | alcohol binding| carboxylic acid binding| cholesterol binding| insulin-activated receptor activity| intramolecular oxidoreductase activity| isoprenoid binding| lipid transporter activity| monocarboxylic acid binding| odorant binding| prostaglandin-D synthase activity| protein tyrosine kinase activity| retinoid binding| retinol transporter activity| steroid binding| sterol binding| transmembrane receptor protein kinase activity| transmembrane receptor protein tyrosine kinase activity| vitamin binding| vitamin transporter activity | aerobic respiration| aging| axon development| axon regeneration| brain development| carbohydrate homeostasis| cell projection organization| cellular hormone metabolic process| cellular respiration| cellular response to lipid| cellular response to nitrogen compound| cellular response to organonitrogen compound| cellular response to peptide| cellular response to peptide hormone stimulus| central nervous system development| circadian behavior| circadian rhythm| detection of abiotic stimulus| detection of light stimulus| detection of visible light| developmental growth| diterpenoid metabolic process| energy reserve metabolic process| fatty acid biosynthetic process| fatty acid derivative biosynthetic process| fatty acid derivative metabolic process| glucose metabolic process| growth| heat generation| hormone metabolic process| icosanoid biosynthetic process| icosanoid metabolic process| insulin receptor signaling pathway| isoprenoid transport| lipid localization| lipid transport| locomotor rhythm| mitochondrion morphogenesis| mitochondrion organization| monocarboxylic acid biosynthetic process| monocarboxylic acid transport| multicellular organismal homeostasis| negative regulation of T cell migration| negative regulation of carbohydrate metabolic process| negative regulation of cell adhesion| negative regulation of cell communication| negative regulation of cell junction assembly| negative regulation of cell migration| negative regulation of cell motility| negative regulation of cell proliferation| negative regulation of cell-matrix adhesion| negative regulation of cell-substrate adhesion| negative regulation of cellular carbohydrate metabolic process| negative regulation of cellular component movement| negative regulation of cellular component organization| negative regulation of chemokine production| negative regulation of cytokine production| negative regulation of cytokine production involved in inflammatory response| negative regulation of focal adhesion assembly| negative regulation of gluconeogenesis| negative regulation of hormone secretion| negative regulation of immune system process| negative regulation of insulin secretion| negative regulation of insulin secretion involved in cellular response to glucose stimulus| negative regulation of intracellular protein transport| negative regulation of intracellular transport| negative regulation of leukocyte migration| negative regulation of lipid biosynthetic process| negative regulation of lipid metabolic process| negative regulation of lipid storage| negative regulation of lipoprotein lipid oxidation| negative regulation of lipoprotein metabolic process| negative regulation of lipoprotein oxidation| negative regulation of locomotion| negative regulation of lymphocyte migration| negative regulation of monocyte chemotactic protein-1 production| negative regulation of multicellular organismal process| negative regulation of nucleocytoplasmic transport| negative regulation of peptide hormone secretion| negative regulation of peptide secretion| negative regulation of platelet-derived growth factor receptor signaling pathway| negative regulation of protein import into nucleus| negative regulation of protein transport| negative regulation of response to stimulus| negative regulation of signaling| negative regulation of smooth muscle cell proliferation| negative regulation of smooth muscle cell-matrix adhesion| negative regulation of transport| neuron development| neuron differentiation| neuron projection development| neuron projection regeneration| peripheral nervous system axon regeneration| positive regulation of carbohydrate metabolic process| positive regulation of cellular carbohydrate metabolic process| positive regulation of glucose metabolic process| positive regulation of intracellular protein kinase cascade| positive regulation of lipid metabolic process| positive regulation of protein kinase B signaling cascade| prostaglandin biosynthetic process| prostanoid biosynthetic process| prostanoid metabolic process| regeneration| regulation of T cell migration| regulation of carbohydrate biosynthetic process| regulation of carbohydrate metabolic process| regulation of cell adhesion| regulation of cell junction assembly| regulation of cell migration| regulation of cell motility| regulation of cell-matrix adhesion| regulation of cell-substrate adhesion| regulation of cell-substrate junction assembly| regulation of cellular carbohydrate metabolic process| regulation of cellular component biogenesis| regulation of cellular component movement| regulation of cellular ketone metabolic process| regulation of chemokine production| regulation of circadian rhythm| regulation of circadian sleep/wake cycle| regulation of cytokine production| regulation of cytokine production involved in inflammatory response| regulation of defense response| regulation of establishment of protein localization| regulation of focal adhesion assembly| regulation of gluconeogenesis| regulation of glucose metabolic process| regulation of homeostatic process| regulation of hormone secretion| regulation of inflammatory response| regulation of insulin secretion| regulation of insulin secretion involved in cellular response to glucose stimulus| regulation of intracellular protein transport| regulation of intracellular transport| regulation of leukocyte migration| regulation of lipid biosynthetic process| regulation of lipid metabolic process| regulation of lipid storage| regulation of lipoprotein lipid oxidation| regulation of lipoprotein metabolic process| regulation of lipoprotein oxidation| regulation of locomotion| regulation of lymphocyte migration| regulation of monocyte chemotactic protein-1 production| regulation of nucleocytoplasmic transport| regulation of peptide hormone secretion| regulation of peptide secretion| regulation of peptide transport| regulation of platelet-derived growth factor receptor signaling pathway| regulation of protein import into nucleus| regulation of protein kinase B signaling cascade| regulation of protein localization| regulation of protein localization to nucleus| regulation of protein transport| regulation of smooth muscle cell proliferation| regulation of smooth muscle cell-matrix adhesion| response to axon injury| response to drug| response to hormone stimulus| response to lipid| response to organonitrogen compound| response to peptide hormone stimulus| response to reactive oxygen species| retinoid metabolic process| retinol metabolic process| rhythmic behavior| rhythmic process| single-organism behavior| temperature homeostasis| tissue regeneration| transmembrane receptor protein tyrosine kinase signaling pathway| unsaturated fatty acid biosynthetic process| unsaturated fatty acid metabolic process| wound healing |
| 270 | PF11254 | Protein of unknown function (DUF3053) | No Pfam Clan | 635 (8) | 229 | 228 | (1) MW0975(SA0943)-like [a.24.27] (22-221) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(22-221) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | No information | No information | No information |
| 271 | PF09959 | Uncharacterized protein conserved in archaea (DUF2193) | No Pfam Clan | 32 (9) | 499 | 499 | (1) ARM repeat [a.118.1] (1-495) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(1-495) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Archaea | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 272 | PF13210 | Domain of unknown function (DUF4018) | No Pfam Clan | 74 (6) | 192 | 194 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (6-191) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(6-191) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 273 | PF11832 | Protein of unknown function (DUF3352) | No Pfam Clan | 156 (32) | 536 | 553 | (1) WD40 repeat-like [b.69.4] (INDIRECT) |
(1) 7-bladed beta-propeller [b.69] |
NO PREDICTION | b.69.4(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | Arp2/3 protein complex| CIA complex| Cdc73/Paf1 complex| Cul4-RING ubiquitin ligase complex| ER to Golgi transport vesicle| SMN complex| SMN-Sm protein complex| Ski complex| THO complex| TORC1 complex| chromosome, centromeric region| cullin-RING ubiquitin ligase complex| eukaryotic translation initiation factor 3 complex| extrinsic to internal side of plasma membrane| extrinsic to membrane| extrinsic to plasma membrane| female germ cell nucleus| germ cell nucleus| heterotrimeric G-protein complex| histone methyltransferase complex| immunological synapse| internal side of plasma membrane| kinetochore| methylosome| methyltransferase complex| nuclear envelope| nuclear pore| nuclear pore outer ring| pore complex| transcription export complex| transcriptionally active chromatin| ubiquitin ligase complex | G-protein gamma-subunit binding| histone binding| peroxisome targeting sequence binding| phosphatidylinositol binding| phosphatidylinositol-3,5-bisphosphate binding| phosphatidylinositol-3-phosphate binding| phosphatidylinositol-5-phosphate binding| signal sequence binding| translation initiation factor activity | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile| T cell homeostasis| TOR signaling cascade| attachment of spindle microtubules to kinetochore| attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation| autophagy| cellular response to starvation| chromosome segregation| embryonic digit morphogenesis| establishment of RNA localization| establishment of chromosome localization| establishment of organelle localization| fruiting body development| histone H3-K4 methylation| histone methylation| histone modification| iron-sulfur cluster assembly| mRNA export from nucleus| membrane disassembly| metallo-sulfur cluster assembly| metaphase plate congression| methylation| microtubule-based process| mitotic metaphase plate congression| mitotic spindle assembly checkpoint| negative regulation of calcium ion transmembrane transporter activity| negative regulation of cation channel activity| negative regulation of cell cycle process| negative regulation of ion transmembrane transporter activity| negative regulation of transporter activity| negative regulation of voltage-gated calcium channel activity| nuclear envelope disassembly| nuclear pore organization| nucleic acid transport| nucleobase-containing compound transport| peptidyl-lysine modification| peptidyl-lysine trimethylation| peroxisomal transport| positive regulation of DNA-dependent transcription, elongation| positive regulation of histone H3-K79 methylation| positive regulation of histone methylation| positive regulation of histone modification| positive regulation of organelle organization| positive regulation of transcription elongation from RNA polymerase II promoter| protein alkylation| protein import| protein targeting| regulation of cell cycle process| regulation of histone H3-K79 methylation| regulation of histone methylation| regulation of histone modification| regulation of metaphase/anaphase transition of cell cycle| regulation of mitotic metaphase/anaphase transition| regulation of reproductive process| regulation of transcription elongation from RNA polymerase II promoter| regulation of voltage-gated calcium channel activity| response to starvation| spindle assembly checkpoint| spindle checkpoint| uropod organization |
| 274 | PF10027 | Predicted integral membrane protein (DUF2269) | CopD_like (CL0430) | 382 (56) | 150 | 150 | (1) Transmembrane di-heme cytochromes [f.21.1] (INDIRECT) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | f.21.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 1.10.2.2 | No information | electron carrier activity | cellular respiration |
| 275 | PF13282 | Domain of unknown function (DUF4070) | No Pfam Clan | 231 (55) | 146 | 145 | (1) Radical SAM enzymes [c.1.28] (1-146) |
(1) TIM beta/alpha-barrel [c.1] |
c.1.28(1-146) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 1.3.99.22| 1.97.1.4| 2.8.1.6| 5.4.3.2 | lipid particle | 4 iron, 4 sulfur cluster binding| biotin synthase activity| intramolecular transferase activity| lipoate synthase activity| lipoate-protein ligase activity| metal cluster binding| oxidoreductase activity, acting on the CH-CH group of donors| protein self-association| radical SAM enzyme activity| sulfurtransferase activity| transferase activity, transferring sulfur-containing groups | CD4-positive, alpha-beta T cell activation| CD4-positive, alpha-beta T cell differentiation| T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| defense response to virus| lipoate biosynthetic process| lipoate metabolic process| lymphocyte differentiation| molybdopterin cofactor biosynthetic process| molybdopterin cofactor metabolic process| monocarboxylic acid biosynthetic process| negative regulation of protein secretion| negative regulation of protein transport| negative regulation of secretion| positive regulation of T cell cytokine production| positive regulation of T cell mediated immunity| positive regulation of T-helper 2 cell cytokine production| positive regulation of adaptive immune response| positive regulation of adaptive immune response based on somatic recombination of immune receptors b| positive regulation of cytokine production| positive regulation of cytokine production involved in immune response| positive regulation of immune effector process| positive regulation of leukocyte mediated immunity| positive regulation of lymphocyte mediated immunity| positive regulation of production of molecular mediator of immune response| positive regulation of toll-like receptor 9 signaling pathway| positive regulation of toll-like receptor signaling pathway| prosthetic group metabolic process| regulation of T cell cytokine production| regulation of T cell mediated immunity| regulation of T-helper 2 cell cytokine production| regulation of adaptive immune response| regulation of cytokine production involved in immune response| regulation of leukocyte mediated immunity| regulation of lymphocyte mediated immunity| regulation of production of molecular mediator of immune response| regulation of protein secretion| regulation of toll-like receptor 7 signaling pathway| regulation of toll-like receptor 9 signaling pathway| regulation of toll-like receptor signaling pathway| regulation of type 2 immune response| response to virus| vitamin biosynthetic process |
| 276 | PF12077 | Transmembrane protein of unknown function (DUF3556) | No Pfam Clan | 188 (14) | 574 | 575 | (1) MFS general substrate transporter [f.38.1] (24-483) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(24-483) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 277 | PF05218 | Protein of unknown function (DUF713) | No Pfam Clan | 53 (6) | 182 | 190 | (1) t-snare proteins [a.47.2] (42-142) |
(1) STAT-like [a.47] |
NO PREDICTION | NO PREDICTION | a.47.2(42-142) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | Golgi apparatus | No information | No information |
| 278 | PF06551 | Protein of unknown function (DUF1120) | Adhesin (CL0204) | 319 (7) | 116 | 102 | (1) Bacterial adhesins [b.2.3] (1-55) |
(1) Common fold of diphtheria toxin/transcription factors/cytochrome f [b.2] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | b.2.3(1-55) | 1 | YES | Eukaryota|Bacteria | No information | pilus | No information | biofilm formation| biological adhesion| cell adhesion| cell adhesion involved in biofilm formation| cell adhesion involved in single-species biofilm formation| multi-organism cellular process| single-species biofilm formation |
| 279 | PF15016 | Domain of unknown function (DUF4520) | No Pfam Clan | 57 (13) | 86 | 80 | (1) Polo-box domain [d.223.1] (12-60) |
(1) Polo-box domain [d.223] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | d.223.1(12-60) | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 280 | PF14643 | Domain of unknown function (DUF4455) | No Pfam Clan | 121 (16) | 474 | 473 | (1) ARM repeat [a.118.1] (24-463) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(24-463) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 281 | PF07758 | Protein of unknown function (DUF1614) | No Pfam Clan | 186 (48) | 176 | 170 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (24-175) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(24-175) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | No information | No information | No information |
| 282 | PF09745 | Coiled-coil domain-containing protein 55 (DUF2040) | No Pfam Clan | 288 (30) | 128 | 128 | (1) MW0975(SA0943)-like [a.24.27] (1-125) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(1-125) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 283 | PF13161 | Protein of unknown function (DUF3996) | No Pfam Clan | 146 (16) | 153 | 169 | (1) OMPA-like [f.4.1] (1-152) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.1(1-152) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | O-acyltransferase activity| O-palmitoyltransferase activity| palmitoyltransferase activity| transferase activity, transferring acyl groups other than amino-acyl groups | glycolipid biosynthetic process| glycolipid metabolic process| lipid A biosynthetic process| lipid A metabolic process| lipooligosaccharide biosynthetic process| lipooligosaccharide metabolic process| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| phospholipid biosynthetic process| phospholipid metabolic process |
| 284 | PF14188 | Domain of unknown function (DUF4311) | No Pfam Clan | 329 (9) | 213 | 213 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (INDIRECT) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 285 | PF10730 | Protein of unknown function (DUF2521) | No Pfam Clan | 131 (10) | 147 | 142 | (1) "Winged helix" DNA-binding domain [a.4.5] (2-136) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
a.4.5(2-136) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 286 | PF10920 | Protein of unknown function (DUF2705) | No Pfam Clan | 30 (2) | 245 | 245 | (1) Bacterial photosystem II reaction centre, L and M subunits [f.26.1] (INDIRECT) |
(1) Bacterial photosystem II reaction centre, L and M subunits [f.26] |
NO PREDICTION | f.26.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 287 | PF15239 | Domain of unknown function (DUF4586) | No Pfam Clan | 143 (41) | 302 | 291 | (1) ssDNA viruses [b.121.5] (1-291) |
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | b.121.5(1-291) | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 288 | PF10881 | Protein of unknown function (DUF2726) | PDDEXK (CL0236) | 880 (35) | 126 | 127 | (1) Restriction endonuclease-like [c.52.1] (INDIRECT) |
(1) Restriction endonuclease-like [c.52] |
NO PREDICTION | c.52.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Bacteria|Viruses | 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 | No information | endonuclease activity| nuclease activity | DNA repair| nucleotide-excision repair |
| 289 | PF13171 | Protein of unknown function (DUF4004) | No Pfam Clan | 172 (9) | 199 | 194 | (1) Putative DNA-binding domain [a.6.1] (3-57) |
(1) Putative DNA-binding domain [a.6] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.6.1(3-57) | 1 | No information | Bacteria|Archaea | No information | No information | nucleic acid binding transcription factor activity| sequence-specific DNA binding transcription factor activity | No information |
| 290 | PF07214 | Protein of unknown function (DUF1418) | No Pfam Clan | 515 (7) | 96 | 95 | (1) RNI-like [c.10.1] (9-88) |
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10] |
c.10.1(9-88) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Bacteria | No information | ubiquitin ligase complex | acid-amino acid ligase activity| small conjugating protein ligase activity| ubiquitin-protein ligase activity | cellular protein catabolic process| entrainment of circadian clock| entrainment of circadian clock by photoperiod| modification-dependent macromolecule catabolic process| photoperiodism| protein catabolic process| protein ubiquitination| proteolysis| regulation of circadian rhythm| ubiquitin-dependent protein catabolic process |
| 291 | PF12021 | Protein of unknown function (DUF3509) | No Pfam Clan | 201 (19) | 94 | 116 | (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (4-82) |
(1) 8-bladed beta-propeller [b.70] |
b.70.1(4-82) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 1.1.2.7| 1.1.98.1 | No information | endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity | ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein |
| 292 | PF07585 | Protein of unknown function (DUF1551) | No Pfam Clan | 57 (14) | 339 | 354 | (1) OMPT-like [f.4.4] (44-338) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.4(44-338) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 3.4.23.48| 3.4.23.49 | No information | No information | No information |
| 293 | PF07957 | Protein of unknown function (DUF3294) | No Pfam Clan | 45 (10) | 216 | 193 | (1) MW0975(SA0943)-like [a.24.27] (1-200) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(1-200) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 294 | PF09365 | Conserved hypothetical protein (DUF2461) | No Pfam Clan | 698 (99) | 212 | 214 | (1) YktB/PF0168-like [d.296.1] (8-211) |
(1) YktB/PF0168-like [d.296] |
NO PREDICTION | d.296.1(8-211) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | No information | No information | No information |
| 295 | PF15488 | Domain of unknown function (DUF4645) | No Pfam Clan | 21 (7) | 294 | 294 | (1) ssDNA viruses [b.121.5] (1-294) |
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | b.121.5(1-294) | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 296 | PF11882 | Domain of unknown function (DUF3402) | No Pfam Clan | 336 (22) | 409 | 476 | (1) ARM repeat [a.118.1] (90-408) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(90-408) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 297 | PF04342 | Protein of unknown function, DUF486 | DMT (CL0184) | 583 (4) | 108 | 108 | (1) Multidrug resistance efflux transporter EmrE [f.39.1] (4-107) |
(1) Multidrug resistance efflux transporter EmrE [f.39] |
NO PREDICTION | f.39.1(4-107) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 298 | PF13870 | Domain of unknown function (DUF4201) | No Pfam Clan | 290 (56) | 177 | 177 | (1) MW0975(SA0943)-like [a.24.27] (1-176) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(1-176) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 299 | PF11250 | Protein of unknown function (DUF3049) | No Pfam Clan | 167 (24) | 56 | 56 | (1) Calcium-dependent phosphotriesterase [b.68.6] (7-51) |
(1) 6-bladed beta-propeller [b.68] |
b.68.6(7-51) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 3.1.1.17| 3.1.1.25| 3.1.8.2| 4.3.3.2 | No information | aryldialkylphosphatase activity| arylesterase activity| calcium ion binding| carboxylic ester hydrolase activity| gluconolactonase activity| zinc ion binding | L-ascorbic acid biosynthetic process| L-ascorbic acid metabolic process| calcium ion homeostasis| cellular calcium ion homeostasis| cellular cation homeostasis| cellular chemical homeostasis| cellular divalent inorganic cation homeostasis| cellular ion homeostasis| cellular metal ion homeostasis| divalent inorganic cation homeostasis| metal ion homeostasis| monosaccharide biosynthetic process| positive regulation of ATPase activity| positive regulation of hydrolase activity| regulation of ATPase activity| regulation of calcium-mediated signaling| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| vitamin biosynthetic process| water-soluble vitamin biosynthetic process| water-soluble vitamin metabolic process |
| 300 | PF11677 | Protein of unknown function (DUF3273) | No Pfam Clan | 59 (9) | 265 | 262 | (1) MFS general substrate transporter [f.38.1] (4-254) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(4-254) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 301 | PF04447 | Protein of unknown function (DUF550) | MazG (CL0231) | 150 (10) | 101 | 100 | (1) all-alpha NTP pyrophosphatases [a.204.1] (18-82) |
(1) all-alpha NTP pyrophosphatases [a.204] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.204.1(18-82) | 1 | No information | Bacteria|Viruses | 3.6.1.19| 3.6.1.23| 3.6.1.31 | No information | magnesium ion binding| nucleoside-triphosphate diphosphatase activity | nucleoside triphosphate catabolic process| organophosphate catabolic process |
| 302 | PF10721 | Protein of unknown function (DUF2514) | EpsM (CL0331) | 309 (17) | 162 | 167 | (1) MW0975(SA0943)-like [a.24.27] (21-161) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(21-161) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | No information | No information | No information | No information |
| 303 | PF09941 | Uncharacterized conserved protein (DUF2173) | No Pfam Clan | 47 (11) | 108 | 108 | (1) Roadblock/LC7 domain [d.110.7] (1-107) |
(1) Profilin-like [d.110] |
NO PREDICTION | d.110.7(1-107) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | Ragulator complex| cytoplasmic dynein complex| dynein complex| endosomal part| endosome membrane| late endosome| late endosome membrane| lysosome| lytic vacuole| membrane raft| microtubule associated complex | ATPase activity, coupled| GTPase regulator activity| guanyl-nucleotide exchange factor activity| nucleoside-triphosphatase regulator activity| protein complex scaffold | ATP catabolic process| ATP metabolic process| cell growth| cellular response to acid| cellular response to amino acid stimulus| cellular response to nitrogen compound| cellular response to organonitrogen compound| glycosyl compound catabolic process| growth| microtubule-based movement| microtubule-based process| nucleoside catabolic process| nucleoside monophosphate catabolic process| nucleoside monophosphate metabolic process| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| organophosphate catabolic process| positive regulation of TOR signaling cascade| protein localization to lysosome| protein localization to vacuole| purine nucleoside catabolic process| purine nucleoside monophosphate catabolic process| purine nucleoside monophosphate metabolic process| purine nucleoside triphosphate catabolic process| purine nucleoside triphosphate metabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside monophosphate catabolic process| purine ribonucleoside monophosphate metabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleoside triphosphate metabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| regulation of GTP catabolic process| regulation of GTPase activity| regulation of TOR signaling cascade| regulation of anatomical structure size| regulation of cell size| regulation of cellular component size| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| response to acid| response to amino acid stimulus| response to organonitrogen compound| ribonucleoside catabolic process| ribonucleoside monophosphate catabolic process| ribonucleoside monophosphate metabolic process| ribonucleoside triphosphate catabolic process| ribonucleoside triphosphate metabolic process| ribonucleotide catabolic process |
| 304 | PF15072 | Domain of unknown function (DUF4539) | No Pfam Clan | 116 (32) | 86 | 86 | (1) Nucleic acid-binding proteins [b.40.4] (21-63) |
(1) OB-fold [b.40] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | b.40.4(21-63) | 1 | No information | Eukaryota | 3.1.13.1| 3.1.26.12| 6.5.1.1 | DNA replication factor A complex| DNA-directed RNA polymerase II, core complex| DNA-directed RNA polymerase II, holoenzyme| DNA-directed RNA polymerase complex| RNA polymerase complex| cytoplasmic exosome (RNase complex)| cytosolic small ribosomal subunit| exosome (RNase complex)| mitochondrial nucleoid| nuclear DNA-directed RNA polymerase complex| nucleoid| organellar ribosome| replisome | RNA polymerase activity| chromatin binding| ribonucleoprotein complex binding| single-stranded DNA binding| structure-specific DNA binding | regulation of DNA-dependent transcription, termination| regulation of RNA stability| regulation of mRNA stability| response to cold| ribonucleoprotein complex biogenesis| telomere maintenance| telomere organization| transcriptional attenuation| translational initiation |
| 305 | PF12013 | Protein of unknown function (DUF3505) | No Pfam Clan | 197 (16) | 109 | 111 | (1) TRAF domain-like [b.8.1] (9-47) |
(1) TRAF domain-like [b.8] |
NO PREDICTION | NO PREDICTION | b.8.1(9-47) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 306 | PF09899 | Putative amidoligase enzyme (DUF2126) | GCS (CL0286) | 471 (40) | 819 | 838 | (1) Cysteine proteinases [d.3.1] (20-111) |
(1) Cysteine proteinases [d.3] |
NO PREDICTION | NO PREDICTION | d.3.1(20-111) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 2.3.1.118| 2.3.1.5| 2.3.2.13| 2.3.2.15| 3.1.1.4| 3.4.14.1| 3.4.18.1| 3.4.19.12| 3.4.22.1| 3.4.22.10| 3.4.22.14| 3.4.22.15| 3.4.22.16| 3.4.22.2| 3.4.22.25| 3.4.22.27| 3.4.22.30| 3.4.22.38| 3.4.22.39| 3.4.22.40| 3.4.22.41| 3.4.22.43| 3.4.22.48| 3.4.22.51| 3.4.22.52| 3.4.22.53| 3.4.22.6| 3.4.22.65| 3.4.22.68| 3.5.1.52| 6.3.1.9 | alveolar lamellar body| endosome lumen| lamellar body| lytic vacuole| vacuolar lumen | MHC class I receptor activity| N-acyltransferase activity| acetyltransferase activity| arylamine N-acetyltransferase activity| cysteine-type carboxypeptidase activity| cysteine-type endopeptidase activity| cysteine-type endopeptidase regulator activity involved in apoptotic process| cysteine-type peptidase activity| hormone binding| peptidase activator activity| peptidase activator activity involved in apoptotic process| peptidase activity| peptidase regulator activity| small conjugating protein binding| thiolester hydrolase activity| thyroid hormone binding| ubiquitin thiolesterase activity | ERK1 and ERK2 cascade| T cell mediated cytotoxicity| T cell mediated immunity| adaptive immune response| anatomical structure maturation| bradykinin catabolic process| catagen| cell killing| cellular response to thyroid hormone stimulus| chemical homeostasis within a tissue| collagen metabolic process| decidualization| dichotomous subdivision of an epithelial terminal unit| dichotomous subdivision of terminal units involved in lung branching| epidermis morphogenesis| epithelial tube branching involved in lung morphogenesis| extracellular matrix disassembly| female pregnancy| hair cycle| hair cycle process| hair follicle development| hair follicle maturation| hair follicle morphogenesis| immune response-regulating signaling pathway| leukocyte mediated cytotoxicity| leukocyte mediated immunity| lung development| lung morphogenesis| lymphocyte mediated immunity| maternal placenta development| maternal process involved in female pregnancy| metanephros development| molting cycle process| multicellular organismal catabolic process| multicellular organismal homeostasis| negative regulation of epithelial cell proliferation| negative regulation of keratinocyte proliferation| neuropeptide catabolic process| peptide catabolic process| peptide metabolic process| placenta development| positive regulation of angiogenesis| positive regulation of apoptotic signaling pathway| positive regulation of developmental process| positive regulation of epithelial cell migration| positive regulation of peptidase activity| posttranscriptional regulation of gene expression| protein destabilization| protein maturation| protein modification by small protein conjugation or removal| protein modification by small protein removal| protein processing| proteolysis| regulation of actin cytoskeleton reorganization| regulation of epithelial cell migration| regulation of keratinocyte proliferation| regulation of peptidase activity| regulation of protein stability| respiratory tube development| response to retinoic acid| response to thyroid hormone stimulus| skin morphogenesis| surfactant homeostasis| tissue homeostasis |
| 307 | PF09889 | Uncharacterized protein containing a Zn-ribbon (DUF2116) | Zn_Beta_Ribbon (CL0167) | 52 (9) | 59 | 58 | (1) Glucocorticoid receptor-like (DNA-binding domain) [g.39.1] (2-27) |
(1) Glucocorticoid receptor-like (DNA-binding domain) [g.39] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | g.39.1(2-27) | 1 | No information | Bacteria|Viruses|Archaea | 2.7.1.21| 4.2.99.18 | No information | No information | No information |
| 308 | PF12482 | Phage integrase protein | No Pfam Clan | 151 (38) | 96 | 94 | (1) C-terminal domain of RNA polymerase alpha subunit [a.60.3] (21-78) |
(1) SAM domain-like [a.60] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.60.3(21-78) | 1 | No information | Bacteria | No information | No information | No information | No information |
| 309 | PF11139 | Protein of unknown function (DUF2910) | NicO_HupE_DsbD (CL0549) | 566 (46) | 214 | 212 | (1) MFS general substrate transporter [f.38.1] (INDIRECT) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 310 | PF02006 | Protein of unknown function DUF137 | No Pfam Clan | 143 (37) | 178 | 176 | (1) DHS-like NAD/FAD-binding domain [c.31.1] (1-167) |
(1) DHS-like NAD/FAD-binding domain [c.31] |
NO PREDICTION | c.31.1(1-167) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | 1.2.5.1| 1.6.1.2| 2.2.1.6| 2.5.1.46| 2.5.1.66| 4.1.1.47| 4.1.1.7| 4.1.1.8 | No information | NAD-dependent protein deacetylase activity| deacetylase activity| histone deacetylase activity| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | chromatin modification| chromatin organization| chromosome organization| covalent chromatin modification| histone H3 deacetylation| histone deacetylation| histone modification| protein deacylation |
| 311 | PF14230 | Domain of unknown function (DUF4333) | No Pfam Clan | 334 (37) | 80 | 81 | (1) Multiheme cytochromes [a.138.1] (8-80) |
(1) Multiheme cytochromes [a.138] |
a.138.1(8-80) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 1.7.2.2| 1.7.3.4 | No information | electron carrier activity| oxidoreductase activity, acting on other nitrogenous compounds as donors | No information |
| 312 | PF09526 | Probable metal-binding protein (DUF2387) | Zn_Beta_Ribbon (CL0167) | 844 (44) | 71 | 61 | (1) Zinc beta-ribbon [g.41.3] (5-45) |
(1) Rubredoxin-like [g.41] |
NO PREDICTION | NO PREDICTION | g.41.3(5-45) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 313 | PF03665 | Uncharacterised protein family (UPF0172) | JAB (CL0366) | 258 (22) | 196 | 186 | (1) JAB1/MPN domain [c.97.3] (1-119) |
(1) Cytidine deaminase-like [c.97] |
NO PREDICTION | c.97.3(1-119) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 3.1.2.15 | No information | No information | No information |
| 314 | PF08876 | Domain of unknown function (DUF1836) | HTH (CL0123) | 1171 (48) | 105 | 97 | (1) Putative DNA-binding domain [a.6.1] (30-86) |
(1) Putative DNA-binding domain [a.6] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.6.1(30-86) | 1 | No information | Eukaryota|Bacteria | No information | No information | nucleic acid binding transcription factor activity| sequence-specific DNA binding transcription factor activity | No information |
| 315 | PF09913 | Predicted membrane protein (DUF2142) | GT-C (CL0111) | 382 (34) | 389 | 404 | (1) MFS general substrate transporter [f.38.1] (72-388) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(72-388) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 316 | PF11954 | Domain of unknown function (DUF3471) | No Pfam Clan | 608 (67) | 100 | 119 | (1) D-aminopeptidase, middle and C-terminal domains [b.61.3] (13-84) |
(1) Streptavidin-like [b.61] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | b.61.3(13-84) | 1 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 317 | PF13099 | Domain of unknown function (DUF3944) | No Pfam Clan | 557 (19) | 35 | 35 | (1) ARM repeat [a.118.1] (13-35) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(13-35) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 318 | PF10106 | Uncharacterized protein conserved in bacteria (DUF2345) | No Pfam Clan | 1108 (93) | 156 | 153 | (1) Phage fibre proteins [b.108.1] (12-153) |
(1) Triple-stranded beta-helix [b.108] |
b.108.1(12-153) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 4.2.2.1 | No information | No information | No information |
| 319 | PF12281 | Protein of unknown function (DUF3620) | No Pfam Clan | 119 (29) | 217 | 212 | (1) Nucleotidyltransferase [d.218.1] (1-198) |
(1) Nucleotidyltransferase [d.218] |
NO PREDICTION | d.218.1(1-198) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 2.7.6.5| 2.7.7.19| 2.7.7.31| 2.7.7.42| 2.7.7.52| 2.7.7.7| 2.7.7.72 | No information | adenylyltransferase activity| double-stranded RNA binding | No information |
| 320 | PF03235 | Protein of unknown function DUF262 | ParBc (CL0248) | 2983 (194) | 221 | 211 | (1) ParB/Sulfiredoxin [d.268.1] (8-220) |
(1) ParB/Sulfiredoxin [d.268] |
NO PREDICTION | d.268.1(8-220) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Viruses|Archaea | 1.8.98.2 | No information | No information | No information |
| 321 | PF11868 | Protein of unknown function (DUF3388) | No Pfam Clan | 391 (8) | 192 | 192 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (42-116) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.37.1(42-116) | 1 | No information | Bacteria | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 322 | PF09842 | Predicted membrane protein (DUF2069) | No Pfam Clan | 494 (61) | 109 | 108 | (1) Respiratory nitrate reductase 1 gamma chain [f.21.3] (1-106) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | f.21.3(1-106) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 323 | PF06787 | Uncharacterised protein family (UPF0254) | No Pfam Clan | 29 (11) | 160 | 160 | (1) CinA-like [c.51.5] (2-160) |
(1) Anticodon-binding domain-like [c.51] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.51.5(2-160) | 1 | No information | Bacteria|Archaea | No information | No information | No information | No information |
| 324 | PF07077 | Protein of unknown function (DUF1345) | No Pfam Clan | 475 (56) | 181 | 186 | (1) Voltage-gated potassium channels [f.14.1] (60-180) |
(1) Voltage-gated potassium channels [f.14] |
NO PREDICTION | f.14.1(60-180) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | cation channel activity| ion channel activity| ion gated channel activity| monovalent inorganic cation transmembrane transporter activity| passive transmembrane transporter activity| substrate-specific channel activity | monovalent inorganic cation transport |
| 325 | PF07867 | Protein of unknown function (DUF1654) | No Pfam Clan | 129 (12) | 73 | 72 | (1) Pseudo ankyrin repeat-like [a.118.24] (15-60) |
(1) alpha-alpha superhelix [a.118] |
a.118.24(15-60) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | No information | No information | No information | No information |
| 326 | PF06163 | Bacterial protein of unknown function (DUF977) | HTH (CL0123) | 656 (3) | 127 | 115 | (1) "Winged helix" DNA-binding domain [a.4.5] (7-83) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.4.5(7-83) | 1 | No information | Eukaryota|Bacteria | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 327 | PF10759 | Protein of unknown function (DUF2587) | No Pfam Clan | 199 (15) | 169 | 170 | (1) Outer membrane efflux proteins (OEP) [f.5.1] (5-168) |
(1) Outer membrane efflux proteins (OEP) [f.5] |
f.5.1(5-168) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Bacteria | No information | No information | efflux transmembrane transporter activity | drug transport| response to drug |
| 328 | PF03699 | Uncharacterised protein family (UPF0182) | No Pfam Clan | 654 (63) | 774 | 791 | (1) Calcium-dependent phosphotriesterase [b.68.6] (255-753) (2) Fumarate reductase respiratory complex transmembrane subunits [f.21.2] (20-271) |
(1) 6-bladed beta-propeller [b.68] (2) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | b.68.6(255-753)| f.21.2(20-271) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 1.3.5.1| 3.1.1.17| 3.1.1.25| 3.1.8.2| 4.3.3.2 | fumarate reductase complex| mitochondrial respiratory chain| mitochondrial respiratory chain complex II| plasma membrane respiratory chain| plasma membrane respiratory chain complex II| respiratory chain| respiratory chain complex II| succinate dehydrogenase complex | aryldialkylphosphatase activity| arylesterase activity| calcium ion binding| carboxylic ester hydrolase activity| cofactor binding| electron carrier activity| gluconolactonase activity| heme binding| oxidoreductase activity, acting on the CH-CH group of donors| quinone binding| succinate dehydrogenase activity| tetrapyrrole binding| ubiquinone binding| zinc ion binding | L-ascorbic acid biosynthetic process| L-ascorbic acid metabolic process| calcium ion homeostasis| cellular calcium ion homeostasis| cellular cation homeostasis| cellular chemical homeostasis| cellular divalent inorganic cation homeostasis| cellular ion homeostasis| cellular metal ion homeostasis| cellular respiration| divalent inorganic cation homeostasis| electron transport chain| energy derivation by oxidation of organic compounds| metal ion homeostasis| mitochondrial ATP synthesis coupled electron transport| mitochondrial electron transport, succinate to ubiquinone| monosaccharide biosynthetic process| oxidative phosphorylation| positive regulation of ATPase activity| positive regulation of hydrolase activity| regulation of ATPase activity| regulation of calcium-mediated signaling| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| tricarboxylic acid cycle| vitamin biosynthetic process| water-soluble vitamin biosynthetic process| water-soluble vitamin metabolic process |
| 329 | PF11364 | Protein of unknown function (DUF3165) | No Pfam Clan | 341 (7) | 82 | 82 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-75) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(1-75) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 330 | PF11878 | Domain of unknown function (DUF3398) | No Pfam Clan | 472 (20) | 98 | 111 | (1) PH domain-like [b.55.1] (14-98) |
(1) PH domain-like barrel [b.55] |
b.55.1(14-98) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 3.1.4.11 | actin cap| apical part of cell| apical plasma membrane| cell cortex| cell cortex part| cell leading edge| cortical actin cytoskeleton| cortical cytoskeleton| extrinsic to membrane| extrinsic to plasma membrane| lamellipodium | alpha-catenin binding| cell adhesion molecule binding| phosphatidylinositol binding| phospholipid binding| phosphotransferase activity, alcohol group as acceptor| protein kinase activity | Schwann cell development| Schwann cell differentiation| actin cytoskeleton organization| cell junction organization| cell projection organization| cellular membrane organization| cellular protein complex localization| cellular response to hormone stimulus| cellular response to insulin stimulus| cellular response to nitrogen compound| cellular response to organonitrogen compound| cellular response to peptide| cellular response to peptide hormone stimulus| ensheathment of neurons| neural precursor cell proliferation| peripheral nervous system development| plasma membrane organization| positive regulation of cellular response to insulin stimulus| positive regulation of glucose import in response to insulin stimulus| positive regulation of polarized epithelial cell differentiation| protein phosphorylation| regulation of GTP catabolic process| regulation of GTPase activity| regulation of Ras GTPase activity| regulation of actin cytoskeleton organization| regulation of actin filament length| regulation of cellular response to insulin stimulus| regulation of cytoskeleton organization| regulation of glucose import in response to insulin stimulus| regulation of glucose transport| regulation of nucleoside metabolic process| regulation of polarized epithelial cell differentiation| regulation of protein polymerization| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| response to organonitrogen compound| response to peptide| response to peptide hormone stimulus| stem cell proliferation| transmembrane receptor protein tyrosine kinase signaling pathway |
| 331 | PF10732 | Protein of unknown function (DUF2524) | No Pfam Clan | 132 (8) | 84 | 84 | (1) TPR-like [a.118.8] (11-66) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(11-66) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 332 | PF14114 | Domain of unknown function (DUF4286) | No Pfam Clan | 171 (46) | 98 | 96 | (1) Dimeric alpha+beta barrel [d.58.4] (1-97) |
(1) Ferredoxin-like [d.58] |
NO PREDICTION | d.58.4(1-97) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 1.13.11.49| 1.13.11.55| 1.14.99.3| 5.3.3.4| 5.4.99.14 | No information | No information | No information |
| 333 | PF07900 | Protein of unknown function (DUF1670) | HTH (CL0123) | 52 (6) | 220 | 218 | (1) "Winged helix" DNA-binding domain [a.4.5] (87-141) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.4.5(87-141) | 1 | No information | Bacteria|Archaea | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 334 | PF14351 | Domain of unknown function (DUF4401) | No Pfam Clan | 202 (44) | 326 | 321 | (1) MFS general substrate transporter [f.38.1] (3-325) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(3-325) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 335 | PF11150 | Protein of unknown function (DUF2927) | No Pfam Clan | 243 (65) | 213 | 205 | (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (27-194) |
(1) Zincin-like [d.92] |
NO PREDICTION | d.92.1(27-194) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 | cortical granule | glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity | biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing |
| 336 | PF09870 | Uncharacterized protein conserved in archaea (DUF2097) | No Pfam Clan | 32 (8) | 86 | 86 | (1) HCP-like [a.118.18] (4-82) |
(1) alpha-alpha superhelix [a.118] |
a.118.18(4-82) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Archaea | No information | No information | No information | No information |
| 337 | PF07760 | Protein of unknown function (DUF1616) | No Pfam Clan | 205 (38) | 287 | 281 | (1) MFS general substrate transporter [f.38.1] (17-166) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | NO PREDICTION | f.38.1(17-166) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 338 | PF06027 | Eukaryotic protein of unknown function (DUF914) | DMT (CL0184) | 558 (5) | 336 | 336 | (1) Multidrug resistance efflux transporter EmrE [f.39.1] (75-152) |
(1) Multidrug resistance efflux transporter EmrE [f.39] |
NO PREDICTION | NO PREDICTION | f.39.1(75-152) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | No information | No information | No information |
| 339 | PF10935 | Protein of unknown function (DUF2637) | No Pfam Clan | 337 (35) | 160 | 158 | (1) MFS general substrate transporter [f.38.1] (6-125) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | NO PREDICTION | f.38.1(6-125) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 340 | PF10571 | Uncharacterised protein family UPF0547 | Zn_Beta_Ribbon (CL0167) | 219 (31) | 26 | 26 | (1) Zn-binding ribosomal proteins [g.41.8] (1-24) |
(1) Rubredoxin-like [g.41] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | g.41.8(1-24) | 1 | No information | Eukaryota|Bacteria|Viruses|Archaea | No information | mitochondrial large ribosomal subunit| mitochondrial ribosome| organellar ribosome | No information | macropinocytosis| pinocytosis |
| 341 | PF11143 | Protein of unknown function (DUF2919) | No Pfam Clan | 662 (29) | 149 | 150 | (1) Respiratory nitrate reductase 1 gamma chain [f.21.3] (1-147) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | f.21.3(1-147) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 342 | PF07870 | Protein of unknown function (DUF1657) | No Pfam Clan | 523 (27) | 50 | 50 | (1) TPR-like [a.118.8] (1-49) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(1-49) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 343 | PF05537 | Borrelia burgdorferi protein of unknown function (DUF759) | No Pfam Clan | 148 (2) | 431 | 422 | (1) ARM repeat [a.118.1] (14-421) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(14-421) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 344 | PF13959 | Domain of unknown function (DUF4217) | No Pfam Clan | 1332 (193) | 65 | 73 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (1-65) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
c.37.1(1-65) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 345 | PF14471 | Domain of unknown function (DUF4428) | No Pfam Clan | 71 (24) | 51 | 55 | (1) Glucocorticoid receptor-like (DNA-binding domain) [g.39.1] (1-29) |
(1) Glucocorticoid receptor-like (DNA-binding domain) [g.39] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | g.39.1(1-29) | 1 | No information | Bacteria|Viruses | 2.7.1.21| 4.2.99.18 | No information | No information | No information |
| 346 | PF08011 | Protein of unknown function (DUF1703) | PDDEXK (CL0236) | 1376 (45) | 105 | 97 | (1) Restriction endonuclease-like [c.52.1] (INDIRECT) |
(1) Restriction endonuclease-like [c.52] |
NO PREDICTION | c.52.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 | No information | endonuclease activity| nuclease activity | DNA repair| nucleotide-excision repair |
| 347 | PF05300 | Protein of unknown function (DUF737) | No Pfam Clan | 182 (21) | 187 | 160 | (1) MW0975(SA0943)-like [a.24.27] (45-186) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(45-186) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 348 | PF13148 | Protein of unknown function (DUF3987) | No Pfam Clan | 899 (117) | 378 | 376 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (12-369) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
NO PREDICTION | c.37.1(12-369) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Viruses|Archaea | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 349 | PF05055 | Protein of unknown function (DUF677) | AT14A-like (CL0133) | 135 (7) | 336 | 336 | (1) Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [a.114.1] (60-335) |
(1) Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [a.114] |
NO PREDICTION | a.114.1(60-335) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | cellular response to cytokine stimulus| cellular response to interferon-gamma| immune response| innate immune response| response to cytokine stimulus| response to interferon-gamma |
| 350 | PF11898 | Domain of unknown function (DUF3418) | No Pfam Clan | 1852 (105) | 586 | 600 | (1) ARM repeat [a.118.1] (27-561) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(27-561) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 351 | PF10094 | Uncharacterized protein conserved in bacteria (DUF2332) | No Pfam Clan | 294 (37) | 343 | 343 | (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (51-291) |
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66] |
NO PREDICTION | c.66.1(51-291) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 | nuclear matrix | glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups | Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process |
| 352 | PF04830 | Possible hemagglutinin (DUF637) | No Pfam Clan | 397 (30) | 178 | 174 | (1) ARM repeat [a.118.1] (38-148) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(38-148) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 353 | PF11365 | Protein of unknown function (DUF3166) | No Pfam Clan | 340 (4) | 97 | 101 | (1) TPR-like [a.118.8] (17-95) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(17-95) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 354 | PF14187 | Domain of unknown function (DUF4310) | No Pfam Clan | 318 (9) | 210 | 210 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (9-208) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(9-208) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 355 | PF11994 | Protein of unknown function (DUF3489) | No Pfam Clan | 127 (26) | 72 | 72 | (1) "Winged helix" DNA-binding domain [a.4.5] (15-69) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
a.4.5(15-69) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 356 | PF10093 | Uncharacterized protein conserved in bacteria (DUF2331) | No Pfam Clan | 370 (50) | 374 | 378 | (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (1-352) |
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87] |
NO PREDICTION | c.87.1(1-352) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 | alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) | UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups | L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process |
| 357 | PF04284 | Protein of unknown function (DUF441) | No Pfam Clan | 1132 (35) | 140 | 140 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-139) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(1-139) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | No information | No information | No information |
| 358 | PF12266 | Protein of unknown function (DUF3613) | No Pfam Clan | 138 (18) | 67 | 68 | (1) Multiheme cytochromes [a.138.1] (5-67) |
(1) Multiheme cytochromes [a.138] |
a.138.1(5-67) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 1.7.2.2| 1.7.3.4 | No information | electron carrier activity| oxidoreductase activity, acting on other nitrogenous compounds as donors | No information |
| 359 | PF15057 | Domain of unknown function (DUF4537) | Tudor (CL0049) | 111 (24) | 124 | 119 | (1) Tudor/PWWP/MBT [b.34.9] (1-52) |
(1) SH3-like barrel [b.34] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | b.34.9(1-52) | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 360 | PF08490 | Domain of unknown function (DUF1744) | DNA_pol_B-like (CL0194) | 355 (17) | 396 | 390 | (1) DNA/RNA polymerases [e.8.1] (141-390) |
(1) DNA/RNA polymerases [e.8] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | e.8.1(141-390) | 1 | No information | Eukaryota | 2.7.7.48| 2.7.7.49| 2.7.7.6| 2.7.7.7 | No information | DNA polymerase activity | DNA replication| RNA-dependent DNA replication |
| 361 | PF04920 | Family of unknown function (DUF656) | No Pfam Clan | 39 (2) | 126 | 126 | (1) Bacterial muramidases [a.118.5] (13-116) |
(1) alpha-alpha superhelix [a.118] |
a.118.5(13-116) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Viruses | No information | No information | No information | No information |
| 362 | PF11996 | Protein of unknown function (DUF3491) | No Pfam Clan | 259 (8) | 936 | 945 | (1) DPP6 N-terminal domain-like [b.70.3] (81-914) |
(1) 8-bladed beta-propeller [b.70] |
NO PREDICTION | b.70.3(81-914) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 363 | PF12616 | Protein of unknown function (DUF3775) | No Pfam Clan | 175 (44) | 75 | 75 | (1) TPR-like [a.118.8] (2-68) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(2-68) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 364 | PF01345 | Domain of unknown function DUF11 | E-set (CL0159) | 6559 (35) | 76 | 76 | (1) Subtilisin-like [c.41.1] (13-76) |
(1) Subtilisin-like [c.41] |
c.41.1(13-76) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 3.4.14.10| 3.4.14.9| 3.4.21.100| 3.4.21.110| 3.4.21.61| 3.4.21.62| 3.4.21.64| 3.4.21.66| 3.4.21.75 | No information | No information | No information |
| 365 | PF09990 | Predicted membrane protein (DUF2231) | No Pfam Clan | 367 (51) | 104 | 116 | (1) Transmembrane di-heme cytochromes [f.21.1] (1-100) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | f.21.1(1-100) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 1.10.2.2 | No information | electron carrier activity | cellular respiration |
| 366 | PF05254 | Uncharacterised protein family (UPF0203) | No Pfam Clan | 246 (19) | 68 | 69 | (1) Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [f.28.1] (5-56) |
(1) Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [f.28] |
NO PREDICTION | NO PREDICTION | f.28.1(5-56) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | respiratory chain | No information | No information |
| 367 | PF09747 | Coiled-coil domain containing protein (DUF2052) | No Pfam Clan | 236 (20) | 181 | 175 | (1) MW0975(SA0943)-like [a.24.27] (1-180) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(1-180) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 368 | PF10812 | Protein of unknown function (DUF2561) | No Pfam Clan | 80 (7) | 207 | 210 | (1) MFS general substrate transporter [f.38.1] (12-206) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(12-206) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 369 | PF08822 | Protein of unknown function (DUF1804) | HTH (CL0123) | 154 (12) | 165 | 165 | (1) Homeodomain-like [a.4.1] (2-49) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.4.1(2-49) | 1 | No information | Bacteria|Viruses | No information | transcription factor complex | chromatin binding| nucleic acid binding transcription factor activity| transposase activity | activin receptor signaling pathway| cell fate commitment| cell fate specification| chordate embryonic development| diencephalon development| embryonic morphogenesis| endoderm development| eye photoreceptor cell differentiation| negative regulation of developmental process| neural tube development| neuron fate commitment| nodal signaling pathway| pancreas development| pattern specification process| positive regulation of neuron differentiation| regulation of cell fate commitment| regulation of epithelial cell differentiation| regulation of gastrulation| retina development in camera-type eye| sensory organ development| somitogenesis| transmembrane receptor protein serine/threonine kinase signaling pathway| transposition| transposition, DNA-mediated| trophectodermal cell differentiation |
| 370 | PF15366 | Domain of unknown function (DUF4597) | No Pfam Clan | 25 (4) | 62 | 63 | (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (5-57) |
(1) 8-bladed beta-propeller [b.70] |
b.70.1(5-57) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 1.1.2.7| 1.1.98.1 | No information | endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity | ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein |
| 371 | PF12027 | Protein of unknown function (DUF3514) | No Pfam Clan | 49 (26) | 255 | 243 | (1) ARM repeat [a.118.1] (3-252) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(3-252) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 372 | PF10790 | Protein of Unknown function (DUF2604) | No Pfam Clan | 5 (3) | 76 | 76 | (1) Ubiquitin-like [d.15.1] (3-74) |
(1) beta-Grasp (ubiquitin-like) [d.15] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | d.15.1(3-74) | 1 | No information | Bacteria | 3.1.2.15| 3.1.4.11 | autophagic vacuole| nuclear body | SUMO ligase activity| non-membrane spanning protein tyrosine phosphatase activity| phosphoprotein phosphatase activity| protein tag| protein tyrosine phosphatase activity| small conjugating protein ligase activity| small conjugating protein ligase binding | autophagy| catechol-containing compound metabolic process| catecholamine metabolic process| catecholamine transport| catecholamine uptake| catecholamine uptake involved in synaptic transmission| dopamine metabolic process| dopamine transport| dopamine uptake| dopamine uptake involved in synaptic transmission| monoamine transport| neurotransmitter uptake| norepinephrine metabolic process| peptidyl-tyrosine dephosphorylation| positive regulation of protein ubiquitination| positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc| protein modification by small protein conjugation or removal| protein sumoylation| proteolysis involved in cellular protein catabolic process| regulation of neurotransmitter secretion| regulation of neurotransmitter transport| regulation of protein catabolic process| regulation of protein ubiquitination| regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process| regulation of proteolysis| response to transforming growth factor beta stimulus| startle response| synaptic transmission, dopaminergic| synaptic transmission, glutamatergic |
| 373 | PF12069 | Protein of unknown function (DUF3549) | No Pfam Clan | 187 (29) | 340 | 343 | (1) ARM repeat [a.118.1] (1-338) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(1-338) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 374 | PF06496 | Protein of unknown function (DUF1097) | No Pfam Clan | 1004 (53) | 144 | 140 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (INDIRECT) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Bacteria|Archaea | No information | No information | No information | No information |
| 375 | PF11071 | Protein of unknown function (DUF2872) | No Pfam Clan | 147 (31) | 141 | 139 | (1) N-(deoxy)ribosyltransferase-like [c.23.14] (1-108) |
(1) Flavodoxin-like [c.23] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.23.14(1-108) | 1 | No information | Eukaryota|Bacteria | 2.4.2.6| 3.2.2.5 | No information | deoxyribonucleoside 5'-monophosphate N-glycosidase activity| hydrolase activity, hydrolyzing N-glycosyl compounds | deoxyribonucleoside monophosphate catabolic process| deoxyribonucleoside monophosphate metabolic process| nucleoside monophosphate catabolic process| nucleoside monophosphate metabolic process| nucleoside phosphate catabolic process| organophosphate catabolic process| positive regulation of cell growth| positive regulation of growth| regulation of cell growth |
| 376 | PF04094 | Protein of unknown function (DUF390) | No Pfam Clan | 813 (2) | 828 | 828 | (1) ARM repeat [a.118.1] (INDIRECT) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 377 | PF07289 | Protein of unknown function (DUF1448) | PH (CL0266) | 172 (13) | 339 | 336 | (1) PH domain-like [b.55.1] (146-207) |
(1) PH domain-like barrel [b.55] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | b.55.1(146-207) | 1 | No information | Eukaryota | 3.1.4.11 | actin cap| apical part of cell| apical plasma membrane| cell cortex| cell cortex part| cell leading edge| cortical actin cytoskeleton| cortical cytoskeleton| extrinsic to membrane| extrinsic to plasma membrane| lamellipodium | alpha-catenin binding| cell adhesion molecule binding| phosphatidylinositol binding| phospholipid binding| phosphotransferase activity, alcohol group as acceptor| protein kinase activity | Schwann cell development| Schwann cell differentiation| actin cytoskeleton organization| cell junction organization| cell projection organization| cellular membrane organization| cellular protein complex localization| cellular response to hormone stimulus| cellular response to insulin stimulus| cellular response to nitrogen compound| cellular response to organonitrogen compound| cellular response to peptide| cellular response to peptide hormone stimulus| ensheathment of neurons| neural precursor cell proliferation| peripheral nervous system development| plasma membrane organization| positive regulation of cellular response to insulin stimulus| positive regulation of glucose import in response to insulin stimulus| positive regulation of polarized epithelial cell differentiation| protein phosphorylation| regulation of GTP catabolic process| regulation of GTPase activity| regulation of Ras GTPase activity| regulation of actin cytoskeleton organization| regulation of actin filament length| regulation of cellular response to insulin stimulus| regulation of cytoskeleton organization| regulation of glucose import in response to insulin stimulus| regulation of glucose transport| regulation of nucleoside metabolic process| regulation of polarized epithelial cell differentiation| regulation of protein polymerization| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| response to organonitrogen compound| response to peptide| response to peptide hormone stimulus| stem cell proliferation| transmembrane receptor protein tyrosine kinase signaling pathway |
| 378 | PF13311 | Protein of unknown function (DUF4080) | No Pfam Clan | 385 (54) | 190 | 187 | (1) Radical SAM enzymes [c.1.28] (1-184) |
(1) TIM beta/alpha-barrel [c.1] |
c.1.28(1-184) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 1.3.99.22| 1.97.1.4| 2.8.1.6| 5.4.3.2 | lipid particle | 4 iron, 4 sulfur cluster binding| biotin synthase activity| intramolecular transferase activity| lipoate synthase activity| lipoate-protein ligase activity| metal cluster binding| oxidoreductase activity, acting on the CH-CH group of donors| protein self-association| radical SAM enzyme activity| sulfurtransferase activity| transferase activity, transferring sulfur-containing groups | CD4-positive, alpha-beta T cell activation| CD4-positive, alpha-beta T cell differentiation| T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| defense response to virus| lipoate biosynthetic process| lipoate metabolic process| lymphocyte differentiation| molybdopterin cofactor biosynthetic process| molybdopterin cofactor metabolic process| monocarboxylic acid biosynthetic process| negative regulation of protein secretion| negative regulation of protein transport| negative regulation of secretion| positive regulation of T cell cytokine production| positive regulation of T cell mediated immunity| positive regulation of T-helper 2 cell cytokine production| positive regulation of adaptive immune response| positive regulation of adaptive immune response based on somatic recombination of immune receptors b| positive regulation of cytokine production| positive regulation of cytokine production involved in immune response| positive regulation of immune effector process| positive regulation of leukocyte mediated immunity| positive regulation of lymphocyte mediated immunity| positive regulation of production of molecular mediator of immune response| positive regulation of toll-like receptor 9 signaling pathway| positive regulation of toll-like receptor signaling pathway| prosthetic group metabolic process| regulation of T cell cytokine production| regulation of T cell mediated immunity| regulation of T-helper 2 cell cytokine production| regulation of adaptive immune response| regulation of cytokine production involved in immune response| regulation of leukocyte mediated immunity| regulation of lymphocyte mediated immunity| regulation of production of molecular mediator of immune response| regulation of protein secretion| regulation of toll-like receptor 7 signaling pathway| regulation of toll-like receptor 9 signaling pathway| regulation of toll-like receptor signaling pathway| regulation of type 2 immune response| response to virus| vitamin biosynthetic process |
| 379 | PF10561 | Uncharacterised protein family UPF0565 | No Pfam Clan | 182 (12) | 303 | 309 | (1) alpha/beta-Hydrolases [c.69.1] (18-302) |
(1) alpha/beta-Hydrolases [c.69] |
NO PREDICTION | c.69.1(18-302) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 | trans-Golgi network transport vesicle | CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity | acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process |
| 380 | PF09860 | Uncharacterized protein conserved in bacteria (DUF2087) | No Pfam Clan | 586 (55) | 71 | 69 | (1) "Winged helix" DNA-binding domain [a.4.5] (1-70) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
a.4.5(1-70) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 381 | PF06156 | Protein of unknown function (DUF972) | No Pfam Clan | 1035 (43) | 107 | 114 | (1) Myosin rod fragments [h.1.26] (8-73) |
(1) Parallel coiled-coil [h.1] |
NO PREDICTION | NO PREDICTION | h.1.26(8-73) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | No information | No information | No information |
| 382 | PF07044 | Protein of unknown function (DUF1329) | No Pfam Clan | 761 (104) | 367 | 372 | (1) Tricorn protease N-terminal domain [b.68.7] (28-361) |
(1) 6-bladed beta-propeller [b.68] |
NO PREDICTION | b.68.7(28-361) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | No information | No information | No information | No information |
| 383 | PF01732 | Putative peptidase (DUF31) | Peptidase_PA (CL0124) | 325 (40) | 374 | 351 | (1) Trypsin-like serine proteases [b.47.1] (34-373) |
(1) Trypsin-like serine proteases [b.47] |
NO PREDICTION | b.47.1(34-373) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Bacteria | 3.4.19.12| 3.4.21.1| 3.4.21.104| 3.4.21.106| 3.4.21.108| 3.4.21.109| 3.4.21.114| 3.4.21.117| 3.4.21.119| 3.4.21.12| 3.4.21.19| 3.4.21.2| 3.4.21.20| 3.4.21.21| 3.4.21.22| 3.4.21.27| 3.4.21.32| 3.4.21.34| 3.4.21.35| 3.4.21.36| 3.4.21.37| 3.4.21.39| 3.4.21.4| 3.4.21.41| 3.4.21.42| 3.4.21.43| 3.4.21.46| 3.4.21.47| 3.4.21.49| 3.4.21.5| 3.4.21.50| 3.4.21.59| 3.4.21.6| 3.4.21.68| 3.4.21.69| 3.4.21.7| 3.4.21.71| 3.4.21.73| 3.4.21.74| 3.4.21.77| 3.4.21.78| 3.4.21.79| 3.4.21.81| 3.4.21.82| 3.4.21.9| 3.4.21.91| 3.4.21.98 | No information | endopeptidase activity| glycosaminoglycan binding| heparin binding| peptidase activity| serine hydrolase activity| serine-type endopeptidase activity| serine-type peptidase activity | blood circulation| cell killing| cellular component disassembly| collagen catabolic process| collagen metabolic process| complement activation, alternative pathway| endocrine process| extracellular matrix disassembly| extracellular matrix organization| extracellular structure organization| immune response| kinin cascade| leukocyte mediated cytotoxicity| memory| multicellular organismal catabolic process| multicellular organismal metabolic process| positive regulation of G-protein coupled receptor protein signaling pathway| positive regulation of Toll signaling pathway| proteolysis| regulation of Toll signaling pathway| regulation of blood coagulation| regulation of blood pressure| regulation of coagulation| regulation of hemostasis| regulation of systemic arterial blood pressure| regulation of systemic arterial blood pressure by hormone| regulation of wound healing |
| 384 | PF05113 | Protein of unknown function (DUF693) | No Pfam Clan | 142 (2) | 314 | 314 | (1) WD40 repeat-like [b.69.4] (1-312) |
(1) 7-bladed beta-propeller [b.69] |
NO PREDICTION | b.69.4(1-312) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | Arp2/3 protein complex| CIA complex| Cdc73/Paf1 complex| Cul4-RING ubiquitin ligase complex| ER to Golgi transport vesicle| SMN complex| SMN-Sm protein complex| Ski complex| THO complex| TORC1 complex| chromosome, centromeric region| cullin-RING ubiquitin ligase complex| eukaryotic translation initiation factor 3 complex| extrinsic to internal side of plasma membrane| extrinsic to membrane| extrinsic to plasma membrane| female germ cell nucleus| germ cell nucleus| heterotrimeric G-protein complex| histone methyltransferase complex| immunological synapse| internal side of plasma membrane| kinetochore| methylosome| methyltransferase complex| nuclear envelope| nuclear pore| nuclear pore outer ring| pore complex| transcription export complex| transcriptionally active chromatin| ubiquitin ligase complex | G-protein gamma-subunit binding| histone binding| peroxisome targeting sequence binding| phosphatidylinositol binding| phosphatidylinositol-3,5-bisphosphate binding| phosphatidylinositol-3-phosphate binding| phosphatidylinositol-5-phosphate binding| signal sequence binding| translation initiation factor activity | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile| T cell homeostasis| TOR signaling cascade| attachment of spindle microtubules to kinetochore| attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation| autophagy| cellular response to starvation| chromosome segregation| embryonic digit morphogenesis| establishment of RNA localization| establishment of chromosome localization| establishment of organelle localization| fruiting body development| histone H3-K4 methylation| histone methylation| histone modification| iron-sulfur cluster assembly| mRNA export from nucleus| membrane disassembly| metallo-sulfur cluster assembly| metaphase plate congression| methylation| microtubule-based process| mitotic metaphase plate congression| mitotic spindle assembly checkpoint| negative regulation of calcium ion transmembrane transporter activity| negative regulation of cation channel activity| negative regulation of cell cycle process| negative regulation of ion transmembrane transporter activity| negative regulation of transporter activity| negative regulation of voltage-gated calcium channel activity| nuclear envelope disassembly| nuclear pore organization| nucleic acid transport| nucleobase-containing compound transport| peptidyl-lysine modification| peptidyl-lysine trimethylation| peroxisomal transport| positive regulation of DNA-dependent transcription, elongation| positive regulation of histone H3-K79 methylation| positive regulation of histone methylation| positive regulation of histone modification| positive regulation of organelle organization| positive regulation of transcription elongation from RNA polymerase II promoter| protein alkylation| protein import| protein targeting| regulation of cell cycle process| regulation of histone H3-K79 methylation| regulation of histone methylation| regulation of histone modification| regulation of metaphase/anaphase transition of cell cycle| regulation of mitotic metaphase/anaphase transition| regulation of reproductive process| regulation of transcription elongation from RNA polymerase II promoter| regulation of voltage-gated calcium channel activity| response to starvation| spindle assembly checkpoint| spindle checkpoint| uropod organization |
| 385 | PF06048 | Domain of unknown function (DUF927) | P-loop_NTPase (CL0023) | 800 (39) | 286 | 281 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (149-265) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.37.1(149-265) | 1 | No information | Bacteria|Viruses|Archaea | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 386 | PF12097 | Protein of unknown function (DUF3573) | No Pfam Clan | 128 (5) | 383 | 376 | (1) Pectin lyase-like [b.80.1] (8-368) |
(1) Single-stranded right-handed beta-helix [b.80] |
NO PREDICTION | b.80.1(8-368) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 3.1.1.11| 3.2.1.11| 3.2.1.15| 3.2.1.157| 3.2.1.57| 3.2.1.58| 3.4.21.72| 4.2.2.10| 4.2.2.18| 4.2.2.19| 4.2.2.2| 4.2.2.7 | anchored to membrane| plant-type cell wall | carbon-oxygen lyase activity, acting on polysaccharides| carboxylic ester hydrolase activity| galacturan 1,4-alpha-galacturonidase activity| pectinesterase activity| polygalacturonase activity | cell growth| cell wall organization or biogenesis| developmental cell growth| developmental growth| developmental growth involved in morphogenesis| external encapsulating structure organization| galacturonan metabolic process| pectin catabolic process| plant-type cell wall organization| plant-type cell wall organization or biogenesis| pollen tube development| pollen tube growth| pollination| polysaccharide catabolic process| polysaccharide metabolic process| unidimensional cell growth |
| 387 | PF10850 | Protein of unknown function (DUF2653) | No Pfam Clan | 127 (4) | 91 | 91 | (1) ARM repeat [a.118.1] (1-90) |
(1) alpha-alpha superhelix [a.118] |
a.118.1(1-90) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 388 | PF11990 | Protein of unknown function (DUF3487) | No Pfam Clan | 230 (25) | 122 | 127 | (1) TPR-like [a.118.8] (29-117) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(29-117) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 389 | PF05852 | Gammaherpesvirus protein of unknown function (DUF848) | No Pfam Clan | 27 (13) | 146 | 144 | (1) RNI-like [c.10.1] (28-139) |
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10] |
c.10.1(28-139) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Viruses | No information | ubiquitin ligase complex | acid-amino acid ligase activity| small conjugating protein ligase activity| ubiquitin-protein ligase activity | cellular protein catabolic process| entrainment of circadian clock| entrainment of circadian clock by photoperiod| modification-dependent macromolecule catabolic process| photoperiodism| protein catabolic process| protein ubiquitination| proteolysis| regulation of circadian rhythm| ubiquitin-dependent protein catabolic process |
| 390 | PF12004 | Domain of unknown function (DUF3498) | No Pfam Clan | 291 (7) | 495 | 506 | (1) ssDNA viruses [b.121.5] (1-354) |
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | b.121.5(1-354) | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 391 | PF15363 | Domain of unknown function (DUF4596) | No Pfam Clan | 87 (10) | 46 | 46 | (1) Calcium-dependent phosphotriesterase [b.68.6] (8-38) |
(1) 6-bladed beta-propeller [b.68] |
b.68.6(8-38) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 3.1.1.17| 3.1.1.25| 3.1.8.2| 4.3.3.2 | No information | aryldialkylphosphatase activity| arylesterase activity| calcium ion binding| carboxylic ester hydrolase activity| gluconolactonase activity| zinc ion binding | L-ascorbic acid biosynthetic process| L-ascorbic acid metabolic process| calcium ion homeostasis| cellular calcium ion homeostasis| cellular cation homeostasis| cellular chemical homeostasis| cellular divalent inorganic cation homeostasis| cellular ion homeostasis| cellular metal ion homeostasis| divalent inorganic cation homeostasis| metal ion homeostasis| monosaccharide biosynthetic process| positive regulation of ATPase activity| positive regulation of hydrolase activity| regulation of ATPase activity| regulation of calcium-mediated signaling| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| vitamin biosynthetic process| water-soluble vitamin biosynthetic process| water-soluble vitamin metabolic process |
| 392 | PF10039 | Predicted integral membrane protein (DUF2275) | No Pfam Clan | 40 (7) | 218 | 212 | (1) Bacterial muramidases [a.118.5] (63-205) |
(1) alpha-alpha superhelix [a.118] |
a.118.5(63-205) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 393 | PF10350 | Putative death-receptor fusion protein (DUF2428) | No Pfam Clan | 333 (33) | 255 | 182 | (1) ARM repeat [a.118.1] (1-246) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(1-246) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 394 | PF13559 | Domain of unknown function (DUF4129) | No Pfam Clan | 1189 (194) | 72 | 80 | (1) TPR-like [a.118.8] (2-49) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(2-49) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 395 | PF09321 | Domain of unknown function (DUF1978) | No Pfam Clan | 49 (6) | 241 | 243 | (1) MW0975(SA0943)-like [a.24.27] (49-225) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(49-225) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 396 | PF04645 | Protein of unknown function, DUF603 | No Pfam Clan | 189 (3) | 181 | 186 | (1) Homeodomain-like [a.4.1] (19-60) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.4.1(19-60) | 1 | No information | Bacteria | No information | transcription factor complex | chromatin binding| nucleic acid binding transcription factor activity| transposase activity | activin receptor signaling pathway| cell fate commitment| cell fate specification| chordate embryonic development| diencephalon development| embryonic morphogenesis| endoderm development| eye photoreceptor cell differentiation| negative regulation of developmental process| neural tube development| neuron fate commitment| nodal signaling pathway| pancreas development| pattern specification process| positive regulation of neuron differentiation| regulation of cell fate commitment| regulation of epithelial cell differentiation| regulation of gastrulation| retina development in camera-type eye| sensory organ development| somitogenesis| transmembrane receptor protein serine/threonine kinase signaling pathway| transposition| transposition, DNA-mediated| trophectodermal cell differentiation |
| 397 | PF12398 | Receptor serine/threonine kinase | No Pfam Clan | 150 (34) | 42 | 42 | (1) Protein kinase-like (PK-like) [d.144.1] (6-42) |
(1) Protein kinase-like (PK-like) [d.144] |
d.144.1(6-42) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 2.7.1.100| 2.7.1.137| 2.7.1.153| 2.7.1.163| 2.7.1.17| 2.7.1.32| 2.7.1.39| 2.7.1.95| 2.7.10.1| 2.7.10.2| 2.7.11.1| 2.7.11.11| 2.7.11.13| 2.7.11.14| 2.7.11.15| 2.7.11.16| 2.7.11.17| 2.7.11.19| 2.7.11.21| 2.7.11.22| 2.7.11.24| 2.7.11.25| 2.7.11.26| 2.7.11.30| 2.7.11.7| 2.7.12.1| 2.7.12.2 | cAMP-dependent protein kinase complex| calcium- and calmodulin-dependent protein kinase complex| cell-substrate adherens junction| cyclin-dependent protein kinase holoenzyme complex| neuromuscular junction| protein kinase CK2 complex| spindle| spindle pole | ATP binding| adenyl nucleotide binding| adenyl ribonucleotide binding| calmodulin binding| cyclin binding| kinase activator activity| kinase regulator activity| magnesium ion binding| molecular transducer activity| nucleoside binding| phosphoprotein binding| phosphotransferase activity, alcohol group as acceptor| phosphotyrosine binding| protein kinase activator activity| protein kinase activity| protein kinase regulator activity| purine nucleoside binding| purine nucleotide binding| purine ribonucleoside binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| receptor signaling protein activity| ribonucleoside binding| ribonucleotide binding | CDP-choline pathway| DNA damage checkpoint| activation of innate immune response| cell cycle phase transition| cell division| cell morphogenesis| cellular component morphogenesis| cellular process involved in reproduction| cellular response to biotic stimulus| cellular response to unfolded protein| embryonic placenta development| enzyme linked receptor protein signaling pathway| ethanolamine-containing compound metabolic process| fruiting body development| germ cell development| glycerolipid biosynthetic process| glycerolipid metabolic process| glycerophospholipid biosynthetic process| heart contraction| heart process| hemostasis| innate immune response| innate immune response-activating signal transduction| intracellular protein kinase cascade| labyrinthine layer development| lens development in camera-type eye| lipopolysaccharide-mediated signaling pathway| microtubule cytoskeleton organization| mitotic cell cycle phase transition| negative regulation of cell cycle process| neurotrophin signaling pathway| oogenesis| organelle fission| organic hydroxy compound biosynthetic process| peptidyl-serine modification| peptidyl-threonine modification| phosphatidylcholine biosynthetic process| phosphatidylcholine metabolic process| phosphatidylinositol-3-phosphate biosynthetic process| phospholipid biosynthetic process| positive regulation of MAP kinase activity| positive regulation of cellular protein metabolic process| positive regulation of determination of dorsal identity| positive regulation of developmental growth| positive regulation of innate immune response| positive regulation of intracellular protein transport| positive regulation of myoblast fusion| positive regulation of myotube differentiation| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of phosphorylation| positive regulation of protein kinase activity| positive regulation of protein phosphorylation| positive regulation of skeletal muscle cell differentiation| positive regulation of syncytium formation by plasma membrane fusion| positive regulation of transferase activity| positive regulation of unidimensional cell growth| programmed necrotic cell death| protein phosphorylation| regulation of Golgi inheritance| regulation of MAPK cascade| regulation of Wnt receptor signaling pathway| regulation of adult chitin-containing cuticle pigmentation| regulation of cell size| regulation of cellular response to stress| regulation of chitin-based cuticle tanning| regulation of early endosome to late endosome transport| regulation of fibroblast apoptotic process| regulation of innate immune response| regulation of intracellular protein kinase cascade| regulation of kinase activity| regulation of muscle cell differentiation| regulation of muscle organ development| regulation of muscle tissue development| regulation of protein kinase activity| regulation of reproductive process| regulation of skeletal muscle fiber development| regulation of sodium ion transport| regulation of transferase activity| response to cadmium ion| response to exogenous dsRNA| response to growth factor stimulus| response to molecule of bacterial origin| response to osmotic stress| salicylic acid biosynthetic process| salicylic acid metabolic process| spindle assembly| spindle midzone assembly| stomatal complex development| stress-activated protein kinase signaling cascade| striated muscle contraction| toll-like receptor signaling pathway |
| 398 | PF07295 | Protein of unknown function (DUF1451) | No Pfam Clan | 784 (31) | 146 | 147 | (1) Microbial and mitochondrial ADK, insert "zinc finger" domain [g.41.2] (112-145) |
(1) Rubredoxin-like [g.41] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | g.41.2(112-145) | 1 | No information | Bacteria|Archaea | No information | No information | No information | No information |
| 399 | PF05128 | Domain of unknown function (DUF697) | No Pfam Clan | 1824 (81) | 162 | 161 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (1-159) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
c.37.1(1-159) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Eukaryota|Bacteria | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 400 | PF11329 | Protein of unknown function (DUF3131) | No Pfam Clan | 249 (24) | 367 | 367 | (1) Six-hairpin glycosidases [a.102.1] (1-364) |
(1) alpha/alpha toroid [a.102] |
NO PREDICTION | a.102.1(1-364) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | 2.4.1.20| 2.4.1.8| 3.2.1.132| 3.2.1.156| 3.2.1.28| 3.2.1.3| 3.2.1.4| 3.2.1.40| 3.2.1.63| 3.2.1.70| 3.2.1.8| 3.2.1.91| 5.1.3.8| 5.3.1.8 | brush border | N-acylglucosamine 2-epimerase activity| cellulase activity| hydrolase activity, hydrolyzing O-glycosyl compounds| racemase and epimerase activity| racemase and epimerase activity, acting on carbohydrates and derivatives | cell wall organization or biogenesis| cellular carbohydrate catabolic process| cellular polysaccharide metabolic process| oligosaccharide catabolic process| oligosaccharide metabolic process| polysaccharide metabolic process |
| 401 | PF11853 | Protein of unknown function (DUF3373) | No Pfam Clan | 144 (18) | 489 | 575 | (1) Porins [f.4.3] (60-488) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.3(60-488) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 402 | PF09910 | Uncharacterized protein conserved in archaea (DUF2139) | No Pfam Clan | 35 (6) | 339 | 336 | (1) 3-carboxy-cis,cis-mucoante lactonizing enzyme [b.69.10] (37-259) |
(1) 7-bladed beta-propeller [b.69] |
NO PREDICTION | NO PREDICTION | b.69.10(37-259) | NO PREDICTION | NO PREDICTION | 1 | No information | Archaea | 5.5.1.5 | No information | No information | No information |
| 403 | PF09973 | Predicted membrane protein (DUF2208) | No Pfam Clan | 43 (13) | 233 | 238 | (1) ABC transporter transmembrane region [f.37.1] (1-151) |
(1) ABC transporter transmembrane region [f.37] |
NO PREDICTION | f.37.1(1-151) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Archaea | No information | No information | No information | No information |
| 404 | PF14858 | Domain of unknown function (DUF4486) | No Pfam Clan | 92 (5) | 542 | 547 | (1) ARM repeat [a.118.1] (1-504) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(1-504) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 405 | PF12983 | Protein of unknown function (DUF3867) | No Pfam Clan | 47 (10) | 186 | 186 | (1) (Trans)glycosidases [c.1.8] (3-182) |
(1) TIM beta/alpha-barrel [c.1] |
c.1.8(3-182) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 2.4.1.18| 2.4.1.19| 2.4.1.25| 2.4.1.4| 2.4.1.5| 2.4.1.7| 2.7.1.31| 2.7.7.43| 3.1.3.16| 3.1.3.18| 3.1.3.2| 3.1.3.23| 3.1.3.24| 3.1.3.29| 3.1.3.3| 3.1.3.41| 3.1.3.45| 3.1.3.48| 3.1.3.5| 3.1.3.70| 3.1.3.71| 3.1.3.74| 3.1.8.2| 3.11.1.1| 3.2.1.1| 3.2.1.10| 3.2.1.105| 3.2.1.123| 3.2.1.133| 3.2.1.135| 3.2.1.136| 3.2.1.139| 3.2.1.14| 3.2.1.141| 3.2.1.147| 3.2.1.151| 3.2.1.165| 3.2.1.17| 3.2.1.2| 3.2.1.20| 3.2.1.21| 3.2.1.22| 3.2.1.23| 3.2.1.25| 3.2.1.31| 3.2.1.32| 3.2.1.35| 3.2.1.37| 3.2.1.39| 3.2.1.4| 3.2.1.41| 3.2.1.45| 3.2.1.48| 3.2.1.49| 3.2.1.51| 3.2.1.52| 3.2.1.54| 3.2.1.55| 3.2.1.58| 3.2.1.60| 3.2.1.68| 3.2.1.70| 3.2.1.73| 3.2.1.78| 3.2.1.8| 3.2.1.85| 3.2.1.86| 3.2.1.89| 3.2.1.96| 3.2.1.98| 3.6.1.1| 3.6.3.10| 3.6.3.4| 3.6.3.6| 3.6.3.8| 3.6.3.9| 3.8.1.2| 4.2.2.13| 5.4.2.6| 5.4.2.8| 5.4.99.11| 5.4.99.15 | anchored to membrane| anchored to plasma membrane| cell wall| fungal-type cell wall| hyaluranon cable| lysosome | beta-mannosidase activity| galactosidase activity| glucanosyltransferase activity| hyaluronan synthase activity| hydrolase activity, hydrolyzing O-glycosyl compounds| transferase activity, transferring glycosyl groups| virus receptor activity | aminoglycan biosynthetic process| aminoglycan catabolic process| aminoglycan metabolic process| autolysis| cartilage development| cell wall beta-glucan metabolic process| cell wall macromolecule catabolic process| cell wall macromolecule metabolic process| cell wall organization or biogenesis| cellular carbohydrate catabolic process| cellular polysaccharide catabolic process| cellular polysaccharide metabolic process| cellular response to UV| cellular response to UV-B| cellular response to abiotic stimulus| cellular response to cytokine stimulus| cellular response to growth factor stimulus| cellular response to interleukin-1| cellular response to light stimulus| cellular response to pH| cellular response to platelet-derived growth factor stimulus| cellular response to radiation| ceramide catabolic process| ceramide metabolic process| connective tissue development| cytolysis| diaphragm contraction| external encapsulating structure organization| glucosamine-containing compound catabolic process| glucosamine-containing compound metabolic process| glycosaminoglycan catabolic process| glycosphingolipid catabolic process| glycosylceramide catabolic process| glycosylceramide metabolic process| hyaluronan biosynthetic process| hyaluronan catabolic process| hyaluronan metabolic process| inflammatory response| involuntary skeletal muscle contraction| lysosome organization| mannan metabolic process| membrane lipid catabolic process| multicellular organismal movement| negative regulation of cell growth| negative regulation of growth| neuromuscular process controlling balance| neuromuscular process controlling posture| peptidoglycan turnover| polysaccharide catabolic process| polysaccharide metabolic process| positive regulation of angiogenesis| positive regulation of cell adhesion| positive regulation of cell growth| positive regulation of epithelial cell migration| positive regulation of epithelial cell proliferation| positive regulation of hyaluranon cable assembly| regulation of angiogenesis| regulation of cell growth| regulation of cell migration| regulation of cell motility| regulation of cellular component movement| regulation of epithelial cell migration| regulation of hyaluranon cable assembly| regulation of locomotion| regulation of vasculature development| respiratory gaseous exchange| respiratory system process| response to UV| response to UV-B| response to antibiotic| response to cytokine stimulus| response to growth factor stimulus| response to interleukin-1| response to pH| response to platelet-derived growth factor stimulus| response to reactive oxygen species| response to toxic substance| response to virus| single-species biofilm formation| skeletal muscle contraction| skeletal system development| sphingolipid catabolic process| vacuole organization |
| 406 | PF07301 | Protein of unknown function (DUF1453) | No Pfam Clan | 613 (20) | 148 | 149 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-145) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(1-145) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | No information | No information | No information |
| 407 | PF09874 | Predicted membrane protein (DUF2101) | No Pfam Clan | 26 (5) | 206 | 206 | (1) MFS general substrate transporter [f.38.1] (17-141) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | NO PREDICTION | f.38.1(17-141) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 408 | PF11489 | Protein of unknown function (DUF3210) | No Pfam Clan | 113 (15) | 711 | 781 | (1) ssDNA viruses [b.121.5] (175-633) |
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | b.121.5(175-633) | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 409 | PF12239 | Protein of unknown function (DUF3605) | No Pfam Clan | 242 (21) | 159 | 129 | (1) HIT-like [d.13.1] (21-158) |
(1) HIT-like [d.13] |
NO PREDICTION | d.13.1(21-158) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Viruses | 2.7.7.12| 3.6.1.26| 3.6.1.29 | histone deacetylase complex | hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides| nucleotide diphosphatase activity | apoptotic process| apoptotic signaling pathway| intrinsic apoptotic signaling pathway| intrinsic apoptotic signaling pathway by p53 class mediator| signal transduction by p53 class mediator |
| 410 | PF09847 | Predicted permease (DUF2074) | No Pfam Clan | 50 (10) | 449 | 448 | (1) MFS general substrate transporter [f.38.1] (1-448) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(1-448) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 411 | PF05553 | Cotton fibre expressed protein | No Pfam Clan | 622 (85) | 38 | 38 | (1) WD40 repeat-like [b.69.4] (2-30) |
(1) 7-bladed beta-propeller [b.69] |
b.69.4(2-30) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | Arp2/3 protein complex| CIA complex| Cdc73/Paf1 complex| Cul4-RING ubiquitin ligase complex| ER to Golgi transport vesicle| SMN complex| SMN-Sm protein complex| Ski complex| THO complex| TORC1 complex| chromosome, centromeric region| cullin-RING ubiquitin ligase complex| eukaryotic translation initiation factor 3 complex| extrinsic to internal side of plasma membrane| extrinsic to membrane| extrinsic to plasma membrane| female germ cell nucleus| germ cell nucleus| heterotrimeric G-protein complex| histone methyltransferase complex| immunological synapse| internal side of plasma membrane| kinetochore| methylosome| methyltransferase complex| nuclear envelope| nuclear pore| nuclear pore outer ring| pore complex| transcription export complex| transcriptionally active chromatin| ubiquitin ligase complex | G-protein gamma-subunit binding| histone binding| peroxisome targeting sequence binding| phosphatidylinositol binding| phosphatidylinositol-3,5-bisphosphate binding| phosphatidylinositol-3-phosphate binding| phosphatidylinositol-5-phosphate binding| signal sequence binding| translation initiation factor activity | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile| T cell homeostasis| TOR signaling cascade| attachment of spindle microtubules to kinetochore| attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation| autophagy| cellular response to starvation| chromosome segregation| embryonic digit morphogenesis| establishment of RNA localization| establishment of chromosome localization| establishment of organelle localization| fruiting body development| histone H3-K4 methylation| histone methylation| histone modification| iron-sulfur cluster assembly| mRNA export from nucleus| membrane disassembly| metallo-sulfur cluster assembly| metaphase plate congression| methylation| microtubule-based process| mitotic metaphase plate congression| mitotic spindle assembly checkpoint| negative regulation of calcium ion transmembrane transporter activity| negative regulation of cation channel activity| negative regulation of cell cycle process| negative regulation of ion transmembrane transporter activity| negative regulation of transporter activity| negative regulation of voltage-gated calcium channel activity| nuclear envelope disassembly| nuclear pore organization| nucleic acid transport| nucleobase-containing compound transport| peptidyl-lysine modification| peptidyl-lysine trimethylation| peroxisomal transport| positive regulation of DNA-dependent transcription, elongation| positive regulation of histone H3-K79 methylation| positive regulation of histone methylation| positive regulation of histone modification| positive regulation of organelle organization| positive regulation of transcription elongation from RNA polymerase II promoter| protein alkylation| protein import| protein targeting| regulation of cell cycle process| regulation of histone H3-K79 methylation| regulation of histone methylation| regulation of histone modification| regulation of metaphase/anaphase transition of cell cycle| regulation of mitotic metaphase/anaphase transition| regulation of reproductive process| regulation of transcription elongation from RNA polymerase II promoter| regulation of voltage-gated calcium channel activity| response to starvation| spindle assembly checkpoint| spindle checkpoint| uropod organization |
| 412 | PF15023 | Protein of unknown function (DUF4523) | No Pfam Clan | 34 (4) | 166 | 166 | (1) RNA-binding domain, RBD [d.58.7] (96-148) |
(1) Ferredoxin-like [d.58] |
NO PREDICTION | NO PREDICTION | d.58.7(96-148) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | RNA cap binding complex| nuclear body| spliceosomal complex | No information | RNA export from nucleus| RNA localization| RNA splicing| establishment of RNA localization| gamete generation| mRNA metabolic process| mRNA processing| nuclear export| nuclear transport| nucleic acid transport| nucleobase-containing compound transport| nucleocytoplasmic transport| positive regulation of RNA export from nucleus| positive regulation of intracellular transport| positive regulation of nucleobase-containing compound transport| posttranscriptional regulation of gene expression| regulation of RNA export from nucleus| regulation of nucleobase-containing compound transport| regulation of translation| response to cold| snRNA export from nucleus| snRNA transport |
| 413 | PF13664 | Domain of unknown function (DUF4149) | CopD_like (CL0430) | 975 (178) | 101 | 100 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-100) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(1-100) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 414 | PF12427 | Branched-chain amino acid aminotransferase | No Pfam Clan | 14 (3) | 23 | 35 | (1) D-aminoacid aminotransferase-like PLP-dependent enzymes [e.17.1] (1-23) |
(1) D-aminoacid aminotransferase-like PLP-dependent enzymes [e.17] |
e.17.1(1-23) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 2.6.1.21| 2.6.1.42| 4.1.3.38 | No information | D-alanine:2-oxoglutarate aminotransferase activity| branched-chain-amino-acid transaminase activity| cofactor binding| pyridoxal phosphate binding| transaminase activity| transferase activity, transferring nitrogenous groups | D-amino acid biosynthetic process| D-amino acid catabolic process| D-amino acid metabolic process| branched-chain amino acid biosynthetic process| branched-chain amino acid catabolic process| branched-chain amino acid metabolic process| cellular amino acid catabolic process| isoleucine metabolic process| toxin metabolic process |
| 415 | PF12038 | Domain of unknown function (DUF3524) | No Pfam Clan | 155 (31) | 168 | 172 | (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (19-140) |
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87] |
NO PREDICTION | NO PREDICTION | c.87.1(19-140) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Viruses | 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 | alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) | UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups | L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process |
| 416 | PF08217 | Fungal domain of unknown function (DUF1712) | No Pfam Clan | 421 (14) | 604 | 646 | (1) ARM repeat [a.118.1] (INDIRECT) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 417 | PF12566 | Protein of unknown function (DUF3748) | No Pfam Clan | 511 (11) | 122 | 119 | (1) DPP6 N-terminal domain-like [b.70.3] (1-122) |
(1) 8-bladed beta-propeller [b.70] |
b.70.3(1-122) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | No information | No information | No information |
| 418 | PF12341 | Protein of unknown function (DUF3639) | No Pfam Clan | 247 (35) | 27 | 27 | (1) DPP6 N-terminal domain-like [b.70.3] (1-27) |
(1) 8-bladed beta-propeller [b.70] |
b.70.3(1-27) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 419 | PF09427 | Domain of unknown function (DUF2014) | No Pfam Clan | 72 (8) | 261 | 264 | (1) ARM repeat [a.118.1] (3-258) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(3-258) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 420 | PF12525 | Protein of unknown function (DUF3726) | No Pfam Clan | 82 (34) | 80 | 60 | (1) L-sulfolactate dehydrogenase-like [c.122.1] (1-52) |
(1) L-sulfolactate dehydrogenase-like [c.122] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.122.1(1-52) | 1 | No information | Eukaryota|Bacteria | 1.1.1.130| 1.1.1.154| 1.1.1.27| 1.1.1.272| 1.1.1.37 | No information | No information | No information |
| 421 | PF07793 | Protein of unknown function (DUF1631) | No Pfam Clan | 372 (36) | 730 | 738 | (1) ARM repeat [a.118.1] (8-729) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(8-729) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Viruses | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 422 | PF11824 | Protein of unknown function (DUF3344) | No Pfam Clan | 118 (42) | 271 | 267 | (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (3-254) |
(1) 8-bladed beta-propeller [b.70] |
b.70.1(3-254) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | 1.1.2.7| 1.1.98.1 | No information | endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity | ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein |
| 423 | PF12531 | DNA-K related protein | No Pfam Clan | 220 (38) | 249 | 249 | (1) ARM repeat [a.118.1] (25-243) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(25-243) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 424 | PF11846 | Domain of unknown function (DUF3366) | No Pfam Clan | 415 (29) | 193 | 203 | (1) TPR-like [a.118.8] (46-183) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(46-183) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 425 | PF07248 | Protein of unknown function (DUF1431) | No Pfam Clan | 156 (17) | 161 | 163 | (1) Growth factor receptor domain [g.3.9] (31-155) |
(1) Knottins (small inhibitors, toxins, lectins) [g.3] |
NO PREDICTION | g.3.9(31-155) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | cell migration| cell motility| enzyme linked receptor protein signaling pathway| localization of cell| transmembrane receptor protein tyrosine kinase signaling pathway |
| 426 | PF10309 | Protein of unknown function (DUF2414) | No Pfam Clan | 181 (19) | 62 | 90 | (1) RNA-binding domain, RBD [d.58.7] (61-88) |
(1) Ferredoxin-like [d.58] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | d.58.7(61-88) | 1 | No information | Eukaryota | No information | RNA cap binding complex| nuclear body| spliceosomal complex | No information | RNA export from nucleus| RNA localization| RNA splicing| establishment of RNA localization| gamete generation| mRNA metabolic process| mRNA processing| nuclear export| nuclear transport| nucleic acid transport| nucleobase-containing compound transport| nucleocytoplasmic transport| positive regulation of RNA export from nucleus| positive regulation of intracellular transport| positive regulation of nucleobase-containing compound transport| posttranscriptional regulation of gene expression| regulation of RNA export from nucleus| regulation of nucleobase-containing compound transport| regulation of translation| response to cold| snRNA export from nucleus| snRNA transport |
| 427 | PF11331 | Protein of unknown function (DUF3133) | No Pfam Clan | 112 (13) | 46 | 46 | (1) L domain-like [c.10.2] (11-44) |
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10] |
c.10.2(11-44) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | U2 snRNP | 3'-5' exonuclease activity| 3'-5'-exoribonuclease activity| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomon| exoribonuclease activity| exoribonuclease activity, producing 5'-phosphomonoesters| phosphatase inhibitor activity| phosphatase regulator activity| poly(A)-specific ribonuclease activity | B cell activation| B cell proliferation| B cell proliferation involved in immune response| RNA phosphodiester bond hydrolysis, exonucleolytic| biological adhesion| nuclear transport| nuclear-transcribed mRNA catabolic process| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay| nucleocytoplasmic transport| post-embryonic morphogenesis| post-embryonic organ development| regulation of JNK cascade| regulation of axonogenesis| regulation of cell size| regulation of extent of cell growth |
| 428 | PF13036 | Protein of unknown function (DUF3897) | TolB_N (CL0342) | 1082 (74) | 180 | 195 | (1) TolB, N-terminal domain [c.51.2] (61-179) |
(1) Anticodon-binding domain-like [c.51] |
NO PREDICTION | c.51.2(61-179) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 429 | PF10704 | Protein of unknown function (DUF2508) | No Pfam Clan | 434 (23) | 71 | 70 | (1) TPR-like [a.118.8] (4-67) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(4-67) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 430 | PF11166 | Protein of unknown function (DUF2951) | No Pfam Clan | 299 (6) | 98 | 97 | (1) TPR-like [a.118.8] (5-71) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(5-71) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Viruses | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 431 | PF14234 | Domain of unknown function (DUF4336) | No Pfam Clan | 413 (47) | 285 | 321 | (1) Metallo-hydrolase/oxidoreductase [d.157.1] (1-284) |
(1) Metallo-hydrolase/oxidoreductase [d.157] |
NO PREDICTION | d.157.1(1-284) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 3.1.1.81| 3.1.2.6| 3.1.26.11| 3.1.4.38| 3.1.8.1| 3.5.2.6 | No information | hydroxyacylglutathione hydrolase activity| thiolester hydrolase activity | aldehyde catabolic process| amide biosynthetic process| cellular aldehyde metabolic process| cellular modified amino acid biosynthetic process| glutathione biosynthetic process| glutathione metabolic process| lactate metabolic process| methylglyoxal metabolic process| nonribosomal peptide biosynthetic process| peptide biosynthetic process| peptide metabolic process |
| 432 | PF04780 | Protein of unknown function (DUF629) | No Pfam Clan | 139 (14) | 466 | 462 | (1) ARM repeat [a.118.1] (8-464) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(8-464) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 433 | PF12259 | Protein of unknown function (DUF3609) | No Pfam Clan | 125 (7) | 361 | 353 | (1) Head and neck region of the ectodomain of NDV fusion glycoprotein [f.12.1] (1-243) |
(1) Head and neck region of the ectodomain of NDV fusion glycoprotein [f.12] |
NO PREDICTION | f.12.1(1-243) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Viruses | No information | No information | No information | No information |
| 434 | PF12640 | UPF0489 domain | Arginase (CL0302) | 190 (34) | 162 | 160 | (1) Arginase/deacetylase [c.42.1] (1-161) |
(1) Arginase/deacetylase [c.42] |
NO PREDICTION | c.42.1(1-161) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 3.5.1.98| 3.5.3.1| 3.5.3.11| 3.5.3.22| 3.5.3.8 | histone deacetylase complex | arginase activity| chromatin DNA binding| chromatin binding| deacetylase activity| histone deacetylase activity| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines| manganese ion binding| protein deacetylase activity| structure-specific DNA binding| transcription factor binding | arginine metabolic process| cellular amino acid catabolic process| chromatin modification| chromosome organization| glutamine family amino acid catabolic process| glutamine family amino acid metabolic process| histone deacetylation| histone modification| negative regulation of transcription from RNA polymerase II promoter| nitrogen cycle metabolic process| ornithine metabolic process| polyamine metabolic process| protein deacetylation| protein deacylation| urea metabolic process |
| 435 | PF03382 | Mycoplasma protein of unknown function, DUF285 | LRR (CL0022) | 2904 (147) | 120 | 123 | (1) RNI-like [c.10.1] (1-113) |
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10] |
c.10.1(1-113) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Viruses|Archaea | No information | ubiquitin ligase complex | acid-amino acid ligase activity| small conjugating protein ligase activity| ubiquitin-protein ligase activity | cellular protein catabolic process| entrainment of circadian clock| entrainment of circadian clock by photoperiod| modification-dependent macromolecule catabolic process| photoperiodism| protein catabolic process| protein ubiquitination| proteolysis| regulation of circadian rhythm| ubiquitin-dependent protein catabolic process |
| 436 | PF13355 | Protein of unknown function (DUF4101) | No Pfam Clan | 153 (63) | 117 | 115 | (1) NTF2-like [d.17.4] (1-116) |
(1) Cystatin-like [d.17] |
NO PREDICTION | d.17.4(1-116) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 3.3.2.8| 4.2.1.94| 5.3.3.1 | T-tubule| axon initial segment| axon part| cell-cell contact zone| main axon| neuromuscular junction| nuclear envelope| pore complex| sarcolemma | Ran GTPase binding | G1/S transition of mitotic cell cycle| RNA export from nucleus| RNA localization| antibiotic biosynthetic process| antibiotic metabolic process| blood circulation| calcium ion transport| cardiac muscle contraction| cell cycle phase| cell cycle phase transition| drug metabolic process| establishment of RNA localization| heart contraction| heart process| interphase| interphase of mitotic cell cycle| mitotic cell cycle phase transition| muscle contraction| muscle system process| nuclear transport| nucleobase-containing compound transport| nucleocytoplasmic transport| peptidyl-serine phosphorylation| poly(A)+ mRNA export from nucleus| positive regulation of antimicrobial peptide biosynthetic process| positive regulation of cellular amide metabolic process| protein autophosphorylation| regulation of antimicrobial humoral response| regulation of antimicrobial peptide biosynthetic process| regulation of antimicrobial peptide production| regulation of cellular amide metabolic process| regulation of humoral immune response| regulation of production of molecular mediator of immune response| regulation of sodium ion transport| striated muscle contraction |
| 437 | PF07187 | Protein of unknown function (DUF1405) | No Pfam Clan | 478 (31) | 164 | 163 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-163) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(1-163) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | No information | No information | No information |
| 438 | PF11889 | Domain of unknown function (DUF3409) | No Pfam Clan | 239 (8) | 56 | 56 | (1) Ubiquitin-like [d.15.1] (2-39) |
(1) beta-Grasp (ubiquitin-like) [d.15] |
d.15.1(2-39) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Viruses | 3.1.2.15| 3.1.4.11 | autophagic vacuole| nuclear body | SUMO ligase activity| non-membrane spanning protein tyrosine phosphatase activity| phosphoprotein phosphatase activity| protein tag| protein tyrosine phosphatase activity| small conjugating protein ligase activity| small conjugating protein ligase binding | autophagy| catechol-containing compound metabolic process| catecholamine metabolic process| catecholamine transport| catecholamine uptake| catecholamine uptake involved in synaptic transmission| dopamine metabolic process| dopamine transport| dopamine uptake| dopamine uptake involved in synaptic transmission| monoamine transport| neurotransmitter uptake| norepinephrine metabolic process| peptidyl-tyrosine dephosphorylation| positive regulation of protein ubiquitination| positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc| protein modification by small protein conjugation or removal| protein sumoylation| proteolysis involved in cellular protein catabolic process| regulation of neurotransmitter secretion| regulation of neurotransmitter transport| regulation of protein catabolic process| regulation of protein ubiquitination| regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process| regulation of proteolysis| response to transforming growth factor beta stimulus| startle response| synaptic transmission, dopaminergic| synaptic transmission, glutamatergic |
| 439 | PF07786 | Protein of unknown function (DUF1624) | Acyl_transf_3 (CL0316) | 1276 (49) | 223 | 227 | (1) Transmembrane di-heme cytochromes [f.21.1] (INDIRECT) (2) Fumarate reductase respiratory complex transmembrane subunits [f.21.2] (INDIRECT) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | f.21.1(INDIRECT)| f.21.2(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 1.10.2.2| 1.3.5.1 | fumarate reductase complex| mitochondrial respiratory chain| mitochondrial respiratory chain complex II| plasma membrane respiratory chain| plasma membrane respiratory chain complex II| respiratory chain| respiratory chain complex II| succinate dehydrogenase complex | cofactor binding| electron carrier activity| heme binding| oxidoreductase activity, acting on the CH-CH group of donors| quinone binding| succinate dehydrogenase activity| tetrapyrrole binding| ubiquinone binding | cellular respiration| electron transport chain| energy derivation by oxidation of organic compounds| mitochondrial ATP synthesis coupled electron transport| mitochondrial electron transport, succinate to ubiquinone| oxidative phosphorylation| tricarboxylic acid cycle |
| 440 | PF13293 | Domain of unknown function (DUF4074) | No Pfam Clan | 230 (14) | 64 | 76 | (1) TPR-like [a.118.8] (19-75) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(19-75) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 441 | PF12315 | Protein of unknown function (DUF3633) | Peptidase_MA (CL0126) | 151 (17) | 212 | 212 | (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (15-211) |
(1) Zincin-like [d.92] |
NO PREDICTION | d.92.1(15-211) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 | cortical granule | glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity | biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing |
| 442 | PF05335 | Protein of unknown function (DUF745) | No Pfam Clan | 190 (14) | 188 | 187 | (1) MW0975(SA0943)-like [a.24.27] (8-187) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(8-187) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 443 | PF11686 | Protein of unknown function (DUF3283) | No Pfam Clan | 120 (10) | 61 | 61 | (1) DNA polymerase III theta subunit-like [a.237.1] (1-60) |
(1) DNA polymerase III theta subunit-like [a.237] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.237.1(1-60) | 1 | No information | Bacteria | No information | No information | No information | No information |
| 444 | PF04357 | Family of unknown function (DUF490) | AsmA-like (CL0401) | 2461 (151) | 379 | 385 | (1) Porins [f.4.3] (INDIRECT) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.3(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Eukaryota|Bacteria|Viruses | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 445 | PF10868 | Protein of unknown function (DUF2667) | Knottin_1 (CL0054) | 19 (5) | 90 | 86 | (1) Scorpion toxin-like [g.3.7] (26-86) |
(1) Knottins (small inhibitors, toxins, lectins) [g.3] |
NO PREDICTION | g.3.7(26-86) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | channel regulator activity| ion channel inhibitor activity | defense response to Gram-positive bacterium| defense response to fungus| pathogenesis| response to fungus |
| 446 | PF09887 | Uncharacterized protein conserved in archaea (DUF2114) | No Pfam Clan | 54 (17) | 448 | 456 | (1) Actin-like ATPase domain [c.55.1] (4-420) |
(1) Ribonuclease H-like motif [c.55] |
NO PREDICTION | c.55.1(4-420) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Archaea | 2.7.1.1| 2.7.1.12| 2.7.1.16| 2.7.1.17| 2.7.1.2| 2.7.1.30| 2.7.1.33| 2.7.1.4| 2.7.1.5| 2.7.1.55| 2.7.1.59| 2.7.1.60| 2.7.1.63| 2.7.2.1| 2.7.2.15| 2.7.2.7| 3.4.24.57| 3.6.1.11| 3.6.1.3 | cell cortex| cell cortex part| cilium part| contractile fiber part| cortical cytoskeleton| motile cilium| sperm flagellum| sperm part| sperm principal piece | carbohydrate kinase activity| hexokinase activity| phosphotransferase activity, alcohol group as acceptor| unfolded protein binding | 'de novo' protein folding| ATP catabolic process| actomyosin structure organization| carbohydrate phosphorylation| chaperone mediated protein folding requiring cofactor| glucose 6-phosphate metabolic process| glycolysis| myofibril assembly| nucleoside monophosphate catabolic process| protein folding| purine nucleoside monophosphate catabolic process| purine nucleoside monophosphate metabolic process| purine ribonucleoside monophosphate catabolic process| purine ribonucleoside monophosphate metabolic process| ribonucleoside monophosphate catabolic process| ribonucleoside monophosphate metabolic process |
| 447 | PF08409 | Domain of unknown function (DUF1736) | No Pfam Clan | 412 (30) | 80 | 79 | (1) TPR-like [a.118.8] (1-79) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(1-79) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 448 | PF04654 | Protein of unknown function, DUF599 | No Pfam Clan | 411 (46) | 216 | 218 | (1) ABC transporter transmembrane region [f.37.1] (1-206) |
(1) ABC transporter transmembrane region [f.37] |
NO PREDICTION | f.37.1(1-206) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 449 | PF06081 | Bacterial protein of unknown function (DUF939) | FUSC (CL0307) | 2302 (33) | 141 | 141 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-140) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(1-140) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 450 | PF15450 | Domain of unknown function (DUF4631) | No Pfam Clan | 50 (8) | 532 | 531 | (1) Cullin repeat-like [a.118.17] (1-531) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.17(1-531) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | No information | protein heterodimerization activity | cellular protein catabolic process| modification-dependent macromolecule catabolic process| modification-dependent protein catabolic process| negative regulation of granulocyte differentiation| negative regulation of leukocyte differentiation| negative regulation of myeloid cell differentiation| negative regulation of myeloid leukocyte differentiation| positive regulation of G1/S transition of mitotic cell cycle| positive regulation of cell cycle phase transition| positive regulation of cell cycle process| positive regulation of mitotic cell cycle phase transition| protein catabolic process| proteolysis| proteolysis involved in cellular protein catabolic process| regulation of DNA damage checkpoint| regulation of DNA metabolic process| regulation of DNA repair| regulation of cell cycle checkpoint| regulation of granulocyte differentiation| regulation of leukocyte differentiation| regulation of myeloid cell differentiation| regulation of myeloid leukocyte differentiation| regulation of nucleotide-excision repair| regulation of response to DNA damage stimulus| somatic stem cell maintenance| stem cell maintenance| ubiquitin-dependent protein catabolic process |
| 451 | PF11168 | Protein of unknown function (DUF2955) | FUSC (CL0307) | 253 (42) | 140 | 140 | (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (INDIRECT) |
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35] |
NO PREDICTION | f.35.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 452 | PF10851 | Protein of unknown function (DUF2652) | No Pfam Clan | 72 (6) | 116 | 116 | (1) Nucleotide cyclase [d.58.29] (1-109) |
(1) Ferredoxin-like [d.58] |
NO PREDICTION | d.58.29(1-109) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 4.6.1.1| 4.6.1.2 | No information | cyclase activity| phosphorus-oxygen lyase activity | No information |
| 453 | PF14357 | Domain of unknown function (DUF4404) | No Pfam Clan | 107 (40) | 85 | 80 | (1) TPR-like [a.118.8] (5-81) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(5-81) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 454 | PF10639 | Uncharacterised protein family UPF0546 | DMT (CL0184) | 235 (16) | 113 | 111 | (1) Multidrug resistance efflux transporter EmrE [f.39.1] (42-112) |
(1) Multidrug resistance efflux transporter EmrE [f.39] |
NO PREDICTION | f.39.1(42-112) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 455 | PF12521 | Protein of unknown function (DUF3724) | No Pfam Clan | 178 (5) | 23 | 23 | (1) Positive stranded ssRNA viruses [b.121.4] (1-23) |
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121] |
b.121.4(1-23) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Viruses | 3.4.23.44 | No information | No information | No information |
| 456 | PF06718 | Protein of unknown function (DUF1203) | No Pfam Clan | 173 (20) | 117 | 118 | (1) TPR-like [a.118.8] (26-110) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(26-110) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 457 | PF06681 | Protein of unknown function (DUF1182) | GPCR_A (CL0192) | 21 (2) | 226 | 203 | (1) Family A G protein-coupled receptor-like [f.13.1] (44-222) |
(1) Family A G protein-coupled receptor-like [f.13] |
NO PREDICTION | f.13.1(44-222) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | cilium| cilium membrane| cilium part| early endosome| integral to plasma membrane| intrinsic to plasma membrane| photoreceptor inner segment| photoreceptor inner segment membrane| photoreceptor outer segment| photoreceptor outer segment membrane| primary cilium | G-protein coupled receptor activity| amide binding| catecholamine binding| chemokine receptor activity| molecular transducer activity| neuropeptide binding| odorant binding| peptide binding| pheromone binding| receptor activity| retinal binding| signaling receptor activity | G-protein coupled receptor signaling pathway| calcium ion homeostasis| cellular calcium ion homeostasis| cellular divalent inorganic cation homeostasis| cellular response to cytokine stimulus| cellular response to disaccharide stimulus| cellular response to sucrose stimulus| chemokine-mediated signaling pathway| complement receptor mediated signaling pathway| detection of chemical stimulus| detection of chemical stimulus involved in sensory perception| detection of light stimulus| detection of stimulus| detection of stimulus involved in sensory perception| diet induced thermogenesis| divalent inorganic cation homeostasis| germ cell migration| histamine secretion| histamine transport| hormone secretion| inflammatory response| mRNA transcription| mRNA transcription from RNA polymerase II promoter| negative regulation of nucleotide biosynthetic process| negative regulation of nucleotide metabolic process| negative regulation of purine nucleotide metabolic process| nonassociative learning| platelet activation| positive regulation of MAPK cascade| positive regulation of cyclase activity| positive regulation of cyclic nucleotide biosynthetic process| positive regulation of cytokinesis| positive regulation of intracellular protein kinase cascade| positive regulation of leukocyte degranulation| positive regulation of lyase activity| positive regulation of mast cell activation| positive regulation of mast cell activation involved in immune response| positive regulation of mucus secretion| positive regulation of multicellular organismal metabolic process| positive regulation of nucleotide biosynthetic process| positive regulation of nucleotide metabolic process| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of purine nucleotide metabolic process| purinergic receptor signaling pathway| regulation of ERK1 and ERK2 cascade| regulation of MAPK cascade| regulation of cAMP biosynthetic process| regulation of cAMP metabolic process| regulation of cyclase activity| regulation of cyclic nucleotide biosynthetic process| regulation of cyclic nucleotide metabolic process| regulation of interleukin-8 secretion| regulation of intracellular protein kinase cascade| regulation of leukocyte degranulation| regulation of lyase activity| regulation of mast cell activation| regulation of mast cell activation involved in immune response| regulation of mucus secretion| regulation of multicellular organismal metabolic process| regulation of myeloid leukocyte mediated immunity| regulation of nucleotide biosynthetic process| regulation of nucleotide metabolic process| regulation of purine nucleotide biosynthetic process| regulation of purine nucleotide metabolic process| regulation of systemic arterial blood pressure by norepinephrine-epinephrine| regulation of vasoconstriction| response to pheromone| sensory perception| sensory perception of chemical stimulus |
| 458 | PF12331 | Protein of unknown function (DUF3636) | No Pfam Clan | 75 (17) | 149 | 155 | (1) ARM repeat [a.118.1] (1-148) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(1-148) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 459 | PF10051 | Uncharacterized protein conserved in archaea (DUF2286) | No Pfam Clan | 37 (12) | 141 | 173 | (1) RNI-like [c.10.1] (46-169) |
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10] |
c.10.1(46-169) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Archaea | No information | ubiquitin ligase complex | acid-amino acid ligase activity| small conjugating protein ligase activity| ubiquitin-protein ligase activity | cellular protein catabolic process| entrainment of circadian clock| entrainment of circadian clock by photoperiod| modification-dependent macromolecule catabolic process| photoperiodism| protein catabolic process| protein ubiquitination| proteolysis| regulation of circadian rhythm| ubiquitin-dependent protein catabolic process |
| 460 | PF11336 | Protein of unknown function (DUF3138) | MBB (CL0193) | 54 (4) | 514 | 524 | (1) Porins [f.4.3] (INDIRECT) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.3(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 461 | PF11116 | Protein of unknown function (DUF2624) | No Pfam Clan | 138 (11) | 86 | 84 | (1) Ankyrin repeat [d.211.1] (2-73) |
(1) beta-hairpin-alpha-hairpin repeat [d.211] |
d.211.1(2-73) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | intercellular bridge | NF-kappaB binding| cyclin-dependent protein serine/threonine kinase inhibitor activity| cyclin-dependent protein serine/threonine kinase regulator activity| enzyme binding| histone deacetylase binding| kinase inhibitor activity| kinase regulator activity| protein kinase inhibitor activity| protein kinase regulator activity| protein serine/threonine kinase inhibitor activity | cell cycle arrest| cytoplasmic sequestering of protein| cytoplasmic sequestering of transcription factor| interphase| maintenance of location| maintenance of location in cell| maintenance of protein location| maintenance of protein location in cell| mitotic cell cycle phase transition| negative regulation of NF-kappaB transcription factor activity| negative regulation of cell cycle| negative regulation of intracellular protein transport| negative regulation of intracellular transport| negative regulation of kinase activity| negative regulation of phosphorylation| negative regulation of protein import into nucleus| negative regulation of protein kinase activity| negative regulation of protein serine/threonine kinase activity| negative regulation of protein transport| negative regulation of transcription factor import into nucleus| positive regulation of NF-kappaB transcription factor activity| positive regulation of transforming growth factor beta receptor signaling pathway| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway| regulation of I-kappaB kinase/NF-kappaB cascade| regulation of NF-kappaB import into nucleus| regulation of cyclin-dependent protein serine/threonine kinase activity| regulation of protein localization to nucleus| regulation of transcription factor import into nucleus| spleen development |
| 462 | PF10151 | Uncharacterised conserved protein (DUF2359) | No Pfam Clan | 158 (6) | 469 | 467 | (1) ARM repeat [a.118.1] (2-468) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(2-468) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 463 | PF09971 | Predicted membrane protein (DUF2206) | No Pfam Clan | 29 (9) | 367 | 366 | (1) MFS general substrate transporter [f.38.1] (INDIRECT) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 464 | PF07185 | Protein of unknown function (DUF1404) | No Pfam Clan | 66 (14) | 169 | 170 | (1) Bacterial photosystem II reaction centre, L and M subunits [f.26.1] (INDIRECT) |
(1) Bacterial photosystem II reaction centre, L and M subunits [f.26] |
NO PREDICTION | f.26.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | No information | No information | No information |
| 465 | PF09348 | Domain of unknown function (DUF1990) | No Pfam Clan | 289 (30) | 158 | 148 | (1) Bet v1-like [d.129.3] (18-157) |
(1) TBP-like [d.129] |
NO PREDICTION | d.129.3(18-157) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 1.14.12.12| 1.14.12.18| 3.1.3.16| 4.2.1.78 | intercellular canaliculus| microvillus | abscisic acid binding| alcohol binding| alcohol transmembrane transporter activity| anion transmembrane transporter activity| carboxylic acid binding| hormone binding| isoprenoid binding| lipid transporter activity| monocarboxylic acid binding| organic anion transmembrane transporter activity| organic cation transmembrane transporter activity| organic hydroxy compound transmembrane transporter activity| phosphate transmembrane transporter activity| phosphatidylcholine transporter activity| phospholipid transporter activity| protein homodimerization activity| quaternary ammonium group transmembrane transporter activity | abscisic acid mediated signaling pathway| acid secretion| bile acid secretion| cellular response to abscisic acid stimulus| cellular response to alcohol| cellular response to hormone stimulus| cellular response to lipid| hormone-mediated signaling pathway| lipid localization| lipid transport| monocarboxylic acid transport| organic anion transport| organophosphate ester transport| phospholipid transport| positive regulation of peroxisome proliferator activated receptor signaling pathway| quaternary ammonium group transport| regulation of peroxisome proliferator activated receptor signaling pathway| regulation of post-embryonic development| response to abscisic acid stimulus| response to alcohol| response to hormone stimulus| response to lipid |
| 466 | PF11949 | Protein of unknown function (DUF3466) | No Pfam Clan | 183 (28) | 599 | 610 | (1) DPP6 N-terminal domain-like [b.70.3] (62-516) |
(1) 8-bladed beta-propeller [b.70] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | b.70.3(62-516) | NO PREDICTION | 1 | YES | Bacteria | No information | No information | No information | No information |
| 467 | PF14687 | Domain of unknown function (DUF4460) | No Pfam Clan | 156 (31) | 113 | 103 | (1) Chaperone J-domain [a.2.3] (5-56) |
(1) Long alpha-hairpin [a.2] |
NO PREDICTION | NO PREDICTION | a.2.3(5-56) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 5.2.1.4 | No information | No information | establishment of protein localization to organelle| mitochondrial transport| protein folding| protein localization to organelle| protein targeting to mitochondrion |
| 468 | PF06244 | Protein of unknown function (DUF1014) | HMG-box (CL0114) | 313 (14) | 122 | 123 | (1) HMG-box [a.21.1] (65-117) |
(1) HMG-box [a.21] |
NO PREDICTION | NO PREDICTION | a.21.1(65-117) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | chromosomal part | DNA binding, bending| chromatin binding| nucleic acid binding transcription factor activity| sequence-specific DNA binding transcription factor activity| structural constituent of chromatin | chromatin organization| chromosome organization |
| 469 | PF14091 | Domain of unknown function (DUF4269) | No Pfam Clan | 134 (29) | 152 | 151 | (1) Nucleotidyltransferase [d.218.1] (1-126) |
(1) Nucleotidyltransferase [d.218] |
NO PREDICTION | d.218.1(1-126) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 2.7.6.5| 2.7.7.19| 2.7.7.31| 2.7.7.42| 2.7.7.52| 2.7.7.7| 2.7.7.72 | No information | adenylyltransferase activity| double-stranded RNA binding | No information |
| 470 | PF05982 | Domain of unknown function (DUF897) | CPA_AT (CL0064) | 322 (7) | 327 | 316 | (1) MFS general substrate transporter [f.38.1] (1-326) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(1-326) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 471 | PF14298 | Domain of unknown function (DUF4374) | No Pfam Clan | 125 (8) | 435 | 432 | (1) DPP6 N-terminal domain-like [b.70.3] (INDIRECT) |
(1) 8-bladed beta-propeller [b.70] |
NO PREDICTION | b.70.3(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 472 | PF14291 | Domain of unknown function (DUF4371) | No Pfam Clan | 987 (19) | 235 | 236 | (1) Ribonuclease H-like [c.55.3] (144-234) |
(1) Ribonuclease H-like motif [c.55] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.55.3(144-234) | 1 | No information | Eukaryota | 2.7.7.7| 3.1.11.1| 3.1.13.1| 3.1.13.4| 3.1.13.5| 3.1.22.4| 3.1.26.4| 3.6.4.12 | CCR4-NOT complex| DNA polymerase complex| cytoplasmic mRNA processing body| micro-ribonucleoprotein complex| nucleolus| ribonuclease H2 complex| ribonucleoprotein granule | DNA polymerase activity| DNA-directed DNA polymerase activity| endoribonuclease activity, producing 5'-phosphomonoesters| exonuclease activity| nuclease activity| ribonuclease H activity| transposase activity | DNA catabolic process| DNA replication| DNA replication, removal of RNA primer| DNA strand elongation| RNA 3'-end processing| RNA catabolic process| RNA phosphodiester bond hydrolysis| cytoplasmic mRNA processing body assembly| gene silencing| gene silencing by RNA| lagging strand elongation| mRNA 3'-end processing| mitochondrial genome maintenance| mitotic DNA integrity checkpoint| mitotic G2 DNA damage checkpoint| ncRNA 3'-end processing| negative regulation of DNA metabolic process| negative regulation of DNA recombination| negative regulation of mitotic recombination| negative regulation of translation| nuclear-transcribed mRNA poly(A) tail shortening| nucleic acid phosphodiester bond hydrolysis| positive regulation of catabolic process| positive regulation of cellular catabolic process| positive regulation of mRNA catabolic process| positive regulation of mRNA processing| regulation of DNA metabolic process| regulation of DNA recombination| regulation of mRNA 3'-end processing| regulation of mRNA catabolic process| regulation of mRNA processing| regulation of mitotic recombination| response to ionizing radiation| ribonucleoprotein complex biogenesis| ribonucleoprotein complex subunit organization| transposition| transposition, DNA-mediated |
| 473 | PF07895 | Protein of unknown function (DUF1673) | No Pfam Clan | 47 (23) | 205 | 198 | (1) Family A G protein-coupled receptor-like [f.13.1] (INDIRECT) |
(1) Family A G protein-coupled receptor-like [f.13] |
NO PREDICTION | f.13.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | cilium| cilium membrane| cilium part| early endosome| integral to plasma membrane| intrinsic to plasma membrane| photoreceptor inner segment| photoreceptor inner segment membrane| photoreceptor outer segment| photoreceptor outer segment membrane| primary cilium | G-protein coupled receptor activity| amide binding| catecholamine binding| chemokine receptor activity| molecular transducer activity| neuropeptide binding| odorant binding| peptide binding| pheromone binding| receptor activity| retinal binding| signaling receptor activity | G-protein coupled receptor signaling pathway| calcium ion homeostasis| cellular calcium ion homeostasis| cellular divalent inorganic cation homeostasis| cellular response to cytokine stimulus| cellular response to disaccharide stimulus| cellular response to sucrose stimulus| chemokine-mediated signaling pathway| complement receptor mediated signaling pathway| detection of chemical stimulus| detection of chemical stimulus involved in sensory perception| detection of light stimulus| detection of stimulus| detection of stimulus involved in sensory perception| diet induced thermogenesis| divalent inorganic cation homeostasis| germ cell migration| histamine secretion| histamine transport| hormone secretion| inflammatory response| mRNA transcription| mRNA transcription from RNA polymerase II promoter| negative regulation of nucleotide biosynthetic process| negative regulation of nucleotide metabolic process| negative regulation of purine nucleotide metabolic process| nonassociative learning| platelet activation| positive regulation of MAPK cascade| positive regulation of cyclase activity| positive regulation of cyclic nucleotide biosynthetic process| positive regulation of cytokinesis| positive regulation of intracellular protein kinase cascade| positive regulation of leukocyte degranulation| positive regulation of lyase activity| positive regulation of mast cell activation| positive regulation of mast cell activation involved in immune response| positive regulation of mucus secretion| positive regulation of multicellular organismal metabolic process| positive regulation of nucleotide biosynthetic process| positive regulation of nucleotide metabolic process| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of purine nucleotide metabolic process| purinergic receptor signaling pathway| regulation of ERK1 and ERK2 cascade| regulation of MAPK cascade| regulation of cAMP biosynthetic process| regulation of cAMP metabolic process| regulation of cyclase activity| regulation of cyclic nucleotide biosynthetic process| regulation of cyclic nucleotide metabolic process| regulation of interleukin-8 secretion| regulation of intracellular protein kinase cascade| regulation of leukocyte degranulation| regulation of lyase activity| regulation of mast cell activation| regulation of mast cell activation involved in immune response| regulation of mucus secretion| regulation of multicellular organismal metabolic process| regulation of myeloid leukocyte mediated immunity| regulation of nucleotide biosynthetic process| regulation of nucleotide metabolic process| regulation of purine nucleotide biosynthetic process| regulation of purine nucleotide metabolic process| regulation of systemic arterial blood pressure by norepinephrine-epinephrine| regulation of vasoconstriction| response to pheromone| sensory perception| sensory perception of chemical stimulus |
| 474 | PF15418 | Domain of unknown function (DUF4625) | E-set (CL0159) | 136 (44) | 132 | 141 | (1) E set domains [b.1.18] (29-129) |
(1) Immunoglobulin-like beta-sandwich [b.1] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | b.1.18(29-129) | 1 | No information | Bacteria | 1.4.99.3| 3.1.4.17 | No information | GDP-dissociation inhibitor activity| Rho GDP-dissociation inhibitor activity| cholesterol binding| lipid antigen binding| lipopolysaccharide binding| lipoteichoic acid binding| peptidoglycan binding| sterol binding | actin cytoskeleton organization| cholesterol efflux| coagulation| detection of abiotic stimulus| detection of external stimulus| detection of light stimulus| detection of stimulus| hemolymph coagulation| hemostasis| intracellular lipid transport| lipid localization| lipid transport| organic hydroxy compound transport| phototransduction| regulation of G-protein coupled receptor protein signaling pathway| sterol transport |
| 475 | PF13785 | Domain of unknown function (DUF4178) | No Pfam Clan | 460 (54) | 140 | 164 | (1) Outer surface protein [b.76.1] (68-147) |
(1) open-sided beta-meander [b.76] |
NO PREDICTION | NO PREDICTION | b.76.1(68-147) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | No information | No information | No information |
| 476 | PF13778 | Domain of unknown function (DUF4174) | Thioredoxin (CL0172) | 508 (85) | 118 | 105 | (1) Thioredoxin-like [c.47.1] (2-100) |
(1) Thioredoxin fold [c.47] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.47.1(2-100) | 1 | No information | Eukaryota|Bacteria | 1.1.4.2| 1.11.1.12| 1.11.1.15| 1.11.1.7| 1.11.1.9| 1.20.4.1| 1.8.1.7| 1.8.1.8| 1.8.1.9| 1.8.4.2| 1.8.4.7| 1.8.4.8| 1.8.5.1| 2.5.1.18| 5.2.1.2| 5.3.4.1| 5.3.99.3 | NADH dehydrogenase complex| chloroplast stroma| ferredoxin hydrogenase complex| formate dehydrogenase complex| myelin sheath| plastid stroma| respiratory chain complex I | antioxidant activity| arsenate reductase activity| disulfide oxidoreductase activity| electron carrier activity| formate dehydrogenase (NAD+) activity| glutathione binding| glutathione transferase activity| intramolecular oxidoreductase activity| intramolecular oxidoreductase activity, interconverting keto- and enol-groups| intramolecular oxidoreductase activity, transposing S-S bonds| oxidoreductase activity, acting on a sulfur group of donors| oxidoreductase activity, acting on hydrogen as donor| oxidoreductase activity, acting on peroxide as acceptor| oxidoreductase activity, acting on phosphorus or arsenic in donors| oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor| peroxidase activity| peroxiredoxin activity| phospholipid-hydroperoxide glutathione peroxidase activity| prostaglandin-F synthase activity| protein disulfide isomerase activity| thioredoxin peroxidase activity | androecium development| anther development| cell redox homeostasis| cellular response to hydrogen peroxide| cellular response to oxidative stress| cellular response to reactive oxygen species| fatty acid derivative biosynthetic process| fatty acid derivative metabolic process| floral organ development| floral whorl development| flower development| formate metabolic process| hydrogen peroxide catabolic process| icosanoid biosynthetic process| nucleolus organization| phyllome development| positive regulation of DNA binding| positive regulation of binding| prostanoid biosynthetic process| protein deglutathionylation| protein folding| reactive oxygen species metabolic process| regulation of DNA binding| regulation of binding| regulation of intracellular transport| regulation of protein import into nucleus| regulation of protein import into nucleus, translocation| regulation of protein localization to nucleus| removal of superoxide radicals| response to hydrogen peroxide| response to hydroperoxide| response to reactive oxygen species| response to selenium ion| shoot system development| stamen development| toxin catabolic process| unsaturated fatty acid biosynthetic process| unsaturated fatty acid metabolic process |
| 477 | PF11178 | Protein of unknown function (DUF2963) | No Pfam Clan | 215 (42) | 51 | 51 | (1) YVTN repeat-like/Quinoprotein amine dehydrogenase [b.69.2] (1-37) |
(1) 7-bladed beta-propeller [b.69] |
b.69.2(1-37) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 2.3.2.5 | No information | No information | No information |
| 478 | PF04657 | Protein of unknown function, DUF606 | DMT (CL0184) | 2941 (147) | 138 | 137 | (1) Multidrug resistance efflux transporter EmrE [f.39.1] (INDIRECT) |
(1) Multidrug resistance efflux transporter EmrE [f.39] |
NO PREDICTION | f.39.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 479 | PF07950 | Protein of unknown function (DUF1691) | FumRed-TM (CL0335) | 223 (38) | 110 | 112 | (1) Fumarate reductase respiratory complex transmembrane subunits [f.21.2] (1-94) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | f.21.2(1-94) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 1.3.5.1 | fumarate reductase complex| mitochondrial respiratory chain| mitochondrial respiratory chain complex II| plasma membrane respiratory chain| plasma membrane respiratory chain complex II| respiratory chain| respiratory chain complex II| succinate dehydrogenase complex | cofactor binding| electron carrier activity| heme binding| oxidoreductase activity, acting on the CH-CH group of donors| quinone binding| succinate dehydrogenase activity| tetrapyrrole binding| ubiquinone binding | cellular respiration| electron transport chain| energy derivation by oxidation of organic compounds| mitochondrial ATP synthesis coupled electron transport| mitochondrial electron transport, succinate to ubiquinone| oxidative phosphorylation| tricarboxylic acid cycle |
| 480 | PF10101 | Predicted membrane protein (DUF2339) | No Pfam Clan | 995 (47) | 745 | 755 | (1) MFS general substrate transporter [f.38.1] (3-387) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(3-387) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Viruses|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 481 | PF10295 | Uncharacterised protein (DUF2406) | No Pfam Clan | 139 (18) | 69 | 67 | (1) Ankyrin repeat [d.211.1] (1-66) |
(1) beta-hairpin-alpha-hairpin repeat [d.211] |
d.211.1(1-66) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | intercellular bridge | NF-kappaB binding| cyclin-dependent protein serine/threonine kinase inhibitor activity| cyclin-dependent protein serine/threonine kinase regulator activity| enzyme binding| histone deacetylase binding| kinase inhibitor activity| kinase regulator activity| protein kinase inhibitor activity| protein kinase regulator activity| protein serine/threonine kinase inhibitor activity | cell cycle arrest| cytoplasmic sequestering of protein| cytoplasmic sequestering of transcription factor| interphase| maintenance of location| maintenance of location in cell| maintenance of protein location| maintenance of protein location in cell| mitotic cell cycle phase transition| negative regulation of NF-kappaB transcription factor activity| negative regulation of cell cycle| negative regulation of intracellular protein transport| negative regulation of intracellular transport| negative regulation of kinase activity| negative regulation of phosphorylation| negative regulation of protein import into nucleus| negative regulation of protein kinase activity| negative regulation of protein serine/threonine kinase activity| negative regulation of protein transport| negative regulation of transcription factor import into nucleus| positive regulation of NF-kappaB transcription factor activity| positive regulation of transforming growth factor beta receptor signaling pathway| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway| regulation of I-kappaB kinase/NF-kappaB cascade| regulation of NF-kappaB import into nucleus| regulation of cyclin-dependent protein serine/threonine kinase activity| regulation of protein localization to nucleus| regulation of transcription factor import into nucleus| spleen development |
| 482 | PF11012 | Protein of unknown function (DUF2850) | No Pfam Clan | 208 (16) | 79 | 80 | (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (30-77) |
(1) 8-bladed beta-propeller [b.70] |
b.70.1(30-77) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Bacteria|Archaea | 1.1.2.7| 1.1.98.1 | No information | endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity | ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein |
| 483 | PF11682 | Protein of unknown function (DUF3279) | No Pfam Clan | 650 (4) | 128 | 127 | (1) Growth factor receptor domain [g.3.9] (27-124) |
(1) Knottins (small inhibitors, toxins, lectins) [g.3] |
NO PREDICTION | g.3.9(27-124) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | cell migration| cell motility| enzyme linked receptor protein signaling pathway| localization of cell| transmembrane receptor protein tyrosine kinase signaling pathway |
| 484 | PF06906 | Protein of unknown function (DUF1272) | No Pfam Clan | 286 (35) | 57 | 57 | (1) RING/U-box [g.44.1] (4-50) |
(1) RING/U-box [g.44] |
NO PREDICTION | g.44.1(4-50) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | nuclear body| nuclear ubiquitin ligase complex| ubiquitin ligase complex | acid-amino acid ligase activity| small conjugating protein ligase activity | activation of cysteine-type endopeptidase activity| anatomical structure homeostasis| intrinsic apoptotic signaling pathway in response to oxidative stress| modification-dependent macromolecule catabolic process| modification-dependent protein catabolic process| protein catabolic process| protein modification by small protein conjugation| protein modification by small protein conjugation or removal| regulation of cell cycle phase transition| regulation of cysteine-type endopeptidase activity| regulation of endopeptidase activity| regulation of peptidase activity |
| 485 | PF07596 | Protein of unknown function (DUF1559) | No Pfam Clan | 1532 (147) | 265 | 273 | (1) Pili subunits [d.24.1] (1-61) |
(1) Pili subunits [d.24] |
NO PREDICTION | NO PREDICTION | d.24.1(1-61) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | pilus | No information | cell projection assembly| cell projection organization| pathogenesis| pilus assembly| pilus organization| protein secretion| protein secretion by the type II secretion system| protein transmembrane transport| secretion by cell |
| 486 | PF10058 | Predicted integral membrane metal-binding protein (DUF2296) | No Pfam Clan | 334 (30) | 54 | 56 | (1) Zn-finger domain of Sec23/24 [g.41.10] (22-54) |
(1) Rubredoxin-like [g.41] |
g.41.10(22-54) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | No information | No information | No information |
| 487 | PF10933 | Protein of unknown function (DUF2827) | No Pfam Clan | 211 (9) | 364 | 363 | (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (3-363) |
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87] |
NO PREDICTION | c.87.1(3-363) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 | alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) | UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups | L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process |
| 488 | PF01944 | Integral membrane protein DUF95 | No Pfam Clan | 1288 (172) | 173 | 152 | (1) MFS general substrate transporter [f.38.1] (INDIRECT) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 489 | PF10776 | Protein of unknown function (DUF2600) | No Pfam Clan | 211 (29) | 330 | 331 | (1) Terpenoid synthases [a.128.1] (1-322) |
(1) Terpenoid synthases [a.128] |
NO PREDICTION | a.128.1(1-322) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 2.5.1.1| 2.5.1.10| 2.5.1.21| 2.5.1.30| 4.2.3.13| 4.2.3.17| 4.2.3.27| 4.2.3.37| 4.2.3.6| 4.2.3.7| 4.2.3.9| 5.5.1.8 | No information | carbon-oxygen lyase activity, acting on phosphates| geranyltranstransferase activity| prenyltransferase activity| terpene synthase activity| transferase activity, transferring alkyl or aryl (other than methyl) groups | alcohol biosynthetic process| carotenoid biosynthetic process| cellular alcohol biosynthetic process| cellular alcohol metabolic process| cellular ketone metabolic process| farnesyl diphosphate biosynthetic process| farnesyl diphosphate metabolic process| geranylgeranyl diphosphate biosynthetic process| geranylgeranyl diphosphate metabolic process| germ cell migration| isoprenoid biosynthetic process| isoprenoid metabolic process| ketone biosynthetic process| phospholipid biosynthetic process| phospholipid metabolic process| phytosteroid metabolic process| pigment biosynthetic process| quinone biosynthetic process| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| steroid metabolic process| sterol biosynthetic process| sterol metabolic process |
| 490 | PF13160 | Protein of unknown function (DUF3995) | No Pfam Clan | 198 (35) | 125 | 123 | (1) Fumarate reductase respiratory complex transmembrane subunits [f.21.2] (1-124) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | f.21.2(1-124) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 1.3.5.1 | fumarate reductase complex| mitochondrial respiratory chain| mitochondrial respiratory chain complex II| plasma membrane respiratory chain| plasma membrane respiratory chain complex II| respiratory chain| respiratory chain complex II| succinate dehydrogenase complex | cofactor binding| electron carrier activity| heme binding| oxidoreductase activity, acting on the CH-CH group of donors| quinone binding| succinate dehydrogenase activity| tetrapyrrole binding| ubiquinone binding | cellular respiration| electron transport chain| energy derivation by oxidation of organic compounds| mitochondrial ATP synthesis coupled electron transport| mitochondrial electron transport, succinate to ubiquinone| oxidative phosphorylation| tricarboxylic acid cycle |
| 491 | PF08590 | Domain of unknown function (DUF1771) | No Pfam Clan | 501 (30) | 66 | 66 | (1) Ankyrin repeat [d.211.1] (9-51) |
(1) beta-hairpin-alpha-hairpin repeat [d.211] |
d.211.1(9-51) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | intercellular bridge | NF-kappaB binding| cyclin-dependent protein serine/threonine kinase inhibitor activity| cyclin-dependent protein serine/threonine kinase regulator activity| enzyme binding| histone deacetylase binding| kinase inhibitor activity| kinase regulator activity| protein kinase inhibitor activity| protein kinase regulator activity| protein serine/threonine kinase inhibitor activity | cell cycle arrest| cytoplasmic sequestering of protein| cytoplasmic sequestering of transcription factor| interphase| maintenance of location| maintenance of location in cell| maintenance of protein location| maintenance of protein location in cell| mitotic cell cycle phase transition| negative regulation of NF-kappaB transcription factor activity| negative regulation of cell cycle| negative regulation of intracellular protein transport| negative regulation of intracellular transport| negative regulation of kinase activity| negative regulation of phosphorylation| negative regulation of protein import into nucleus| negative regulation of protein kinase activity| negative regulation of protein serine/threonine kinase activity| negative regulation of protein transport| negative regulation of transcription factor import into nucleus| positive regulation of NF-kappaB transcription factor activity| positive regulation of transforming growth factor beta receptor signaling pathway| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway| regulation of I-kappaB kinase/NF-kappaB cascade| regulation of NF-kappaB import into nucleus| regulation of cyclin-dependent protein serine/threonine kinase activity| regulation of protein localization to nucleus| regulation of transcription factor import into nucleus| spleen development |
| 492 | PF13151 | Protein of unknown function (DUF3990) | No Pfam Clan | 384 (47) | 154 | 163 | (1) ADP-ribosylation [d.166.1] (4-66) |
(1) ADP-ribosylation [d.166] |
NO PREDICTION | NO PREDICTION | d.166.1(4-66) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Viruses | 2.4.2.30| 2.4.2.31| 2.4.2.36 | No information | transferase activity, transferring pentosyl groups | glycoprotein biosynthetic process| glycoprotein metabolic process| glycosylation| macromolecule glycosylation| protein ADP-ribosylation| protein glycosylation |
| 493 | PF04407 | Protein of unknown function (DUF531) | No Pfam Clan | 38 (9) | 174 | 175 | (1) alpha/beta knot [c.116.1] (1-170) |
(1) alpha/beta knot [c.116] |
NO PREDICTION | c.116.1(1-170) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Archaea | 2.1.1.31| 2.1.1.34| 2.1.1.66 | No information | RNA methyltransferase activity| methyltransferase activity| rRNA (pseudouridine) methyltransferase activity| rRNA methyltransferase activity| transferase activity, transferring one-carbon groups | RNA methylation| RNA modification| macromolecule methylation| methylation| ncRNA processing| rRNA modification| ribonucleoprotein complex biogenesis| ribosome biogenesis |
| 494 | PF07784 | Protein of unknown function (DUF1622) | No Pfam Clan | 422 (51) | 77 | 78 | (1) ABC transporter involved in vitamin B12 uptake, BtuC [f.22.1] (1-71) |
(1) ABC transporter involved in vitamin B12 uptake, BtuC [f.22] |
NO PREDICTION | NO PREDICTION | f.22.1(1-71) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | No information | ATPase activity| ATPase activity, coupled| ATPase activity, coupled to movement of substances| ATPase activity, coupled to transmembrane movement of substances| P-P-bond-hydrolysis-driven transmembrane transporter activity| hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances| iron ion transmembrane transporter activity| primary active transmembrane transporter activity| siderophore transporter activity| transition metal ion transmembrane transporter activity | cellular cation homeostasis| cellular chemical homeostasis| cellular ion homeostasis| cellular iron ion homeostasis| cellular metal ion homeostasis| cellular transition metal ion homeostasis| iron assimilation| iron assimilation by chelation and transport| iron chelate transport| iron coordination entity transport| iron ion homeostasis| metal ion homeostasis| siderophore transport| transition metal ion homeostasis| transition metal ion transport |
| 495 | PF15509 | Domain of unknown function (DUF4650) | No Pfam Clan | 46 (16) | 520 | 487 | (1) ssDNA viruses [b.121.5] (1-450) |
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | b.121.5(1-450) | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 496 | PF05620 | Protein of unknown function (DUF788) | No Pfam Clan | 317 (30) | 170 | 164 | (1) ABC transporter transmembrane region [f.37.1] (5-169) |
(1) ABC transporter transmembrane region [f.37] |
NO PREDICTION | f.37.1(5-169) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 497 | PF10218 | Uncharacterized conserved protein (DUF2054) | No Pfam Clan | 153 (9) | 132 | 131 | (1) Growth factor receptor domain [g.3.9] (7-113) |
(1) Knottins (small inhibitors, toxins, lectins) [g.3] |
NO PREDICTION | g.3.9(7-113) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | cell migration| cell motility| enzyme linked receptor protein signaling pathway| localization of cell| transmembrane receptor protein tyrosine kinase signaling pathway |
| 498 | PF01901 | Protein of unknown function DUF70 | No Pfam Clan | 72 (16) | 332 | 312 | (1) MFS general substrate transporter [f.38.1] (3-331) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(3-331) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 499 | PF09318 | Domain of unknown function (DUF1975) | No Pfam Clan | 2040 (51) | 203 | 182 | (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (3-202) |
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87] |
c.87.1(3-202) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 | alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) | UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups | L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process |
| 500 | PF09950 | Uncharacterized protein conserved in bacteria (DUF2184) | Phage-coat (CL0373) | 275 (26) | 249 | 246 | (1) Major capsid protein gp5 [d.183.1] (1-248) |
(1) Major capsid protein gp5 [d.183] |
NO PREDICTION | d.183.1(1-248) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | No information | No information | No information | No information |
| 501 | PF12228 | Protein of unknown function (DUF3604) | Amidohydrolase (CL0034) | 171 (34) | 592 | 584 | (1) PHP domain-like [c.6.3] (4-408) |
(1) 7-stranded beta/alpha barrel [c.6] |
NO PREDICTION | c.6.3(4-408) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 3.1.3.15 | No information | No information | No information |
| 502 | PF11136 | Protein of unknown function (DUF2889) | No Pfam Clan | 270 (49) | 117 | 125 | (1) Clathrin adaptor appendage domain [b.1.10] (17-92) |
(1) Immunoglobulin-like beta-sandwich [b.1] |
b.1.10(17-92) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | No information | No information | No information |
| 503 | PF11885 | Protein of unknown function (DUF3405) | No Pfam Clan | 217 (25) | 496 | 545 | (1) Nucleotide-diphospho-sugar transferases [c.68.1] (101-429) |
(1) Nucleotide-diphospho-sugar transferases [c.68] |
NO PREDICTION | c.68.1(101-429) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 2.4.1.101| 2.4.1.131| 2.4.1.135| 2.4.1.186| 2.4.1.217| 2.4.1.222| 2.4.1.223| 2.4.1.37| 2.4.1.41| 2.4.1.44| 2.4.1.87| 2.7.7.13| 2.7.7.23| 2.7.7.24| 2.7.7.27| 2.7.7.33| 2.7.7.38| 2.7.7.43| 2.7.7.60| 2.7.7.64| 2.7.7.9 | Golgi apparatus| Golgi apparatus part| Golgi membrane| cis-Golgi network| mannosyltransferase complex | UDP-glycosyltransferase activity| acetylgalactosaminyltransferase activity| ceramide glucosyltransferase activity| cytidylyltransferase activity| galactosyltransferase activity| glucose-1-phosphate thymidylyltransferase activity| guanylyltransferase activity| magnesium ion binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups | aminoglycan biosynthetic process| aminoglycan metabolic process| cell wall biogenesis| cell wall mannoprotein biosynthetic process| cell wall organization or biogenesis| cellular carbohydrate biosynthetic process| cellular component macromolecule biosynthetic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| chondroitin sulfate biosynthetic process| chondroitin sulfate metabolic process| chondroitin sulfate proteoglycan biosynthetic process| chondroitin sulfate proteoglycan metabolic process| dolichol metabolic process| extracellular fibril organization| extracellular matrix organization| extracellular structure organization| fibril organization| galactose metabolic process| gametophyte development| glycolipid metabolic process| glycoprotein biosynthetic process| glycoprotein metabolic process| glycosaminoglycan biosynthetic process| glycosphingolipid biosynthetic process| glycosylation| heparan sulfate proteoglycan biosynthetic process| heparan sulfate proteoglycan metabolic process| lipopolysaccharide metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| negative regulation of fibroblast proliferation| nucleotide-sugar metabolic process| peptidyl-asparagine modification| phosphatidylinositol biosynthetic process| phosphatidylinositol metabolic process| pollen development| polyprenol metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein O-linked glycosylation| protein glycosylation| regulation of Notch signaling pathway| regulation of fibroblast proliferation| sphingolipid biosynthetic process| sphingolipid metabolic process |
| 504 | PF08898 | Domain of unknown function (DUF1843) | No Pfam Clan | 126 (15) | 53 | 53 | (1) Ankyrin repeat [d.211.1] (3-50) |
(1) beta-hairpin-alpha-hairpin repeat [d.211] |
d.211.1(3-50) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | intercellular bridge | NF-kappaB binding| cyclin-dependent protein serine/threonine kinase inhibitor activity| cyclin-dependent protein serine/threonine kinase regulator activity| enzyme binding| histone deacetylase binding| kinase inhibitor activity| kinase regulator activity| protein kinase inhibitor activity| protein kinase regulator activity| protein serine/threonine kinase inhibitor activity | cell cycle arrest| cytoplasmic sequestering of protein| cytoplasmic sequestering of transcription factor| interphase| maintenance of location| maintenance of location in cell| maintenance of protein location| maintenance of protein location in cell| mitotic cell cycle phase transition| negative regulation of NF-kappaB transcription factor activity| negative regulation of cell cycle| negative regulation of intracellular protein transport| negative regulation of intracellular transport| negative regulation of kinase activity| negative regulation of phosphorylation| negative regulation of protein import into nucleus| negative regulation of protein kinase activity| negative regulation of protein serine/threonine kinase activity| negative regulation of protein transport| negative regulation of transcription factor import into nucleus| positive regulation of NF-kappaB transcription factor activity| positive regulation of transforming growth factor beta receptor signaling pathway| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway| regulation of I-kappaB kinase/NF-kappaB cascade| regulation of NF-kappaB import into nucleus| regulation of cyclin-dependent protein serine/threonine kinase activity| regulation of protein localization to nucleus| regulation of transcription factor import into nucleus| spleen development |
| 505 | PF14964 | Domain of unknown function (DUF4507) | No Pfam Clan | 101 (18) | 362 | 360 | (1) ARM repeat [a.118.1] (4-359) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(4-359) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 506 | PF06241 | Protein of unknown function (DUF1012) | No Pfam Clan | 84 (2) | 206 | 206 | (1) TrkA C-terminal domain-like [d.286.1] (101-151) |
(1) TrkA C-terminal domain-like [d.286] |
NO PREDICTION | NO PREDICTION | d.286.1(101-151) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 507 | PF03961 | Protein of unknown function (DUF342) | No Pfam Clan | 994 (100) | 451 | 441 | (1) Cell-division inhibitor MinC, C-terminal domain [b.80.3] (185-247) |
(1) Single-stranded right-handed beta-helix [b.80] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | b.80.3(185-247) | 1 | No information | Bacteria | No information | No information | No information | No information |
| 508 | PF04936 | Protein of unknown function (DUF658) | No Pfam Clan | 26 (2) | 186 | 186 | (1) Homeodomain-like [a.4.1] (16-38) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.4.1(16-38) | 1 | No information | Bacteria|Viruses | No information | transcription factor complex | chromatin binding| nucleic acid binding transcription factor activity| transposase activity | activin receptor signaling pathway| cell fate commitment| cell fate specification| chordate embryonic development| diencephalon development| embryonic morphogenesis| endoderm development| eye photoreceptor cell differentiation| negative regulation of developmental process| neural tube development| neuron fate commitment| nodal signaling pathway| pancreas development| pattern specification process| positive regulation of neuron differentiation| regulation of cell fate commitment| regulation of epithelial cell differentiation| regulation of gastrulation| retina development in camera-type eye| sensory organ development| somitogenesis| transmembrane receptor protein serine/threonine kinase signaling pathway| transposition| transposition, DNA-mediated| trophectodermal cell differentiation |
| 509 | PF07756 | Protein of unknown function (DUF1612) | No Pfam Clan | 141 (18) | 129 | 130 | (1) Fic-like [a.265.1] (19-117) |
(1) Fic-like [a.265] |
a.265.1(19-117) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 510 | PF05667 | Protein of unknown function (DUF812) | No Pfam Clan | 190 (10) | 594 | 517 | (1) ARM repeat [a.118.1] (2-593) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(2-593) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 511 | PF06980 | Protein of unknown function (DUF1302) | MBB (CL0193) | 345 (64) | 554 | 637 | (1) Porins [f.4.3] (1-553) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.3(1-553) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 512 | PF13628 | Domain of unknown function (DUF4142) | Ferritin (CL0044) | 804 (144) | 139 | 138 | (1) Ferritin-like [a.25.1] (INDIRECT) |
(1) Ferritin-like [a.25] |
NO PREDICTION | a.25.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 1.11.1.6| 1.14.13.25| 1.14.19.2| 1.16.3.1| 1.17.4.1| 4.2.1.52 | ferritin complex| intracellular ferritin complex| ribonucleoside-diphosphate reductase complex | iron ion binding| oxidoreductase activity, acting on CH or CH2 groups| oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor| ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | DNA replication| cellular ketone metabolic process| cellular transition metal ion homeostasis| deoxyribonucleoside triphosphate metabolic process| deoxyribonucleotide biosynthetic process| deoxyribonucleotide metabolic process| immune response| intracellular sequestering of iron ion| iron ion homeostasis| ketone biosynthetic process| kidney development| maintenance of location| maintenance of location in cell| metal ion homeostasis| mitochondrial DNA metabolic process| mitochondrial DNA replication| mitochondrial genome maintenance| mitochondrion organization| negative regulation of apoptotic signaling pathway| negative regulation of cell proliferation| negative regulation of intrinsic apoptotic signaling pathway| negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator| negative regulation of signal transduction by p53 class mediator| oxidoreduction coenzyme metabolic process| photosynthesis| quinone biosynthetic process| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of apoptotic signaling pathway| regulation of intrinsic apoptotic signaling pathway| regulation of intrinsic apoptotic signaling pathway by p53 class mediator| regulation of signal transduction by p53 class mediator| renal system process| response to iron ion| sequestering of metal ion| transition metal ion homeostasis| ubiquinone biosynthetic process| ubiquinone metabolic process |
| 513 | PF14258 | Domain of unknown function (DUF4350) | No Pfam Clan | 383 (163) | 70 | 72 | (1) Class I glutamine amidotransferase-like [c.23.16] (1-70) |
(1) Flavodoxin-like [c.23] |
c.23.16(1-70) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 2.3.1.46| 2.4.1.211| 3.4.13.21| 3.4.15.6| 3.4.17.13| 3.4.19.9| 4.2.1.103| 6.3.5.2| 6.3.5.5 | No information | 4-amino-4-deoxychorismate synthase activity| anthranilate synthase activity| antioxidant activity| carbon-carbon lyase activity| carbon-nitrogen ligase activity, with glutamine as amido-N-donor| glyoxalase III activity| oxidoreductase activity, acting on peroxide as acceptor| oxo-acid-lyase activity| peptidase activity| peroxidase activity| peroxiredoxin activity| transaminase activity| transferase activity, transferring nitrogenous groups | adult behavior| adult locomotory behavior| amine biosynthetic process| aromatic amino acid family biosynthetic process| aromatic amino acid family metabolic process| catecholamine transport| catecholamine uptake| catecholamine uptake involved in synaptic transmission| cellular biogenic amine biosynthetic process| cellular response to oxidative stress| cellular response to reactive oxygen species| dopamine transport| dopamine uptake| dopamine uptake involved in synaptic transmission| folic acid-containing compound biosynthetic process| folic acid-containing compound metabolic process| hydrogen peroxide metabolic process| indolalkylamine biosynthetic process| indole-containing compound biosynthetic process| indole-containing compound metabolic process| lactate biosynthetic process| lactate metabolic process| membrane depolarization| membrane hyperpolarization| monoamine transport| negative regulation of binding| negative regulation of protein binding| neuron-neuron synaptic transmission| neurotransmitter transport| neurotransmitter uptake| organic hydroxy compound transport| positive regulation of oxidative phosphorylation uncoupler activity| positive regulation of transporter activity| protein stabilization| pteridine-containing compound biosynthetic process| pteridine-containing compound metabolic process| reactive oxygen species metabolic process| regulation of binding| regulation of neuron apoptotic process| regulation of neuron death| regulation of neurotransmitter levels| regulation of oxidative phosphorylation uncoupler activity| regulation of protein binding| regulation of protein stability| regulation of proton transport| regulation of transmembrane transport| regulation of transmembrane transporter activity| regulation of transporter activity| response to hydrogen peroxide| response to reactive oxygen species| synaptic transmission, dopaminergic| thiamine biosynthetic process| thiamine-containing compound biosynthetic process| thiamine-containing compound metabolic process| tryptophan biosynthetic process| tryptophan metabolic process| water-soluble vitamin biosynthetic process |
| 514 | PF12447 | Protein of unknown function (DUF3683) | No Pfam Clan | 271 (42) | 117 | 117 | (1) Ankyrin repeat [d.211.1] (2-105) |
(1) beta-hairpin-alpha-hairpin repeat [d.211] |
d.211.1(2-105) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | intercellular bridge | NF-kappaB binding| cyclin-dependent protein serine/threonine kinase inhibitor activity| cyclin-dependent protein serine/threonine kinase regulator activity| enzyme binding| histone deacetylase binding| kinase inhibitor activity| kinase regulator activity| protein kinase inhibitor activity| protein kinase regulator activity| protein serine/threonine kinase inhibitor activity | cell cycle arrest| cytoplasmic sequestering of protein| cytoplasmic sequestering of transcription factor| interphase| maintenance of location| maintenance of location in cell| maintenance of protein location| maintenance of protein location in cell| mitotic cell cycle phase transition| negative regulation of NF-kappaB transcription factor activity| negative regulation of cell cycle| negative regulation of intracellular protein transport| negative regulation of intracellular transport| negative regulation of kinase activity| negative regulation of phosphorylation| negative regulation of protein import into nucleus| negative regulation of protein kinase activity| negative regulation of protein serine/threonine kinase activity| negative regulation of protein transport| negative regulation of transcription factor import into nucleus| positive regulation of NF-kappaB transcription factor activity| positive regulation of transforming growth factor beta receptor signaling pathway| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway| regulation of I-kappaB kinase/NF-kappaB cascade| regulation of NF-kappaB import into nucleus| regulation of cyclin-dependent protein serine/threonine kinase activity| regulation of protein localization to nucleus| regulation of transcription factor import into nucleus| spleen development |
| 515 | PF14391 | Domain of unknown function (DUF4421) | No Pfam Clan | 119 (31) | 306 | 310 | (1) Autotransporter [f.4.5] (1-305) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.5(1-305) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 516 | PF10867 | Protein of unknown function (DUF2664) | No Pfam Clan | 32 (8) | 89 | 89 | (1) TPR-like [a.118.8] (4-76) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(4-76) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Viruses | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 517 | PF05610 | Protein of unknown function (DUF779) | No Pfam Clan | 460 (40) | 95 | 95 | (1) HesB-like domain [b.124.1] (3-84) |
(1) HesB-like domain [b.124] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | b.124.1(3-84) | 1 | No information | Eukaryota|Bacteria|Archaea | No information | No information | iron ion binding| metal cluster binding | iron-sulfur cluster assembly| metallo-sulfur cluster assembly |
| 518 | PF11822 | Domain of unknown function (DUF3342) | POZ (CL0033) | 124 (9) | 317 | 302 | (1) POZ domain [d.42.1] (13-110) |
(1) POZ domain [d.42] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | d.42.1(13-110) | 1 | No information | Eukaryota | No information | cullin-RING ubiquitin ligase complex| ubiquitin ligase complex | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor a| RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor| acid-amino acid ligase activity| nucleic acid binding transcription factor activity| protein homodimerization activity| sequence-specific DNA binding transcription factor activity| small conjugating protein ligase activity| ubiquitin-protein ligase activity | negative regulation of RNA metabolic process| negative regulation of gene expression| negative regulation of nitrogen compound metabolic process| negative regulation of nucleobase-containing compound metabolic process| protein ubiquitination| regulation of CD4-positive, alpha-beta T cell activation| regulation of CD4-positive, alpha-beta T cell differentiation| regulation of CD8-positive, alpha-beta T cell activation| regulation of CD8-positive, alpha-beta T cell differentiation| regulation of T cell differentiation| regulation of leukocyte differentiation| ubiquitin-dependent protein catabolic process |
| 519 | PF08648 | Protein of unknown function (DUF1777) | No Pfam Clan | 315 (7) | 180 | 155 | (1) MW0975(SA0943)-like [a.24.27] (INDIRECT) |
(1) Four-helical up-and-down bundle [a.24] |
NO PREDICTION | a.24.27(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 520 | PF07864 | Protein of unknown function (DUF1651) | No Pfam Clan | 133 (45) | 75 | 76 | (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (2-72) |
(1) 8-bladed beta-propeller [b.70] |
b.70.1(2-72) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 1.1.2.7| 1.1.98.1 | No information | endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity | ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein |
| 521 | PF06075 | Plant protein of unknown function (DUF936) | No Pfam Clan | 173 (13) | 580 | 613 | (1) Nucleic acid-binding proteins [b.40.4] (1-125) |
(1) OB-fold [b.40] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | b.40.4(1-125) | 1 | No information | Eukaryota | 3.1.13.1| 3.1.26.12| 6.5.1.1 | DNA replication factor A complex| DNA-directed RNA polymerase II, core complex| DNA-directed RNA polymerase II, holoenzyme| DNA-directed RNA polymerase complex| RNA polymerase complex| cytoplasmic exosome (RNase complex)| cytosolic small ribosomal subunit| exosome (RNase complex)| mitochondrial nucleoid| nuclear DNA-directed RNA polymerase complex| nucleoid| organellar ribosome| replisome | RNA polymerase activity| chromatin binding| ribonucleoprotein complex binding| single-stranded DNA binding| structure-specific DNA binding | regulation of DNA-dependent transcription, termination| regulation of RNA stability| regulation of mRNA stability| response to cold| ribonucleoprotein complex biogenesis| telomere maintenance| telomere organization| transcriptional attenuation| translational initiation |
| 522 | PF06012 | Domain of Unknown Function (DUF908) | No Pfam Clan | 318 (25) | 329 | 303 | (1) ARM repeat [a.118.1] (1-328) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(1-328) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 523 | PF09909 | Uncharacterized protein conserved in bacteria (DUF2138) | No Pfam Clan | 352 (14) | 555 | 552 | (1) WD40 repeat-like [b.69.4] (40-515) |
(1) 7-bladed beta-propeller [b.69] |
NO PREDICTION | b.69.4(40-515) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | Arp2/3 protein complex| CIA complex| Cdc73/Paf1 complex| Cul4-RING ubiquitin ligase complex| ER to Golgi transport vesicle| SMN complex| SMN-Sm protein complex| Ski complex| THO complex| TORC1 complex| chromosome, centromeric region| cullin-RING ubiquitin ligase complex| eukaryotic translation initiation factor 3 complex| extrinsic to internal side of plasma membrane| extrinsic to membrane| extrinsic to plasma membrane| female germ cell nucleus| germ cell nucleus| heterotrimeric G-protein complex| histone methyltransferase complex| immunological synapse| internal side of plasma membrane| kinetochore| methylosome| methyltransferase complex| nuclear envelope| nuclear pore| nuclear pore outer ring| pore complex| transcription export complex| transcriptionally active chromatin| ubiquitin ligase complex | G-protein gamma-subunit binding| histone binding| peroxisome targeting sequence binding| phosphatidylinositol binding| phosphatidylinositol-3,5-bisphosphate binding| phosphatidylinositol-3-phosphate binding| phosphatidylinositol-5-phosphate binding| signal sequence binding| translation initiation factor activity | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile| T cell homeostasis| TOR signaling cascade| attachment of spindle microtubules to kinetochore| attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation| autophagy| cellular response to starvation| chromosome segregation| embryonic digit morphogenesis| establishment of RNA localization| establishment of chromosome localization| establishment of organelle localization| fruiting body development| histone H3-K4 methylation| histone methylation| histone modification| iron-sulfur cluster assembly| mRNA export from nucleus| membrane disassembly| metallo-sulfur cluster assembly| metaphase plate congression| methylation| microtubule-based process| mitotic metaphase plate congression| mitotic spindle assembly checkpoint| negative regulation of calcium ion transmembrane transporter activity| negative regulation of cation channel activity| negative regulation of cell cycle process| negative regulation of ion transmembrane transporter activity| negative regulation of transporter activity| negative regulation of voltage-gated calcium channel activity| nuclear envelope disassembly| nuclear pore organization| nucleic acid transport| nucleobase-containing compound transport| peptidyl-lysine modification| peptidyl-lysine trimethylation| peroxisomal transport| positive regulation of DNA-dependent transcription, elongation| positive regulation of histone H3-K79 methylation| positive regulation of histone methylation| positive regulation of histone modification| positive regulation of organelle organization| positive regulation of transcription elongation from RNA polymerase II promoter| protein alkylation| protein import| protein targeting| regulation of cell cycle process| regulation of histone H3-K79 methylation| regulation of histone methylation| regulation of histone modification| regulation of metaphase/anaphase transition of cell cycle| regulation of mitotic metaphase/anaphase transition| regulation of reproductive process| regulation of transcription elongation from RNA polymerase II promoter| regulation of voltage-gated calcium channel activity| response to starvation| spindle assembly checkpoint| spindle checkpoint| uropod organization |
| 524 | PF10997 | Protein of unknown function (DUF2837) | No Pfam Clan | 271 (23) | 254 | 253 | (1) MFS general substrate transporter [f.38.1] (1-253) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | f.38.1(1-253) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 525 | PF07011 | Protein of unknown function (DUF1313) | No Pfam Clan | 107 (12) | 89 | 93 | (1) TPR-like [a.118.8] (2-85) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(2-85) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 526 | PF04312 | Protein of unknown function (DUF460) | No Pfam Clan | 115 (30) | 138 | 139 | (1) Ribonuclease H-like [c.55.3] (33-139) |
(1) Ribonuclease H-like motif [c.55] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.55.3(33-139) | 1 | No information | Archaea | 2.7.7.7| 3.1.11.1| 3.1.13.1| 3.1.13.4| 3.1.13.5| 3.1.22.4| 3.1.26.4| 3.6.4.12 | CCR4-NOT complex| DNA polymerase complex| cytoplasmic mRNA processing body| micro-ribonucleoprotein complex| nucleolus| ribonuclease H2 complex| ribonucleoprotein granule | DNA polymerase activity| DNA-directed DNA polymerase activity| endoribonuclease activity, producing 5'-phosphomonoesters| exonuclease activity| nuclease activity| ribonuclease H activity| transposase activity | DNA catabolic process| DNA replication| DNA replication, removal of RNA primer| DNA strand elongation| RNA 3'-end processing| RNA catabolic process| RNA phosphodiester bond hydrolysis| cytoplasmic mRNA processing body assembly| gene silencing| gene silencing by RNA| lagging strand elongation| mRNA 3'-end processing| mitochondrial genome maintenance| mitotic DNA integrity checkpoint| mitotic G2 DNA damage checkpoint| ncRNA 3'-end processing| negative regulation of DNA metabolic process| negative regulation of DNA recombination| negative regulation of mitotic recombination| negative regulation of translation| nuclear-transcribed mRNA poly(A) tail shortening| nucleic acid phosphodiester bond hydrolysis| positive regulation of catabolic process| positive regulation of cellular catabolic process| positive regulation of mRNA catabolic process| positive regulation of mRNA processing| regulation of DNA metabolic process| regulation of DNA recombination| regulation of mRNA 3'-end processing| regulation of mRNA catabolic process| regulation of mRNA processing| regulation of mitotic recombination| response to ionizing radiation| ribonucleoprotein complex biogenesis| ribonucleoprotein complex subunit organization| transposition| transposition, DNA-mediated |
| 527 | PF05344 | Domain of Unknown Function (DUF746) | No Pfam Clan | 78 (10) | 65 | 65 | (1) Homeodomain-like [a.4.1] (6-39) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.4.1(6-39) | 1 | No information | Eukaryota|Bacteria | No information | transcription factor complex | chromatin binding| nucleic acid binding transcription factor activity| transposase activity | activin receptor signaling pathway| cell fate commitment| cell fate specification| chordate embryonic development| diencephalon development| embryonic morphogenesis| endoderm development| eye photoreceptor cell differentiation| negative regulation of developmental process| neural tube development| neuron fate commitment| nodal signaling pathway| pancreas development| pattern specification process| positive regulation of neuron differentiation| regulation of cell fate commitment| regulation of epithelial cell differentiation| regulation of gastrulation| retina development in camera-type eye| sensory organ development| somitogenesis| transmembrane receptor protein serine/threonine kinase signaling pathway| transposition| transposition, DNA-mediated| trophectodermal cell differentiation |
| 528 | PF14127 | Domain of unknown function (DUF4294) | No Pfam Clan | 181 (44) | 157 | 159 | (1) TPR-like [a.118.8] (39-152) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(39-152) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 529 | PF05633 | Protein of unknown function (DUF793) | AT14A-like (CL0133) | 188 (7) | 389 | 382 | (1) ARM repeat [a.118.1] (38-388) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(38-388) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 530 | PF07293 | Protein of unknown function (DUF1450) | No Pfam Clan | 826 (14) | 78 | 78 | (1) Thioredoxin-like [c.47.1] (5-75) |
(1) Thioredoxin fold [c.47] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.47.1(5-75) | 1 | No information | Bacteria | 1.1.4.2| 1.11.1.12| 1.11.1.15| 1.11.1.7| 1.11.1.9| 1.20.4.1| 1.8.1.7| 1.8.1.8| 1.8.1.9| 1.8.4.2| 1.8.4.7| 1.8.4.8| 1.8.5.1| 2.5.1.18| 5.2.1.2| 5.3.4.1| 5.3.99.3 | NADH dehydrogenase complex| chloroplast stroma| ferredoxin hydrogenase complex| formate dehydrogenase complex| myelin sheath| plastid stroma| respiratory chain complex I | antioxidant activity| arsenate reductase activity| disulfide oxidoreductase activity| electron carrier activity| formate dehydrogenase (NAD+) activity| glutathione binding| glutathione transferase activity| intramolecular oxidoreductase activity| intramolecular oxidoreductase activity, interconverting keto- and enol-groups| intramolecular oxidoreductase activity, transposing S-S bonds| oxidoreductase activity, acting on a sulfur group of donors| oxidoreductase activity, acting on hydrogen as donor| oxidoreductase activity, acting on peroxide as acceptor| oxidoreductase activity, acting on phosphorus or arsenic in donors| oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor| peroxidase activity| peroxiredoxin activity| phospholipid-hydroperoxide glutathione peroxidase activity| prostaglandin-F synthase activity| protein disulfide isomerase activity| thioredoxin peroxidase activity | androecium development| anther development| cell redox homeostasis| cellular response to hydrogen peroxide| cellular response to oxidative stress| cellular response to reactive oxygen species| fatty acid derivative biosynthetic process| fatty acid derivative metabolic process| floral organ development| floral whorl development| flower development| formate metabolic process| hydrogen peroxide catabolic process| icosanoid biosynthetic process| nucleolus organization| phyllome development| positive regulation of DNA binding| positive regulation of binding| prostanoid biosynthetic process| protein deglutathionylation| protein folding| reactive oxygen species metabolic process| regulation of DNA binding| regulation of binding| regulation of intracellular transport| regulation of protein import into nucleus| regulation of protein import into nucleus, translocation| regulation of protein localization to nucleus| removal of superoxide radicals| response to hydrogen peroxide| response to hydroperoxide| response to reactive oxygen species| response to selenium ion| shoot system development| stamen development| toxin catabolic process| unsaturated fatty acid biosynthetic process| unsaturated fatty acid metabolic process |
| 531 | PF03672 | Uncharacterised protein family (UPF0154) | No Pfam Clan | 1101 (5) | 64 | 64 | (1) EF-hand [a.39.1] (31-63) |
(1) EF Hand-like [a.39] |
NO PREDICTION | NO PREDICTION | a.39.1(31-63) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 1.13.12.5| 2.7.1.107| 2.7.11.1| 2.7.11.17| 3.1.3.16 | actin filament| calcineurin complex| cell division site| cell division site part| cell leading edge| centriole| cilium| cilium part| contractile fiber| contractile fiber part| contractile ring| extracellular membrane-bounded organelle| lamellipodium| leading edge membrane| mast cell granule| microtubule organizing center part| myosin complex| nonmotile primary cilium| phagocytic cup| protein serine/threonine phosphatase complex| ruffle| sarcoplasm| sarcoplasmic reticulum| site of polarized growth | G-protein beta/gamma-subunit complex binding| RAGE receptor binding| S100 protein binding| actin-dependent ATPase activity| calcium channel activity| calcium ion binding| calcium ion transmembrane transporter activity| calcium sensitive guanylate cyclase activator activity| calcium-dependent protein binding| cation channel activity| cyclase regulator activity| divalent inorganic cation transmembrane transporter activity| glutamate receptor binding| guanylate cyclase activator activity| heterotrimeric G-protein binding| ion channel binding| phosphatase regulator activity| protein serine/threonine phosphatase activity| structural constituent of muscle | Golgi localization| Rac protein signal transduction| actin filament bundle assembly| actin filament bundle organization| actin filament-based movement| actin-myosin filament sliding| activation of cysteine-type endopeptidase activity| actomyosin structure organization| calcium ion transmembrane transport| calcium-mediated signaling| cellular component assembly involved in morphogenesis| cellular component morphogenesis| cellular membrane organization| cellular response to acidity| cellular response to nerve growth factor stimulus| cytoplasmic microtubule organization| detection of abiotic stimulus| detection of calcium ion| detection of external stimulus| detection of light stimulus| detection of stimulus| divalent inorganic cation transport| establishment of protein localization to membrane| establishment of protein localization to plasma membrane| fruiting body development in response to starvation| heart contraction| homotypic cell-cell adhesion| leukocyte aggregation| leukocyte cell-cell adhesion| leukocyte migration involved in inflammatory response| mast cell degranulation| mast cell mediated immunity| microtubule bundle formation| microtubule-based process| mitochondrion localization| muscle cell development| muscle cell differentiation| muscle cell fate specification| muscle structure development| muscle system process| muscle tissue development| myeloid leukocyte activation| myofibril assembly| negative regulation of microtubule depolymerization| negative regulation of microtubule polymerization or depolymerization| negative regulation of neuron projection development| negative regulation of protein complex disassembly| negative regulation of protein depolymerization| negative regulation of protein modification process| neutrophil chemotaxis| peroxisome localization| phagocytosis, engulfment| phototransduction| positive regulation of G1/S transition of mitotic cell cycle| positive regulation of NF-kappaB transcription factor activity| positive regulation of T cell migration| positive regulation of T cell proliferation| positive regulation of calcineurin-NFAT signaling cascade| positive regulation of cell activation| positive regulation of cell cycle phase transition| positive regulation of cyclase activity| positive regulation of glycoprotein biosynthetic process| positive regulation of granulocyte differentiation| positive regulation of guanylate cyclase activity| positive regulation of intracellular transport| positive regulation of intrinsic apoptotic signaling pathway| positive regulation of ion transmembrane transporter activity| positive regulation of leukocyte chemotaxis| positive regulation of leukocyte migration| positive regulation of leukocyte proliferation| positive regulation of locomotion| positive regulation of lyase activity| positive regulation of lymphocyte migration| positive regulation of lymphocyte proliferation| positive regulation of mitotic cell cycle phase transition| positive regulation of monocyte chemotaxis| positive regulation of response to external stimulus| positive regulation of smooth muscle cell chemotaxis| positive regulation of smooth muscle cell migration| positive regulation of smooth muscle cell proliferation| positive regulation of transporter activity| protein localization to membrane| protein polymerization| protein stabilization| protein targeting to membrane| protein targeting to plasma membrane| regulation of G1/S transition of mitotic cell cycle| regulation of T cell migration| regulation of T cell proliferation| regulation of cGMP biosynthetic process| regulation of cGMP metabolic process| regulation of calcineurin-NFAT signaling cascade| regulation of calcium-mediated signaling| regulation of cyclase activity| regulation of cyclic nucleotide metabolic process| regulation of endopeptidase activity| regulation of glycoprotein biosynthetic process| regulation of granulocyte differentiation| regulation of guanylate cyclase activity| regulation of intrinsic apoptotic signaling pathway| regulation of ion transmembrane transport| regulation of ion transmembrane transporter activity| regulation of leukocyte chemotaxis| regulation of leukocyte migration| regulation of lyase activity| regulation of lymphocyte proliferation| regulation of megakaryocyte differentiation| regulation of microtubule depolymerization| regulation of monocyte chemotaxis| regulation of mononuclear cell proliferation| regulation of neuron projection development| regulation of nucleotide biosynthetic process| regulation of nucleotide metabolic process| regulation of protein depolymerization| regulation of purine nucleotide metabolic process| regulation of rhodopsin mediated signaling pathway| regulation of sequence-specific DNA binding transcription factor activity| regulation of smooth muscle cell chemotaxis| regulation of smooth muscle cell migration| regulation of smooth muscle cell proliferation| regulation of sodium ion transmembrane transport| regulation of sodium ion transmembrane transporter activity| regulation of sodium:hydrogen antiporter activity| regulation of transmembrane transport| regulation of transmembrane transporter activity| regulation of transporter activity| response to acidity| response to calcium ion| rhodopsin mediated signaling pathway| ruffle assembly| ruffle organization| second-messenger-mediated signaling| stomatal movement| striated muscle cell development| striated muscle cell differentiation| systemic acquired resistance |
| 532 | PF12636 | Protein of unknown function (DUF3781) | No Pfam Clan | 84 (19) | 73 | 73 | (1) beta-beta-alpha zinc fingers [g.37.1] (15-73) |
(1) beta-beta-alpha zinc fingers [g.37] |
g.37.1(15-73) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | No information | chromatin binding | inflammatory response to antigenic stimulus| mesenchyme development| negative regulation of T-helper 2 cell differentiation| negative regulation of T-helper cell differentiation| negative regulation of type 2 immune response| palate development| positive regulation of gene expression| positive regulation of nucleobase-containing compound metabolic process| regulation of T cell differentiation| regulation of T-helper 2 cell differentiation| regulation of T-helper cell differentiation| regulation of alpha-beta T cell activation| regulation of leukocyte activation| regulation of leukocyte differentiation| regulation of lymphocyte activation| regulation of lymphocyte differentiation| regulation of type 2 immune response| tongue development |
| 533 | PF12520 | Protein of unknown function (DUF3723) | No Pfam Clan | 202 (20) | 511 | 468 | (1) ARM repeat [a.118.1] (15-449) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(15-449) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 534 | PF04819 | Family of unknown function (DUF716) | No Pfam Clan | 388 (32) | 137 | 141 | (1) Family A G protein-coupled receptor-like [f.13.1] (1-136) |
(1) Family A G protein-coupled receptor-like [f.13] |
NO PREDICTION | f.13.1(1-136) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | cilium| cilium membrane| cilium part| early endosome| integral to plasma membrane| intrinsic to plasma membrane| photoreceptor inner segment| photoreceptor inner segment membrane| photoreceptor outer segment| photoreceptor outer segment membrane| primary cilium | G-protein coupled receptor activity| amide binding| catecholamine binding| chemokine receptor activity| molecular transducer activity| neuropeptide binding| odorant binding| peptide binding| pheromone binding| receptor activity| retinal binding| signaling receptor activity | G-protein coupled receptor signaling pathway| calcium ion homeostasis| cellular calcium ion homeostasis| cellular divalent inorganic cation homeostasis| cellular response to cytokine stimulus| cellular response to disaccharide stimulus| cellular response to sucrose stimulus| chemokine-mediated signaling pathway| complement receptor mediated signaling pathway| detection of chemical stimulus| detection of chemical stimulus involved in sensory perception| detection of light stimulus| detection of stimulus| detection of stimulus involved in sensory perception| diet induced thermogenesis| divalent inorganic cation homeostasis| germ cell migration| histamine secretion| histamine transport| hormone secretion| inflammatory response| mRNA transcription| mRNA transcription from RNA polymerase II promoter| negative regulation of nucleotide biosynthetic process| negative regulation of nucleotide metabolic process| negative regulation of purine nucleotide metabolic process| nonassociative learning| platelet activation| positive regulation of MAPK cascade| positive regulation of cyclase activity| positive regulation of cyclic nucleotide biosynthetic process| positive regulation of cytokinesis| positive regulation of intracellular protein kinase cascade| positive regulation of leukocyte degranulation| positive regulation of lyase activity| positive regulation of mast cell activation| positive regulation of mast cell activation involved in immune response| positive regulation of mucus secretion| positive regulation of multicellular organismal metabolic process| positive regulation of nucleotide biosynthetic process| positive regulation of nucleotide metabolic process| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of purine nucleotide metabolic process| purinergic receptor signaling pathway| regulation of ERK1 and ERK2 cascade| regulation of MAPK cascade| regulation of cAMP biosynthetic process| regulation of cAMP metabolic process| regulation of cyclase activity| regulation of cyclic nucleotide biosynthetic process| regulation of cyclic nucleotide metabolic process| regulation of interleukin-8 secretion| regulation of intracellular protein kinase cascade| regulation of leukocyte degranulation| regulation of lyase activity| regulation of mast cell activation| regulation of mast cell activation involved in immune response| regulation of mucus secretion| regulation of multicellular organismal metabolic process| regulation of myeloid leukocyte mediated immunity| regulation of nucleotide biosynthetic process| regulation of nucleotide metabolic process| regulation of purine nucleotide biosynthetic process| regulation of purine nucleotide metabolic process| regulation of systemic arterial blood pressure by norepinephrine-epinephrine| regulation of vasoconstriction| response to pheromone| sensory perception| sensory perception of chemical stimulus |
| 535 | PF11696 | Protein of unknown function (DUF3292) | No Pfam Clan | 115 (8) | 642 | 641 | (1) ARM repeat [a.118.1] (39-502) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(39-502) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 536 | PF12964 | Protein of unknown function (DUF3853) | HTH (CL0123) | 97 (8) | 96 | 96 | (1) Homeodomain-like [a.4.1] (47-70) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.4.1(47-70) | 1 | No information | Bacteria | No information | transcription factor complex | chromatin binding| nucleic acid binding transcription factor activity| transposase activity | activin receptor signaling pathway| cell fate commitment| cell fate specification| chordate embryonic development| diencephalon development| embryonic morphogenesis| endoderm development| eye photoreceptor cell differentiation| negative regulation of developmental process| neural tube development| neuron fate commitment| nodal signaling pathway| pancreas development| pattern specification process| positive regulation of neuron differentiation| regulation of cell fate commitment| regulation of epithelial cell differentiation| regulation of gastrulation| retina development in camera-type eye| sensory organ development| somitogenesis| transmembrane receptor protein serine/threonine kinase signaling pathway| transposition| transposition, DNA-mediated| trophectodermal cell differentiation |
| 537 | PF07079 | Protein of unknown function (DUF1347) | No Pfam Clan | 40 (6) | 550 | 550 | (1) ARM repeat [a.118.1] (1-548) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(1-548) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 538 | PF14344 | Domain of unknown function (DUF4397) | No Pfam Clan | 801 (91) | 122 | 123 | (1) Subtilisin-like [c.41.1] (2-84) |
(1) Subtilisin-like [c.41] |
c.41.1(2-84) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 3.4.14.10| 3.4.14.9| 3.4.21.100| 3.4.21.110| 3.4.21.61| 3.4.21.62| 3.4.21.64| 3.4.21.66| 3.4.21.75 | No information | No information | No information |
| 539 | PF13803 | Domain of unknown function (DUF4184) | PhosC-NucP1 (CL0368) | 172 (38) | 247 | 243 | (1) Phospholipase C/P1 nuclease [a.124.1] (INDIRECT) |
(1) Phospholipase C/P1 nuclease [a.124] |
NO PREDICTION | a.124.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 3.1.30.1| 3.1.4.3 | No information | nuclease activity | No information |
| 540 | PF04575 | Protein of unknown function (DUF560) | MBB (CL0193) | 575 (22) | 285 | 291 | (1) Porins [f.4.3] (1-291) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | f.4.3(1-291) | NO PREDICTION | 1 | No information | Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 541 | PF09948 | Predicted metal-binding integral membrane protein (DUF2182) | No Pfam Clan | 254 (51) | 191 | 186 | (1) Acid phosphatase/Vanadium-dependent haloperoxidase [a.111.1] (1-190) |
(1) Acid phosphatase/Vanadium-dependent haloperoxidase [a.111] |
NO PREDICTION | a.111.1(1-190) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | 1.11.1.10| 1.11.1.18| 3.1.3.2 | intrinsic to organelle membrane | inositol phosphoceramide synthase activity| lipid phosphatase activity| phosphatase activity| phosphatidate phosphatase activity| sphingosine-1-phosphate phosphatase activity| sugar-phosphatase activity| sugar-terminal-phosphatase activity | dephosphorylation| germ cell migration| membrane lipid biosynthetic process| membrane lipid metabolic process| phospholipid metabolic process| sphingolipid biosynthetic process| sphingolipid metabolic process |
| 542 | PF06685 | Protein of unknown function (DUF1186) | No Pfam Clan | 84 (7) | 249 | 185 | (1) ARM repeat [a.118.1] (15-241) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(15-241) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 543 | PF10686 | Protein of unknown function (DUF2493) | No Pfam Clan | 308 (34) | 71 | 71 | (1) TPR-like [a.118.8] (3-70) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(3-70) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Viruses|Archaea | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 544 | PF06157 | Protein of unknown function (DUF973) | No Pfam Clan | 109 (8) | 285 | 277 | (1) Bacterial photosystem II reaction centre, L and M subunits [f.26.1] (INDIRECT) |
(1) Bacterial photosystem II reaction centre, L and M subunits [f.26] |
NO PREDICTION | f.26.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | No information | No information | No information | No information |
| 545 | PF04276 | Protein of unknown function (DUF443) | No Pfam Clan | 1105 (22) | 199 | 196 | (1) Family A G protein-coupled receptor-like [f.13.1] (1-188) |
(1) Family A G protein-coupled receptor-like [f.13] |
NO PREDICTION | f.13.1(1-188) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | cilium| cilium membrane| cilium part| early endosome| integral to plasma membrane| intrinsic to plasma membrane| photoreceptor inner segment| photoreceptor inner segment membrane| photoreceptor outer segment| photoreceptor outer segment membrane| primary cilium | G-protein coupled receptor activity| amide binding| catecholamine binding| chemokine receptor activity| molecular transducer activity| neuropeptide binding| odorant binding| peptide binding| pheromone binding| receptor activity| retinal binding| signaling receptor activity | G-protein coupled receptor signaling pathway| calcium ion homeostasis| cellular calcium ion homeostasis| cellular divalent inorganic cation homeostasis| cellular response to cytokine stimulus| cellular response to disaccharide stimulus| cellular response to sucrose stimulus| chemokine-mediated signaling pathway| complement receptor mediated signaling pathway| detection of chemical stimulus| detection of chemical stimulus involved in sensory perception| detection of light stimulus| detection of stimulus| detection of stimulus involved in sensory perception| diet induced thermogenesis| divalent inorganic cation homeostasis| germ cell migration| histamine secretion| histamine transport| hormone secretion| inflammatory response| mRNA transcription| mRNA transcription from RNA polymerase II promoter| negative regulation of nucleotide biosynthetic process| negative regulation of nucleotide metabolic process| negative regulation of purine nucleotide metabolic process| nonassociative learning| platelet activation| positive regulation of MAPK cascade| positive regulation of cyclase activity| positive regulation of cyclic nucleotide biosynthetic process| positive regulation of cytokinesis| positive regulation of intracellular protein kinase cascade| positive regulation of leukocyte degranulation| positive regulation of lyase activity| positive regulation of mast cell activation| positive regulation of mast cell activation involved in immune response| positive regulation of mucus secretion| positive regulation of multicellular organismal metabolic process| positive regulation of nucleotide biosynthetic process| positive regulation of nucleotide metabolic process| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of purine nucleotide metabolic process| purinergic receptor signaling pathway| regulation of ERK1 and ERK2 cascade| regulation of MAPK cascade| regulation of cAMP biosynthetic process| regulation of cAMP metabolic process| regulation of cyclase activity| regulation of cyclic nucleotide biosynthetic process| regulation of cyclic nucleotide metabolic process| regulation of interleukin-8 secretion| regulation of intracellular protein kinase cascade| regulation of leukocyte degranulation| regulation of lyase activity| regulation of mast cell activation| regulation of mast cell activation involved in immune response| regulation of mucus secretion| regulation of multicellular organismal metabolic process| regulation of myeloid leukocyte mediated immunity| regulation of nucleotide biosynthetic process| regulation of nucleotide metabolic process| regulation of purine nucleotide biosynthetic process| regulation of purine nucleotide metabolic process| regulation of systemic arterial blood pressure by norepinephrine-epinephrine| regulation of vasoconstriction| response to pheromone| sensory perception| sensory perception of chemical stimulus |
| 546 | PF11658 | Protein of unknown function (DUF3260) | No Pfam Clan | 576 (23) | 518 | 552 | (1) Alkaline phosphatase-like [c.76.1] (229-506) |
(1) Alkaline phosphatase-like [c.76] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.76.1(229-506) | 1 | No information | Bacteria | 3.1.3.1| 3.1.6.1| 3.1.6.12| 3.1.6.2| 3.1.6.8| 3.11.1.2| 3.6.1.9| 5.4.2.1 | endoplasmic reticulum lumen| extracellular membrane-bounded organelle| extracellular organelle| lysosomal lumen| vacuolar lumen| vacuolar part | alkaline phosphatase activity| glycerophosphocholine cholinephosphodiesterase activity| phospholipase activity| phosphoric diester hydrolase activity| sulfuric ester hydrolase activity| zinc ion binding | aminoglycan catabolic process| aminoglycan metabolic process| bone development| bone morphogenesis| choline metabolic process| dephosphorylation| endochondral bone morphogenesis| endochondral ossification| ethanolamine-containing compound metabolic process| glycolipid metabolic process| glycoprotein metabolic process| glycosaminoglycan catabolic process| glycosaminoglycan metabolic process| heparan sulfate proteoglycan metabolic process| membrane lipid metabolic process| organ morphogenesis| ossification| post-translational protein modification| proteoglycan metabolic process| replacement ossification| response to antibiotic| response to organic cyclic compound| response to toxic substance| skeletal system development| skeletal system morphogenesis| sphingolipid metabolic process| sulfur compound catabolic process |
| 547 | PF12452 | Protein of unknown function (DUF3685) | No Pfam Clan | 133 (37) | 193 | 193 | (1) GTPase activation domain, GAP [a.116.1] (6-191) |
(1) GTPase activation domain, GAP [a.116] |
NO PREDICTION | a.116.1(6-191) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 3.1.3.36 | No information | GTPase regulator activity| Rho GTPase activator activity| nucleoside-triphosphatase regulator activity| small GTPase regulator activity | positive regulation of GTPase activity| positive regulation of Ras GTPase activity| positive regulation of Rho GTPase activity| positive regulation of hydrolase activity| regulation of GTP catabolic process| regulation of GTPase activity| regulation of Ras GTPase activity| regulation of Rho GTPase activity| regulation of Rho protein signal transduction| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| regulation of small GTPase mediated signal transduction |
| 548 | PF06974 | Protein of unknown function (DUF1298) | No Pfam Clan | 691 (14) | 153 | 153 | (1) CoA-dependent acyltransferases [c.43.1] (6-149) |
(1) CoA-dependent acyltransferases [c.43] |
c.43.1(6-149) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Viruses|Archaea | 2.3.1.12| 2.3.1.137| 2.3.1.160| 2.3.1.168| 2.3.1.21| 2.3.1.28| 2.3.1.6| 2.3.1.61| 2.3.1.7 | No information | transferase activity, transferring acyl groups other than amino-acyl groups | No information |
| 549 | PF11207 | Protein of unknown function (DUF2989) | No Pfam Clan | 162 (26) | 203 | 205 | (1) HCP-like [a.118.18] (139-202) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | NO PREDICTION | a.118.18(57-78)| a.118.18(139-202) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 550 | PF09536 | Protein of unknown function (DUF2378) | No Pfam Clan | 82 (27) | 178 | 182 | (1) Ligand-binding domain in the NO signalling and Golgi transport [d.278.1] (9-177) |
(1) Ligand-binding domain in the NO signalling and Golgi transport [d.278] |
NO PREDICTION | d.278.1(9-177) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | TRAPP complex | No information | ER to Golgi vesicle-mediated transport| Golgi vesicle transport |
| 551 | PF08852 | Protein of unknown function (DUF1822) | TPR (CL0020) | 120 (27) | 368 | 380 | (1) ARM repeat [a.118.1] (196-273) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | NO PREDICTION | a.118.1(196-273) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 552 | PF04747 | Protein of unknown function, DUF612 | No Pfam Clan | 50 (2) | 510 | 489 | (1) Rap30/74 interaction domains [b.65.1] (INDIRECT) (2) "Winged helix" DNA-binding domain [a.4.5] (INDIRECT) |
(1) DNA/RNA-binding 3-helical bundle [a.4] (2) triple barrel [b.65] |
NO PREDICTION | b.65.1(INDIRECT)| a.4.5(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | cytosolic small ribosomal subunit| small ribosomal subunit | nucleic acid binding transcription factor activity| transcription regulatory region DNA binding | CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production |
| 553 | PF13211 | Protein of unknown function (DUF4019) | No Pfam Clan | 143 (34) | 105 | 103 | (1) NTF2-like [d.17.4] (1-103) |
(1) Cystatin-like [d.17] |
NO PREDICTION | d.17.4(1-103) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 3.3.2.8| 4.2.1.94| 5.3.3.1 | T-tubule| axon initial segment| axon part| cell-cell contact zone| main axon| neuromuscular junction| nuclear envelope| pore complex| sarcolemma | Ran GTPase binding | G1/S transition of mitotic cell cycle| RNA export from nucleus| RNA localization| antibiotic biosynthetic process| antibiotic metabolic process| blood circulation| calcium ion transport| cardiac muscle contraction| cell cycle phase| cell cycle phase transition| drug metabolic process| establishment of RNA localization| heart contraction| heart process| interphase| interphase of mitotic cell cycle| mitotic cell cycle phase transition| muscle contraction| muscle system process| nuclear transport| nucleobase-containing compound transport| nucleocytoplasmic transport| peptidyl-serine phosphorylation| poly(A)+ mRNA export from nucleus| positive regulation of antimicrobial peptide biosynthetic process| positive regulation of cellular amide metabolic process| protein autophosphorylation| regulation of antimicrobial humoral response| regulation of antimicrobial peptide biosynthetic process| regulation of antimicrobial peptide production| regulation of cellular amide metabolic process| regulation of humoral immune response| regulation of production of molecular mediator of immune response| regulation of sodium ion transport| striated muscle contraction |
| 554 | PF15135 | Uncharacterised protein UPF0515 | No Pfam Clan | 53 (4) | 278 | 272 | (1) GlpP-like [c.1.29] (95-262) |
(1) TIM beta/alpha-barrel [c.1] |
c.1.29(95-262) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 555 | PF07482 | Domain of Unknown Function (DUF1522) | No Pfam Clan | 54 (20) | 109 | 111 | (1) Phase 1 flagellin [e.32.1] (1-109) |
(1) Phase 1 flagellin [e.32] |
e.32.1(1-109) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | bacterial-type flagellum| bacterial-type flagellum part | No information | ciliary or bacterial-type flagellar motility| localization of cell |
| 556 | PF05811 | Eukaryotic protein of unknown function (DUF842) | No Pfam Clan | 215 (17) | 131 | 119 | (1) Metallo-dependent hydrolases [c.1.9] (3-118) |
(1) TIM beta/alpha-barrel [c.1] |
c.1.9(3-118) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 2.7.1.2| 2.7.1.29| 3.1.1.57| 3.1.3.48| 3.1.8.1| 3.4.13.19| 3.5.1.25| 3.5.1.5| 3.5.1.81| 3.5.1.82| 3.5.2.18| 3.5.2.2| 3.5.2.3| 3.5.2.5| 3.5.2.7| 3.5.4.1| 3.5.4.2| 3.5.4.3| 3.5.4.4| 3.5.99.4| 4.1.1.18| 4.1.1.32| 4.1.1.45| 5.3.1.12 | apical part of cell | GPI anchor binding| adenosine deaminase activity| amino acid binding| aminocarboxymuconate-semialdehyde decarboxylase activity| carbon-carbon lyase activity| carboxylic acid binding| cysteine-type endopeptidase inhibitor activity| cysteine-type endopeptidase inhibitor activity involved in apoptotic process| cysteine-type endopeptidase regulator activity involved in apoptotic process| deaminase activity| deoxyribonuclease activity| dipeptidase activity| endopeptidase inhibitor activity| endopeptidase regulator activity| exopeptidase activity| glycolipid binding| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines| metallodipeptidase activity| metalloexopeptidase activity| metallopeptidase activity| peptidase inhibitor activity| peptidase regulator activity| phosphatidylinositol binding| zinc ion binding | adenosine catabolic process| adenosine metabolic process| apoptotic process| cellular response to calcium ion| cellular response to drug| cellular response to metal ion| cellular response to nitric oxide| cellular response to reactive nitrogen species| cellular response to reactive oxygen species| drug metabolic process| glycosyl compound biosynthetic process| glycosyl compound catabolic process| homocysteine metabolic process| hypoxanthine biosynthetic process| inosine biosynthetic process| inosine metabolic process| negative regulation of apoptotic process| negative regulation of cell death| negative regulation of cell migration| negative regulation of cell motility| negative regulation of cellular component movement| negative regulation of cysteine-type endopeptidase activity| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process| negative regulation of endopeptidase activity| negative regulation of hydrolase activity| negative regulation of locomotion| negative regulation of peptidase activity| negative regulation of programmed cell death| nucleobase biosynthetic process| nucleobase metabolic process| nucleoside biosynthetic process| purine ribonucleoside catabolic process| purine-containing compound biosynthetic process| quinolinate metabolic process| regulation of cell migration| regulation of cell motility| regulation of cellular component movement| regulation of cysteine-type endopeptidase activity| regulation of cysteine-type endopeptidase activity involved in apoptotic process| regulation of endopeptidase activity| regulation of locomotion| regulation of peptidase activity| response to calcium ion| response to drug| response to nitric oxide| sulfur amino acid metabolic process |
| 557 | PF12463 | Protein of unknown function (DUF3689) | No Pfam Clan | 115 (8) | 303 | 307 | (1) ARM repeat [a.118.1] (1-297) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(1-297) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 558 | PF11297 | Protein of unknown function (DUF3098) | No Pfam Clan | 232 (28) | 69 | 69 | (1) Cytochrome c oxidase subunit II-like, transmembrane region [f.17.2] (5-68) |
(1) Transmembrane helix hairpin [f.17] |
NO PREDICTION | f.17.2(5-68) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Bacteria | No information | respiratory chain| respiratory chain complex IV | No information | No information |
| 559 | PF15087 | Protein of unknown function (DUF4551) | No Pfam Clan | 68 (7) | 617 | 635 | (1) ARM repeat [a.118.1] (309-616) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(309-616) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 560 | PF06299 | Protein of unknown function (DUF1045) | 2H (CL0247) | 281 (43) | 160 | 161 | (1) LigT-like [d.61.1] (1-152) |
(1) LigT-like [d.61] |
NO PREDICTION | d.61.1(1-152) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 3.1.4.37| 6.5.1.3 | No information | No information | No information |
| 561 | PF07754 | Domain of unknown function (DUF1610) | Zn_Beta_Ribbon (CL0167) | 205 (21) | 24 | 24 | (1) Zinc beta-ribbon [g.41.3] (1-24) |
(1) Rubredoxin-like [g.41] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | g.41.3(1-24) | 1 | No information | Archaea | No information | No information | No information | No information |
| 562 | PF06082 | Bacterial putative lipoprotein (DUF940) | No Pfam Clan | 1147 (38) | 658 | 682 | (1) Porins [f.4.3] (2-648) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.3(2-648) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | cell envelope| cell outer membrane| external encapsulating structure part| outer membrane | amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity | fatty acid transport| lipid localization| long-chain fatty acid transport |
| 563 | PF11081 | Protein of unknown function (DUF2890) | No Pfam Clan | 154 (18) | 187 | 175 | (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (5-113) |
(1) 8-bladed beta-propeller [b.70] |
b.70.1(5-113) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Viruses | 1.1.2.7| 1.1.98.1 | No information | endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity | ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein |
| 564 | PF13699 | Domain of unknown function (DUF4157) | Peptidase_MA (CL0126) | 470 (185) | 79 | 78 | (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (20-78) |
(1) Zincin-like [d.92] |
NO PREDICTION | d.92.1(20-78) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 | cortical granule | glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity | biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing |
| 565 | PF09855 | Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) | No Pfam Clan | 259 (18) | 64 | 64 | (1) Zn-binding ribosomal proteins [g.41.8] (36-53) |
(1) Rubredoxin-like [g.41] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | g.41.8(36-53) | 1 | No information | Eukaryota|Bacteria|Archaea | No information | mitochondrial large ribosomal subunit| mitochondrial ribosome| organellar ribosome | No information | macropinocytosis| pinocytosis |
| 566 | PF14224 | Domain of unknown function (DUF4331) | No Pfam Clan | 155 (47) | 359 | 470 | (1) Putative isomerase YbhE [b.69.11] (16-310) |
(1) 7-bladed beta-propeller [b.69] |
NO PREDICTION | b.69.11(16-310) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 567 | PF06802 | Protein of unknown function (DUF1231) | No Pfam Clan | 51 (3) | 340 | 340 | (1) Clathrin heavy-chain terminal domain [b.69.6] (15-336) |
(1) 7-bladed beta-propeller [b.69] |
NO PREDICTION | b.69.6(15-336) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Viruses | No information | No information | No information | No information |
| 568 | PF12969 | Domain of Unknown Function with PDB structure (DUF3857) | No Pfam Clan | 529 (94) | 177 | 176 | (1) TPR-like [a.118.8] (4-125) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(4-125) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 569 | PF10223 | Uncharacterized conserved protein (DUF2181) | No Pfam Clan | 192 (10) | 244 | 257 | (1) PLC-like phosphodiesterases [c.1.18] (8-241) |
(1) TIM beta/alpha-barrel [c.1] |
NO PREDICTION | c.1.18(8-241) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 3.1.4.1| 3.1.4.11| 3.1.4.41| 3.1.4.46| 4.6.1.13 | No information | glycerophosphodiester phosphodiesterase activity| lipase activity| phospholipase activity| phosphoric diester hydrolase activity | phospholipid metabolic process |
| 570 | PF13105 | Protein of unknown function (DUF3959) | No Pfam Clan | 82 (5) | 239 | 245 | (1) MFS general substrate transporter [f.38.1] (20-160) |
(1) MFS general substrate transporter [f.38] |
NO PREDICTION | NO PREDICTION | f.38.1(20-160) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane | calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity | amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport |
| 571 | PF06025 | Domain of Unknown Function (DUF913) | No Pfam Clan | 332 (11) | 379 | 445 | (1) ARM repeat [a.118.1] (1-373) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(1-373) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 572 | PF09943 | Uncharacterized protein conserved in archaea (DUF2175) | No Pfam Clan | 32 (10) | 101 | 98 | (1) Glucocorticoid receptor-like (DNA-binding domain) [g.39.1] (1-32) |
(1) Glucocorticoid receptor-like (DNA-binding domain) [g.39] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | g.39.1(1-32) | 1 | No information | Bacteria|Archaea | 2.7.1.21| 4.2.99.18 | No information | No information | No information |
| 573 | PF05263 | Protein of unknown function (DUF722) | No Pfam Clan | 87 (7) | 130 | 135 | (1) Sigma3 and sigma4 domains of RNA polymerase sigma factors [a.4.13] (71-133) |
(1) DNA/RNA-binding 3-helical bundle [a.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.4.13(71-133) | 1 | No information | Bacteria|Viruses | No information | No information | No information | No information |
| 574 | PF05947 | Bacterial protein of unknown function (DUF879) | No Pfam Clan | 1615 (134) | 602 | 570 | (1) Galactose mutarotase-like [b.30.5] (83-600) |
(1) Supersandwich [b.30] |
NO PREDICTION | b.30.5(83-600) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | YES | Eukaryota|Bacteria|Viruses | 4.2.2.10| 4.2.2.13| 5.1.3.15| 5.1.3.3 | No information | aldose 1-epimerase activity| racemase and epimerase activity| racemase and epimerase activity, acting on carbohydrates and derivatives | galactose metabolic process |
| 575 | PF11883 | Domain of unknown function (DUF3403) | No Pfam Clan | 401 (31) | 48 | 50 | (1) Protein kinase-like (PK-like) [d.144.1] (2-30) |
(1) Protein kinase-like (PK-like) [d.144] |
d.144.1(2-30) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 2.7.1.100| 2.7.1.137| 2.7.1.153| 2.7.1.163| 2.7.1.17| 2.7.1.32| 2.7.1.39| 2.7.1.95| 2.7.10.1| 2.7.10.2| 2.7.11.1| 2.7.11.11| 2.7.11.13| 2.7.11.14| 2.7.11.15| 2.7.11.16| 2.7.11.17| 2.7.11.19| 2.7.11.21| 2.7.11.22| 2.7.11.24| 2.7.11.25| 2.7.11.26| 2.7.11.30| 2.7.11.7| 2.7.12.1| 2.7.12.2 | cAMP-dependent protein kinase complex| calcium- and calmodulin-dependent protein kinase complex| cell-substrate adherens junction| cyclin-dependent protein kinase holoenzyme complex| neuromuscular junction| protein kinase CK2 complex| spindle| spindle pole | ATP binding| adenyl nucleotide binding| adenyl ribonucleotide binding| calmodulin binding| cyclin binding| kinase activator activity| kinase regulator activity| magnesium ion binding| molecular transducer activity| nucleoside binding| phosphoprotein binding| phosphotransferase activity, alcohol group as acceptor| phosphotyrosine binding| protein kinase activator activity| protein kinase activity| protein kinase regulator activity| purine nucleoside binding| purine nucleotide binding| purine ribonucleoside binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| receptor signaling protein activity| ribonucleoside binding| ribonucleotide binding | CDP-choline pathway| DNA damage checkpoint| activation of innate immune response| cell cycle phase transition| cell division| cell morphogenesis| cellular component morphogenesis| cellular process involved in reproduction| cellular response to biotic stimulus| cellular response to unfolded protein| embryonic placenta development| enzyme linked receptor protein signaling pathway| ethanolamine-containing compound metabolic process| fruiting body development| germ cell development| glycerolipid biosynthetic process| glycerolipid metabolic process| glycerophospholipid biosynthetic process| heart contraction| heart process| hemostasis| innate immune response| innate immune response-activating signal transduction| intracellular protein kinase cascade| labyrinthine layer development| lens development in camera-type eye| lipopolysaccharide-mediated signaling pathway| microtubule cytoskeleton organization| mitotic cell cycle phase transition| negative regulation of cell cycle process| neurotrophin signaling pathway| oogenesis| organelle fission| organic hydroxy compound biosynthetic process| peptidyl-serine modification| peptidyl-threonine modification| phosphatidylcholine biosynthetic process| phosphatidylcholine metabolic process| phosphatidylinositol-3-phosphate biosynthetic process| phospholipid biosynthetic process| positive regulation of MAP kinase activity| positive regulation of cellular protein metabolic process| positive regulation of determination of dorsal identity| positive regulation of developmental growth| positive regulation of innate immune response| positive regulation of intracellular protein transport| positive regulation of myoblast fusion| positive regulation of myotube differentiation| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of phosphorylation| positive regulation of protein kinase activity| positive regulation of protein phosphorylation| positive regulation of skeletal muscle cell differentiation| positive regulation of syncytium formation by plasma membrane fusion| positive regulation of transferase activity| positive regulation of unidimensional cell growth| programmed necrotic cell death| protein phosphorylation| regulation of Golgi inheritance| regulation of MAPK cascade| regulation of Wnt receptor signaling pathway| regulation of adult chitin-containing cuticle pigmentation| regulation of cell size| regulation of cellular response to stress| regulation of chitin-based cuticle tanning| regulation of early endosome to late endosome transport| regulation of fibroblast apoptotic process| regulation of innate immune response| regulation of intracellular protein kinase cascade| regulation of kinase activity| regulation of muscle cell differentiation| regulation of muscle organ development| regulation of muscle tissue development| regulation of protein kinase activity| regulation of reproductive process| regulation of skeletal muscle fiber development| regulation of sodium ion transport| regulation of transferase activity| response to cadmium ion| response to exogenous dsRNA| response to growth factor stimulus| response to molecule of bacterial origin| response to osmotic stress| salicylic acid biosynthetic process| salicylic acid metabolic process| spindle assembly| spindle midzone assembly| stomatal complex development| stress-activated protein kinase signaling cascade| striated muscle contraction| toll-like receptor signaling pathway |
| 576 | PF11557 | Protein of unknown function (DUF3233) | No Pfam Clan | 107 (6) | 328 | 331 | (1) Autotransporter [f.4.5] (45-327) |
(1) Transmembrane beta-barrels [f.4] |
NO PREDICTION | f.4.5(45-327) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 577 | PF09957 | Uncharacterized protein conserved in bacteria (DUF2191) | Met_repress (CL0057) | 685 (51) | 47 | 47 | (1) Ribbon-helix-helix [a.43.1] (2-40) |
(1) Ribbon-helix-helix [a.43] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | a.43.1(2-40) | 1 | No information | Eukaryota|Bacteria|Viruses|Archaea | No information | No information | No information | positive regulation of growth |
| 578 | PF13136 | Protein of unknown function (DUF3984) | No Pfam Clan | 72 (20) | 325 | 357 | (1) ssDNA viruses [b.121.5] (1-322) |
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | b.121.5(1-322) | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 579 | PF08928 | Domain of unknown function (DUF1910) | No Pfam Clan | 185 (16) | 117 | 126 | (1) PA2201 C-terminal domain-like [a.254.1] (89-126) |
(1) PA2201 C-terminal domain-like [a.254] |
NO PREDICTION | NO PREDICTION | a.254.1(89-126) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 580 | PF09933 | Predicted small integral membrane protein (DUF2165) | No Pfam Clan | 244 (25) | 160 | 162 | (1) Fumarate reductase respiratory complex transmembrane subunits [f.21.2] (1-159) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | f.21.2(1-159) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | 1.3.5.1 | fumarate reductase complex| mitochondrial respiratory chain| mitochondrial respiratory chain complex II| plasma membrane respiratory chain| plasma membrane respiratory chain complex II| respiratory chain| respiratory chain complex II| succinate dehydrogenase complex | cofactor binding| electron carrier activity| heme binding| oxidoreductase activity, acting on the CH-CH group of donors| quinone binding| succinate dehydrogenase activity| tetrapyrrole binding| ubiquinone binding | cellular respiration| electron transport chain| energy derivation by oxidation of organic compounds| mitochondrial ATP synthesis coupled electron transport| mitochondrial electron transport, succinate to ubiquinone| oxidative phosphorylation| tricarboxylic acid cycle |
| 581 | PF07274 | Protein of unknown function (DUF1440) | No Pfam Clan | 965 (27) | 135 | 137 | (1) Respiratory nitrate reductase 1 gamma chain [f.21.3] (37-102) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | NO PREDICTION | f.21.3(37-102) | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 582 | PF12263 | Protein of unknown function (DUF3611) | No Pfam Clan | 164 (21) | 183 | 182 | (1) Rhomboid-like [f.51.1] (3-180) |
(1) Rhomboid-like [f.51] |
NO PREDICTION | f.51.1(3-180) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 3.4.21.105 | No information | No information | No information |
| 583 | PF06744 | Protein of unknown function (DUF1215) | No Pfam Clan | 1351 (111) | 125 | 125 | (1) RNI-like [c.10.1] (8-111) |
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10] |
c.10.1(8-111) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | ubiquitin ligase complex | acid-amino acid ligase activity| small conjugating protein ligase activity| ubiquitin-protein ligase activity | cellular protein catabolic process| entrainment of circadian clock| entrainment of circadian clock by photoperiod| modification-dependent macromolecule catabolic process| photoperiodism| protein catabolic process| protein ubiquitination| proteolysis| regulation of circadian rhythm| ubiquitin-dependent protein catabolic process |
| 584 | PF12036 | Protein of unknown function (DUF3522) | No Pfam Clan | 294 (24) | 186 | 181 | (1) Family A G protein-coupled receptor-like [f.13.1] (1-173) |
(1) Family A G protein-coupled receptor-like [f.13] |
NO PREDICTION | f.13.1(1-173) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | cilium| cilium membrane| cilium part| early endosome| integral to plasma membrane| intrinsic to plasma membrane| photoreceptor inner segment| photoreceptor inner segment membrane| photoreceptor outer segment| photoreceptor outer segment membrane| primary cilium | G-protein coupled receptor activity| amide binding| catecholamine binding| chemokine receptor activity| molecular transducer activity| neuropeptide binding| odorant binding| peptide binding| pheromone binding| receptor activity| retinal binding| signaling receptor activity | G-protein coupled receptor signaling pathway| calcium ion homeostasis| cellular calcium ion homeostasis| cellular divalent inorganic cation homeostasis| cellular response to cytokine stimulus| cellular response to disaccharide stimulus| cellular response to sucrose stimulus| chemokine-mediated signaling pathway| complement receptor mediated signaling pathway| detection of chemical stimulus| detection of chemical stimulus involved in sensory perception| detection of light stimulus| detection of stimulus| detection of stimulus involved in sensory perception| diet induced thermogenesis| divalent inorganic cation homeostasis| germ cell migration| histamine secretion| histamine transport| hormone secretion| inflammatory response| mRNA transcription| mRNA transcription from RNA polymerase II promoter| negative regulation of nucleotide biosynthetic process| negative regulation of nucleotide metabolic process| negative regulation of purine nucleotide metabolic process| nonassociative learning| platelet activation| positive regulation of MAPK cascade| positive regulation of cyclase activity| positive regulation of cyclic nucleotide biosynthetic process| positive regulation of cytokinesis| positive regulation of intracellular protein kinase cascade| positive regulation of leukocyte degranulation| positive regulation of lyase activity| positive regulation of mast cell activation| positive regulation of mast cell activation involved in immune response| positive regulation of mucus secretion| positive regulation of multicellular organismal metabolic process| positive regulation of nucleotide biosynthetic process| positive regulation of nucleotide metabolic process| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of purine nucleotide metabolic process| purinergic receptor signaling pathway| regulation of ERK1 and ERK2 cascade| regulation of MAPK cascade| regulation of cAMP biosynthetic process| regulation of cAMP metabolic process| regulation of cyclase activity| regulation of cyclic nucleotide biosynthetic process| regulation of cyclic nucleotide metabolic process| regulation of interleukin-8 secretion| regulation of intracellular protein kinase cascade| regulation of leukocyte degranulation| regulation of lyase activity| regulation of mast cell activation| regulation of mast cell activation involved in immune response| regulation of mucus secretion| regulation of multicellular organismal metabolic process| regulation of myeloid leukocyte mediated immunity| regulation of nucleotide biosynthetic process| regulation of nucleotide metabolic process| regulation of purine nucleotide biosynthetic process| regulation of purine nucleotide metabolic process| regulation of systemic arterial blood pressure by norepinephrine-epinephrine| regulation of vasoconstriction| response to pheromone| sensory perception| sensory perception of chemical stimulus |
| 585 | PF13777 | Domain of unknown function (DUF4173) | Cache (CL0165) | 229 (54) | 188 | 194 | (1) Bacterial photosystem II reaction centre, L and M subunits [f.26.1] (INDIRECT) |
(1) Bacterial photosystem II reaction centre, L and M subunits [f.26] |
NO PREDICTION | f.26.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
| 586 | PF09591 | Protein of unknown function (DUF2463) | No Pfam Clan | 38 (23) | 210 | 202 | (1) Family A G protein-coupled receptor-like [f.13.1] (1-209) |
(1) Family A G protein-coupled receptor-like [f.13] |
NO PREDICTION | f.13.1(1-209) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | cilium| cilium membrane| cilium part| early endosome| integral to plasma membrane| intrinsic to plasma membrane| photoreceptor inner segment| photoreceptor inner segment membrane| photoreceptor outer segment| photoreceptor outer segment membrane| primary cilium | G-protein coupled receptor activity| amide binding| catecholamine binding| chemokine receptor activity| molecular transducer activity| neuropeptide binding| odorant binding| peptide binding| pheromone binding| receptor activity| retinal binding| signaling receptor activity | G-protein coupled receptor signaling pathway| calcium ion homeostasis| cellular calcium ion homeostasis| cellular divalent inorganic cation homeostasis| cellular response to cytokine stimulus| cellular response to disaccharide stimulus| cellular response to sucrose stimulus| chemokine-mediated signaling pathway| complement receptor mediated signaling pathway| detection of chemical stimulus| detection of chemical stimulus involved in sensory perception| detection of light stimulus| detection of stimulus| detection of stimulus involved in sensory perception| diet induced thermogenesis| divalent inorganic cation homeostasis| germ cell migration| histamine secretion| histamine transport| hormone secretion| inflammatory response| mRNA transcription| mRNA transcription from RNA polymerase II promoter| negative regulation of nucleotide biosynthetic process| negative regulation of nucleotide metabolic process| negative regulation of purine nucleotide metabolic process| nonassociative learning| platelet activation| positive regulation of MAPK cascade| positive regulation of cyclase activity| positive regulation of cyclic nucleotide biosynthetic process| positive regulation of cytokinesis| positive regulation of intracellular protein kinase cascade| positive regulation of leukocyte degranulation| positive regulation of lyase activity| positive regulation of mast cell activation| positive regulation of mast cell activation involved in immune response| positive regulation of mucus secretion| positive regulation of multicellular organismal metabolic process| positive regulation of nucleotide biosynthetic process| positive regulation of nucleotide metabolic process| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of purine nucleotide metabolic process| purinergic receptor signaling pathway| regulation of ERK1 and ERK2 cascade| regulation of MAPK cascade| regulation of cAMP biosynthetic process| regulation of cAMP metabolic process| regulation of cyclase activity| regulation of cyclic nucleotide biosynthetic process| regulation of cyclic nucleotide metabolic process| regulation of interleukin-8 secretion| regulation of intracellular protein kinase cascade| regulation of leukocyte degranulation| regulation of lyase activity| regulation of mast cell activation| regulation of mast cell activation involved in immune response| regulation of mucus secretion| regulation of multicellular organismal metabolic process| regulation of myeloid leukocyte mediated immunity| regulation of nucleotide biosynthetic process| regulation of nucleotide metabolic process| regulation of purine nucleotide biosynthetic process| regulation of purine nucleotide metabolic process| regulation of systemic arterial blood pressure by norepinephrine-epinephrine| regulation of vasoconstriction| response to pheromone| sensory perception| sensory perception of chemical stimulus |
| 587 | PF13698 | Domain of unknown function (DUF4156) | No Pfam Clan | 839 (49) | 93 | 93 | (1) YbjQ-like [d.230.5] (16-69) |
(1) Dodecin subunit-like [d.230] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | d.230.5(16-69) | 1 | YES | Bacteria | No information | No information | No information | No information |
| 588 | PF14315 | Domain of unknown function (DUF4380) | No Pfam Clan | 128 (21) | 274 | 270 | (1) Galactose mutarotase-like [b.30.5] (1-270) |
(1) Supersandwich [b.30] |
NO PREDICTION | b.30.5(1-270) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria|Archaea | 4.2.2.10| 4.2.2.13| 5.1.3.15| 5.1.3.3 | No information | aldose 1-epimerase activity| racemase and epimerase activity| racemase and epimerase activity, acting on carbohydrates and derivatives | galactose metabolic process |
| 589 | PF12037 | Domain of unknown function (DUF3523) | No Pfam Clan | 270 (14) | 276 | 257 | (1) C-terminal domain of PLC-beta [h.4.10] (5-200) |
(1) Antiparallel coiled-coil [h.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | h.4.10(5-200) | NO PREDICTION | 1 | No information | Eukaryota | 3.1.4.11 | No information | No information | No information |
| 590 | PF12991 | Domain of unknown function, B. Theta Gene description (DUF3875) | No Pfam Clan | 294 (17) | 54 | 54 | (1) Ankyrin repeat [d.211.1] (1-53) |
(1) beta-hairpin-alpha-hairpin repeat [d.211] |
d.211.1(1-53) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | intercellular bridge | NF-kappaB binding| cyclin-dependent protein serine/threonine kinase inhibitor activity| cyclin-dependent protein serine/threonine kinase regulator activity| enzyme binding| histone deacetylase binding| kinase inhibitor activity| kinase regulator activity| protein kinase inhibitor activity| protein kinase regulator activity| protein serine/threonine kinase inhibitor activity | cell cycle arrest| cytoplasmic sequestering of protein| cytoplasmic sequestering of transcription factor| interphase| maintenance of location| maintenance of location in cell| maintenance of protein location| maintenance of protein location in cell| mitotic cell cycle phase transition| negative regulation of NF-kappaB transcription factor activity| negative regulation of cell cycle| negative regulation of intracellular protein transport| negative regulation of intracellular transport| negative regulation of kinase activity| negative regulation of phosphorylation| negative regulation of protein import into nucleus| negative regulation of protein kinase activity| negative regulation of protein serine/threonine kinase activity| negative regulation of protein transport| negative regulation of transcription factor import into nucleus| positive regulation of NF-kappaB transcription factor activity| positive regulation of transforming growth factor beta receptor signaling pathway| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway| regulation of I-kappaB kinase/NF-kappaB cascade| regulation of NF-kappaB import into nucleus| regulation of cyclin-dependent protein serine/threonine kinase activity| regulation of protein localization to nucleus| regulation of transcription factor import into nucleus| spleen development |
| 591 | PF13689 | Domain of unknown function (DUF4154) | No Pfam Clan | 788 (103) | 145 | 147 | (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (53-143) |
(1) P-loop containing nucleoside triphosphate hydrolases [c.37] |
c.37.1(53-143) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 | ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle | ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding | 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation |
| 592 | PF07550 | Protein of unknown function (DUF1533) | No Pfam Clan | 199 (25) | 65 | 60 | (1) TPR-like [a.118.8] (3-56) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(3-56) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 593 | PF11363 | Protein of unknown function (DUF3164) | No Pfam Clan | 235 (30) | 195 | 194 | (1) EF-hand [a.39.1] (26-174) |
(1) EF Hand-like [a.39] |
a.39.1(26-174) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Viruses | 1.13.12.5| 2.7.1.107| 2.7.11.1| 2.7.11.17| 3.1.3.16 | actin filament| calcineurin complex| cell division site| cell division site part| cell leading edge| centriole| cilium| cilium part| contractile fiber| contractile fiber part| contractile ring| extracellular membrane-bounded organelle| lamellipodium| leading edge membrane| mast cell granule| microtubule organizing center part| myosin complex| nonmotile primary cilium| phagocytic cup| protein serine/threonine phosphatase complex| ruffle| sarcoplasm| sarcoplasmic reticulum| site of polarized growth | G-protein beta/gamma-subunit complex binding| RAGE receptor binding| S100 protein binding| actin-dependent ATPase activity| calcium channel activity| calcium ion binding| calcium ion transmembrane transporter activity| calcium sensitive guanylate cyclase activator activity| calcium-dependent protein binding| cation channel activity| cyclase regulator activity| divalent inorganic cation transmembrane transporter activity| glutamate receptor binding| guanylate cyclase activator activity| heterotrimeric G-protein binding| ion channel binding| phosphatase regulator activity| protein serine/threonine phosphatase activity| structural constituent of muscle | Golgi localization| Rac protein signal transduction| actin filament bundle assembly| actin filament bundle organization| actin filament-based movement| actin-myosin filament sliding| activation of cysteine-type endopeptidase activity| actomyosin structure organization| calcium ion transmembrane transport| calcium-mediated signaling| cellular component assembly involved in morphogenesis| cellular component morphogenesis| cellular membrane organization| cellular response to acidity| cellular response to nerve growth factor stimulus| cytoplasmic microtubule organization| detection of abiotic stimulus| detection of calcium ion| detection of external stimulus| detection of light stimulus| detection of stimulus| divalent inorganic cation transport| establishment of protein localization to membrane| establishment of protein localization to plasma membrane| fruiting body development in response to starvation| heart contraction| homotypic cell-cell adhesion| leukocyte aggregation| leukocyte cell-cell adhesion| leukocyte migration involved in inflammatory response| mast cell degranulation| mast cell mediated immunity| microtubule bundle formation| microtubule-based process| mitochondrion localization| muscle cell development| muscle cell differentiation| muscle cell fate specification| muscle structure development| muscle system process| muscle tissue development| myeloid leukocyte activation| myofibril assembly| negative regulation of microtubule depolymerization| negative regulation of microtubule polymerization or depolymerization| negative regulation of neuron projection development| negative regulation of protein complex disassembly| negative regulation of protein depolymerization| negative regulation of protein modification process| neutrophil chemotaxis| peroxisome localization| phagocytosis, engulfment| phototransduction| positive regulation of G1/S transition of mitotic cell cycle| positive regulation of NF-kappaB transcription factor activity| positive regulation of T cell migration| positive regulation of T cell proliferation| positive regulation of calcineurin-NFAT signaling cascade| positive regulation of cell activation| positive regulation of cell cycle phase transition| positive regulation of cyclase activity| positive regulation of glycoprotein biosynthetic process| positive regulation of granulocyte differentiation| positive regulation of guanylate cyclase activity| positive regulation of intracellular transport| positive regulation of intrinsic apoptotic signaling pathway| positive regulation of ion transmembrane transporter activity| positive regulation of leukocyte chemotaxis| positive regulation of leukocyte migration| positive regulation of leukocyte proliferation| positive regulation of locomotion| positive regulation of lyase activity| positive regulation of lymphocyte migration| positive regulation of lymphocyte proliferation| positive regulation of mitotic cell cycle phase transition| positive regulation of monocyte chemotaxis| positive regulation of response to external stimulus| positive regulation of smooth muscle cell chemotaxis| positive regulation of smooth muscle cell migration| positive regulation of smooth muscle cell proliferation| positive regulation of transporter activity| protein localization to membrane| protein polymerization| protein stabilization| protein targeting to membrane| protein targeting to plasma membrane| regulation of G1/S transition of mitotic cell cycle| regulation of T cell migration| regulation of T cell proliferation| regulation of cGMP biosynthetic process| regulation of cGMP metabolic process| regulation of calcineurin-NFAT signaling cascade| regulation of calcium-mediated signaling| regulation of cyclase activity| regulation of cyclic nucleotide metabolic process| regulation of endopeptidase activity| regulation of glycoprotein biosynthetic process| regulation of granulocyte differentiation| regulation of guanylate cyclase activity| regulation of intrinsic apoptotic signaling pathway| regulation of ion transmembrane transport| regulation of ion transmembrane transporter activity| regulation of leukocyte chemotaxis| regulation of leukocyte migration| regulation of lyase activity| regulation of lymphocyte proliferation| regulation of megakaryocyte differentiation| regulation of microtubule depolymerization| regulation of monocyte chemotaxis| regulation of mononuclear cell proliferation| regulation of neuron projection development| regulation of nucleotide biosynthetic process| regulation of nucleotide metabolic process| regulation of protein depolymerization| regulation of purine nucleotide metabolic process| regulation of rhodopsin mediated signaling pathway| regulation of sequence-specific DNA binding transcription factor activity| regulation of smooth muscle cell chemotaxis| regulation of smooth muscle cell migration| regulation of smooth muscle cell proliferation| regulation of sodium ion transmembrane transport| regulation of sodium ion transmembrane transporter activity| regulation of sodium:hydrogen antiporter activity| regulation of transmembrane transport| regulation of transmembrane transporter activity| regulation of transporter activity| response to acidity| response to calcium ion| rhodopsin mediated signaling pathway| ruffle assembly| ruffle organization| second-messenger-mediated signaling| stomatal movement| striated muscle cell development| striated muscle cell differentiation| systemic acquired resistance |
| 594 | PF12514 | Protein of unknown function (DUF3718) | No Pfam Clan | 115 (41) | 68 | 69 | (1) TPR-like [a.118.8] (2-66) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(2-66) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 595 | PF05600 | Protein of unknown function (DUF773) | No Pfam Clan | 218 (14) | 507 | 504 | (1) ARM repeat [a.118.1] (45-506) |
(1) alpha-alpha superhelix [a.118] |
NO PREDICTION | a.118.1(45-506) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network | alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding | RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation |
| 596 | PF10231 | Uncharacterised conserved protein (DUF2315) | No Pfam Clan | 120 (6) | 127 | 125 | (1) LuxS/MPP-like metallohydrolase [d.185.1] (9-98) |
(1) LuxS/MPP-like metallohydrolase [d.185] |
NO PREDICTION | NO PREDICTION | d.185.1(9-98) | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 3.4.24.55| 3.4.24.56| 3.4.24.64| 4.4.1.21 | No information | No information | No information |
| 597 | PF11917 | Protein of unknown function (DUF3435) | DNA-mend (CL0382) | 446 (20) | 418 | 407 | (1) DNA breaking-rejoining enzymes [d.163.1] (28-233) |
(1) DNA breaking-rejoining enzymes [d.163] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | d.163.1(28-233) | 1 | No information | Eukaryota | 5.99.1.2 | No information | No information | No information |
| 598 | PF03698 | Uncharacterised protein family (UPF0180) | No Pfam Clan | 218 (18) | 80 | 81 | (1) Class I glutamine amidotransferase-like [c.23.16] (1-50) |
(1) Flavodoxin-like [c.23] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | c.23.16(1-50) | 1 | No information | Bacteria | 2.3.1.46| 2.4.1.211| 3.4.13.21| 3.4.15.6| 3.4.17.13| 3.4.19.9| 4.2.1.103| 6.3.5.2| 6.3.5.5 | No information | 4-amino-4-deoxychorismate synthase activity| anthranilate synthase activity| antioxidant activity| carbon-carbon lyase activity| carbon-nitrogen ligase activity, with glutamine as amido-N-donor| glyoxalase III activity| oxidoreductase activity, acting on peroxide as acceptor| oxo-acid-lyase activity| peptidase activity| peroxidase activity| peroxiredoxin activity| transaminase activity| transferase activity, transferring nitrogenous groups | adult behavior| adult locomotory behavior| amine biosynthetic process| aromatic amino acid family biosynthetic process| aromatic amino acid family metabolic process| catecholamine transport| catecholamine uptake| catecholamine uptake involved in synaptic transmission| cellular biogenic amine biosynthetic process| cellular response to oxidative stress| cellular response to reactive oxygen species| dopamine transport| dopamine uptake| dopamine uptake involved in synaptic transmission| folic acid-containing compound biosynthetic process| folic acid-containing compound metabolic process| hydrogen peroxide metabolic process| indolalkylamine biosynthetic process| indole-containing compound biosynthetic process| indole-containing compound metabolic process| lactate biosynthetic process| lactate metabolic process| membrane depolarization| membrane hyperpolarization| monoamine transport| negative regulation of binding| negative regulation of protein binding| neuron-neuron synaptic transmission| neurotransmitter transport| neurotransmitter uptake| organic hydroxy compound transport| positive regulation of oxidative phosphorylation uncoupler activity| positive regulation of transporter activity| protein stabilization| pteridine-containing compound biosynthetic process| pteridine-containing compound metabolic process| reactive oxygen species metabolic process| regulation of binding| regulation of neuron apoptotic process| regulation of neuron death| regulation of neurotransmitter levels| regulation of oxidative phosphorylation uncoupler activity| regulation of protein binding| regulation of protein stability| regulation of proton transport| regulation of transmembrane transport| regulation of transmembrane transporter activity| regulation of transporter activity| response to hydrogen peroxide| response to reactive oxygen species| synaptic transmission, dopaminergic| thiamine biosynthetic process| thiamine-containing compound biosynthetic process| thiamine-containing compound metabolic process| tryptophan biosynthetic process| tryptophan metabolic process| water-soluble vitamin biosynthetic process |
| 599 | PF15479 | Domain of unknown function (DUF4639) | No Pfam Clan | 53 (12) | 576 | 576 | (1) ssDNA viruses [b.121.5] (94-576) |
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | b.121.5(94-576) | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 600 | PF10009 | Uncharacterized protein conserved in bacteria (DUF2252) | PKinase (CL0016) | 553 (62) | 385 | 404 | (1) Protein kinase-like (PK-like) [d.144.1] (37-117) |
(1) Protein kinase-like (PK-like) [d.144] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | d.144.1(37-117) | 1 | No information | Eukaryota|Bacteria|Archaea | 2.7.1.100| 2.7.1.137| 2.7.1.153| 2.7.1.163| 2.7.1.17| 2.7.1.32| 2.7.1.39| 2.7.1.95| 2.7.10.1| 2.7.10.2| 2.7.11.1| 2.7.11.11| 2.7.11.13| 2.7.11.14| 2.7.11.15| 2.7.11.16| 2.7.11.17| 2.7.11.19| 2.7.11.21| 2.7.11.22| 2.7.11.24| 2.7.11.25| 2.7.11.26| 2.7.11.30| 2.7.11.7| 2.7.12.1| 2.7.12.2 | cAMP-dependent protein kinase complex| calcium- and calmodulin-dependent protein kinase complex| cell-substrate adherens junction| cyclin-dependent protein kinase holoenzyme complex| neuromuscular junction| protein kinase CK2 complex| spindle| spindle pole | ATP binding| adenyl nucleotide binding| adenyl ribonucleotide binding| calmodulin binding| cyclin binding| kinase activator activity| kinase regulator activity| magnesium ion binding| molecular transducer activity| nucleoside binding| phosphoprotein binding| phosphotransferase activity, alcohol group as acceptor| phosphotyrosine binding| protein kinase activator activity| protein kinase activity| protein kinase regulator activity| purine nucleoside binding| purine nucleotide binding| purine ribonucleoside binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| receptor signaling protein activity| ribonucleoside binding| ribonucleotide binding | CDP-choline pathway| DNA damage checkpoint| activation of innate immune response| cell cycle phase transition| cell division| cell morphogenesis| cellular component morphogenesis| cellular process involved in reproduction| cellular response to biotic stimulus| cellular response to unfolded protein| embryonic placenta development| enzyme linked receptor protein signaling pathway| ethanolamine-containing compound metabolic process| fruiting body development| germ cell development| glycerolipid biosynthetic process| glycerolipid metabolic process| glycerophospholipid biosynthetic process| heart contraction| heart process| hemostasis| innate immune response| innate immune response-activating signal transduction| intracellular protein kinase cascade| labyrinthine layer development| lens development in camera-type eye| lipopolysaccharide-mediated signaling pathway| microtubule cytoskeleton organization| mitotic cell cycle phase transition| negative regulation of cell cycle process| neurotrophin signaling pathway| oogenesis| organelle fission| organic hydroxy compound biosynthetic process| peptidyl-serine modification| peptidyl-threonine modification| phosphatidylcholine biosynthetic process| phosphatidylcholine metabolic process| phosphatidylinositol-3-phosphate biosynthetic process| phospholipid biosynthetic process| positive regulation of MAP kinase activity| positive regulation of cellular protein metabolic process| positive regulation of determination of dorsal identity| positive regulation of developmental growth| positive regulation of innate immune response| positive regulation of intracellular protein transport| positive regulation of myoblast fusion| positive regulation of myotube differentiation| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of phosphorylation| positive regulation of protein kinase activity| positive regulation of protein phosphorylation| positive regulation of skeletal muscle cell differentiation| positive regulation of syncytium formation by plasma membrane fusion| positive regulation of transferase activity| positive regulation of unidimensional cell growth| programmed necrotic cell death| protein phosphorylation| regulation of Golgi inheritance| regulation of MAPK cascade| regulation of Wnt receptor signaling pathway| regulation of adult chitin-containing cuticle pigmentation| regulation of cell size| regulation of cellular response to stress| regulation of chitin-based cuticle tanning| regulation of early endosome to late endosome transport| regulation of fibroblast apoptotic process| regulation of innate immune response| regulation of intracellular protein kinase cascade| regulation of kinase activity| regulation of muscle cell differentiation| regulation of muscle organ development| regulation of muscle tissue development| regulation of protein kinase activity| regulation of reproductive process| regulation of skeletal muscle fiber development| regulation of sodium ion transport| regulation of transferase activity| response to cadmium ion| response to exogenous dsRNA| response to growth factor stimulus| response to molecule of bacterial origin| response to osmotic stress| salicylic acid biosynthetic process| salicylic acid metabolic process| spindle assembly| spindle midzone assembly| stomatal complex development| stress-activated protein kinase signaling cascade| striated muscle contraction| toll-like receptor signaling pathway |
| 601 | PF04489 | Protein of unknown function (DUF570) | dUTPase (CL0153) | 48 (4) | 429 | 429 | (1) WD40 repeat-like [b.69.4] (30-420) |
(1) 7-bladed beta-propeller [b.69] |
NO PREDICTION | b.69.4(30-420) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Viruses | No information | Arp2/3 protein complex| CIA complex| Cdc73/Paf1 complex| Cul4-RING ubiquitin ligase complex| ER to Golgi transport vesicle| SMN complex| SMN-Sm protein complex| Ski complex| THO complex| TORC1 complex| chromosome, centromeric region| cullin-RING ubiquitin ligase complex| eukaryotic translation initiation factor 3 complex| extrinsic to internal side of plasma membrane| extrinsic to membrane| extrinsic to plasma membrane| female germ cell nucleus| germ cell nucleus| heterotrimeric G-protein complex| histone methyltransferase complex| immunological synapse| internal side of plasma membrane| kinetochore| methylosome| methyltransferase complex| nuclear envelope| nuclear pore| nuclear pore outer ring| pore complex| transcription export complex| transcriptionally active chromatin| ubiquitin ligase complex | G-protein gamma-subunit binding| histone binding| peroxisome targeting sequence binding| phosphatidylinositol binding| phosphatidylinositol-3,5-bisphosphate binding| phosphatidylinositol-3-phosphate binding| phosphatidylinositol-5-phosphate binding| signal sequence binding| translation initiation factor activity | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile| T cell homeostasis| TOR signaling cascade| attachment of spindle microtubules to kinetochore| attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation| autophagy| cellular response to starvation| chromosome segregation| embryonic digit morphogenesis| establishment of RNA localization| establishment of chromosome localization| establishment of organelle localization| fruiting body development| histone H3-K4 methylation| histone methylation| histone modification| iron-sulfur cluster assembly| mRNA export from nucleus| membrane disassembly| metallo-sulfur cluster assembly| metaphase plate congression| methylation| microtubule-based process| mitotic metaphase plate congression| mitotic spindle assembly checkpoint| negative regulation of calcium ion transmembrane transporter activity| negative regulation of cation channel activity| negative regulation of cell cycle process| negative regulation of ion transmembrane transporter activity| negative regulation of transporter activity| negative regulation of voltage-gated calcium channel activity| nuclear envelope disassembly| nuclear pore organization| nucleic acid transport| nucleobase-containing compound transport| peptidyl-lysine modification| peptidyl-lysine trimethylation| peroxisomal transport| positive regulation of DNA-dependent transcription, elongation| positive regulation of histone H3-K79 methylation| positive regulation of histone methylation| positive regulation of histone modification| positive regulation of organelle organization| positive regulation of transcription elongation from RNA polymerase II promoter| protein alkylation| protein import| protein targeting| regulation of cell cycle process| regulation of histone H3-K79 methylation| regulation of histone methylation| regulation of histone modification| regulation of metaphase/anaphase transition of cell cycle| regulation of mitotic metaphase/anaphase transition| regulation of reproductive process| regulation of transcription elongation from RNA polymerase II promoter| regulation of voltage-gated calcium channel activity| response to starvation| spindle assembly checkpoint| spindle checkpoint| uropod organization |
| 602 | PF10446 | Protein of unknown function (DUF2457) | No Pfam Clan | 78 (10) | 458 | 443 | (1) BAR/IMD domain-like [a.238.1] (INDIRECT) |
(1) BAR/IMD domain-like [a.238] |
NO PREDICTION | a.238.1(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | axon part| axon terminus| neuron projection terminus| synapse part| trans-Golgi network | GTPase activator activity| GTPase regulator activity| Ras GTPase activator activity| Rho GTPase activator activity| enzyme activator activity| nucleoside-triphosphatase regulator activity | endocytosis| establishment of organelle localization| establishment of synaptic vesicle localization| establishment of vesicle localization| negative regulation of cellular component organization| negative regulation of endocytosis| negative regulation of transport| positive regulation of GTPase activity| positive regulation of Rho GTPase activity| positive regulation of hydrolase activity| regulation of GTP catabolic process| regulation of GTPase activity| regulation of Rho GTPase activity| regulation of Rho protein signal transduction| regulation of endocytosis| regulation of neurological system process| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| regulation of receptor internalization| regulation of small GTPase mediated signal transduction| regulation of synaptic transmission| regulation of system process| regulation of transmission of nerve impulse| regulation of vesicle-mediated transport| synaptic transmission| synaptic vesicle endocytosis| synaptic vesicle localization| synaptic vesicle transport| vesicle localization |
| 603 | PF07086 | Protein of unknown function (DUF1352) | No Pfam Clan | 145 (10) | 186 | 187 | (1) Transmembrane di-heme cytochromes [f.21.1] (35-179) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | f.21.1(35-179) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 1.10.2.2 | No information | electron carrier activity | cellular respiration |
| 604 | PF06582 | Repeat of unknown function (DUF1136) | No Pfam Clan | 617 (78) | 28 | 29 | (1) Immunoglobulin [b.1.1] (1-27) |
(1) Immunoglobulin-like beta-sandwich [b.1] |
b.1.1(1-27) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 1.14.17.3| 2.5.1.63| 3.4.23.44| 3.5.1.52 | B cell receptor complex| blood microparticle| external side of plasma membrane| extracellular membrane-bounded organelle| extracellular organelle| growth cone| immunoglobulin complex| immunoglobulin complex, circulating| neuron projection| perinuclear region of cytoplasm| receptor complex| site of polarized growth | GPI anchor binding| MHC protein binding| Rho GTPase activator activity| amide binding| antigen binding| calmodulin-dependent protein kinase activity| fibroblast growth factor binding| glycolipid binding| growth factor binding| molecular transducer activity| myosin light chain kinase activity| peptide binding| protein kinase activity| protein tyrosine kinase activity| receptor activity| structural constituent of cytoskeleton| transmembrane receptor protein kinase activity| transmembrane receptor protein tyrosine kinase activity| transmembrane signaling receptor activity | B cell mediated immunity| Fc receptor mediated stimulatory signaling pathway| Fc receptor signaling pathway| Fc-gamma receptor signaling pathway| Fc-gamma receptor signaling pathway involved in phagocytosis| activation of immune response| adaptive immune response| adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli| angiogenesis| biological adhesion| blood vessel development| blood vessel morphogenesis| camera-type eye development| cell adhesion| cell junction assembly| cell junction organization| cell-cell adhesion| cellular response to fibroblast growth factor stimulus| cellular response to growth factor stimulus| complement activation| endocytosis| humoral immune response| humoral immune response mediated by circulating immunoglobulin| immune effector process| immune response| immune response-activating cell surface receptor signaling pathway| immune response-activating signal transduction| immune response-regulating cell surface receptor signaling pathway| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis| immune response-regulating signaling pathway| innate immune response| leukocyte mediated immunity| lymphocyte mediated immunity| negative regulation of antigen receptor-mediated signaling pathway| negative regulation of cellular component movement| negative regulation of cellular component organization| negative regulation of locomotion| neural retina development| neuron development| neuron differentiation| organ morphogenesis| phagocytosis| positive regulation of MAPK cascade| positive regulation of T cell mediated cytotoxicity| positive regulation of T cell mediated immunity| positive regulation of adaptive immune response based on somatic recombination of immune receptors b| positive regulation of cell activation| positive regulation of cell proliferation| positive regulation of immune response| positive regulation of immune system process| positive regulation of leukocyte mediated cytotoxicity| positive regulation of leukocyte mediated immunity| positive regulation of leukocyte proliferation| positive regulation of lymphocyte mediated immunity| positive regulation of peptidyl-tyrosine phosphorylation| positive regulation of positive chemotaxis| positive regulation of protein serine/threonine kinase activity| protein activation cascade| regulation of MAPK cascade| regulation of T cell mediated cytotoxicity| regulation of T cell mediated immunity| regulation of antigen receptor-mediated signaling pathway| regulation of calcium ion transport into cytosol| regulation of cell activation| regulation of cell morphogenesis involved in differentiation| regulation of immune response| regulation of leukocyte mediated cytotoxicity| regulation of leukocyte proliferation| regulation of metal ion transport| regulation of mononuclear cell proliferation| regulation of nervous system development| regulation of peptidyl-tyrosine phosphorylation| regulation of positive chemotaxis| regulation of protein phosphorylation| regulation of release of sequestered calcium ion into cytosol| regulation of transferase activity| response to bacterium| response to fibroblast growth factor stimulus| response to growth factor stimulus| retina morphogenesis in camera-type eye| retinal cone cell development| retinal cone cell differentiation| sensory organ development| transmembrane receptor protein tyrosine kinase signaling pathway| vasculature development |
| 605 | PF12092 | Protein of unknown function (DUF3568) | No Pfam Clan | 164 (8) | 131 | 141 | (1) TPR-like [a.118.8] (8-115) |
(1) alpha-alpha superhelix [a.118] |
a.118.8(8-115) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane | heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity | SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission |
| 606 | PF07312 | Protein of unknown function (DUF1459) | No Pfam Clan | 33 (2) | 84 | 84 | (1) Calcium-dependent phosphotriesterase [b.68.6] (7-81) |
(1) 6-bladed beta-propeller [b.68] |
b.68.6(7-81) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | 3.1.1.17| 3.1.1.25| 3.1.8.2| 4.3.3.2 | No information | aryldialkylphosphatase activity| arylesterase activity| calcium ion binding| carboxylic ester hydrolase activity| gluconolactonase activity| zinc ion binding | L-ascorbic acid biosynthetic process| L-ascorbic acid metabolic process| calcium ion homeostasis| cellular calcium ion homeostasis| cellular cation homeostasis| cellular chemical homeostasis| cellular divalent inorganic cation homeostasis| cellular ion homeostasis| cellular metal ion homeostasis| divalent inorganic cation homeostasis| metal ion homeostasis| monosaccharide biosynthetic process| positive regulation of ATPase activity| positive regulation of hydrolase activity| regulation of ATPase activity| regulation of calcium-mediated signaling| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| vitamin biosynthetic process| water-soluble vitamin biosynthetic process| water-soluble vitamin metabolic process |
| 607 | PF10084 | Uncharacterized protein conserved in bacteria (DUF2322) | No Pfam Clan | 258 (17) | 100 | 100 | (1) RNI-like [c.10.1] (5-65) |
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10] |
c.10.1(5-65) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | ubiquitin ligase complex | acid-amino acid ligase activity| small conjugating protein ligase activity| ubiquitin-protein ligase activity | cellular protein catabolic process| entrainment of circadian clock| entrainment of circadian clock by photoperiod| modification-dependent macromolecule catabolic process| photoperiodism| protein catabolic process| protein ubiquitination| proteolysis| regulation of circadian rhythm| ubiquitin-dependent protein catabolic process |
| 608 | PF14112 | Domain of unknown function (DUF4284) | No Pfam Clan | 158 (22) | 122 | 124 | (1) RNI-like [c.10.1] (11-114) |
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10] |
c.10.1(11-114) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota|Bacteria | No information | ubiquitin ligase complex | acid-amino acid ligase activity| small conjugating protein ligase activity| ubiquitin-protein ligase activity | cellular protein catabolic process| entrainment of circadian clock| entrainment of circadian clock by photoperiod| modification-dependent macromolecule catabolic process| photoperiodism| protein catabolic process| protein ubiquitination| proteolysis| regulation of circadian rhythm| ubiquitin-dependent protein catabolic process |
| 609 | PF14692 | Domain of unknown function (DUF4462) | No Pfam Clan | 153 (24) | 28 | 28 | (1) Tachylectin-2 [b.67.1] (9-26) |
(1) 5-bladed beta-propeller [b.67] |
b.67.1(9-26) | NO PREDICTION | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 610 | PF11299 | Protein of unknown function (DUF3100) | No Pfam Clan | 247 (27) | 241 | 237 | (1) Acid phosphatase/Vanadium-dependent haloperoxidase [a.111.1] (INDIRECT) (2) Fumarate reductase respiratory complex transmembrane subunits [f.21.2] (INDIRECT) |
(1) Acid phosphatase/Vanadium-dependent haloperoxidase [a.111] (2) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | a.111.1(INDIRECT)| f.21.2(INDIRECT) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria|Archaea | 1.11.1.10| 1.11.1.18| 1.3.5.1| 3.1.3.2 | fumarate reductase complex| intrinsic to organelle membrane| mitochondrial respiratory chain| mitochondrial respiratory chain complex II| plasma membrane respiratory chain| plasma membrane respiratory chain complex II| respiratory chain| respiratory chain complex II| succinate dehydrogenase complex | cofactor binding| electron carrier activity| heme binding| inositol phosphoceramide synthase activity| lipid phosphatase activity| oxidoreductase activity, acting on the CH-CH group of donors| phosphatase activity| phosphatidate phosphatase activity| quinone binding| sphingosine-1-phosphate phosphatase activity| succinate dehydrogenase activity| sugar-phosphatase activity| sugar-terminal-phosphatase activity| tetrapyrrole binding| ubiquinone binding | cellular respiration| dephosphorylation| electron transport chain| energy derivation by oxidation of organic compounds| germ cell migration| membrane lipid biosynthetic process| membrane lipid metabolic process| mitochondrial ATP synthesis coupled electron transport| mitochondrial electron transport, succinate to ubiquinone| oxidative phosphorylation| phospholipid metabolic process| sphingolipid biosynthetic process| sphingolipid metabolic process| tricarboxylic acid cycle |
| 611 | PF10337 | Protein of unknown function (DUF2422) | FUSC (CL0307) | 237 (27) | 459 | 444 | (1) ABC transporter transmembrane region [f.37.1] (3-333) |
(1) ABC transporter transmembrane region [f.37] |
NO PREDICTION | f.37.1(3-333) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 612 | PF15373 | Domain of unknown function (DUF4601) | No Pfam Clan | 46 (11) | 440 | 433 | (1) ssDNA viruses [b.121.5] (1-433) |
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | b.121.5(1-433) | NO PREDICTION | 1 | No information | Eukaryota | No information | No information | No information | No information |
| 613 | PF15558 | Domain of unknown function (DUF4659) | No Pfam Clan | 78 (21) | 376 | 376 | (1) C-terminal domain of PLC-beta [h.4.10] (71-376) |
(1) Antiparallel coiled-coil [h.4] |
NO PREDICTION | NO PREDICTION | NO PREDICTION | h.4.10(71-376) | NO PREDICTION | 1 | No information | Eukaryota | 3.1.4.11 | No information | No information | No information |
| 614 | PF11982 | Domain of unknown function (DUF3483) | No Pfam Clan | 145 (14) | 224 | 230 | (1) Respiratory nitrate reductase 1 gamma chain [f.21.3] (1-201) |
(1) Heme-binding four-helical bundle [f.21] |
NO PREDICTION | f.21.3(1-201) | NO PREDICTION | NO PREDICTION | NO PREDICTION | 1 | No information | Bacteria | No information | No information | No information | No information |
The low confidence predictions for all target DUF/UPF families (3087 families) by the five databases/methods can be accessed from the following link
http://proline.biochem.iisc.ernet.in/RHD_DUFS/ALL_RESULTS