Browse predicted 'distant evolutionary relationships' for protein families with unknown structure and function (DUFs/UPFs)

For each of 3087 protein family with unknown function (DUFs/UPFs) and no known structures, family profile (hidden Markov model) or a representative sequence were queried against SCOP-NrichD database, SUPFAM+ database , SUPERFAMILY database, pDomTHREADER and HHsearch against SCOP-profile database (1.75v). For 614 DUF families, a SCOP superfamily could be associated at various stringent cut-offs using 5 different sensitive computational methods.
15 DUF families were predicted to have same SCOP superfamily by all 5 methods.
39 DUF families were predicted to have same SCOP superfamily by any 4 methods.
50 DUF families were predicted to have same SCOP superfamily by any of the 3 methods.
89 DUF families were predicted to have same SCOP superfamily by any of the 2 methods.
421 DUF families were predicted to have SCOP superfamily by any 1 method.

S. No. Pfam Accession Description Pfam Clan Number of sequences (Full and Seed) Profile Length Query Sequence length SCOP-superfamily prediction (domain boundry) SCOP-Fold SCOP-NrichD Predictions SUPFAM+ Predictions SUPERFAMILY database Predictions pDomTHREADER Predictions HHsearch Predictions Confidence Score Essential DUF Phylogenetic Kingdoms Associated EC numbers GO (Cellular component) GO (Molecular function) GO (Biological process)
1 PF04311 Protein of unknown function (DUF459) SGNH_hydrolase (CL0264) 172 (2) 327 327 (1) SGNH hydrolase [c.23.10] (80-324)
(1) Flavodoxin-like [c.23]
c.23.10(7-241) c.23.10(110-325) c.23.10(113-321) c.23.10(80-324) c.23.10(114-321) 5 No information Eukaryota|Bacteria 3.1.1.2| 3.1.1.47| 3.1.1.5| 3.1.1.53| 3.1.1.72| 3.2.1.4 No information carboxylic ester hydrolase activity sexual reproduction| spermatogenesis
2 PF04601 Protein of unknown function (DUF569) Trefoil (CL0066) 184 (7) 142 144 (1) Actin-crosslinking proteins [b.42.5] (2-144)
(1) beta-Trefoil [b.42]
b.42.5(10-142) b.42.5(7-129) b.42.5(5-134) b.42.5(2-144) b.42.5(9-120) 5 No information Eukaryota No information No information actin binding| actin filament binding actin cytoskeleton organization| actin filament organization
3 PF06866 Protein of unknown function (DUF1256) Peptidase_ML (CL0095) 439 (13) 164 165 (1) HybD-like [c.56.1] (1-165)
(1) Phosphorylase/hydrolase-like [c.56]
c.56.1(6-125) c.56.1(1-163) c.56.1(2-164) c.56.1(1-165) c.56.1(4-123) 5 No information Bacteria|Viruses 3.4.23.51| 3.4.24.78 No information No information No information
4 PF07588 Protein of unknown function (DUF1554) No Pfam Clan 119 (15) 142 144 (1) C-type lectin-like [d.169.1] (1-144)
(1) C-type lectin-like [d.169]
d.169.1(2-141) d.169.1(6-133) d.169.1(4-135) d.169.1(1-144) d.169.1(4-137) 5 No information Bacteria No information extracellular matrix| extracellular matrix part| proteinaceous extracellular matrix carbohydrate binding| galactose binding| receptor activity biological adhesion| cell adhesion| negative regulation of epidermal cell differentiation| negative regulation of epidermis development| negative regulation of epithelial cell differentiation| negative regulation of keratinocyte differentiation| ossification| positive regulation of keratinocyte proliferation| positive regulation of wound healing| regulation of epidermal cell differentiation| regulation of epidermis development| regulation of keratinocyte differentiation| regulation of keratinocyte proliferation
5 PF11813 Protein of unknown function (DUF3334) CheC-like (CL0355) 187 (19) 229 233 (1) CheC-like [d.252.1] (7-228)
(1) CheC-like [d.252]
d.252.1(10-173) d.252.1(7-228) d.252.1(11-173) d.252.1(3-177) d.252.1(11-173) 5 No information Bacteria No information No information No information No information
6 PF07602 Protein of unknown function (DUF1565) Pec_lyase-like (CL0268) 240 (8) 246 273 (1) Pectin lyase-like [b.80.1] (1-273)
(1) Single-stranded right-handed beta-helix [b.80]
b.80.1(1-241) b.80.1(1-245) b.80.1(2-253) b.80.1(1-273) b.80.1(2-219) 5 No information Eukaryota|Bacteria|Archaea 3.1.1.11| 3.2.1.11| 3.2.1.15| 3.2.1.157| 3.2.1.57| 3.2.1.58| 3.4.21.72| 4.2.2.10| 4.2.2.18| 4.2.2.19| 4.2.2.2| 4.2.2.7 anchored to membrane| plant-type cell wall carbon-oxygen lyase activity, acting on polysaccharides| carboxylic ester hydrolase activity| galacturan 1,4-alpha-galacturonidase activity| pectinesterase activity| polygalacturonase activity cell growth| cell wall organization or biogenesis| developmental cell growth| developmental growth| developmental growth involved in morphogenesis| external encapsulating structure organization| galacturonan metabolic process| pectin catabolic process| plant-type cell wall organization| plant-type cell wall organization or biogenesis| pollen tube development| pollen tube growth| pollination| polysaccharide catabolic process| polysaccharide metabolic process| unidimensional cell growth
7 PF07609 Protein of unknown function (DUF1572) DinB (CL0310) 202 (15) 163 163 (1) DinB/YfiT-like putative metalloenzymes [a.213.1] (1-155)
(1) DinB/YfiT-like putative metalloenzymes [a.213]
a.213.1(2-152) a.213.1(3-151) a.213.1(7-150) a.213.1(1-155) a.213.1(3-149) 5 No information Bacteria 5.2.1.4 No information No information No information
8 PF07894 Protein of unknown function (DUF1669) PLD (CL0479) 379 (23) 284 284 (1) Phospholipase D/nuclease [d.136.1] (84-283)
(1) Phospholipase D/nuclease [d.136]
d.136.1(84-283) d.136.1(90-283) d.136.1(120-283) d.136.1(118-282) d.136.1(118-284) 5 No information Eukaryota 2.7.4.1| 2.7.8.8| 3.1.21.4| 3.1.4.4 mitochondrial outer membrane| organelle outer membrane| outer membrane cardiolipin hydrolase activity| lipase activity| phospholipase activity| phosphoric diester hydrolase activity| protein homodimerization activity DNA alkylation| DNA methylation| DNA methylation involved in gamete generation| DNA methylation or demethylation| DNA modification| P granule organization| anterior/posterior axis specification| anterior/posterior axis specification, embryo| anterior/posterior pattern specification| axis specification| blastoderm segmentation| cell maturation| cellular membrane fusion| cellular membrane organization| cellular process involved in reproduction in multicellular organism| cytoplasm organization| developmental maturation| embryonic axis specification| embryonic pattern specification| epithelial cell development| female gamete generation| germ cell development| macromolecule methylation| maternal determination of anterior/posterior axis, embryo| meiosis| meiotic cell cycle| membrane fusion| mitochondrial fusion| mitochondrion organization| oocyte anterior/posterior axis specification| oocyte axis specification| oocyte construction| oocyte development| oocyte differentiation| oogenesis| organelle fusion| piRNA metabolic process| pole plasm assembly| regulation of gene expression, epigenetic| ribonucleoprotein complex subunit organization| segmentation| spermatid development| spermatid differentiation| spermatogenesis| tripartite regional subdivision
9 PF04862 Protein of unknown function (DUF642) GBD (CL0202) 419 (56) 159 157 (1) Galactose-binding domain-like [b.18.1] (2-158)
(1) Galactose-binding domain-like [b.18]
b.18.1(3-158) b.18.1(2-158) b.18.1(2-156) b.18.1(2-157) b.18.1(2-156) 5 No information Eukaryota|Bacteria 3.2.1.165| 3.2.1.31| 3.2.1.40| 3.2.1.50| 3.2.1.97| 3.5.3.4| 4.2.2.10 cullin-RING ubiquitin ligase complex| nuclear ubiquitin ligase complex| ubiquitin ligase complex carbohydrate binding| fucose binding| hydrolase activity, hydrolyzing O-glycosyl compounds| ubiquitin-protein ligase activity branching involved in mammary gland duct morphogenesis| branching morphogenesis of an epithelial tube| embryo implantation| gland morphogenesis| mammary gland alveolus development| mammary gland development| mammary gland duct morphogenesis| mammary gland epithelium development| mammary gland lobule development| mammary gland morphogenesis| morphogenesis of a branching structure| morphogenesis of an epithelium| multi-multicellular organism process| peptidyl-tyrosine modification| peptidyl-tyrosine phosphorylation| proteasomal ubiquitin-dependent protein catabolic process| regulation of acute inflammatory response| regulation of cell adhesion| regulation of cell growth| regulation of cell-matrix adhesion| regulation of cell-substrate adhesion| regulation of cellular defense response| regulation of complement activation| regulation of complement activation, lectin pathway| regulation of humoral immune response| regulation of protein activation cascade| regulation of protein processing
10 PF05705 Eukaryotic protein of unknown function (DUF829) AB_hydrolase (CL0028) 555 (43) 240 264 (1) alpha/beta-Hydrolases [c.69.1] (1-264)
(1) alpha/beta-Hydrolases [c.69]
c.69.1(52-239) c.69.1(1-239) c.69.1(2-115)| c.69.1(191-264) c.69.1(1-264) c.69.1(1-264) 5 No information Eukaryota 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 trans-Golgi network transport vesicle CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process
11 PF04007 Protein of unknown function (DUF354) GT-B (CL0113) 167 (4) 335 338 (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (1-334)
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87]
c.87.1(1-333) c.87.1(1-334) c.87.1(4-313) c.87.1(2-180) c.87.1(10-336) 5 No information Bacteria|Archaea 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process
12 PF09865 Predicted periplasmic protein (DUF2092) No Pfam Clan 95 (17) 215 218 (1) Prokaryotic lipoproteins and lipoprotein localization factors [b.125.1] (4-215)
(1) LolA-like prokaryotic lipoproteins and lipoprotein localization factors [b.125]
b.125.1(5-212) b.125.1(4-213) b.125.1(4-207) b.125.1(4-215) b.125.1(6-213) 5 No information Bacteria No information No information No information No information
13 PF07944 Putative glycosyl hydrolase of unknown function (DUF1680) 6_Hairpin (CL0059) 1388 (20) 520 521 (1) Six-hairpin glycosidases [a.102.1] (1-417)
(1) alpha/alpha toroid [a.102]
a.102.1(19-331) a.102.1(59-391) a.102.1(73-327) a.102.1(1-417) a.102.1(87-345) 5 No information Eukaryota|Bacteria|Archaea 2.4.1.20| 2.4.1.8| 3.2.1.132| 3.2.1.156| 3.2.1.28| 3.2.1.3| 3.2.1.4| 3.2.1.40| 3.2.1.63| 3.2.1.70| 3.2.1.8| 3.2.1.91| 5.1.3.8| 5.3.1.8 brush border N-acylglucosamine 2-epimerase activity| cellulase activity| hydrolase activity, hydrolyzing O-glycosyl compounds| racemase and epimerase activity| racemase and epimerase activity, acting on carbohydrates and derivatives cell wall organization or biogenesis| cellular carbohydrate catabolic process| cellular polysaccharide metabolic process| oligosaccharide catabolic process| oligosaccharide metabolic process| polysaccharide metabolic process
14 PF11230 Protein of unknown function (DUF3029) PFL-like (CL0339) 631 (19) 487 484 (1) PFL-like glycyl radical enzymes [c.7.1] (1-486)
(1) PFL-like glycyl radical enzymes [c.7]
c.7.1(1-468) c.7.1(1-486) c.7.1(5-450) c.7.1(1-468) c.7.1(6-447) 5 No information Bacteria 1.17.4.1| 1.17.4.2| 2.3.1.54 No information No information No information
15 PF06080 Protein of unknown function (DUF938) NADP_Rossmann (CL0063) 529 (6) 204 204 (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (1-204)
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66]
c.66.1(22-189) c.66.1(1-197) c.66.1(10-202) c.66.1(1-204) c.66.1(4-201) 5 No information Eukaryota|Bacteria|Viruses 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 nuclear matrix glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process
16 PF10007 Uncharacterized protein conserved in archaea (DUF2250) HTH (CL0123) 100 (18) 93 93 (1) "Winged helix" DNA-binding domain [a.4.5] (3-92)
(1) DNA/RNA-binding 3-helical bundle [a.4]
a.4.5(6-88) a.4.5(3-92) a.4.5(2-61) NO PREDICTION a.4.5(3-92) 4 No information Bacteria|Archaea No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
17 PF06162 Caenorhabditis elegans protein of unknown function (DUF976) PgaPase (CL0379) 29 (6) 166 157 (1) Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase) [c.56.4] (22-166)
(1) Phosphorylase/hydrolase-like [c.56]
c.56.4(22-166) c.56.4(24-160) NO PREDICTION c.56.4(23-157) c.56.4(25-139) 4 No information Eukaryota 3.4.19.3 No information No information No information
18 PF06779 Protein of unknown function (DUF1228) MFS (CL0015) 952 (12) 85 85 (1) MFS general substrate transporter [f.38.1] (3-84)
(1) MFS general substrate transporter [f.38]
f.38.1(7-85) f.38.1(1-79) f.38.1(3-84) NO PREDICTION f.38.1(4-83) 4 No information Eukaryota|Bacteria|Viruses No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
19 PF09970 Nucleotidyl transferase of unknown function (DUF2204) NTP_transf (CL0260) 161 (15) 181 179 (1) Nucleotidyltransferase [d.218.1] (3-152)
(1) Nucleotidyltransferase [d.218]
d.218.1(3-152) d.218.1(1-148) d.218.1(10-146) NO PREDICTION d.218.1(2-142) 4 No information Eukaryota|Bacteria|Archaea 2.7.6.5| 2.7.7.19| 2.7.7.31| 2.7.7.42| 2.7.7.52| 2.7.7.7| 2.7.7.72 No information adenylyltransferase activity| double-stranded RNA binding No information
20 PF10184 Uncharacterized conserved protein (DUF2358) NTF2 (CL0051) 393 (29) 113 107 (1) NTF2-like [d.17.4] (1-112)
(1) Cystatin-like [d.17]
d.17.4(2-113) d.17.4(1-112) d.17.4(3-107) NO PREDICTION d.17.4(17-107) 4 No information Eukaryota|Bacteria 3.3.2.8| 4.2.1.94| 5.3.3.1 T-tubule| axon initial segment| axon part| cell-cell contact zone| main axon| neuromuscular junction| nuclear envelope| pore complex| sarcolemma Ran GTPase binding G1/S transition of mitotic cell cycle| RNA export from nucleus| RNA localization| antibiotic biosynthetic process| antibiotic metabolic process| blood circulation| calcium ion transport| cardiac muscle contraction| cell cycle phase| cell cycle phase transition| drug metabolic process| establishment of RNA localization| heart contraction| heart process| interphase| interphase of mitotic cell cycle| mitotic cell cycle phase transition| muscle contraction| muscle system process| nuclear transport| nucleobase-containing compound transport| nucleocytoplasmic transport| peptidyl-serine phosphorylation| poly(A)+ mRNA export from nucleus| positive regulation of antimicrobial peptide biosynthetic process| positive regulation of cellular amide metabolic process| protein autophosphorylation| regulation of antimicrobial humoral response| regulation of antimicrobial peptide biosynthetic process| regulation of antimicrobial peptide production| regulation of cellular amide metabolic process| regulation of humoral immune response| regulation of production of molecular mediator of immune response| regulation of sodium ion transport| striated muscle contraction
21 PF04305 Protein of unknown function (DUF455) No Pfam Clan 772 (81) 253 249 (1) Ferritin-like [a.25.1] (10-227)
(1) Ferritin-like [a.25]
a.25.1(69-225) a.25.1(10-227) a.25.1(64-215) NO PREDICTION a.25.1(64-204) 4 YES Eukaryota|Bacteria 1.11.1.6| 1.14.13.25| 1.14.19.2| 1.16.3.1| 1.17.4.1| 4.2.1.52 ferritin complex| intracellular ferritin complex| ribonucleoside-diphosphate reductase complex iron ion binding| oxidoreductase activity, acting on CH or CH2 groups| oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor| ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor DNA replication| cellular ketone metabolic process| cellular transition metal ion homeostasis| deoxyribonucleoside triphosphate metabolic process| deoxyribonucleotide biosynthetic process| deoxyribonucleotide metabolic process| immune response| intracellular sequestering of iron ion| iron ion homeostasis| ketone biosynthetic process| kidney development| maintenance of location| maintenance of location in cell| metal ion homeostasis| mitochondrial DNA metabolic process| mitochondrial DNA replication| mitochondrial genome maintenance| mitochondrion organization| negative regulation of apoptotic signaling pathway| negative regulation of cell proliferation| negative regulation of intrinsic apoptotic signaling pathway| negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator| negative regulation of signal transduction by p53 class mediator| oxidoreduction coenzyme metabolic process| photosynthesis| quinone biosynthetic process| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of apoptotic signaling pathway| regulation of intrinsic apoptotic signaling pathway| regulation of intrinsic apoptotic signaling pathway by p53 class mediator| regulation of signal transduction by p53 class mediator| renal system process| response to iron ion| sequestering of metal ion| transition metal ion homeostasis| ubiquinone biosynthetic process| ubiquinone metabolic process
22 PF11350 Protein of unknown function (DUF3152) Peptidase_MA (CL0126) 313 (17) 204 206 (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (28-203)
(1) Zincin-like [d.92]
d.92.1(32-158) d.92.1(28-203) d.92.1(30-191) NO PREDICTION d.92.1(31-185) 4 No information Bacteria 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 cortical granule glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing
23 PF08551 Eukaryotic integral membrane protein (DUF1751) Rhomboid-like (CL0207) 355 (23) 99 96 (1) Rhomboid-like [f.51.1] (1-99)
(1) Rhomboid-like [f.51]
f.51.1(1-99) f.51.1(5-96) f.51.1(5-94) NO PREDICTION f.51.1(5-63) 4 No information Eukaryota|Bacteria 3.4.21.105 No information No information No information
24 PF14125 Domain of unknown function (DUF4292) No Pfam Clan 228 (73) 210 205 (1) Prokaryotic lipoproteins and lipoprotein localization factors [b.125.1] (2-210)
(1) LolA-like prokaryotic lipoproteins and lipoprotein localization factors [b.125]
b.125.1(2-210) b.125.1(1-193) b.125.1(7-104) NO PREDICTION b.125.1(5-185) 4 YES Bacteria No information No information No information No information
25 PF03754 Domain of unknown function (DUF313) DNA_b-psBarrel (CL0405) 95 (14) 114 113 (1) DNA-binding pseudobarrel domain [b.142.1] (17-113)
(1) DNA-binding pseudobarrel domain [b.142]
b.142.1(19-113) NO PREDICTION b.142.1(20-113) b.142.1(17-113) b.142.1(19-113) 4 No information Eukaryota No information No information No information No information
26 PF04301 Protein of unknown function (DUF452) AB_hydrolase (CL0028) 358 (2) 213 212 (1) alpha/beta-Hydrolases [c.69.1] (3-212)
(1) alpha/beta-Hydrolases [c.69]
NO PREDICTION c.69.1(3-212) c.69.1(52-203) c.69.1(8-212) c.69.1(13-114) 4 YES Bacteria 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 trans-Golgi network transport vesicle CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process
27 PF05631 Protein of unknown function (DUF791) MFS (CL0015) 263 (3) 354 377 (1) MFS general substrate transporter [f.38.1] (29-374)
(1) MFS general substrate transporter [f.38]
f.38.1(29-374) f.38.1(27-333) f.38.1(40-147)| f.38.1(198-352) NO PREDICTION f.38.1(54-327) 4 No information Eukaryota|Bacteria No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
28 PF10230 Uncharacterised conserved protein (DUF2305) AB_hydrolase (CL0028) 346 (27) 266 258 (1) alpha/beta-Hydrolases [c.69.1] (1-265)
(1) alpha/beta-Hydrolases [c.69]
c.69.1(2-265) c.69.1(1-265) c.69.1(4-166) NO PREDICTION c.69.1(2-140) 4 No information Eukaryota|Bacteria 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 trans-Golgi network transport vesicle CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process
29 PF07082 Protein of unknown function (DUF1350) AB_hydrolase (CL0028) 176 (3) 250 248 (1) alpha/beta-Hydrolases [c.69.1] (14-249)
(1) alpha/beta-Hydrolases [c.69]
c.69.1(4-236) c.69.1(14-249) c.69.1(8-126)| c.69.1(153-206) NO PREDICTION c.69.1(23-207) 4 No information Eukaryota|Bacteria 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 trans-Golgi network transport vesicle CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process
30 PF11010 Protein of unknown function (DUF2848) FAH (CL0377) 154 (37) 194 193 (1) FAH [d.177.1] (10-183)
(1) FAH [d.177]
d.177.1(12-182) d.177.1(10-183) d.177.1(17-182) NO PREDICTION d.177.1(12-181) 4 No information Bacteria|Archaea 3.7.1.2| 4.2.1.80| 5.3.3.10 No information hydrolase activity, acting on acid carbon-carbon bonds No information
31 PF14372 Domain of unknown function (DUF4413) No Pfam Clan 377 (79) 101 103 (1) Ribonuclease H-like [c.55.3] (2-102)
(1) Ribonuclease H-like motif [c.55]
c.55.3(1-101) c.55.3(1-100) c.55.3(2-102) NO PREDICTION c.55.3(1-64) 4 No information Eukaryota|Bacteria 2.7.7.7| 3.1.11.1| 3.1.13.1| 3.1.13.4| 3.1.13.5| 3.1.22.4| 3.1.26.4| 3.6.4.12 CCR4-NOT complex| DNA polymerase complex| cytoplasmic mRNA processing body| micro-ribonucleoprotein complex| nucleolus| ribonuclease H2 complex| ribonucleoprotein granule DNA polymerase activity| DNA-directed DNA polymerase activity| endoribonuclease activity, producing 5'-phosphomonoesters| exonuclease activity| nuclease activity| ribonuclease H activity| transposase activity DNA catabolic process| DNA replication| DNA replication, removal of RNA primer| DNA strand elongation| RNA 3'-end processing| RNA catabolic process| RNA phosphodiester bond hydrolysis| cytoplasmic mRNA processing body assembly| gene silencing| gene silencing by RNA| lagging strand elongation| mRNA 3'-end processing| mitochondrial genome maintenance| mitotic DNA integrity checkpoint| mitotic G2 DNA damage checkpoint| ncRNA 3'-end processing| negative regulation of DNA metabolic process| negative regulation of DNA recombination| negative regulation of mitotic recombination| negative regulation of translation| nuclear-transcribed mRNA poly(A) tail shortening| nucleic acid phosphodiester bond hydrolysis| positive regulation of catabolic process| positive regulation of cellular catabolic process| positive regulation of mRNA catabolic process| positive regulation of mRNA processing| regulation of DNA metabolic process| regulation of DNA recombination| regulation of mRNA 3'-end processing| regulation of mRNA catabolic process| regulation of mRNA processing| regulation of mitotic recombination| response to ionizing radiation| ribonucleoprotein complex biogenesis| ribonucleoprotein complex subunit organization| transposition| transposition, DNA-mediated
32 PF05677 Chlamydia CHLPS protein (DUF818) AB_hydrolase (CL0028) 50 (5) 365 361 (1) alpha/beta-Hydrolases [c.69.1] (105-361)
(1) alpha/beta-Hydrolases [c.69]
NO PREDICTION c.69.1(108-364) c.69.1(157-297) c.69.1(105-361) c.69.1(102-232) 4 No information Eukaryota|Bacteria 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 trans-Golgi network transport vesicle CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process
33 PF08937 MTH538 TIR-like domain (DUF1863) STIR (CL0173) 389 (55) 130 188 (1) Hypothetical protein MTH538 [c.23.3] (66-168)
(2) Toll/Interleukin receptor TIR domain [c.23.2] (3-120)
(1) Flavodoxin-like [c.23]
c.23.2(3-120) c.23.2(1-111) c.23.2(1-102) NO PREDICTION c.23.3(66-168)| c.23.2(1-113) 4 No information Bacteria|Viruses|Archaea No information No information No information No information
34 PF11251 Protein of unknown function (DUF3050) HO (CL0230) 145 (32) 232 230 (1) Heme oxygenase-like [a.132.1] (1-232)
(1) Heme oxygenase-like [a.132]
a.132.1(1-232) a.132.1(1-231) a.132.1(3-229) NO PREDICTION a.132.1(2-230) 4 No information Eukaryota|Bacteria 1.14.99.3| 1.3.3.11| 2.5.1.2| 3.5.99.2 No information No information heme metabolic process| pigment metabolic process| porphyrin-containing compound metabolic process| tetrapyrrole metabolic process
35 PF11695 Domain of unknown function (DUF3291) Dim_A_B_barrel (CL0032) 150 (34) 140 138 (1) Dimeric alpha+beta barrel [d.58.4] (2-107)
(1) Ferredoxin-like [d.58]
d.58.4(12-99) d.58.4(2-107) d.58.4(18-111) NO PREDICTION d.58.4(18-94) 4 No information Bacteria 1.13.11.49| 1.13.11.55| 1.14.99.3| 5.3.3.4| 5.4.99.14 No information No information No information
36 PF11274 Protein of unknown function (DUF3074) Bet_V_1_like (CL0209) 152 (28) 184 194 (1) Bet v1-like [d.129.3] (1-183)
(1) TBP-like [d.129]
d.129.3(38-172) d.129.3(1-183) d.129.3(14-193) NO PREDICTION d.129.3(18-185) 4 No information Eukaryota 1.14.12.12| 1.14.12.18| 3.1.3.16| 4.2.1.78 intercellular canaliculus| microvillus abscisic acid binding| alcohol binding| alcohol transmembrane transporter activity| anion transmembrane transporter activity| carboxylic acid binding| hormone binding| isoprenoid binding| lipid transporter activity| monocarboxylic acid binding| organic anion transmembrane transporter activity| organic cation transmembrane transporter activity| organic hydroxy compound transmembrane transporter activity| phosphate transmembrane transporter activity| phosphatidylcholine transporter activity| phospholipid transporter activity| protein homodimerization activity| quaternary ammonium group transmembrane transporter activity abscisic acid mediated signaling pathway| acid secretion| bile acid secretion| cellular response to abscisic acid stimulus| cellular response to alcohol| cellular response to hormone stimulus| cellular response to lipid| hormone-mediated signaling pathway| lipid localization| lipid transport| monocarboxylic acid transport| organic anion transport| organophosphate ester transport| phospholipid transport| positive regulation of peroxisome proliferator activated receptor signaling pathway| quaternary ammonium group transport| regulation of peroxisome proliferator activated receptor signaling pathway| regulation of post-embryonic development| response to abscisic acid stimulus| response to alcohol| response to hormone stimulus| response to lipid
37 PF07845 Protein of unknown function (DUF1636) No Pfam Clan 189 (52) 116 114 (1) Thioredoxin-like [c.47.1] (1-105)
(1) Thioredoxin fold [c.47]
c.47.1(1-84) c.47.1(1-105) c.47.1(2-102) NO PREDICTION c.47.1(1-82) 4 No information Bacteria 1.1.4.2| 1.11.1.12| 1.11.1.15| 1.11.1.7| 1.11.1.9| 1.20.4.1| 1.8.1.7| 1.8.1.8| 1.8.1.9| 1.8.4.2| 1.8.4.7| 1.8.4.8| 1.8.5.1| 2.5.1.18| 5.2.1.2| 5.3.4.1| 5.3.99.3 NADH dehydrogenase complex| chloroplast stroma| ferredoxin hydrogenase complex| formate dehydrogenase complex| myelin sheath| plastid stroma| respiratory chain complex I antioxidant activity| arsenate reductase activity| disulfide oxidoreductase activity| electron carrier activity| formate dehydrogenase (NAD+) activity| glutathione binding| glutathione transferase activity| intramolecular oxidoreductase activity| intramolecular oxidoreductase activity, interconverting keto- and enol-groups| intramolecular oxidoreductase activity, transposing S-S bonds| oxidoreductase activity, acting on a sulfur group of donors| oxidoreductase activity, acting on hydrogen as donor| oxidoreductase activity, acting on peroxide as acceptor| oxidoreductase activity, acting on phosphorus or arsenic in donors| oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor| peroxidase activity| peroxiredoxin activity| phospholipid-hydroperoxide glutathione peroxidase activity| prostaglandin-F synthase activity| protein disulfide isomerase activity| thioredoxin peroxidase activity androecium development| anther development| cell redox homeostasis| cellular response to hydrogen peroxide| cellular response to oxidative stress| cellular response to reactive oxygen species| fatty acid derivative biosynthetic process| fatty acid derivative metabolic process| floral organ development| floral whorl development| flower development| formate metabolic process| hydrogen peroxide catabolic process| icosanoid biosynthetic process| nucleolus organization| phyllome development| positive regulation of DNA binding| positive regulation of binding| prostanoid biosynthetic process| protein deglutathionylation| protein folding| reactive oxygen species metabolic process| regulation of DNA binding| regulation of binding| regulation of intracellular transport| regulation of protein import into nucleus| regulation of protein import into nucleus, translocation| regulation of protein localization to nucleus| removal of superoxide radicals| response to hydrogen peroxide| response to hydroperoxide| response to reactive oxygen species| response to selenium ion| shoot system development| stamen development| toxin catabolic process| unsaturated fatty acid biosynthetic process| unsaturated fatty acid metabolic process
38 PF11854 Protein of unknown function (DUF3374) MBB (CL0193) 127 (30) 637 599 (1) Porins [f.4.3] (14-636)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION f.4.3(14-636) f.4.3(343-564)| f.4.3(164-376) f.4.3(51-599) f.4.3(156-567) 4 No information Bacteria No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity fatty acid transport| lipid localization| long-chain fatty acid transport
39 PF12048 Protein of unknown function (DUF3530) AB_hydrolase (CL0028) 175 (36) 310 303 (1) alpha/beta-Hydrolases [c.69.1] (61-309)
(1) alpha/beta-Hydrolases [c.69]
NO PREDICTION c.69.1(61-309) c.69.1(101-244) c.69.1(64-302) c.69.1(78-302) 4 No information Bacteria 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 trans-Golgi network transport vesicle CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process
40 PF09314 Domain of unknown function (DUF1972) GT-B (CL0113) 494 (12) 185 185 (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (3-184)
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87]
c.87.1(3-183) c.87.1(3-184) c.87.1(6-171) NO PREDICTION c.87.1(3-184) 4 No information Bacteria|Archaea 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process
41 PF14358 Domain of unknown function (DUF4405) 2heme_cytochrom (CL0328) 320 (112) 64 63 (1) Transmembrane di-heme cytochromes [f.21.1] (1-63)
(1) Heme-binding four-helical bundle [f.21]
f.21.1(7-64) f.21.1(1-63) f.21.1(8-61) NO PREDICTION f.21.1(4-61) 4 No information Bacteria|Archaea 1.10.2.2 No information electron carrier activity cellular respiration
42 PF04937 Protein of unknown function (DUF 659) No Pfam Clan 467 (15) 153 164 (1) Ribonuclease H-like [c.55.3] (5-153)
(1) Ribonuclease H-like motif [c.55]
c.55.3(5-153) c.55.3(22-152) c.55.3(26-138) NO PREDICTION c.55.3(23-163) 4 No information Eukaryota 2.7.7.7| 3.1.11.1| 3.1.13.1| 3.1.13.4| 3.1.13.5| 3.1.22.4| 3.1.26.4| 3.6.4.12 CCR4-NOT complex| DNA polymerase complex| cytoplasmic mRNA processing body| micro-ribonucleoprotein complex| nucleolus| ribonuclease H2 complex| ribonucleoprotein granule DNA polymerase activity| DNA-directed DNA polymerase activity| endoribonuclease activity, producing 5'-phosphomonoesters| exonuclease activity| nuclease activity| ribonuclease H activity| transposase activity DNA catabolic process| DNA replication| DNA replication, removal of RNA primer| DNA strand elongation| RNA 3'-end processing| RNA catabolic process| RNA phosphodiester bond hydrolysis| cytoplasmic mRNA processing body assembly| gene silencing| gene silencing by RNA| lagging strand elongation| mRNA 3'-end processing| mitochondrial genome maintenance| mitotic DNA integrity checkpoint| mitotic G2 DNA damage checkpoint| ncRNA 3'-end processing| negative regulation of DNA metabolic process| negative regulation of DNA recombination| negative regulation of mitotic recombination| negative regulation of translation| nuclear-transcribed mRNA poly(A) tail shortening| nucleic acid phosphodiester bond hydrolysis| positive regulation of catabolic process| positive regulation of cellular catabolic process| positive regulation of mRNA catabolic process| positive regulation of mRNA processing| regulation of DNA metabolic process| regulation of DNA recombination| regulation of mRNA 3'-end processing| regulation of mRNA catabolic process| regulation of mRNA processing| regulation of mitotic recombination| response to ionizing radiation| ribonucleoprotein complex biogenesis| ribonucleoprotein complex subunit organization| transposition| transposition, DNA-mediated
43 PF05872 Bacterial protein of unknown function (DUF853) P-loop_NTPase (CL0023) 1311 (9) 504 499 (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (7-422)
(1) P-loop containing nucleoside triphosphate hydrolases [c.37]
c.37.1(7-422) c.37.1(17-376) c.37.1(9-379) NO PREDICTION c.37.1(12-321) 4 YES Eukaryota|Bacteria|Archaea 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
44 PF14237 Domain of unknown function (DUF4339) No Pfam Clan 701 (59) 45 45 (1) GYF domain [d.76.1] (3-44)
(1) GYF/BRK domain-like [d.76]
d.76.1(2-38) d.76.1(1-41) d.76.1(3-44) NO PREDICTION d.76.1(2-40) 4 No information Eukaryota|Bacteria|Archaea No information No information No information No information
45 PF11997 Domain of unknown function (DUF3492) GT-B (CL0113) 322 (39) 268 281 (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (INDIRECT)
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87]
c.87.1(1-268) c.87.1(INDIRECT) c.87.1(3-89)| c.87.1(173-209)| c.87.1(237-280) NO PREDICTION c.87.1(1-43) 4 No information Eukaryota|Bacteria|Viruses|Archaea 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process
46 PF10698 Protein of unknown function (DUF2505) Bet_V_1_like (CL0209) 427 (34) 159 163 (1) Bet v1-like [d.129.3] (1-162)
(1) TBP-like [d.129]
d.129.3(5-149) d.129.3(1-158) NO PREDICTION d.129.3(1-162) d.129.3(2-156) 4 No information Eukaryota|Bacteria|Viruses 1.14.12.12| 1.14.12.18| 3.1.3.16| 4.2.1.78 intercellular canaliculus| microvillus abscisic acid binding| alcohol binding| alcohol transmembrane transporter activity| anion transmembrane transporter activity| carboxylic acid binding| hormone binding| isoprenoid binding| lipid transporter activity| monocarboxylic acid binding| organic anion transmembrane transporter activity| organic cation transmembrane transporter activity| organic hydroxy compound transmembrane transporter activity| phosphate transmembrane transporter activity| phosphatidylcholine transporter activity| phospholipid transporter activity| protein homodimerization activity| quaternary ammonium group transmembrane transporter activity abscisic acid mediated signaling pathway| acid secretion| bile acid secretion| cellular response to abscisic acid stimulus| cellular response to alcohol| cellular response to hormone stimulus| cellular response to lipid| hormone-mediated signaling pathway| lipid localization| lipid transport| monocarboxylic acid transport| organic anion transport| organophosphate ester transport| phospholipid transport| positive regulation of peroxisome proliferator activated receptor signaling pathway| quaternary ammonium group transport| regulation of peroxisome proliferator activated receptor signaling pathway| regulation of post-embryonic development| response to abscisic acid stimulus| response to alcohol| response to hormone stimulus| response to lipid
47 PF13200 Putative glycosyl hydrolase domain Glyco_hydro_tim (CL0058) 311 (62) 316 321 (1) (Trans)glycosidases [c.1.8] (1-321)
(1) TIM beta/alpha-barrel [c.1]
NO PREDICTION c.1.8(14-314) c.1.8(15-319) c.1.8(1-321) c.1.8(12-315) 4 No information Eukaryota|Bacteria|Archaea 2.4.1.18| 2.4.1.19| 2.4.1.25| 2.4.1.4| 2.4.1.5| 2.4.1.7| 2.7.1.31| 2.7.7.43| 3.1.3.16| 3.1.3.18| 3.1.3.2| 3.1.3.23| 3.1.3.24| 3.1.3.29| 3.1.3.3| 3.1.3.41| 3.1.3.45| 3.1.3.48| 3.1.3.5| 3.1.3.70| 3.1.3.71| 3.1.3.74| 3.1.8.2| 3.11.1.1| 3.2.1.1| 3.2.1.10| 3.2.1.105| 3.2.1.123| 3.2.1.133| 3.2.1.135| 3.2.1.136| 3.2.1.139| 3.2.1.14| 3.2.1.141| 3.2.1.147| 3.2.1.151| 3.2.1.165| 3.2.1.17| 3.2.1.2| 3.2.1.20| 3.2.1.21| 3.2.1.22| 3.2.1.23| 3.2.1.25| 3.2.1.31| 3.2.1.32| 3.2.1.35| 3.2.1.37| 3.2.1.39| 3.2.1.4| 3.2.1.41| 3.2.1.45| 3.2.1.48| 3.2.1.49| 3.2.1.51| 3.2.1.52| 3.2.1.54| 3.2.1.55| 3.2.1.58| 3.2.1.60| 3.2.1.68| 3.2.1.70| 3.2.1.73| 3.2.1.78| 3.2.1.8| 3.2.1.85| 3.2.1.86| 3.2.1.89| 3.2.1.96| 3.2.1.98| 3.6.1.1| 3.6.3.10| 3.6.3.4| 3.6.3.6| 3.6.3.8| 3.6.3.9| 3.8.1.2| 4.2.2.13| 5.4.2.6| 5.4.2.8| 5.4.99.11| 5.4.99.15 anchored to membrane| anchored to plasma membrane| cell wall| fungal-type cell wall| hyaluranon cable| lysosome beta-mannosidase activity| galactosidase activity| glucanosyltransferase activity| hyaluronan synthase activity| hydrolase activity, hydrolyzing O-glycosyl compounds| transferase activity, transferring glycosyl groups| virus receptor activity aminoglycan biosynthetic process| aminoglycan catabolic process| aminoglycan metabolic process| autolysis| cartilage development| cell wall beta-glucan metabolic process| cell wall macromolecule catabolic process| cell wall macromolecule metabolic process| cell wall organization or biogenesis| cellular carbohydrate catabolic process| cellular polysaccharide catabolic process| cellular polysaccharide metabolic process| cellular response to UV| cellular response to UV-B| cellular response to abiotic stimulus| cellular response to cytokine stimulus| cellular response to growth factor stimulus| cellular response to interleukin-1| cellular response to light stimulus| cellular response to pH| cellular response to platelet-derived growth factor stimulus| cellular response to radiation| ceramide catabolic process| ceramide metabolic process| connective tissue development| cytolysis| diaphragm contraction| external encapsulating structure organization| glucosamine-containing compound catabolic process| glucosamine-containing compound metabolic process| glycosaminoglycan catabolic process| glycosphingolipid catabolic process| glycosylceramide catabolic process| glycosylceramide metabolic process| hyaluronan biosynthetic process| hyaluronan catabolic process| hyaluronan metabolic process| inflammatory response| involuntary skeletal muscle contraction| lysosome organization| mannan metabolic process| membrane lipid catabolic process| multicellular organismal movement| negative regulation of cell growth| negative regulation of growth| neuromuscular process controlling balance| neuromuscular process controlling posture| peptidoglycan turnover| polysaccharide catabolic process| polysaccharide metabolic process| positive regulation of angiogenesis| positive regulation of cell adhesion| positive regulation of cell growth| positive regulation of epithelial cell migration| positive regulation of epithelial cell proliferation| positive regulation of hyaluranon cable assembly| regulation of angiogenesis| regulation of cell growth| regulation of cell migration| regulation of cell motility| regulation of cellular component movement| regulation of epithelial cell migration| regulation of hyaluranon cable assembly| regulation of locomotion| regulation of vasculature development| respiratory gaseous exchange| respiratory system process| response to UV| response to UV-B| response to antibiotic| response to cytokine stimulus| response to growth factor stimulus| response to interleukin-1| response to pH| response to platelet-derived growth factor stimulus| response to reactive oxygen species| response to toxic substance| response to virus| single-species biofilm formation| skeletal muscle contraction| skeletal system development| sphingolipid catabolic process| vacuole organization
48 PF09967 VWA-like domain (DUF2201) vWA-like (CL0128) 512 (16) 126 126 (1) vWA-like [c.62.1] (1-125)
(1) vWA-like [c.62]
c.62.1(1-118) c.62.1(1-125) c.62.1(1-101) NO PREDICTION c.62.1(1-94) 4 No information Eukaryota|Bacteria|Viruses|Archaea No information extracellular matrix No information DNA repair| double-strand break repair| double-strand break repair via nonhomologous end joining| non-recombinational repair| response to ionizing radiation
49 PF11968 Putative methyltransferase (DUF3321) NADP_Rossmann (CL0063) 219 (25) 220 221 (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (4-216)
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66]
c.66.1(4-216) c.66.1(1-197) c.66.1(45-183) NO PREDICTION c.66.1(28-187) 4 No information Eukaryota 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 nuclear matrix glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process
50 PF11288 Protein of unknown function (DUF3089) AB_hydrolase (CL0028) 100 (25) 208 199 (1) alpha/beta-Hydrolases [c.69.1] (2-197)
(1) alpha/beta-Hydrolases [c.69]
c.69.1(2-197) c.69.1(1-139) c.69.1(77-132) NO PREDICTION c.69.1(77-138) 4 No information Eukaryota|Bacteria|Archaea 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 trans-Golgi network transport vesicle CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process
51 PF10890 Protein of unknown function (DUF2741) UcrQ-like (CL0429) 42 (4) 72 72 (1) Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [f.23.13] (5-71)
(1) Single transmembrane helix [f.23]
f.23.13(7-71) f.23.13(5-71) f.23.13(10-66) NO PREDICTION f.23.13(10-62) 4 No information Eukaryota No information No information No information No information
52 PF11865 Domain of unknown function (DUF3385) TPR (CL0020) 388 (32) 160 161 (1) ARM repeat [a.118.1] (1-160)
(1) alpha-alpha superhelix [a.118]
a.118.1(1-160) a.118.1(6-159) a.118.1(4-46)| a.118.1(80-159) NO PREDICTION a.118.1(2-160) 4 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
53 PF05988 Bacterial protein of unknown function (DUF899) Thioredoxin (CL0172) 520 (51) 211 233 (1) Thioredoxin-like [c.47.1] (48-213)
(1) Thioredoxin fold [c.47]
c.47.1(42-174) c.47.1(38-193) c.47.1(58-152) NO PREDICTION c.47.1(48-213) 4 No information Eukaryota|Bacteria 1.1.4.2| 1.11.1.12| 1.11.1.15| 1.11.1.7| 1.11.1.9| 1.20.4.1| 1.8.1.7| 1.8.1.8| 1.8.1.9| 1.8.4.2| 1.8.4.7| 1.8.4.8| 1.8.5.1| 2.5.1.18| 5.2.1.2| 5.3.4.1| 5.3.99.3 NADH dehydrogenase complex| chloroplast stroma| ferredoxin hydrogenase complex| formate dehydrogenase complex| myelin sheath| plastid stroma| respiratory chain complex I antioxidant activity| arsenate reductase activity| disulfide oxidoreductase activity| electron carrier activity| formate dehydrogenase (NAD+) activity| glutathione binding| glutathione transferase activity| intramolecular oxidoreductase activity| intramolecular oxidoreductase activity, interconverting keto- and enol-groups| intramolecular oxidoreductase activity, transposing S-S bonds| oxidoreductase activity, acting on a sulfur group of donors| oxidoreductase activity, acting on hydrogen as donor| oxidoreductase activity, acting on peroxide as acceptor| oxidoreductase activity, acting on phosphorus or arsenic in donors| oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor| peroxidase activity| peroxiredoxin activity| phospholipid-hydroperoxide glutathione peroxidase activity| prostaglandin-F synthase activity| protein disulfide isomerase activity| thioredoxin peroxidase activity androecium development| anther development| cell redox homeostasis| cellular response to hydrogen peroxide| cellular response to oxidative stress| cellular response to reactive oxygen species| fatty acid derivative biosynthetic process| fatty acid derivative metabolic process| floral organ development| floral whorl development| flower development| formate metabolic process| hydrogen peroxide catabolic process| icosanoid biosynthetic process| nucleolus organization| phyllome development| positive regulation of DNA binding| positive regulation of binding| prostanoid biosynthetic process| protein deglutathionylation| protein folding| reactive oxygen species metabolic process| regulation of DNA binding| regulation of binding| regulation of intracellular transport| regulation of protein import into nucleus| regulation of protein import into nucleus, translocation| regulation of protein localization to nucleus| removal of superoxide radicals| response to hydrogen peroxide| response to hydroperoxide| response to reactive oxygen species| response to selenium ion| shoot system development| stamen development| toxin catabolic process| unsaturated fatty acid biosynthetic process| unsaturated fatty acid metabolic process
54 PF05951 Bacterial protein of unknown function (DUF882) Peptidase_MD (CL0170) 1137 (10) 153 151 (1) Hedgehog/DD-peptidase [d.65.1] (22-152)
(1) Hedgehog/DD-peptidase [d.65]
d.65.1(23-153) d.65.1(22-152) d.65.1(24-151) NO PREDICTION d.65.1(35-151) 4 YES Eukaryota|Bacteria 3.4.13.22| 3.4.17.14 No information No information No information
55 PF10356 Protein of unknown function (DUF2034) PDDEXK (CL0236) 178 (11) 185 185 (1) Restriction endonuclease-like [c.52.1] (INDIRECT)
(1) Restriction endonuclease-like [c.52]
c.52.1(9-154) c.52.1(INDIRECT) NO PREDICTION NO PREDICTION c.52.1(9-153) 3 No information Eukaryota 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 No information endonuclease activity| nuclease activity DNA repair| nucleotide-excision repair
56 PF12010 Domain of unknown function (DUF3502) No Pfam Clan 679 (18) 134 140 (1) Periplasmic binding protein-like II [c.94.1] (1-135)
(1) Periplasmic binding protein-like II [c.94]
c.94.1(1-132) NO PREDICTION c.94.1(4-135) NO PREDICTION c.94.1(1-135) 3 No information Eukaryota|Bacteria 1.16.1.2| 2.4.2.17| 2.5.1.2| 2.5.1.61| 3.13.1.3| 3.6.3.24 ATP-binding cassette (ABC) transporter complex| cell envelope| coated pit| early endosome| external encapsulating structure part| periplasmic space| recycling endosome ATPase activity| ATPase activity, coupled| ATPase activity, coupled to movement of substances| P-P-bond-hydrolysis-driven transmembrane transporter activity| amino acid transmembrane transporter activity| amino acid-transporting ATPase activity| anion transmembrane-transporting ATPase activity| hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances| iron ion binding| primary active transmembrane transporter activity SMAD protein signal transduction| iron ion transport| phosphate ion transport| polyamine transmembrane transport| polyamine transport| thiamine biosynthetic process| thiamine-containing compound biosynthetic process| thiamine-containing compound metabolic process| water-soluble vitamin biosynthetic process
57 PF05973 Phage derived protein Gp49-like (DUF891) Plasmid_toxin (CL0136) 2071 (226) 91 83 (1) RelE-like [d.298.1] (2-75)
(1) RelE-like [d.298]
d.298.1(2-75) d.298.1(1-71) NO PREDICTION NO PREDICTION d.298.1(3-66) 3 No information Eukaryota|Bacteria|Viruses No information No information endonuclease activity| nuclease activity RNA catabolic process| nucleic acid phosphodiester bond hydrolysis
58 PF11841 Domain of unknown function (DUF3361) No Pfam Clan 228 (9) 160 156 (1) ARM repeat [a.118.1] (2-159)
(1) alpha-alpha superhelix [a.118]
a.118.1(7-145) a.118.1(2-159) a.118.1(8-140) NO PREDICTION NO PREDICTION 3 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
59 PF07394 Protein of unknown function (DUF1501) Alk_phosphatase (CL0088) 1229 (51) 392 419 (1) Alkaline phosphatase-like [c.76.1] (1-391)
(1) Alkaline phosphatase-like [c.76]
NO PREDICTION c.76.1(1-391) c.76.1(243-405) NO PREDICTION c.76.1(259-394) 3 No information Eukaryota|Bacteria 3.1.3.1| 3.1.6.1| 3.1.6.12| 3.1.6.2| 3.1.6.8| 3.11.1.2| 3.6.1.9| 5.4.2.1 endoplasmic reticulum lumen| extracellular membrane-bounded organelle| extracellular organelle| lysosomal lumen| vacuolar lumen| vacuolar part alkaline phosphatase activity| glycerophosphocholine cholinephosphodiesterase activity| phospholipase activity| phosphoric diester hydrolase activity| sulfuric ester hydrolase activity| zinc ion binding aminoglycan catabolic process| aminoglycan metabolic process| bone development| bone morphogenesis| choline metabolic process| dephosphorylation| endochondral bone morphogenesis| endochondral ossification| ethanolamine-containing compound metabolic process| glycolipid metabolic process| glycoprotein metabolic process| glycosaminoglycan catabolic process| glycosaminoglycan metabolic process| heparan sulfate proteoglycan metabolic process| membrane lipid metabolic process| organ morphogenesis| ossification| post-translational protein modification| proteoglycan metabolic process| replacement ossification| response to antibiotic| response to organic cyclic compound| response to toxic substance| skeletal system development| skeletal system morphogenesis| sphingolipid metabolic process| sulfur compound catabolic process
60 PF11019 Protein of unknown function (DUF2608) No Pfam Clan 271 (27) 253 272 (1) HAD-like [c.108.1] (17-240)
(1) HAD-like [c.108]
c.108.1(36-191) c.108.1(17-240) NO PREDICTION NO PREDICTION c.108.1(83-226) 3 No information Bacteria 2.7.7.43| 3.1.3.16| 3.1.3.18| 3.1.3.2| 3.1.3.23| 3.1.3.24| 3.1.3.29| 3.1.3.3| 3.1.3.41| 3.1.3.45| 3.1.3.48| 3.1.3.5| 3.1.3.70| 3.1.3.74| 3.1.8.2| 3.11.1.1| 3.6.1.1| 3.6.3.10| 3.6.3.4| 3.6.3.6| 3.6.3.8| 3.6.3.9| 3.8.1.2| 5.4.2.6| 5.4.2.8 Nem1-Spo7 phosphatase complex| nuclear envelope| nuclear membrane| protein serine/threonine phosphatase complex D,D-heptose 1,7-bisphosphate phosphatase activity| acireductone synthase activity| inorganic diphosphatase activity| intramolecular transferase activity| intramolecular transferase activity, phosphotransferases| magnesium ion binding| phosphatase activity L-methionine biosynthetic process| L-methionine salvage| L-methionine salvage from methylthioadenosine| L-serine metabolic process| amino acid salvage| cellular carbohydrate biosynthetic process| cellular membrane organization| cellular metabolic compound salvage| cofactor catabolic process| deoxyribonucleotide catabolic process| dephosphorylation| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| methionine metabolic process| nuclear envelope organization| nucleus organization| organophosphate catabolic process| positive regulation of lipid biosynthetic process| positive regulation of lipid metabolic process| positive regulation of triglyceride biosynthetic process| positive regulation of triglyceride metabolic process| regulation of lipid biosynthetic process| regulation of lipid metabolic process| regulation of triglyceride biosynthetic process| regulation of triglyceride metabolic process
61 PF06862 Protein of unknown function (DUF1253) P-loop_NTPase (CL0023) 368 (36) 442 459 (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (103-386)
(1) P-loop containing nucleoside triphosphate hydrolases [c.37]
c.37.1(103-386) NO PREDICTION NO PREDICTION c.37.1(255-459) c.37.1(135-241) 3 No information Eukaryota 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
62 PF14371 Domain of unknown function (DUF4412) No Pfam Clan 199 (91) 89 81 (1) Prokaryotic lipoproteins and lipoprotein localization factors [b.125.1] (2-89)
(1) LolA-like prokaryotic lipoproteins and lipoprotein localization factors [b.125]
b.125.1(2-89) NO PREDICTION b.125.1(8-81) NO PREDICTION b.125.1(2-50) 3 No information Eukaryota|Bacteria|Archaea No information No information No information No information
63 PF07642 Outer membrane protein family (DUF1597) MBB (CL0193) 396 (89) 344 469 (1) Porins [f.4.3] (1-343)
(1) Transmembrane beta-barrels [f.4]
f.4.3(76-314) f.4.3(1-343) f.4.3(2-22)| f.4.3(50-298)| f.4.3(344-381)| f.4.3(414-469) NO PREDICTION NO PREDICTION 3 No information Eukaryota|Bacteria No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity fatty acid transport| lipid localization| long-chain fatty acid transport
64 PF12030 Domain of unknown function (DUF3517) No Pfam Clan 66 (7) 337 337 (1) ARM repeat [a.118.1] (1-323)
(1) alpha-alpha superhelix [a.118]
a.118.1(10-322) a.118.1(1-323) a.118.1(124-272) NO PREDICTION NO PREDICTION 3 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
65 PF10302 DUF2407 ubiquitin-like domain Ubiquitin (CL0072) 152 (46) 97 90 (1) Ubiquitin-like [d.15.1] (5-80)
(1) beta-Grasp (ubiquitin-like) [d.15]
d.15.1(5-80) d.15.1(1-64) NO PREDICTION NO PREDICTION d.15.1(3-68) 3 No information Eukaryota 3.1.2.15| 3.1.4.11 autophagic vacuole| nuclear body SUMO ligase activity| non-membrane spanning protein tyrosine phosphatase activity| phosphoprotein phosphatase activity| protein tag| protein tyrosine phosphatase activity| small conjugating protein ligase activity| small conjugating protein ligase binding autophagy| catechol-containing compound metabolic process| catecholamine metabolic process| catecholamine transport| catecholamine uptake| catecholamine uptake involved in synaptic transmission| dopamine metabolic process| dopamine transport| dopamine uptake| dopamine uptake involved in synaptic transmission| monoamine transport| neurotransmitter uptake| norepinephrine metabolic process| peptidyl-tyrosine dephosphorylation| positive regulation of protein ubiquitination| positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc| protein modification by small protein conjugation or removal| protein sumoylation| proteolysis involved in cellular protein catabolic process| regulation of neurotransmitter secretion| regulation of neurotransmitter transport| regulation of protein catabolic process| regulation of protein ubiquitination| regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process| regulation of proteolysis| response to transforming growth factor beta stimulus| startle response| synaptic transmission, dopaminergic| synaptic transmission, glutamatergic
66 PF10006 Uncharacterized conserved protein (DUF2249) TusA-like (CL0397) 821 (163) 69 70 (1) SirA-like [d.68.3] (1-70)
(1) IF3-like [d.68]
d.68.3(1-69) d.68.3(1-68) NO PREDICTION NO PREDICTION d.68.3(1-70) 3 No information Eukaryota|Bacteria|Archaea No information No information No information No information
67 PF08843 Nucleotidyl transferase of unknown function (DUF1814) NTP_transf (CL0260) 2210 (177) 233 250 (1) Nucleotidyltransferase [d.218.1] (1-170)
(1) Nucleotidyltransferase [d.218]
d.218.1(2-166) d.218.1(1-170) NO PREDICTION NO PREDICTION d.218.1(10-61) 3 No information Eukaryota|Bacteria|Viruses|Archaea 2.7.6.5| 2.7.7.19| 2.7.7.31| 2.7.7.42| 2.7.7.52| 2.7.7.7| 2.7.7.72 No information adenylyltransferase activity| double-stranded RNA binding No information
68 PF12965 Domain of unknown function (DUF3854) Toprim-like (CL0413) 235 (54) 130 115 (1) DNA primase core [e.13.1] (1-130)
(1) DNA primase core [e.13]
e.13.1(1-130) e.13.1(10-125) NO PREDICTION NO PREDICTION e.13.1(9-115) 3 No information Eukaryota|Bacteria|Viruses No information No information No information No information
69 PF14868 Domain of unknown function (DUF4487) No Pfam Clan 134 (12) 559 548 (1) ARM repeat [a.118.1] (3-555)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(3-555) a.118.1(142-210)| a.118.1(279-334)| a.118.1(397-541) a.118.1(1-548) NO PREDICTION 3 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
70 PF02721 Domain of unknown function DUF223 OB (CL0021) 441 (15) 95 95 (1) Nucleic acid-binding proteins [b.40.4] (2-83)
(1) OB-fold [b.40]
b.40.4(2-83) NO PREDICTION b.40.4(2-74) NO PREDICTION b.40.4(1-73) 3 No information Eukaryota 3.1.13.1| 3.1.26.12| 6.5.1.1 DNA replication factor A complex| DNA-directed RNA polymerase II, core complex| DNA-directed RNA polymerase II, holoenzyme| DNA-directed RNA polymerase complex| RNA polymerase complex| cytoplasmic exosome (RNase complex)| cytosolic small ribosomal subunit| exosome (RNase complex)| mitochondrial nucleoid| nuclear DNA-directed RNA polymerase complex| nucleoid| organellar ribosome| replisome RNA polymerase activity| chromatin binding| ribonucleoprotein complex binding| single-stranded DNA binding| structure-specific DNA binding regulation of DNA-dependent transcription, termination| regulation of RNA stability| regulation of mRNA stability| response to cold| ribonucleoprotein complex biogenesis| telomere maintenance| telomere organization| transcriptional attenuation| translational initiation
71 PF12530 Protein of unknown function (DUF3730) No Pfam Clan 180 (25) 234 196 (1) ARM repeat [a.118.1] (1-233)
(1) alpha-alpha superhelix [a.118]
a.118.1(1-161) a.118.1(1-233) a.118.1(3-192) NO PREDICTION NO PREDICTION 3 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
72 PF03445 Putative nucleotidyltransferase DUF294 NTP_transf (CL0260) 1219 (86) 138 142 (1) Nucleotidyltransferase [d.218.1] (5-140)
(1) Nucleotidyltransferase [d.218]
d.218.1(5-99) d.218.1(1-103) NO PREDICTION NO PREDICTION d.218.1(5-140) 3 No information Eukaryota|Bacteria|Viruses|Archaea 2.7.6.5| 2.7.7.19| 2.7.7.31| 2.7.7.42| 2.7.7.52| 2.7.7.7| 2.7.7.72 No information adenylyltransferase activity| double-stranded RNA binding No information
73 PF12043 Domain of unknown function (DUF3527) No Pfam Clan 128 (12) 346 264 (1) Tubby C-terminal domain-like [d.23.1] (1-261)
(1) Tubby C-terminal domain-like [d.23]
NO PREDICTION NO PREDICTION d.23.1(214-259) d.23.1(1-261) d.23.1(103-261) 3 No information Eukaryota No information No information G-protein coupled photoreceptor activity| G-protein coupled receptor activity| molecular transducer activity| photoreceptor activity| receptor activity| signaling receptor activity| transmembrane signaling receptor activity detection of abiotic stimulus| detection of external stimulus| detection of light stimulus| detection of stimulus| detection of visible light| eye development| phototransduction| retina development in camera-type eye| sensory organ development
74 PF09960 Uncharacterized protein conserved in bacteria (DUF2194) No Pfam Clan 111 (8) 585 718 (1) Class I glutamine amidotransferase-like [c.23.16] (52-261)
(2) Glycoside hydrolase/deacetylase [c.6.2] (251-534)
(1) Flavodoxin-like [c.23]
(2) 7-stranded beta/alpha barrel [c.6]
NO PREDICTION c.23.16(52-261)| c.6.2(251-534) c.6.2(428-561) NO PREDICTION c.6.2(415-664) 3 No information Bacteria|Archaea 2.3.1.46| 2.4.1.18| 2.4.1.211| 2.4.1.25| 3.1.1.72| 3.2.1.1| 3.2.1.114| 3.2.1.24| 3.4.13.21| 3.4.15.6| 3.4.17.13| 3.4.19.9| 3.5.1.33| 3.5.1.41| 3.5.2.5| 4.2.1.103| 6.3.5.2| 6.3.5.5 No information 4-amino-4-deoxychorismate synthase activity| anthranilate synthase activity| antioxidant activity| carbon-carbon lyase activity| carbon-nitrogen ligase activity, with glutamine as amido-N-donor| deacetylase activity| glyoxalase III activity| oxidoreductase activity, acting on peroxide as acceptor| oxo-acid-lyase activity| peptidase activity| peroxidase activity| peroxiredoxin activity| transaminase activity| transferase activity, transferring nitrogenous groups adult behavior| adult locomotory behavior| amine biosynthetic process| aromatic amino acid family biosynthetic process| aromatic amino acid family metabolic process| catecholamine transport| catecholamine uptake| catecholamine uptake involved in synaptic transmission| cellular biogenic amine biosynthetic process| cellular response to oxidative stress| cellular response to reactive oxygen species| dopamine transport| dopamine uptake| dopamine uptake involved in synaptic transmission| folic acid-containing compound biosynthetic process| folic acid-containing compound metabolic process| hydrogen peroxide metabolic process| indolalkylamine biosynthetic process| indole-containing compound biosynthetic process| indole-containing compound metabolic process| lactate biosynthetic process| lactate metabolic process| membrane depolarization| membrane hyperpolarization| monoamine transport| negative regulation of binding| negative regulation of protein binding| neuron-neuron synaptic transmission| neurotransmitter transport| neurotransmitter uptake| organic hydroxy compound transport| positive regulation of oxidative phosphorylation uncoupler activity| positive regulation of transporter activity| protein stabilization| pteridine-containing compound biosynthetic process| pteridine-containing compound metabolic process| reactive oxygen species metabolic process| regulation of binding| regulation of neuron apoptotic process| regulation of neuron death| regulation of neurotransmitter levels| regulation of oxidative phosphorylation uncoupler activity| regulation of protein binding| regulation of protein stability| regulation of proton transport| regulation of transmembrane transport| regulation of transmembrane transporter activity| regulation of transporter activity| response to hydrogen peroxide| response to reactive oxygen species| synaptic transmission, dopaminergic| thiamine biosynthetic process| thiamine-containing compound biosynthetic process| thiamine-containing compound metabolic process| tryptophan biosynthetic process| tryptophan metabolic process| water-soluble vitamin biosynthetic process
75 PF10096 Uncharacterized protein conserved in bacteria (DUF2334) GH_CE (CL0158) 444 (40) 243 256 (1) Glycoside hydrolase/deacetylase [c.6.2] (1-242)
(1) 7-stranded beta/alpha barrel [c.6]
NO PREDICTION c.6.2(1-242) c.6.2(24-154) NO PREDICTION c.6.2(18-191) 3 No information Bacteria|Archaea 2.4.1.18| 2.4.1.25| 3.1.1.72| 3.2.1.1| 3.2.1.114| 3.2.1.24| 3.5.1.33| 3.5.1.41| 3.5.2.5 No information deacetylase activity No information
76 PF10923 P-loop Domain of unknown function (DUF2791) P-loop_NTPase (CL0023) 286 (28) 417 408 (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (25-397)
(1) P-loop containing nucleoside triphosphate hydrolases [c.37]
NO PREDICTION c.37.1(25-397) c.37.1(28-116)| c.37.1(233-357) NO PREDICTION c.37.1(26-362) 3 No information Bacteria|Archaea 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
77 PF12074 Domain of unknown function (DUF3554) No Pfam Clan 248 (30) 339 351 (1) ARM repeat [a.118.1] (1-338)
(1) alpha-alpha superhelix [a.118]
a.118.1(11-338) a.118.1(1-338) a.118.1(8-248)| a.118.1(276-320) NO PREDICTION NO PREDICTION 3 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
78 PF12340 Protein of unknown function (DUF3638) No Pfam Clan 218 (26) 229 229 (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (1-226)
(1) P-loop containing nucleoside triphosphate hydrolases [c.37]
NO PREDICTION c.37.1(1-226) c.37.1(18-189) NO PREDICTION c.37.1(3-187) 3 No information Eukaryota|Bacteria 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
79 PF05152 Protein of unknown function (DUF705) HAD (CL0137) 75 (27) 297 313 (1) HAD-like [c.108.1] (114-296)
(1) HAD-like [c.108]
NO PREDICTION c.108.1(114-296) c.108.1(125-200) NO PREDICTION c.108.1(121-200) 3 No information Eukaryota|Bacteria|Viruses 2.7.7.43| 3.1.3.16| 3.1.3.18| 3.1.3.2| 3.1.3.23| 3.1.3.24| 3.1.3.29| 3.1.3.3| 3.1.3.41| 3.1.3.45| 3.1.3.48| 3.1.3.5| 3.1.3.70| 3.1.3.74| 3.1.8.2| 3.11.1.1| 3.6.1.1| 3.6.3.10| 3.6.3.4| 3.6.3.6| 3.6.3.8| 3.6.3.9| 3.8.1.2| 5.4.2.6| 5.4.2.8 Nem1-Spo7 phosphatase complex| nuclear envelope| nuclear membrane| protein serine/threonine phosphatase complex D,D-heptose 1,7-bisphosphate phosphatase activity| acireductone synthase activity| inorganic diphosphatase activity| intramolecular transferase activity| intramolecular transferase activity, phosphotransferases| magnesium ion binding| phosphatase activity L-methionine biosynthetic process| L-methionine salvage| L-methionine salvage from methylthioadenosine| L-serine metabolic process| amino acid salvage| cellular carbohydrate biosynthetic process| cellular membrane organization| cellular metabolic compound salvage| cofactor catabolic process| deoxyribonucleotide catabolic process| dephosphorylation| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| methionine metabolic process| nuclear envelope organization| nucleus organization| organophosphate catabolic process| positive regulation of lipid biosynthetic process| positive regulation of lipid metabolic process| positive regulation of triglyceride biosynthetic process| positive regulation of triglyceride metabolic process| regulation of lipid biosynthetic process| regulation of lipid metabolic process| regulation of triglyceride biosynthetic process| regulation of triglyceride metabolic process
80 PF14908 Domain of unknown function (DUF4496) No Pfam Clan 151 (29) 140 154 (1) IHF-like DNA-binding proteins [a.55.1] (3-134)
(1) IHF-like DNA-binding proteins [a.55]
a.55.1(3-134) NO PREDICTION a.55.1(4-67) NO PREDICTION a.55.1(2-70) 3 No information Eukaryota No information No information No information DNA packaging
81 PF11229 Protein of unknown function (DUF3028) No Pfam Clan 60 (3) 589 589 (1) ARM repeat [a.118.1] (1-589)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(2-580) a.118.1(10-358) a.118.1(1-589) NO PREDICTION 3 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
82 PF11918 Domain of unknown function (DUF3436) No Pfam Clan 2173 (47) 55 55 (1) ClpP/crotonase [c.14.1] (1-55)
(1) ClpP/crotonase [c.14]
c.14.1(1-55) NO PREDICTION c.14.1(2-54) NO PREDICTION c.14.1(1-55) 3 No information Eukaryota 2.1.3.1| 3.1.2.4| 3.4.21.92| 3.7.1.7| 3.8.1.7| 4.1.1.41| 4.1.1.70| 4.1.3.36| 4.2.1.101| 4.2.1.17| 4.2.1.18| 4.2.1.55| 5.3.3.8| 6.4.1.2| 6.4.1.3 acetyl-CoA carboxylase complex| chloroplastic endopeptidase Clp complex| endopeptidase Clp complex| microbody| organelle subcompartment| plastid envelope 1,4-dihydroxy-2-naphthoyl-CoA synthase activity| enoyl-CoA hydratase activity| hydro-lyase activity| intramolecular oxidoreductase activity| intramolecular oxidoreductase activity, transposing C=C bonds| ligase activity, forming carbon-carbon bonds RNA catabolic process| cellular lipid catabolic process| fatty acid catabolic process| fatty acid oxidation| ketone biosynthetic process| lipid modification| lipid oxidation| mRNA catabolic process| monocarboxylic acid catabolic process| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay| quinone biosynthetic process| quinone metabolic process
83 PF10826 Protein of unknown function (DUF2551) No Pfam Clan 39 (12) 83 81 (1) "Winged helix" DNA-binding domain [a.4.5] (6-82)
(1) DNA/RNA-binding 3-helical bundle [a.4]
a.4.5(22-75) a.4.5(6-82) NO PREDICTION NO PREDICTION a.4.5(11-75) 3 No information Bacteria|Archaea No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
84 PF05277 Protein of unknown function (DUF726) AB_hydrolase (CL0028) 559 (9) 345 339 (1) alpha/beta-Hydrolases [c.69.1] (12-343)
(1) alpha/beta-Hydrolases [c.69]
c.69.1(79-323) c.69.1(12-343) c.69.1(198-284) NO PREDICTION NO PREDICTION 3 No information Eukaryota|Bacteria|Archaea 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 trans-Golgi network transport vesicle CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process
85 PF14134 Domain of unknown function (DUF4301) No Pfam Clan 177 (43) 513 508 (1) Nucleotide-diphospho-sugar transferases [c.68.1] (4-511)
(1) Nucleotide-diphospho-sugar transferases [c.68]
NO PREDICTION c.68.1(4-511) c.68.1(163-334)| c.68.1(384-504) NO PREDICTION c.68.1(157-504) 3 No information Bacteria 2.4.1.101| 2.4.1.131| 2.4.1.135| 2.4.1.186| 2.4.1.217| 2.4.1.222| 2.4.1.223| 2.4.1.37| 2.4.1.41| 2.4.1.44| 2.4.1.87| 2.7.7.13| 2.7.7.23| 2.7.7.24| 2.7.7.27| 2.7.7.33| 2.7.7.38| 2.7.7.43| 2.7.7.60| 2.7.7.64| 2.7.7.9 Golgi apparatus| Golgi apparatus part| Golgi membrane| cis-Golgi network| mannosyltransferase complex UDP-glycosyltransferase activity| acetylgalactosaminyltransferase activity| ceramide glucosyltransferase activity| cytidylyltransferase activity| galactosyltransferase activity| glucose-1-phosphate thymidylyltransferase activity| guanylyltransferase activity| magnesium ion binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups aminoglycan biosynthetic process| aminoglycan metabolic process| cell wall biogenesis| cell wall mannoprotein biosynthetic process| cell wall organization or biogenesis| cellular carbohydrate biosynthetic process| cellular component macromolecule biosynthetic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| chondroitin sulfate biosynthetic process| chondroitin sulfate metabolic process| chondroitin sulfate proteoglycan biosynthetic process| chondroitin sulfate proteoglycan metabolic process| dolichol metabolic process| extracellular fibril organization| extracellular matrix organization| extracellular structure organization| fibril organization| galactose metabolic process| gametophyte development| glycolipid metabolic process| glycoprotein biosynthetic process| glycoprotein metabolic process| glycosaminoglycan biosynthetic process| glycosphingolipid biosynthetic process| glycosylation| heparan sulfate proteoglycan biosynthetic process| heparan sulfate proteoglycan metabolic process| lipopolysaccharide metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| negative regulation of fibroblast proliferation| nucleotide-sugar metabolic process| peptidyl-asparagine modification| phosphatidylinositol biosynthetic process| phosphatidylinositol metabolic process| pollen development| polyprenol metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein O-linked glycosylation| protein glycosylation| regulation of Notch signaling pathway| regulation of fibroblast proliferation| sphingolipid biosynthetic process| sphingolipid metabolic process
86 PF09844 Uncharacterized conserved protein (COG2071) ADC-like (CL0403) 298 (36) 217 213 (1) Acetoacetate decarboxylase-like [d.347.1] (1-214)
(1) Acetoacetate decarboxylase-like [d.347]
d.347.1(1-214) NO PREDICTION d.347.1(5-207) NO PREDICTION d.347.1(7-125) 3 No information Bacteria|Archaea 4.1.1.4 No information No information No information
87 PF11751 Protein of unknown function (DUF3308) MBB (CL0193) 599 (103) 274 286 (1) Porins [f.4.3] (1-286)
(1) Transmembrane beta-barrels [f.4]
f.4.3(17-191) f.4.3(14-273) NO PREDICTION f.4.3(1-286) NO PREDICTION 3 No information Bacteria No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity fatty acid transport| lipid localization| long-chain fatty acid transport
88 PF11144 Protein of unknown function (DUF2920) AB_hydrolase (CL0028) 738 (20) 403 409 (1) alpha/beta-Hydrolases [c.69.1] (10-367)
(1) alpha/beta-Hydrolases [c.69]
NO PREDICTION c.69.1(10-367) c.69.1(32-82)| c.69.1(151-229)| c.69.1(260-337) NO PREDICTION c.69.1(10-337) 3 No information Bacteria 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 trans-Golgi network transport vesicle CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process
89 PF04391 Protein of unknown function (DUF533) TerB (CL0414) 974 (61) 189 210 (1) TerB-like [a.287.1] (64-207)
(1) TerB-like [a.287]
a.287.1(62-189) NO PREDICTION a.287.1(64-207) NO PREDICTION a.287.1(99-209) 3 YES Bacteria|Viruses No information No information No information No information
90 PF13251 Domain of unknown function (DUF4042) No Pfam Clan 156 (19) 182 184 (1) ARM repeat [a.118.1] (1-182)
(1) alpha-alpha superhelix [a.118]
a.118.1(1-182) a.118.1(1-177) a.118.1(1-175) NO PREDICTION NO PREDICTION 3 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
91 PF07381 Winged helix DNA-binding domain (DUF1495) HTH (CL0123) 58 (11) 90 90 (1) "Winged helix" DNA-binding domain [a.4.5] (1-89)
(1) DNA/RNA-binding 3-helical bundle [a.4]
a.4.5(3-82) a.4.5(1-89) NO PREDICTION NO PREDICTION a.4.5(1-88) 3 No information Archaea No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
92 PF11152 Protein of unknown function (DUF2930) GAF (CL0161) 160 (30) 195 194 (1) GAF domain-like [d.110.2] (71-192)
(1) Profilin-like [d.110]
d.110.2(74-194) d.110.2(74-194) NO PREDICTION NO PREDICTION d.110.2(71-192) 3 No information Eukaryota|Bacteria 1.8.4.14| 4.6.1.1 No information No information No information
93 PF11313 Protein of unknown function (DUF3116) HTH (CL0123) 124 (6) 85 86 (1) "Winged helix" DNA-binding domain [a.4.5] (3-84)
(1) DNA/RNA-binding 3-helical bundle [a.4]
a.4.5(7-83) a.4.5(3-84) NO PREDICTION NO PREDICTION a.4.5(5-84) 3 No information Bacteria No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
94 PF12541 Protein of unknown function (DUF3737) Pec_lyase-like (CL0268) 223 (36) 278 278 (1) Pectin lyase-like [b.80.1] (12-277)
(1) Single-stranded right-handed beta-helix [b.80]
NO PREDICTION b.80.1(12-277) b.80.1(87-258) NO PREDICTION b.80.1(49-229) 3 No information Eukaryota|Bacteria|Archaea 3.1.1.11| 3.2.1.11| 3.2.1.15| 3.2.1.157| 3.2.1.57| 3.2.1.58| 3.4.21.72| 4.2.2.10| 4.2.2.18| 4.2.2.19| 4.2.2.2| 4.2.2.7 anchored to membrane| plant-type cell wall carbon-oxygen lyase activity, acting on polysaccharides| carboxylic ester hydrolase activity| galacturan 1,4-alpha-galacturonidase activity| pectinesterase activity| polygalacturonase activity cell growth| cell wall organization or biogenesis| developmental cell growth| developmental growth| developmental growth involved in morphogenesis| external encapsulating structure organization| galacturonan metabolic process| pectin catabolic process| plant-type cell wall organization| plant-type cell wall organization or biogenesis| pollen tube development| pollen tube growth| pollination| polysaccharide catabolic process| polysaccharide metabolic process| unidimensional cell growth
95 PF14367 Domain of unknown function (DUF4411) PIN (CL0280) 237 (58) 162 162 (1) PIN domain-like [c.120.1] (2-159)
(1) PIN domain-like [c.120]
c.120.1(1-138) c.120.1(1-152) NO PREDICTION NO PREDICTION c.120.1(2-159) 3 No information Bacteria|Archaea 3.1.11.3| 3.1.26.4 No information nuclease activity RNA phosphodiester bond hydrolysis| interspecies interaction between organisms| negative regulation of growth| nucleic acid phosphodiester bond hydrolysis| posttranscriptional regulation of gene expression
96 PF10711 Hypothetical protein (DUF2513) No Pfam Clan 250 (27) 102 98 (1) "Winged helix" DNA-binding domain [a.4.5] (1-101)
(1) DNA/RNA-binding 3-helical bundle [a.4]
a.4.5(4-82) a.4.5(1-101) NO PREDICTION NO PREDICTION a.4.5(20-84) 3 No information Eukaryota|Bacteria|Viruses No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
97 PF12128 Protein of unknown function (DUF3584) P-loop_NTPase (CL0023) 142 (10) 1201 1195 (1) Ribonuclease domain of colicin E3 [b.101.1] (595-769)
(2) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (9-154)
(1) Ribonuclease domain of colicin E3 [b.101]
(2) P-loop containing nucleoside triphosphate hydrolases [c.37]
NO PREDICTION NO PREDICTION c.37.1(9-81) b.101.1(595-769) c.37.1(9-154) 3 No information Eukaryota|Bacteria|Viruses|Archaea 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
98 PF11339 Protein of unknown function (DUF3141) AB_hydrolase (CL0028) 171 (28) 581 579 (1) alpha/beta-Hydrolases [c.69.1] (4-373)
(1) alpha/beta-Hydrolases [c.69]
NO PREDICTION c.69.1(4-373) c.69.1(30-352) NO PREDICTION c.69.1(59-173) 3 No information Eukaryota|Bacteria|Archaea 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 trans-Golgi network transport vesicle CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process
99 PF01796 DUF35 OB-fold domain OB (CL0021) 1861 (157) 68 66 (1) Nucleic acid-binding proteins [b.40.4] (1-68)
(1) OB-fold [b.40]
b.40.4(1-68) NO PREDICTION b.40.4(1-65) NO PREDICTION b.40.4(1-65) 3 No information Eukaryota|Bacteria|Archaea 3.1.13.1| 3.1.26.12| 6.5.1.1 DNA replication factor A complex| DNA-directed RNA polymerase II, core complex| DNA-directed RNA polymerase II, holoenzyme| DNA-directed RNA polymerase complex| RNA polymerase complex| cytoplasmic exosome (RNase complex)| cytosolic small ribosomal subunit| exosome (RNase complex)| mitochondrial nucleoid| nuclear DNA-directed RNA polymerase complex| nucleoid| organellar ribosome| replisome RNA polymerase activity| chromatin binding| ribonucleoprotein complex binding| single-stranded DNA binding| structure-specific DNA binding regulation of DNA-dependent transcription, termination| regulation of RNA stability| regulation of mRNA stability| response to cold| ribonucleoprotein complex biogenesis| telomere maintenance| telomere organization| transcriptional attenuation| translational initiation
100 PF11379 Protein of unknown function (DUF3182) No Pfam Clan 90 (15) 355 353 (1) Glutathione synthetase ATP-binding domain-like [d.142.1] (17-312)
(1) ATP-grasp [d.142]
NO PREDICTION d.142.1(17-312) d.142.1(110-219) NO PREDICTION d.142.1(115-303) 3 No information Eukaryota|Bacteria 4.1.1.21| 6.3.1.9| 6.3.2.23| 6.3.2.3| 6.3.2.4| 6.3.4.13| 6.3.4.14| 6.3.4.18 No information glutathione synthase activity microtubule-based process| response to cadmium ion
101 PF09986 Uncharacterized protein conserved in bacteria (DUF2225) TPR (CL0020) 252 (23) 214 212 (1) TPR-like [a.118.8] (37-196)
(1) alpha-alpha superhelix [a.118]
a.118.8(37-196) NO PREDICTION a.118.8(94-192) NO PREDICTION a.118.8(87-194) 3 No information Bacteria|Archaea No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
102 PF06537 Protein of unknown function (DUF1111) Cytochrome-c (CL0318) 817 (6) 499 499 (1) Cytochrome c [a.3.1] (335-499)
(1) Cytochrome c [a.3]
NO PREDICTION NO PREDICTION a.3.1(350-499) a.3.1(335-499) a.3.1(359-499) 3 No information Bacteria|Viruses 1.11.1.5| 1.4.99.3| 1.7.99.7 periplasmic space electron carrier activity| electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrom| heme binding| tetrapyrrole binding DNA catabolic process| DNA catabolic process, endonucleolytic| apoptotic DNA fragmentation| apoptotic nuclear changes| apoptotic process| cellular component disassembly| cellular component disassembly involved in execution phase of apoptosis| cellular respiration| electron transport chain| execution phase of apoptosis| mitochondrial ATP synthesis coupled electron transport| mitochondrial electron transport, cytochrome c to oxygen| nucleic acid phosphodiester bond hydrolysis| oxidative phosphorylation
103 PF10335 Putative nucleotidyltransferase substrate binding domain KNTase_C (CL0291) 1001 (86) 145 145 (1) Nucleotidyltransferase substrate binding subunit/domain [a.24.16] (2-144)
(1) Four-helical up-and-down bundle [a.24]
a.24.16(36-124) a.24.16(2-144) NO PREDICTION NO PREDICTION a.24.16(36-102) 3 No information Eukaryota|Bacteria|Archaea 2.7.7.42 No information No information No information
104 PF14121 Domain of unknown function (DUF4289) MBB (CL0193) 213 (62) 614 621 (1) Porins [f.4.3] (90-619)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION f.4.3(83-611) NO PREDICTION f.4.3(90-619) f.4.3(102-619) 3 YES Bacteria No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity fatty acid transport| lipid localization| long-chain fatty acid transport
105 PF10521 Protein of unknown function (DUF2454) No Pfam Clan 199 (29) 282 249 (1) ARM repeat [a.118.1] (1-277)
(1) alpha-alpha superhelix [a.118]
a.118.1(36-243) a.118.1(1-277) NO PREDICTION NO PREDICTION NO PREDICTION 2 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
106 PF11340 Protein of unknown function (DUF3142) No Pfam Clan 151 (16) 181 166 (1) (Trans)glycosidases [c.1.8] (29-121)
(1) TIM beta/alpha-barrel [c.1]
NO PREDICTION NO PREDICTION c.1.8(29-121) NO PREDICTION c.1.8(22-110) 2 No information Bacteria 2.4.1.18| 2.4.1.19| 2.4.1.25| 2.4.1.4| 2.4.1.5| 2.4.1.7| 2.7.1.31| 2.7.7.43| 3.1.3.16| 3.1.3.18| 3.1.3.2| 3.1.3.23| 3.1.3.24| 3.1.3.29| 3.1.3.3| 3.1.3.41| 3.1.3.45| 3.1.3.48| 3.1.3.5| 3.1.3.70| 3.1.3.71| 3.1.3.74| 3.1.8.2| 3.11.1.1| 3.2.1.1| 3.2.1.10| 3.2.1.105| 3.2.1.123| 3.2.1.133| 3.2.1.135| 3.2.1.136| 3.2.1.139| 3.2.1.14| 3.2.1.141| 3.2.1.147| 3.2.1.151| 3.2.1.165| 3.2.1.17| 3.2.1.2| 3.2.1.20| 3.2.1.21| 3.2.1.22| 3.2.1.23| 3.2.1.25| 3.2.1.31| 3.2.1.32| 3.2.1.35| 3.2.1.37| 3.2.1.39| 3.2.1.4| 3.2.1.41| 3.2.1.45| 3.2.1.48| 3.2.1.49| 3.2.1.51| 3.2.1.52| 3.2.1.54| 3.2.1.55| 3.2.1.58| 3.2.1.60| 3.2.1.68| 3.2.1.70| 3.2.1.73| 3.2.1.78| 3.2.1.8| 3.2.1.85| 3.2.1.86| 3.2.1.89| 3.2.1.96| 3.2.1.98| 3.6.1.1| 3.6.3.10| 3.6.3.4| 3.6.3.6| 3.6.3.8| 3.6.3.9| 3.8.1.2| 4.2.2.13| 5.4.2.6| 5.4.2.8| 5.4.99.11| 5.4.99.15 anchored to membrane| anchored to plasma membrane| cell wall| fungal-type cell wall| hyaluranon cable| lysosome beta-mannosidase activity| galactosidase activity| glucanosyltransferase activity| hyaluronan synthase activity| hydrolase activity, hydrolyzing O-glycosyl compounds| transferase activity, transferring glycosyl groups| virus receptor activity aminoglycan biosynthetic process| aminoglycan catabolic process| aminoglycan metabolic process| autolysis| cartilage development| cell wall beta-glucan metabolic process| cell wall macromolecule catabolic process| cell wall macromolecule metabolic process| cell wall organization or biogenesis| cellular carbohydrate catabolic process| cellular polysaccharide catabolic process| cellular polysaccharide metabolic process| cellular response to UV| cellular response to UV-B| cellular response to abiotic stimulus| cellular response to cytokine stimulus| cellular response to growth factor stimulus| cellular response to interleukin-1| cellular response to light stimulus| cellular response to pH| cellular response to platelet-derived growth factor stimulus| cellular response to radiation| ceramide catabolic process| ceramide metabolic process| connective tissue development| cytolysis| diaphragm contraction| external encapsulating structure organization| glucosamine-containing compound catabolic process| glucosamine-containing compound metabolic process| glycosaminoglycan catabolic process| glycosphingolipid catabolic process| glycosylceramide catabolic process| glycosylceramide metabolic process| hyaluronan biosynthetic process| hyaluronan catabolic process| hyaluronan metabolic process| inflammatory response| involuntary skeletal muscle contraction| lysosome organization| mannan metabolic process| membrane lipid catabolic process| multicellular organismal movement| negative regulation of cell growth| negative regulation of growth| neuromuscular process controlling balance| neuromuscular process controlling posture| peptidoglycan turnover| polysaccharide catabolic process| polysaccharide metabolic process| positive regulation of angiogenesis| positive regulation of cell adhesion| positive regulation of cell growth| positive regulation of epithelial cell migration| positive regulation of epithelial cell proliferation| positive regulation of hyaluranon cable assembly| regulation of angiogenesis| regulation of cell growth| regulation of cell migration| regulation of cell motility| regulation of cellular component movement| regulation of epithelial cell migration| regulation of hyaluranon cable assembly| regulation of locomotion| regulation of vasculature development| respiratory gaseous exchange| respiratory system process| response to UV| response to UV-B| response to antibiotic| response to cytokine stimulus| response to growth factor stimulus| response to interleukin-1| response to pH| response to platelet-derived growth factor stimulus| response to reactive oxygen species| response to toxic substance| response to virus| single-species biofilm formation| skeletal muscle contraction| skeletal system development| sphingolipid catabolic process| vacuole organization
107 PF05331 Protein of unknown function (DUF742) HTH (CL0123) 710 (14) 114 129 (1) "Winged helix" DNA-binding domain [a.4.5] (63-110)
(1) DNA/RNA-binding 3-helical bundle [a.4]
NO PREDICTION NO PREDICTION a.4.5(63-110) NO PREDICTION a.4.5(60-106) 2 No information Bacteria|Archaea No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
108 PF11864 Domain of unknown function (DUF3384) No Pfam Clan 254 (26) 464 714 (1) ARM repeat [a.118.1] (1-463)
(1) alpha-alpha superhelix [a.118]
a.118.1(11-464) a.118.1(1-463) NO PREDICTION NO PREDICTION NO PREDICTION 2 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
109 PF04510 Family of unknown function (DUF577) No Pfam Clan 53 (17) 174 177 (1) ARM repeat [a.118.1] (3-156)
(1) alpha-alpha superhelix [a.118]
a.118.1(3-156) NO PREDICTION a.118.1(14-140) NO PREDICTION NO PREDICTION 2 No information Eukaryota|Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
110 PF13258 Domain of unknown function (DUF4049) No Pfam Clan 501 (3) 318 310 (1) Metallo-dependent phosphatases [d.159.1] (16-225)
(1) Metallo-dependent phosphatases [d.159]
NO PREDICTION d.159.1(16-225) d.159.1(97-193) NO PREDICTION NO PREDICTION 2 No information Bacteria 3.1.3.16| 3.1.3.2| 3.1.3.3| 3.1.3.48| 3.1.3.5| 3.1.3.53| 3.1.4.17| 3.1.4.46| 3.6.1.41 cis-Golgi network| endoplasmic reticulum exit site| endoplasmic reticulum-Golgi intermediate compartment| protein serine/threonine phosphatase complex GPI anchor binding| RNA lariat debranching enzyme activity| acid phosphatase activity| endonuclease activity| endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomo| endoribonuclease activity| endoribonuclease activity, producing 5'-phosphomonoesters| ferric iron binding| glycolipid binding| manganese ion binding| phosphatidylinositol binding| phospholipid binding ER to Golgi vesicle-mediated transport| GPI anchor biosynthetic process| GPI anchor metabolic process| Golgi vesicle transport| RNA phosphodiester bond hydrolysis, endonucleolytic| dephosphorylation| glycerolipid biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| lipoprotein biosynthetic process| lipoprotein metabolic process| membrane lipid biosynthetic process| membrane lipid metabolic process| phosphatidylinositol biosynthetic process| phosphatidylinositol metabolic process| phospholipid biosynthetic process| protein lipidation
111 PF06382 Protein of unknown function (DUF1074) HMG-box (CL0114) 76 (3) 183 125 (1) HMG-box [a.21.1] (24-69)
(1) HMG-box [a.21]
NO PREDICTION NO PREDICTION a.21.1(24-69) NO PREDICTION a.21.1(25-69) 2 No information Eukaryota No information chromosomal part DNA binding, bending| chromatin binding| nucleic acid binding transcription factor activity| sequence-specific DNA binding transcription factor activity| structural constituent of chromatin chromatin organization| chromosome organization
112 PF11287 Protein of unknown function (DUF3088) No Pfam Clan 111 (19) 112 111 (1) Thioredoxin-like [c.47.1] (20-111)
(1) Thioredoxin fold [c.47]
NO PREDICTION c.47.1(20-111) NO PREDICTION NO PREDICTION c.47.1(20-107) 2 No information Eukaryota|Bacteria 1.1.4.2| 1.11.1.12| 1.11.1.15| 1.11.1.7| 1.11.1.9| 1.20.4.1| 1.8.1.7| 1.8.1.8| 1.8.1.9| 1.8.4.2| 1.8.4.7| 1.8.4.8| 1.8.5.1| 2.5.1.18| 5.2.1.2| 5.3.4.1| 5.3.99.3 NADH dehydrogenase complex| chloroplast stroma| ferredoxin hydrogenase complex| formate dehydrogenase complex| myelin sheath| plastid stroma| respiratory chain complex I antioxidant activity| arsenate reductase activity| disulfide oxidoreductase activity| electron carrier activity| formate dehydrogenase (NAD+) activity| glutathione binding| glutathione transferase activity| intramolecular oxidoreductase activity| intramolecular oxidoreductase activity, interconverting keto- and enol-groups| intramolecular oxidoreductase activity, transposing S-S bonds| oxidoreductase activity, acting on a sulfur group of donors| oxidoreductase activity, acting on hydrogen as donor| oxidoreductase activity, acting on peroxide as acceptor| oxidoreductase activity, acting on phosphorus or arsenic in donors| oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor| peroxidase activity| peroxiredoxin activity| phospholipid-hydroperoxide glutathione peroxidase activity| prostaglandin-F synthase activity| protein disulfide isomerase activity| thioredoxin peroxidase activity androecium development| anther development| cell redox homeostasis| cellular response to hydrogen peroxide| cellular response to oxidative stress| cellular response to reactive oxygen species| fatty acid derivative biosynthetic process| fatty acid derivative metabolic process| floral organ development| floral whorl development| flower development| formate metabolic process| hydrogen peroxide catabolic process| icosanoid biosynthetic process| nucleolus organization| phyllome development| positive regulation of DNA binding| positive regulation of binding| prostanoid biosynthetic process| protein deglutathionylation| protein folding| reactive oxygen species metabolic process| regulation of DNA binding| regulation of binding| regulation of intracellular transport| regulation of protein import into nucleus| regulation of protein import into nucleus, translocation| regulation of protein localization to nucleus| removal of superoxide radicals| response to hydrogen peroxide| response to hydroperoxide| response to reactive oxygen species| response to selenium ion| shoot system development| stamen development| toxin catabolic process| unsaturated fatty acid biosynthetic process| unsaturated fatty acid metabolic process
113 PF12955 Domain of unknown function (DUF3844) No Pfam Clan 106 (32) 103 91 (1) EGF/Laminin [g.3.11] (4-50)
(1) Knottins (small inhibitors, toxins, lectins) [g.3]
NO PREDICTION NO PREDICTION g.3.11(6-52) NO PREDICTION g.3.11(4-50) 2 No information Eukaryota No information No information No information No information
114 PF04063 Domain of unknown function (DUF383) No Pfam Clan 308 (31) 192 261 (1) ARM repeat [a.118.1] (11-191)
(1) alpha-alpha superhelix [a.118]
a.118.1(4-153) a.118.1(11-191) NO PREDICTION NO PREDICTION NO PREDICTION 2 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
115 PF14262 Domain of unknown function (DUF4353) No Pfam Clan 568 (51) 264 266 (1) Pectin lyase-like [b.80.1] (2-263)
(1) Single-stranded right-handed beta-helix [b.80]
NO PREDICTION b.80.1(2-263) NO PREDICTION b.80.1(6-266) NO PREDICTION 2 No information Bacteria|Archaea 3.1.1.11| 3.2.1.11| 3.2.1.15| 3.2.1.157| 3.2.1.57| 3.2.1.58| 3.4.21.72| 4.2.2.10| 4.2.2.18| 4.2.2.19| 4.2.2.2| 4.2.2.7 anchored to membrane| plant-type cell wall carbon-oxygen lyase activity, acting on polysaccharides| carboxylic ester hydrolase activity| galacturan 1,4-alpha-galacturonidase activity| pectinesterase activity| polygalacturonase activity cell growth| cell wall organization or biogenesis| developmental cell growth| developmental growth| developmental growth involved in morphogenesis| external encapsulating structure organization| galacturonan metabolic process| pectin catabolic process| plant-type cell wall organization| plant-type cell wall organization or biogenesis| pollen tube development| pollen tube growth| pollination| polysaccharide catabolic process| polysaccharide metabolic process| unidimensional cell growth
116 PF11849 Domain of unknown function (DUF3369) GAF (CL0161) 346 (63) 174 172 (1) GAF domain-like [d.110.2] (15-170)
(1) Profilin-like [d.110]
d.110.2(34-173) d.110.2(15-170) NO PREDICTION NO PREDICTION NO PREDICTION 2 No information Eukaryota|Bacteria 1.8.4.14| 4.6.1.1 No information No information No information
117 PF12416 Cep120 protein No Pfam Clan 109 (16) 340 333 (1) C2 domain (Calcium/lipid-binding domain, CaLB) [b.7.1] (2-134)
(1) C2 domain-like [b.7]
NO PREDICTION NO PREDICTION b.7.1(2-134) NO PREDICTION b.7.1(2-125) 2 No information Eukaryota No information No information No information No information
118 PF15008 Domain of unknown function (DUF4518) No Pfam Clan 96 (14) 262 274 (1) NTF2-like [d.17.4] (133-271)
(1) Cystatin-like [d.17]
NO PREDICTION NO PREDICTION d.17.4(135-270) NO PREDICTION d.17.4(133-271) 2 No information Eukaryota 3.3.2.8| 4.2.1.94| 5.3.3.1 T-tubule| axon initial segment| axon part| cell-cell contact zone| main axon| neuromuscular junction| nuclear envelope| pore complex| sarcolemma Ran GTPase binding G1/S transition of mitotic cell cycle| RNA export from nucleus| RNA localization| antibiotic biosynthetic process| antibiotic metabolic process| blood circulation| calcium ion transport| cardiac muscle contraction| cell cycle phase| cell cycle phase transition| drug metabolic process| establishment of RNA localization| heart contraction| heart process| interphase| interphase of mitotic cell cycle| mitotic cell cycle phase transition| muscle contraction| muscle system process| nuclear transport| nucleobase-containing compound transport| nucleocytoplasmic transport| peptidyl-serine phosphorylation| poly(A)+ mRNA export from nucleus| positive regulation of antimicrobial peptide biosynthetic process| positive regulation of cellular amide metabolic process| protein autophosphorylation| regulation of antimicrobial humoral response| regulation of antimicrobial peptide biosynthetic process| regulation of antimicrobial peptide production| regulation of cellular amide metabolic process| regulation of humoral immune response| regulation of production of molecular mediator of immune response| regulation of sodium ion transport| striated muscle contraction
119 PF11946 Domain of unknown function (DUF3463) No Pfam Clan 326 (67) 138 143 (1) Radical SAM enzymes [c.1.28] (4-118)
(1) TIM beta/alpha-barrel [c.1]
c.1.28(1-114) NO PREDICTION c.1.28(4-118) NO PREDICTION NO PREDICTION 2 No information Bacteria|Archaea 1.3.99.22| 1.97.1.4| 2.8.1.6| 5.4.3.2 lipid particle 4 iron, 4 sulfur cluster binding| biotin synthase activity| intramolecular transferase activity| lipoate synthase activity| lipoate-protein ligase activity| metal cluster binding| oxidoreductase activity, acting on the CH-CH group of donors| protein self-association| radical SAM enzyme activity| sulfurtransferase activity| transferase activity, transferring sulfur-containing groups CD4-positive, alpha-beta T cell activation| CD4-positive, alpha-beta T cell differentiation| T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| defense response to virus| lipoate biosynthetic process| lipoate metabolic process| lymphocyte differentiation| molybdopterin cofactor biosynthetic process| molybdopterin cofactor metabolic process| monocarboxylic acid biosynthetic process| negative regulation of protein secretion| negative regulation of protein transport| negative regulation of secretion| positive regulation of T cell cytokine production| positive regulation of T cell mediated immunity| positive regulation of T-helper 2 cell cytokine production| positive regulation of adaptive immune response| positive regulation of adaptive immune response based on somatic recombination of immune receptors b| positive regulation of cytokine production| positive regulation of cytokine production involved in immune response| positive regulation of immune effector process| positive regulation of leukocyte mediated immunity| positive regulation of lymphocyte mediated immunity| positive regulation of production of molecular mediator of immune response| positive regulation of toll-like receptor 9 signaling pathway| positive regulation of toll-like receptor signaling pathway| prosthetic group metabolic process| regulation of T cell cytokine production| regulation of T cell mediated immunity| regulation of T-helper 2 cell cytokine production| regulation of adaptive immune response| regulation of cytokine production involved in immune response| regulation of leukocyte mediated immunity| regulation of lymphocyte mediated immunity| regulation of production of molecular mediator of immune response| regulation of protein secretion| regulation of toll-like receptor 7 signaling pathway| regulation of toll-like receptor 9 signaling pathway| regulation of toll-like receptor signaling pathway| regulation of type 2 immune response| response to virus| vitamin biosynthetic process
120 PF07611 Protein of unknown function (DUF1574) No Pfam Clan 48 (4) 345 350 (1) SGNH hydrolase [c.23.10] (38-344)
(1) Flavodoxin-like [c.23]
NO PREDICTION c.23.10(38-344) NO PREDICTION NO PREDICTION c.23.10(256-348) 2 No information Bacteria 3.1.1.2| 3.1.1.47| 3.1.1.5| 3.1.1.53| 3.1.1.72| 3.2.1.4 No information carboxylic ester hydrolase activity sexual reproduction| spermatogenesis
121 PF06972 Protein of unknown function (DUF1296) UBA (CL0214) 106 (7) 60 60 (1) UBA-like [a.5.2] (3-60)
(1) RuvA C-terminal domain-like [a.5]
NO PREDICTION NO PREDICTION a.5.2(3-60) NO PREDICTION a.5.2(4-55) 2 No information Eukaryota No information No information No information No information
122 PF12094 Protein of unknown function (DUF3570) No Pfam Clan 141 (41) 420 406 (1) Porins [f.4.3] (1-406)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION f.4.3(24-419) NO PREDICTION f.4.3(1-406) NO PREDICTION 2 No information Bacteria|Viruses No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity fatty acid transport| lipid localization| long-chain fatty acid transport
123 PF10649 Protein of unknown function (DUF2478) P-loop_NTPase (CL0023) 205 (57) 159 150 (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (INDIRECT)
(1) P-loop containing nucleoside triphosphate hydrolases [c.37]
c.37.1(4-140) c.37.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 2 No information Eukaryota|Bacteria 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
124 PF08873 Domain of unknown function (DUF1834) No Pfam Clan 142 (15) 188 202 (1) Phage tail protein-like [d.323.1] (1-150)
(1) Phage tail protein-like [d.323]
NO PREDICTION d.323.1(1-150) NO PREDICTION NO PREDICTION d.323.1(4-150) 2 No information Bacteria|Viruses No information No information No information No information
125 PF11687 Domain of unknown function (DUF3284) Bet_V_1_like (CL0209) 343 (15) 120 120 (1) Bet v1-like [d.129.3] (1-109)
(1) TBP-like [d.129]
NO PREDICTION NO PREDICTION d.129.3(6-110) NO PREDICTION d.129.3(1-109) 2 No information Bacteria 1.14.12.12| 1.14.12.18| 3.1.3.16| 4.2.1.78 intercellular canaliculus| microvillus abscisic acid binding| alcohol binding| alcohol transmembrane transporter activity| anion transmembrane transporter activity| carboxylic acid binding| hormone binding| isoprenoid binding| lipid transporter activity| monocarboxylic acid binding| organic anion transmembrane transporter activity| organic cation transmembrane transporter activity| organic hydroxy compound transmembrane transporter activity| phosphate transmembrane transporter activity| phosphatidylcholine transporter activity| phospholipid transporter activity| protein homodimerization activity| quaternary ammonium group transmembrane transporter activity abscisic acid mediated signaling pathway| acid secretion| bile acid secretion| cellular response to abscisic acid stimulus| cellular response to alcohol| cellular response to hormone stimulus| cellular response to lipid| hormone-mediated signaling pathway| lipid localization| lipid transport| monocarboxylic acid transport| organic anion transport| organophosphate ester transport| phospholipid transport| positive regulation of peroxisome proliferator activated receptor signaling pathway| quaternary ammonium group transport| regulation of peroxisome proliferator activated receptor signaling pathway| regulation of post-embryonic development| response to abscisic acid stimulus| response to alcohol| response to hormone stimulus| response to lipid
126 PF14247 Domain of unknown function (DUF4344) No Pfam Clan 149 (33) 220 230 (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (9-149)
(1) Zincin-like [d.92]
NO PREDICTION d.92.1(9-149) d.92.1(12-68)| d.92.1(99-179) NO PREDICTION NO PREDICTION 2 No information Bacteria|Archaea 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 cortical granule glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing
127 PF11443 Domain of unknown function (DUF2828) No Pfam Clan 303 (19) 534 510 (1) vWA-like [c.62.1] (299-503)
(1) vWA-like [c.62]
NO PREDICTION NO PREDICTION c.62.1(301-408) NO PREDICTION c.62.1(299-503) 2 No information Eukaryota|Bacteria|Viruses No information extracellular matrix No information DNA repair| double-strand break repair| double-strand break repair via nonhomologous end joining| non-recombinational repair| response to ionizing radiation
128 PF07607 Protein of unknown function (DUF1570) Peptidase_MA (CL0126) 34 (9) 128 125 (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (1-127)
(1) Zincin-like [d.92]
NO PREDICTION d.92.1(1-127) NO PREDICTION NO PREDICTION d.92.1(2-41) 2 No information Bacteria 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 cortical granule glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing
129 PF09894 Uncharacterized protein conserved in archaea (DUF2121) No Pfam Clan 34 (13) 194 193 (1) N-terminal nucleophile aminohydrolases (Ntn hydrolases) [d.153.1] (2-180)
(1) Ntn hydrolase-like [d.153]
NO PREDICTION d.153.1(INDIRECT) NO PREDICTION NO PREDICTION d.153.1(2-180) 2 No information Archaea 2.3.2.2| 2.4.2.14| 2.6.1.16| 3.4.19.5| 3.4.25.1| 3.4.25.2| 3.5.1.11| 3.5.1.24| 3.5.1.26| 3.5.1.93| 3.5.1.97 cytoplasmic mRNA processing body| cytosolic proteasome complex| proteasome complex| proteasome core complex| proteasome core complex, alpha-subunit complex| proteasome core complex, beta-subunit complex| ribonucleoprotein granule N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity| asparaginase activity| gamma-glutamyltransferase activity| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides| omega peptidase activity| peptidase activity| threonine-type endopeptidase activity| threonine-type peptidase activity| transferase activity, transferring amino-acyl groups DNA damage checkpoint| DNA damage response, signal transduction by p53 class mediator| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest| DNA integrity checkpoint| G1 DNA damage checkpoint| G1/S transition of mitotic cell cycle| antigen processing and presentation| antigen processing and presentation of exogenous peptide antigen| antigen processing and presentation of exogenous peptide antigen via MHC class I| antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent| antigen processing and presentation of peptide antigen via MHC class I| asparagine catabolic process| asparagine catabolic process via L-aspartate| asparagine metabolic process| aspartate family amino acid catabolic process| aspartate family amino acid metabolic process| cell cycle checkpoint| cell cycle phase| cell cycle phase transition| cellular amino acid catabolic process| cellular protein catabolic process| cellular protein complex assembly| fat cell differentiation| fatty acid beta-oxidation| gluconeogenesis| glucose catabolic process| glutamine family amino acid metabolic process| glutathione metabolic process| glycolysis| hexose biosynthetic process| hexose catabolic process| interphase| interphase of mitotic cell cycle| interspecies interaction between organisms| lipid modification| lipid oxidation| mitotic DNA damage checkpoint| mitotic DNA integrity checkpoint| mitotic G1 DNA damage checkpoint| mitotic cell cycle| mitotic cell cycle checkpoint| mitotic cell cycle phase transition| mitotic spindle elongation| modification-dependent macromolecule catabolic process| monosaccharide biosynthetic process| monosaccharide catabolic process| multi-organism cellular process| negative regulation of G1/S transition of mitotic cell cycle| negative regulation of apoptotic process| negative regulation of cell cycle phase transition| negative regulation of cell cycle process| negative regulation of ligase activity| negative regulation of mitotic cell cycle phase transition| negative regulation of protein modification process| negative regulation of protein ubiquitination| photorespiration| positive regulation of cell cycle arrest| positive regulation of cell cycle process| positive regulation of ligase activity| positive regulation of protein modification process| positive regulation of protein ubiquitination| positive regulation of ubiquitin-protein ligase activity| positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle| proteasomal protein catabolic process| proteasome assembly| protein catabolic process| protein deglycosylation| protein polyubiquitination| protein ubiquitination| proteolysis| proteolysis involved in cellular protein catabolic process| regulation of G1/S transition of mitotic cell cycle| regulation of cell cycle arrest| regulation of cell cycle phase transition| regulation of cellular amine metabolic process| regulation of cellular amino acid metabolic process| regulation of cellular ketone metabolic process| regulation of ligase activity| regulation of mitotic cell cycle| regulation of protein ubiquitination| regulation of ubiquitin-protein ligase activity| regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle| response to misfolded protein| response to salt stress| response to topologically incorrect protein| signal transduction by p53 class mediator| signal transduction in response to DNA damage| signal transduction involved in DNA damage checkpoint| signal transduction involved in DNA integrity checkpoint| signal transduction involved in cell cycle checkpoint| signal transduction involved in mitotic G1 DNA damage checkpoint| signal transduction involved in mitotic cell cycle checkpoint| spindle elongation| symbiosis, encompassing mutualism through parasitism| viral process
130 PF09983 Uncharacterized protein conserved in bacteria C-term(DUF2220) Toprim-like (CL0413) 376 (31) 181 178 (1) DNA topoisomerase IV, alpha subunit [e.12.1] (2-172)
(1) DNA topoisomerase IV, alpha subunit [e.12]
e.12.1(2-172) NO PREDICTION NO PREDICTION NO PREDICTION e.12.1(29-170) 2 No information Eukaryota|Bacteria|Viruses No information No information No information DNA recombination| cellular process involved in reproduction| chromosome organization| chromosome organization involved in meiosis| meiosis| meiosis I| meiotic cell cycle| reciprocal meiotic recombination
131 PF11001 Protein of unknown function (DUF2841) No Pfam Clan 181 (34) 126 157 (1) DNA-binding domain of EIN3-like [a.140.5] (13-124)
(1) LEM/SAP HeH motif [a.140]
NO PREDICTION a.140.5(13-124) NO PREDICTION NO PREDICTION a.140.5(28-120) 2 No information Eukaryota No information No information No information No information
132 PF07510 Protein of unknown function (DUF1524) His-Me_finger (CL0263) 2469 (240) 142 168 (1) His-Me finger endonucleases [d.4.1] (1-141)
(1) His-Me finger endonucleases [d.4]
d.4.1(17-103) d.4.1(1-141) NO PREDICTION NO PREDICTION NO PREDICTION 2 No information Eukaryota|Bacteria|Viruses|Archaea 3.1.21.1| 3.1.22.4| 3.1.30.2 No information No information No information
133 PF10288 Protein of unknown function (DUF2392) No Pfam Clan 268 (35) 107 113 (1) Adenine nucleotide alpha hydrolases-like [c.26.2] (2-113)
(1) Adenine nucleotide alpha hydrolase-like [c.26]
c.26.2(2-105) NO PREDICTION NO PREDICTION NO PREDICTION c.26.2(2-113) 2 No information Eukaryota 1.8.4.8| 2.1.1.61| 2.7.7.2| 6.3.1.5| 6.3.4.5| 6.3.5.1| 6.3.5.2| 6.3.5.4 No information electron carrier activity| oxidoreductase activity, acting on a sulfur group of donors| phosphoadenylyl-sulfate reductase (thioredoxin) activity response to fungus| response to molecule of fungal origin| sulfate assimilation
134 PF03314 Protein of unknown function, DUF273 GT-A (CL0110) 87 (12) 222 222 (1) Nucleotide-diphospho-sugar transferases [c.68.1] (2-201)
(1) Nucleotide-diphospho-sugar transferases [c.68]
NO PREDICTION c.68.1(2-201) c.68.1(6-128) NO PREDICTION NO PREDICTION 2 No information Eukaryota 2.4.1.101| 2.4.1.131| 2.4.1.135| 2.4.1.186| 2.4.1.217| 2.4.1.222| 2.4.1.223| 2.4.1.37| 2.4.1.41| 2.4.1.44| 2.4.1.87| 2.7.7.13| 2.7.7.23| 2.7.7.24| 2.7.7.27| 2.7.7.33| 2.7.7.38| 2.7.7.43| 2.7.7.60| 2.7.7.64| 2.7.7.9 Golgi apparatus| Golgi apparatus part| Golgi membrane| cis-Golgi network| mannosyltransferase complex UDP-glycosyltransferase activity| acetylgalactosaminyltransferase activity| ceramide glucosyltransferase activity| cytidylyltransferase activity| galactosyltransferase activity| glucose-1-phosphate thymidylyltransferase activity| guanylyltransferase activity| magnesium ion binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups aminoglycan biosynthetic process| aminoglycan metabolic process| cell wall biogenesis| cell wall mannoprotein biosynthetic process| cell wall organization or biogenesis| cellular carbohydrate biosynthetic process| cellular component macromolecule biosynthetic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| chondroitin sulfate biosynthetic process| chondroitin sulfate metabolic process| chondroitin sulfate proteoglycan biosynthetic process| chondroitin sulfate proteoglycan metabolic process| dolichol metabolic process| extracellular fibril organization| extracellular matrix organization| extracellular structure organization| fibril organization| galactose metabolic process| gametophyte development| glycolipid metabolic process| glycoprotein biosynthetic process| glycoprotein metabolic process| glycosaminoglycan biosynthetic process| glycosphingolipid biosynthetic process| glycosylation| heparan sulfate proteoglycan biosynthetic process| heparan sulfate proteoglycan metabolic process| lipopolysaccharide metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| negative regulation of fibroblast proliferation| nucleotide-sugar metabolic process| peptidyl-asparagine modification| phosphatidylinositol biosynthetic process| phosphatidylinositol metabolic process| pollen development| polyprenol metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein O-linked glycosylation| protein glycosylation| regulation of Notch signaling pathway| regulation of fibroblast proliferation| sphingolipid biosynthetic process| sphingolipid metabolic process
135 PF04317 YcjX-like family, DUF463 P-loop_NTPase (CL0023) 1031 (51) 443 442 (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (2-134)
(1) P-loop containing nucleoside triphosphate hydrolases [c.37]
NO PREDICTION NO PREDICTION c.37.1(2-134) NO PREDICTION c.37.1(1-27) 2 YES Bacteria 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
136 PF14243 Domain of unknown function (DUF4343) No Pfam Clan 270 (33) 130 131 (1) Glutathione synthetase ATP-binding domain-like [d.142.1] (1-122)
(1) ATP-grasp [d.142]
NO PREDICTION d.142.1(1-122) NO PREDICTION NO PREDICTION d.142.1(2-117) 2 No information Eukaryota|Bacteria|Viruses 4.1.1.21| 6.3.1.9| 6.3.2.23| 6.3.2.3| 6.3.2.4| 6.3.4.13| 6.3.4.14| 6.3.4.18 No information glutathione synthase activity microtubule-based process| response to cadmium ion
137 PF14213 Domain of unknown function (DUF4325) No Pfam Clan 205 (60) 74 76 (1) SpoIIaa-like [c.13.2] (1-71)
(1) SpoIIaa-like [c.13]
NO PREDICTION c.13.2(1-71) c.13.2(6-65) NO PREDICTION NO PREDICTION 2 No information Eukaryota|Bacteria|Viruses|Archaea No information No information No information No information
138 PF10354 Domain of unknown function (DUF2431) NADP_Rossmann (CL0063) 435 (47) 166 204 (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (1-165)
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66]
c.66.1(1-130) c.66.1(1-165) NO PREDICTION NO PREDICTION NO PREDICTION 2 No information Eukaryota|Bacteria 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 nuclear matrix glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process
139 PF09994 Uncharacterized alpha/beta hydrolase domain (DUF2235) AB_hydrolase (CL0028) 1245 (90) 277 265 (1) alpha/beta-Hydrolases [c.69.1] (1-276)
(1) alpha/beta-Hydrolases [c.69]
NO PREDICTION c.69.1(1-276) c.69.1(32-189) NO PREDICTION NO PREDICTION 2 No information Eukaryota|Bacteria|Viruses 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 trans-Golgi network transport vesicle CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process
140 PF11959 Domain of unknown function (DUF3473) No Pfam Clan 224 (51) 134 133 (1) Glycoside hydrolase/deacetylase [c.6.2] (1-132)
(1) 7-stranded beta/alpha barrel [c.6]
c.6.2(1-132) NO PREDICTION c.6.2(16-108) NO PREDICTION NO PREDICTION 2 No information Bacteria|Viruses|Archaea 2.4.1.18| 2.4.1.25| 3.1.1.72| 3.2.1.1| 3.2.1.114| 3.2.1.24| 3.5.1.33| 3.5.1.41| 3.5.2.5 No information deacetylase activity No information
141 PF12054 Domain of unknown function (DUF3535) No Pfam Clan 289 (32) 441 467 (1) ARM repeat [a.118.1] (1-441)
(1) alpha-alpha superhelix [a.118]
a.118.1(1-441) a.118.1(1-440) NO PREDICTION NO PREDICTION NO PREDICTION 2 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
142 PF10962 Protein of unknown function (DUF2764) No Pfam Clan 168 (10) 271 299 (1) V-type ATP synthase subunit C [f.40.1] (8-266)
(1) V-type ATP synthase subunit C [f.40]
NO PREDICTION f.40.1(8-266) NO PREDICTION NO PREDICTION f.40.1(31-276) 2 No information Bacteria No information apical part of cell| apical plasma membrane| vacuolar membrane| vacuolar part No information No information
143 PF07223 Protein of unknown function (DUF1421) No Pfam Clan 104 (9) 358 299 (1) ssDNA viruses [b.121.5] (1-262)
(2) UBA-like [a.5.2] (259-285)
(1) RuvA C-terminal domain-like [a.5]
(2) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121]
NO PREDICTION NO PREDICTION NO PREDICTION b.121.5(1-262) a.5.2(259-285) 2 No information Eukaryota No information No information No information No information
144 PF11059 Protein of unknown function (DUF2860) MBB (CL0193) 262 (29) 297 301 (1) Porins [f.4.3] (1-296)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION f.4.3(1-296) f.4.3(2-80)| f.4.3(111-149)| f.4.3(191-261) NO PREDICTION NO PREDICTION 2 No information Bacteria No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity fatty acid transport| lipid localization| long-chain fatty acid transport
145 PF15390 Domain of unknown function (DUF4613) No Pfam Clan 69 (23) 671 675 (1) 3-carboxy-cis,cis-mucoante lactonizing enzyme [b.69.10] (315-400)
(2) WD40 repeat-like [b.69.4] (26-221)
(1) 7-bladed beta-propeller [b.69]
NO PREDICTION NO PREDICTION b.69.4(26-221)| b.69.10(315-400) NO PREDICTION b.69.4(20-185) 2 No information Eukaryota 5.5.1.5 Arp2/3 protein complex| CIA complex| Cdc73/Paf1 complex| Cul4-RING ubiquitin ligase complex| ER to Golgi transport vesicle| SMN complex| SMN-Sm protein complex| Ski complex| THO complex| TORC1 complex| chromosome, centromeric region| cullin-RING ubiquitin ligase complex| eukaryotic translation initiation factor 3 complex| extrinsic to internal side of plasma membrane| extrinsic to membrane| extrinsic to plasma membrane| female germ cell nucleus| germ cell nucleus| heterotrimeric G-protein complex| histone methyltransferase complex| immunological synapse| internal side of plasma membrane| kinetochore| methylosome| methyltransferase complex| nuclear envelope| nuclear pore| nuclear pore outer ring| pore complex| transcription export complex| transcriptionally active chromatin| ubiquitin ligase complex G-protein gamma-subunit binding| histone binding| peroxisome targeting sequence binding| phosphatidylinositol binding| phosphatidylinositol-3,5-bisphosphate binding| phosphatidylinositol-3-phosphate binding| phosphatidylinositol-5-phosphate binding| signal sequence binding| translation initiation factor activity RNA splicing, via transesterification reactions with bulged adenosine as nucleophile| T cell homeostasis| TOR signaling cascade| attachment of spindle microtubules to kinetochore| attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation| autophagy| cellular response to starvation| chromosome segregation| embryonic digit morphogenesis| establishment of RNA localization| establishment of chromosome localization| establishment of organelle localization| fruiting body development| histone H3-K4 methylation| histone methylation| histone modification| iron-sulfur cluster assembly| mRNA export from nucleus| membrane disassembly| metallo-sulfur cluster assembly| metaphase plate congression| methylation| microtubule-based process| mitotic metaphase plate congression| mitotic spindle assembly checkpoint| negative regulation of calcium ion transmembrane transporter activity| negative regulation of cation channel activity| negative regulation of cell cycle process| negative regulation of ion transmembrane transporter activity| negative regulation of transporter activity| negative regulation of voltage-gated calcium channel activity| nuclear envelope disassembly| nuclear pore organization| nucleic acid transport| nucleobase-containing compound transport| peptidyl-lysine modification| peptidyl-lysine trimethylation| peroxisomal transport| positive regulation of DNA-dependent transcription, elongation| positive regulation of histone H3-K79 methylation| positive regulation of histone methylation| positive regulation of histone modification| positive regulation of organelle organization| positive regulation of transcription elongation from RNA polymerase II promoter| protein alkylation| protein import| protein targeting| regulation of cell cycle process| regulation of histone H3-K79 methylation| regulation of histone methylation| regulation of histone modification| regulation of metaphase/anaphase transition of cell cycle| regulation of mitotic metaphase/anaphase transition| regulation of reproductive process| regulation of transcription elongation from RNA polymerase II promoter| regulation of voltage-gated calcium channel activity| response to starvation| spindle assembly checkpoint| spindle checkpoint| uropod organization
146 PF06727 Protein of unknown function (DUF1207) No Pfam Clan 77 (8) 338 350 (1) OMPA-like [f.4.1] (138-297)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION f.4.1(138-297) f.4.1(155-262)| f.4.1(292-350) NO PREDICTION NO PREDICTION 2 No information Bacteria No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane O-acyltransferase activity| O-palmitoyltransferase activity| palmitoyltransferase activity| transferase activity, transferring acyl groups other than amino-acyl groups glycolipid biosynthetic process| glycolipid metabolic process| lipid A biosynthetic process| lipid A metabolic process| lipooligosaccharide biosynthetic process| lipooligosaccharide metabolic process| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| phospholipid biosynthetic process| phospholipid metabolic process
147 PF13154 Protein of unknown function (DUF3991) No Pfam Clan 763 (113) 77 76 (1) DNA primase core [e.13.1] (1-77)
(1) DNA primase core [e.13]
e.13.1(1-77) NO PREDICTION NO PREDICTION NO PREDICTION e.13.1(1-70) 2 No information Bacteria No information No information No information No information
148 PF13635 Domain of unknown function (DUF4143) PDDEXK (CL0236) 2818 (579) 90 141 (1) Restriction endonuclease-like [c.52.1] (1-89)
(1) Restriction endonuclease-like [c.52]
c.52.1(36-90) c.52.1(1-89) NO PREDICTION NO PREDICTION NO PREDICTION 2 No information Eukaryota|Bacteria|Viruses|Archaea 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 No information endonuclease activity| nuclease activity DNA repair| nucleotide-excision repair
149 PF06852 Protein of unknown function (DUF1248) Acetyltrans (CL0257) 63 (10) 181 181 (1) Acyl-CoA N-acyltransferases (Nat) [d.108.1] (28-181)
(1) Acyl-CoA N-acyltransferases (Nat) [d.108]
d.108.1(28-181) NO PREDICTION NO PREDICTION NO PREDICTION d.108.1(29-137) 2 No information Eukaryota 2.3.1.1| 2.3.1.128| 2.3.1.178| 2.3.1.4| 2.3.1.48| 2.3.1.57| 2.3.1.82| 2.3.1.87| 2.3.1.88| 2.3.1.97| 2.3.2.10| 2.3.2.6 N-terminal protein acetyltransferase complex| perinuclear region of cytoplasm| protein acetyltransferase complex N-acetyltransferase activity| N-acyltransferase activity| acetyltransferase activity| ornithine decarboxylase inhibitor activity| ornithine decarboxylase regulator activity| transferase activity, transferring acyl groups other than amino-acyl groups DNA packaging| N-terminal protein amino acid acetylation| N-terminal protein amino acid modification| UDP-N-acetylglucosamine biosynthetic process| UDP-N-acetylglucosamine metabolic process| amide biosynthetic process| amino sugar biosynthetic process| amino sugar metabolic process| cellular hormone metabolic process| cellular response to cAMP| cellular response to nitrogen compound| cellular response to organic cyclic compound| cellular response to organonitrogen compound| chromatin assembly| chromatin organization| chromosome organization| chromosome segregation| circadian rhythm| covalent chromatin modification| gastrulation with mouth forming second| histone acetylation| histone modification| hormone biosynthetic process| hormone metabolic process| indole-containing compound biosynthetic process| indole-containing compound metabolic process| melatonin biosynthetic process| melatonin metabolic process| mitotic sister chromatid cohesion| mitotic sister chromatid segregation| nucleotide-sugar biosynthetic process| nucleotide-sugar metabolic process| peptidyl-lysine modification| peptidyl-methionine modification| polyamine metabolic process| protein acetylation| protein acylation| protein-DNA complex assembly| protein-DNA complex subunit organization| regulation of hormone levels| response to cAMP| response to organophosphorus| response to purine-containing compound| response to toxic substance| rhythmic process
150 PF10105 Uncharacterized protein conserved in bacteria (DUF2344) No Pfam Clan 639 (74) 187 176 (1) Pseudouridine synthase [d.265.1] (19-141)
(1) Pseudouridine synthase [d.265]
d.265.1(54-169) NO PREDICTION NO PREDICTION NO PREDICTION d.265.1(19-141) 2 No information Eukaryota|Bacteria 4.2.1.70| 5.4.99.12 nucleolus hydro-lyase activity| intramolecular transferase activity| pseudouridine synthase activity| pseudouridylate synthase activity| ribonucleoprotein complex binding| snoRNP binding RNA modification| ncRNA processing| rRNA modification| ribonucleoprotein complex biogenesis| ribosome biogenesis| tRNA pseudouridine synthesis
151 PF09366 Protein of unknown function (DUF1997) No Pfam Clan 280 (34) 159 161 (1) Bet v1-like [d.129.3] (3-149)
(1) TBP-like [d.129]
NO PREDICTION d.129.3(1-147) NO PREDICTION NO PREDICTION d.129.3(3-149) 2 No information Eukaryota|Bacteria 1.14.12.12| 1.14.12.18| 3.1.3.16| 4.2.1.78 intercellular canaliculus| microvillus abscisic acid binding| alcohol binding| alcohol transmembrane transporter activity| anion transmembrane transporter activity| carboxylic acid binding| hormone binding| isoprenoid binding| lipid transporter activity| monocarboxylic acid binding| organic anion transmembrane transporter activity| organic cation transmembrane transporter activity| organic hydroxy compound transmembrane transporter activity| phosphate transmembrane transporter activity| phosphatidylcholine transporter activity| phospholipid transporter activity| protein homodimerization activity| quaternary ammonium group transmembrane transporter activity abscisic acid mediated signaling pathway| acid secretion| bile acid secretion| cellular response to abscisic acid stimulus| cellular response to alcohol| cellular response to hormone stimulus| cellular response to lipid| hormone-mediated signaling pathway| lipid localization| lipid transport| monocarboxylic acid transport| organic anion transport| organophosphate ester transport| phospholipid transport| positive regulation of peroxisome proliferator activated receptor signaling pathway| quaternary ammonium group transport| regulation of peroxisome proliferator activated receptor signaling pathway| regulation of post-embryonic development| response to abscisic acid stimulus| response to alcohol| response to hormone stimulus| response to lipid
152 PF10013 Uncharacterized protein conserved in bacteria (DUF2256) TRASH (CL0175) 341 (71) 42 42 (1) Glucocorticoid receptor-like (DNA-binding domain) [g.39.1] (7-41)
(1) Glucocorticoid receptor-like (DNA-binding domain) [g.39]
NO PREDICTION g.39.1(7-41) NO PREDICTION NO PREDICTION g.39.1(7-40) 2 YES Eukaryota|Bacteria|Viruses 2.7.1.21| 4.2.99.18 No information No information No information
153 PF07855 Protein of unknown function (DUF1649) No Pfam Clan 256 (11) 163 153 (1) The spindle assembly checkpoint protein mad2 [d.135.1] (6-150)
(1) The spindle assembly checkpoint protein mad2 [d.135]
NO PREDICTION d.135.1(6-150) NO PREDICTION NO PREDICTION d.135.1(8-149) 2 No information Eukaryota No information DNA polymerase complex| anaphase-promoting complex| chromosomal part| chromosome, centromeric region| cullin-RING ubiquitin ligase complex| kinetochore| nuclear ubiquitin ligase complex| spindle| ubiquitin ligase complex| zeta DNA polymerase complex No information DNA damage response, signal transduction resulting in transcription| chromosome organization| chromosome segregation| mitotic sister chromatid segregation| mitotic spindle assembly checkpoint| mitotic spindle checkpoint| negative regulation of catabolic process| negative regulation of cell cycle| negative regulation of cell cycle phase transition| negative regulation of cell cycle process| negative regulation of cellular catabolic process| negative regulation of cellular component organization| negative regulation of cellular protein metabolic process| negative regulation of ligase activity| negative regulation of metaphase/anaphase transition of cell cycle| negative regulation of mitosis| negative regulation of mitotic anaphase-promoting complex activity| negative regulation of mitotic metaphase/anaphase transition| negative regulation of nuclear division| negative regulation of organelle organization| negative regulation of proteasomal protein catabolic process| negative regulation of proteasomal ubiquitin-dependent protein catabolic process| negative regulation of protein catabolic process| negative regulation of protein modification process| negative regulation of protein ubiquitination| negative regulation of proteolysis| negative regulation of ubiquitin-protein ligase activity| negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle| nuclear division| positive regulation of cellular protein metabolic process| positive regulation of peptidyl-serine phosphorylation| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of phosphorylation| positive regulation of protein phosphorylation| positive regulation of transcription, DNA-dependent| regulation of cell cycle phase transition| regulation of cell cycle process| regulation of ligase activity| regulation of metaphase/anaphase transition of cell cycle| regulation of mitosis| regulation of mitotic metaphase/anaphase transition| regulation of nuclear division| regulation of peptidyl-serine phosphorylation| regulation of proteasomal protein catabolic process| regulation of proteasomal ubiquitin-dependent protein catabolic process| regulation of protein catabolic process| regulation of protein ubiquitination| regulation of proteolysis| regulation of ubiquitin-protein ligase activity| regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle| signal transduction in response to DNA damage| spindle assembly checkpoint| spindle checkpoint
154 PF03269 Caenorhabditis protein of unknown function, DUF268 NADP_Rossmann (CL0063) 72 (6) 177 164 (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (1-146)
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66]
NO PREDICTION c.66.1(1-146) c.66.1(41-108) NO PREDICTION NO PREDICTION 2 No information Eukaryota|Bacteria|Archaea 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 nuclear matrix glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process
155 PF12345 Protein of unknown function (DUF3641) No Pfam Clan 232 (83) 134 135 (1) Radical SAM enzymes [c.1.28] (1-127)
(1) TIM beta/alpha-barrel [c.1]
c.1.28(1-127) NO PREDICTION c.1.28(11-132) NO PREDICTION NO PREDICTION 2 No information Eukaryota|Bacteria 1.3.99.22| 1.97.1.4| 2.8.1.6| 5.4.3.2 lipid particle 4 iron, 4 sulfur cluster binding| biotin synthase activity| intramolecular transferase activity| lipoate synthase activity| lipoate-protein ligase activity| metal cluster binding| oxidoreductase activity, acting on the CH-CH group of donors| protein self-association| radical SAM enzyme activity| sulfurtransferase activity| transferase activity, transferring sulfur-containing groups CD4-positive, alpha-beta T cell activation| CD4-positive, alpha-beta T cell differentiation| T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| defense response to virus| lipoate biosynthetic process| lipoate metabolic process| lymphocyte differentiation| molybdopterin cofactor biosynthetic process| molybdopterin cofactor metabolic process| monocarboxylic acid biosynthetic process| negative regulation of protein secretion| negative regulation of protein transport| negative regulation of secretion| positive regulation of T cell cytokine production| positive regulation of T cell mediated immunity| positive regulation of T-helper 2 cell cytokine production| positive regulation of adaptive immune response| positive regulation of adaptive immune response based on somatic recombination of immune receptors b| positive regulation of cytokine production| positive regulation of cytokine production involved in immune response| positive regulation of immune effector process| positive regulation of leukocyte mediated immunity| positive regulation of lymphocyte mediated immunity| positive regulation of production of molecular mediator of immune response| positive regulation of toll-like receptor 9 signaling pathway| positive regulation of toll-like receptor signaling pathway| prosthetic group metabolic process| regulation of T cell cytokine production| regulation of T cell mediated immunity| regulation of T-helper 2 cell cytokine production| regulation of adaptive immune response| regulation of cytokine production involved in immune response| regulation of leukocyte mediated immunity| regulation of lymphocyte mediated immunity| regulation of production of molecular mediator of immune response| regulation of protein secretion| regulation of toll-like receptor 7 signaling pathway| regulation of toll-like receptor 9 signaling pathway| regulation of toll-like receptor signaling pathway| regulation of type 2 immune response| response to virus| vitamin biosynthetic process
156 PF12916 Protein of unknown function (DUF3834) PBP (CL0177) 19 (10) 201 204 (1) Periplasmic binding protein-like II [c.94.1] (7-198)
(1) Periplasmic binding protein-like II [c.94]
NO PREDICTION NO PREDICTION c.94.1(74-140) NO PREDICTION c.94.1(7-198) 2 No information Eukaryota|Bacteria|Archaea 1.16.1.2| 2.4.2.17| 2.5.1.2| 2.5.1.61| 3.13.1.3| 3.6.3.24 ATP-binding cassette (ABC) transporter complex| cell envelope| coated pit| early endosome| external encapsulating structure part| periplasmic space| recycling endosome ATPase activity| ATPase activity, coupled| ATPase activity, coupled to movement of substances| P-P-bond-hydrolysis-driven transmembrane transporter activity| amino acid transmembrane transporter activity| amino acid-transporting ATPase activity| anion transmembrane-transporting ATPase activity| hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances| iron ion binding| primary active transmembrane transporter activity SMAD protein signal transduction| iron ion transport| phosphate ion transport| polyamine transmembrane transport| polyamine transport| thiamine biosynthetic process| thiamine-containing compound biosynthetic process| thiamine-containing compound metabolic process| water-soluble vitamin biosynthetic process
157 PF07318 Protein of unknown function (DUF1464) Actin_ATPase (CL0108) 65 (11) 343 318 (1) Actin-like ATPase domain [c.55.1] (1-320)
(1) Ribonuclease H-like motif [c.55]
NO PREDICTION c.55.1(1-320) NO PREDICTION NO PREDICTION c.55.1(150-288) 2 No information Bacteria|Archaea 2.7.1.1| 2.7.1.12| 2.7.1.16| 2.7.1.17| 2.7.1.2| 2.7.1.30| 2.7.1.33| 2.7.1.4| 2.7.1.5| 2.7.1.55| 2.7.1.59| 2.7.1.60| 2.7.1.63| 2.7.2.1| 2.7.2.15| 2.7.2.7| 3.4.24.57| 3.6.1.11| 3.6.1.3 cell cortex| cell cortex part| cilium part| contractile fiber part| cortical cytoskeleton| motile cilium| sperm flagellum| sperm part| sperm principal piece carbohydrate kinase activity| hexokinase activity| phosphotransferase activity, alcohol group as acceptor| unfolded protein binding 'de novo' protein folding| ATP catabolic process| actomyosin structure organization| carbohydrate phosphorylation| chaperone mediated protein folding requiring cofactor| glucose 6-phosphate metabolic process| glycolysis| myofibril assembly| nucleoside monophosphate catabolic process| protein folding| purine nucleoside monophosphate catabolic process| purine nucleoside monophosphate metabolic process| purine ribonucleoside monophosphate catabolic process| purine ribonucleoside monophosphate metabolic process| ribonucleoside monophosphate catabolic process| ribonucleoside monophosphate metabolic process
158 PF09892 Uncharacterized protein conserved in archaea (DUF2119) No Pfam Clan 27 (10) 193 194 (1) Zn-dependent exopeptidases [c.56.5] (2-192)
(1) Phosphorylase/hydrolase-like [c.56]
NO PREDICTION c.56.5(2-192) NO PREDICTION NO PREDICTION c.56.5(8-93) 2 No information Archaea 2.3.2.5| 3.4.11.1| 3.4.11.10| 3.4.11.21| 3.4.11.24| 3.4.11.4| 3.4.11.7| 3.4.13.18| 3.4.13.20| 3.4.13.3| 3.4.17.1| 3.4.17.11| 3.4.17.12| 3.4.17.15| 3.4.17.18| 3.4.17.2| 3.4.17.20| 3.4.17.21| 3.4.17.3| 3.5.1.14| 3.5.1.15| 3.5.1.16| 3.5.1.18| 3.5.1.28| 3.5.1.6| 3.5.1.96 No information aminoacylase activity| exopeptidase activity| glutaminyl-peptide cyclotransferase activity| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides| transferase activity, transferring amino-acyl groups arginine metabolic process| peptidyl-glutamine modification
159 PF09324 Domain of unknown function (DUF1981) No Pfam Clan 681 (41) 86 87 (1) ARM repeat [a.118.1] (13-87)
(1) alpha-alpha superhelix [a.118]
a.118.1(23-84) NO PREDICTION a.118.1(13-87) NO PREDICTION NO PREDICTION 2 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
160 PF11684 Protein of unknown function (DUF2380) No Pfam Clan 121 (26) 140 146 (1) TolB, N-terminal domain [c.51.2] (2-145)
(1) Anticodon-binding domain-like [c.51]
NO PREDICTION c.51.2(1-139) NO PREDICTION NO PREDICTION c.51.2(2-145) 2 No information Bacteria No information No information No information No information
161 PF08961 Domain of unknown function (DUF1875) No Pfam Clan 73 (3) 243 243 (1) MIT domain-like [a.7.16] (1-42)
(1) Spectrin repeat-like [a.7]
NO PREDICTION NO PREDICTION a.7.16(1-40) NO PREDICTION a.7.16(1-42) 2 No information Eukaryota|Bacteria No information No information No information No information
162 PF10677 Protein of unknown function (DUF2490) MBB (CL0193) 262 (62) 194 233 (1) Porins [f.4.3] (1-193)
(1) Transmembrane beta-barrels [f.4]
f.4.3(40-181) f.4.3(1-193) NO PREDICTION NO PREDICTION NO PREDICTION 2 YES Bacteria No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity fatty acid transport| lipid localization| long-chain fatty acid transport
163 PF07632 Protein of unknown function (DUF1593) No Pfam Clan 158 (29) 260 329 (1) Nucleoside hydrolase [c.70.1] (1-260)
(1) Nucleoside hydrolase [c.70]
c.70.1(1-260) NO PREDICTION NO PREDICTION NO PREDICTION c.70.1(1-189) 2 No information Eukaryota|Bacteria 3.2.2.1| 3.2.2.8 No information hydrolase activity, hydrolyzing N-glycosyl compounds| ribosylpyrimidine nucleosidase activity cellular metabolic compound salvage| glycosyl compound catabolic process| pyrimidine nucleoside catabolic process| pyrimidine nucleoside metabolic process| pyrimidine ribonucleoside catabolic process| pyrimidine ribonucleoside metabolic process| pyrimidine-containing compound catabolic process| pyrimidine-containing compound metabolic process
164 PF07279 Protein of unknown function (DUF1442) NADP_Rossmann (CL0063) 79 (4) 218 215 (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (27-187)
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66]
c.66.1(26-185) NO PREDICTION NO PREDICTION NO PREDICTION c.66.1(27-187) 2 No information Eukaryota|Bacteria 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 nuclear matrix glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process
165 PF06672 Protein of unknown function (DUF1175) Peptidase_CA (CL0125) 358 (13) 217 205 (1) Cysteine proteinases [d.3.1] (27-215)
(1) Cysteine proteinases [d.3]
NO PREDICTION d.3.1(27-215) NO PREDICTION NO PREDICTION d.3.1(21-201) 2 No information Bacteria 2.3.1.118| 2.3.1.5| 2.3.2.13| 2.3.2.15| 3.1.1.4| 3.4.14.1| 3.4.18.1| 3.4.19.12| 3.4.22.1| 3.4.22.10| 3.4.22.14| 3.4.22.15| 3.4.22.16| 3.4.22.2| 3.4.22.25| 3.4.22.27| 3.4.22.30| 3.4.22.38| 3.4.22.39| 3.4.22.40| 3.4.22.41| 3.4.22.43| 3.4.22.48| 3.4.22.51| 3.4.22.52| 3.4.22.53| 3.4.22.6| 3.4.22.65| 3.4.22.68| 3.5.1.52| 6.3.1.9 alveolar lamellar body| endosome lumen| lamellar body| lytic vacuole| vacuolar lumen MHC class I receptor activity| N-acyltransferase activity| acetyltransferase activity| arylamine N-acetyltransferase activity| cysteine-type carboxypeptidase activity| cysteine-type endopeptidase activity| cysteine-type endopeptidase regulator activity involved in apoptotic process| cysteine-type peptidase activity| hormone binding| peptidase activator activity| peptidase activator activity involved in apoptotic process| peptidase activity| peptidase regulator activity| small conjugating protein binding| thiolester hydrolase activity| thyroid hormone binding| ubiquitin thiolesterase activity ERK1 and ERK2 cascade| T cell mediated cytotoxicity| T cell mediated immunity| adaptive immune response| anatomical structure maturation| bradykinin catabolic process| catagen| cell killing| cellular response to thyroid hormone stimulus| chemical homeostasis within a tissue| collagen metabolic process| decidualization| dichotomous subdivision of an epithelial terminal unit| dichotomous subdivision of terminal units involved in lung branching| epidermis morphogenesis| epithelial tube branching involved in lung morphogenesis| extracellular matrix disassembly| female pregnancy| hair cycle| hair cycle process| hair follicle development| hair follicle maturation| hair follicle morphogenesis| immune response-regulating signaling pathway| leukocyte mediated cytotoxicity| leukocyte mediated immunity| lung development| lung morphogenesis| lymphocyte mediated immunity| maternal placenta development| maternal process involved in female pregnancy| metanephros development| molting cycle process| multicellular organismal catabolic process| multicellular organismal homeostasis| negative regulation of epithelial cell proliferation| negative regulation of keratinocyte proliferation| neuropeptide catabolic process| peptide catabolic process| peptide metabolic process| placenta development| positive regulation of angiogenesis| positive regulation of apoptotic signaling pathway| positive regulation of developmental process| positive regulation of epithelial cell migration| positive regulation of peptidase activity| posttranscriptional regulation of gene expression| protein destabilization| protein maturation| protein modification by small protein conjugation or removal| protein modification by small protein removal| protein processing| proteolysis| regulation of actin cytoskeleton reorganization| regulation of epithelial cell migration| regulation of keratinocyte proliferation| regulation of peptidase activity| regulation of protein stability| respiratory tube development| response to retinoic acid| response to thyroid hormone stimulus| skin morphogenesis| surfactant homeostasis| tissue homeostasis
166 PF10934 Protein of unknown function (DUF2634) No Pfam Clan 250 (26) 112 103 (1) gpW/gp25-like [d.373.1] (19-107)
(1) gpW/gp25-like [d.373]
d.373.1(19-107) NO PREDICTION NO PREDICTION NO PREDICTION d.373.1(10-96) 2 No information Bacteria|Viruses No information No information No information No information
167 PF13826 Domain of unknown function (DUF4188) Dim_A_B_barrel (CL0032) 173 (48) 117 126 (1) Dimeric alpha+beta barrel [d.58.4] (1-102)
(1) Ferredoxin-like [d.58]
NO PREDICTION d.58.4(1-102) NO PREDICTION NO PREDICTION d.58.4(22-117) 2 No information Eukaryota|Bacteria|Archaea 1.13.11.49| 1.13.11.55| 1.14.99.3| 5.3.3.4| 5.4.99.14 No information No information No information
168 PF04412 Protein of unknown function (DUF521) No Pfam Clan 289 (42) 400 420 (1) Aconitase iron-sulfur domain [c.83.1] (280-379)
(1) Aconitase iron-sulfur domain [c.83]
NO PREDICTION c.83.1(INDIRECT) NO PREDICTION NO PREDICTION c.83.1(280-379) 2 No information Eukaryota|Bacteria|Archaea 4.2.1.3 No information hydro-lyase activity No information
169 PF11903 Protein of unknown function (DUF3423) Met_repress (CL0057) 485 (57) 73 73 (1) Ribbon-helix-helix [a.43.1] (1-59)
(1) Ribbon-helix-helix [a.43]
NO PREDICTION a.43.1(1-59) NO PREDICTION NO PREDICTION a.43.1(3-52) 2 No information Eukaryota|Bacteria No information No information No information positive regulation of growth
170 PF10908 Protein of unknown function (DUF2778) No Pfam Clan 375 (28) 120 107 (1) L,D-transpeptidase catalytic domain-like [b.160.1] (22-118)
(1) L,D-transpeptidase catalytic domain-like [b.160]
NO PREDICTION b.160.1(22-118) NO PREDICTION NO PREDICTION b.160.1(26-104) 2 No information Eukaryota|Bacteria No information No information No information No information
171 PF11925 Protein of unknown function (DUF3443) No Pfam Clan 153 (24) 371 381 (1) Acid proteases [b.50.1] (23-370)
(1) Acid proteases [b.50]
NO PREDICTION b.50.1(23-370) NO PREDICTION NO PREDICTION b.50.1(29-370) 2 No information Bacteria 3.4.23.1| 3.4.23.15| 3.4.23.16| 3.4.23.18| 3.4.23.20| 3.4.23.21| 3.4.23.22| 3.4.23.23| 3.4.23.24| 3.4.23.25| 3.4.23.29| 3.4.23.3| 3.4.23.34| 3.4.23.39| 3.4.23.4| 3.4.23.40| 3.4.23.45| 3.4.23.46| 3.4.23.5 alveolar lamellar body| lamellar body| lytic vacuole aspartic-type endopeptidase activity| aspartic-type peptidase activity| endopeptidase activity| peptidase activity anatomical structure homeostasis| antigen processing and presentation| antigen processing and presentation of exogenous antigen| antigen processing and presentation of exogenous peptide antigen| antigen processing and presentation of exogenous peptide antigen via MHC class II| antigen processing and presentation of peptide antigen| antigen processing and presentation of peptide antigen via MHC class II| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II| autophagic vacuole assembly| autophagy| cellular response to external stimulus| cellular response to extracellular stimulus| cellular response to nutrient levels| cellular response to starvation| chemical homeostasis within a tissue| macroautophagy| membrane protein proteolysis| multicellular organismal homeostasis| organelle assembly| protein processing| proteolysis| response to extracellular stimulus| response to nutrient levels| response to starvation| surfactant homeostasis| tissue homeostasis| vacuole organization
172 PF06940 Domain of unknown function (DUF1287) Peptidase_CA (CL0125) 504 (25) 164 165 (1) Cysteine proteinases [d.3.1] (35-155)
(1) Cysteine proteinases [d.3]
NO PREDICTION d.3.1(INDIRECT) NO PREDICTION NO PREDICTION d.3.1(35-155) 2 No information Bacteria 2.3.1.118| 2.3.1.5| 2.3.2.13| 2.3.2.15| 3.1.1.4| 3.4.14.1| 3.4.18.1| 3.4.19.12| 3.4.22.1| 3.4.22.10| 3.4.22.14| 3.4.22.15| 3.4.22.16| 3.4.22.2| 3.4.22.25| 3.4.22.27| 3.4.22.30| 3.4.22.38| 3.4.22.39| 3.4.22.40| 3.4.22.41| 3.4.22.43| 3.4.22.48| 3.4.22.51| 3.4.22.52| 3.4.22.53| 3.4.22.6| 3.4.22.65| 3.4.22.68| 3.5.1.52| 6.3.1.9 alveolar lamellar body| endosome lumen| lamellar body| lytic vacuole| vacuolar lumen MHC class I receptor activity| N-acyltransferase activity| acetyltransferase activity| arylamine N-acetyltransferase activity| cysteine-type carboxypeptidase activity| cysteine-type endopeptidase activity| cysteine-type endopeptidase regulator activity involved in apoptotic process| cysteine-type peptidase activity| hormone binding| peptidase activator activity| peptidase activator activity involved in apoptotic process| peptidase activity| peptidase regulator activity| small conjugating protein binding| thiolester hydrolase activity| thyroid hormone binding| ubiquitin thiolesterase activity ERK1 and ERK2 cascade| T cell mediated cytotoxicity| T cell mediated immunity| adaptive immune response| anatomical structure maturation| bradykinin catabolic process| catagen| cell killing| cellular response to thyroid hormone stimulus| chemical homeostasis within a tissue| collagen metabolic process| decidualization| dichotomous subdivision of an epithelial terminal unit| dichotomous subdivision of terminal units involved in lung branching| epidermis morphogenesis| epithelial tube branching involved in lung morphogenesis| extracellular matrix disassembly| female pregnancy| hair cycle| hair cycle process| hair follicle development| hair follicle maturation| hair follicle morphogenesis| immune response-regulating signaling pathway| leukocyte mediated cytotoxicity| leukocyte mediated immunity| lung development| lung morphogenesis| lymphocyte mediated immunity| maternal placenta development| maternal process involved in female pregnancy| metanephros development| molting cycle process| multicellular organismal catabolic process| multicellular organismal homeostasis| negative regulation of epithelial cell proliferation| negative regulation of keratinocyte proliferation| neuropeptide catabolic process| peptide catabolic process| peptide metabolic process| placenta development| positive regulation of angiogenesis| positive regulation of apoptotic signaling pathway| positive regulation of developmental process| positive regulation of epithelial cell migration| positive regulation of peptidase activity| posttranscriptional regulation of gene expression| protein destabilization| protein maturation| protein modification by small protein conjugation or removal| protein modification by small protein removal| protein processing| proteolysis| regulation of actin cytoskeleton reorganization| regulation of epithelial cell migration| regulation of keratinocyte proliferation| regulation of peptidase activity| regulation of protein stability| respiratory tube development| response to retinoic acid| response to thyroid hormone stimulus| skin morphogenesis| surfactant homeostasis| tissue homeostasis
173 PF10026 Predicted Zn-dependent protease (DUF2268) Peptidase_MA (CL0126) 528 (29) 195 183 (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (1-194)
(1) Zincin-like [d.92]
d.92.1(7-146) d.92.1(1-194) NO PREDICTION NO PREDICTION NO PREDICTION 2 No information Bacteria|Archaea 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 cortical granule glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing
174 PF09807 Uncharacterized conserved protein (DUF2348) No Pfam Clan 176 (5) 249 251 (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (1-213)
(1) P-loop containing nucleoside triphosphate hydrolases [c.37]
NO PREDICTION c.37.1(1-213) NO PREDICTION NO PREDICTION c.37.1(2-211) 2 No information Eukaryota 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
175 PF06245 Protein of unknown function (DUF1015) No Pfam Clan 830 (97) 416 438 (1) ParB/Sulfiredoxin [d.268.1] (102-404)
(1) ParB/Sulfiredoxin [d.268]
NO PREDICTION d.268.1(102-404) NO PREDICTION NO PREDICTION d.268.1(199-435) 2 YES Eukaryota|Bacteria|Archaea 1.8.98.2 No information No information No information
176 PF04781 Protein of unknown function (DUF627) No Pfam Clan 70 (17) 112 122 (1) TPR-like [a.118.8] (2-109)
(1) alpha-alpha superhelix [a.118]
a.118.8(2-107) NO PREDICTION NO PREDICTION NO PREDICTION a.118.8(2-109) 2 No information Eukaryota No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
177 PF12099 Protein of unknown function (DUF3575) MBB (CL0193) 605 (39) 189 193 (1) Autotransporter [f.4.5] (23-188)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION f.4.5(23-188) f.4.5(88-181) NO PREDICTION NO PREDICTION 2 YES Bacteria No information No information No information No information
178 PF13020 Domain of unknown function (DUF3883) PDDEXK (CL0236) 729 (140) 91 102 (1) Restriction endonuclease-like [c.52.1] (1-90)
(1) Restriction endonuclease-like [c.52]
NO PREDICTION c.52.1(1-90) NO PREDICTION NO PREDICTION c.52.1(36-80) 2 No information Eukaryota|Bacteria|Archaea 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 No information endonuclease activity| nuclease activity DNA repair| nucleotide-excision repair
179 PF11929 Domain of unknown function (DUF3447) Ank (CL0465) 1243 (607) 76 82 (1) Ankyrin repeat [d.211.1] (1-76)
(1) beta-hairpin-alpha-hairpin repeat [d.211]
d.211.1(1-76) NO PREDICTION d.211.1(3-62) NO PREDICTION NO PREDICTION 2 No information Eukaryota No information intercellular bridge NF-kappaB binding| cyclin-dependent protein serine/threonine kinase inhibitor activity| cyclin-dependent protein serine/threonine kinase regulator activity| enzyme binding| histone deacetylase binding| kinase inhibitor activity| kinase regulator activity| protein kinase inhibitor activity| protein kinase regulator activity| protein serine/threonine kinase inhibitor activity cell cycle arrest| cytoplasmic sequestering of protein| cytoplasmic sequestering of transcription factor| interphase| maintenance of location| maintenance of location in cell| maintenance of protein location| maintenance of protein location in cell| mitotic cell cycle phase transition| negative regulation of NF-kappaB transcription factor activity| negative regulation of cell cycle| negative regulation of intracellular protein transport| negative regulation of intracellular transport| negative regulation of kinase activity| negative regulation of phosphorylation| negative regulation of protein import into nucleus| negative regulation of protein kinase activity| negative regulation of protein serine/threonine kinase activity| negative regulation of protein transport| negative regulation of transcription factor import into nucleus| positive regulation of NF-kappaB transcription factor activity| positive regulation of transforming growth factor beta receptor signaling pathway| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway| regulation of I-kappaB kinase/NF-kappaB cascade| regulation of NF-kappaB import into nucleus| regulation of cyclin-dependent protein serine/threonine kinase activity| regulation of protein localization to nucleus| regulation of transcription factor import into nucleus| spleen development
180 PF11897 Protein of unknown function (DUF3417) No Pfam Clan 640 (79) 119 119 (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (3-119)
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87]
c.87.1(3-119) NO PREDICTION c.87.1(21-119) NO PREDICTION NO PREDICTION 2 No information Bacteria|Viruses|Archaea 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process
181 PF04285 Protein of unknown function (DUF444) vWA-like (CL0128) 1564 (8) 421 423 (1) vWA-like [c.62.1] (252-418)
(1) vWA-like [c.62]
NO PREDICTION NO PREDICTION c.62.1(252-418) NO PREDICTION c.62.1(246-352) 2 No information Bacteria|Viruses|Archaea No information extracellular matrix No information DNA repair| double-strand break repair| double-strand break repair via nonhomologous end joining| non-recombinational repair| response to ionizing radiation
182 PF04789 Protein of unknown function (DUF621) GPCR_A (CL0192) 52 (14) 306 308 (1) Family A G protein-coupled receptor-like [f.13.1] (12-296)
(1) Family A G protein-coupled receptor-like [f.13]
NO PREDICTION f.13.1(12-296) NO PREDICTION NO PREDICTION f.13.1(49-297) 2 No information Eukaryota No information cilium| cilium membrane| cilium part| early endosome| integral to plasma membrane| intrinsic to plasma membrane| photoreceptor inner segment| photoreceptor inner segment membrane| photoreceptor outer segment| photoreceptor outer segment membrane| primary cilium G-protein coupled receptor activity| amide binding| catecholamine binding| chemokine receptor activity| molecular transducer activity| neuropeptide binding| odorant binding| peptide binding| pheromone binding| receptor activity| retinal binding| signaling receptor activity G-protein coupled receptor signaling pathway| calcium ion homeostasis| cellular calcium ion homeostasis| cellular divalent inorganic cation homeostasis| cellular response to cytokine stimulus| cellular response to disaccharide stimulus| cellular response to sucrose stimulus| chemokine-mediated signaling pathway| complement receptor mediated signaling pathway| detection of chemical stimulus| detection of chemical stimulus involved in sensory perception| detection of light stimulus| detection of stimulus| detection of stimulus involved in sensory perception| diet induced thermogenesis| divalent inorganic cation homeostasis| germ cell migration| histamine secretion| histamine transport| hormone secretion| inflammatory response| mRNA transcription| mRNA transcription from RNA polymerase II promoter| negative regulation of nucleotide biosynthetic process| negative regulation of nucleotide metabolic process| negative regulation of purine nucleotide metabolic process| nonassociative learning| platelet activation| positive regulation of MAPK cascade| positive regulation of cyclase activity| positive regulation of cyclic nucleotide biosynthetic process| positive regulation of cytokinesis| positive regulation of intracellular protein kinase cascade| positive regulation of leukocyte degranulation| positive regulation of lyase activity| positive regulation of mast cell activation| positive regulation of mast cell activation involved in immune response| positive regulation of mucus secretion| positive regulation of multicellular organismal metabolic process| positive regulation of nucleotide biosynthetic process| positive regulation of nucleotide metabolic process| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of purine nucleotide metabolic process| purinergic receptor signaling pathway| regulation of ERK1 and ERK2 cascade| regulation of MAPK cascade| regulation of cAMP biosynthetic process| regulation of cAMP metabolic process| regulation of cyclase activity| regulation of cyclic nucleotide biosynthetic process| regulation of cyclic nucleotide metabolic process| regulation of interleukin-8 secretion| regulation of intracellular protein kinase cascade| regulation of leukocyte degranulation| regulation of lyase activity| regulation of mast cell activation| regulation of mast cell activation involved in immune response| regulation of mucus secretion| regulation of multicellular organismal metabolic process| regulation of myeloid leukocyte mediated immunity| regulation of nucleotide biosynthetic process| regulation of nucleotide metabolic process| regulation of purine nucleotide biosynthetic process| regulation of purine nucleotide metabolic process| regulation of systemic arterial blood pressure by norepinephrine-epinephrine| regulation of vasoconstriction| response to pheromone| sensory perception| sensory perception of chemical stimulus
183 PF14394 Domain of unknown function (DUF4423) No Pfam Clan 72 (52) 171 175 (1) "Winged helix" DNA-binding domain [a.4.5] (20-146)
(1) DNA/RNA-binding 3-helical bundle [a.4]
NO PREDICTION a.4.5(20-146) NO PREDICTION NO PREDICTION a.4.5(22-87) 2 No information Bacteria No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
184 PF10082 Uncharacterized protein conserved in bacteria (DUF2320) MBB (CL0193) 519 (39) 381 373 (1) Porins [f.4.3] (6-380)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION f.4.3(6-380) NO PREDICTION f.4.3(1-373) NO PREDICTION 2 No information Eukaryota|Bacteria No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity fatty acid transport| lipid localization| long-chain fatty acid transport
185 PF11312 Protein of unknown function (DUF3115) No Pfam Clan 129 (20) 315 318 (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (22-307)
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66]
NO PREDICTION c.66.1(22-307) NO PREDICTION NO PREDICTION c.66.1(107-253) 2 No information Eukaryota 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 nuclear matrix glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process
186 PF05911 Plant protein of unknown function (DUF869) No Pfam Clan 276 (12) 769 821 (1) C-terminal domain of PLC-beta [h.4.10] (66-333)
(2) Tropomyosin [h.1.5] (648-815)
(1) Parallel coiled-coil [h.1]
(2) Antiparallel coiled-coil [h.4]
NO PREDICTION NO PREDICTION h.1.5(648-815) h.4.10(66-333) NO PREDICTION 2 No information Eukaryota 3.1.4.11 actin filament| cell cortex| cell cortex part| cell division site| cell division site part| contractile fiber| contractile fiber part| contractile ring| dendritic spine head| filamentous actin| growth cone| muscle thin filament tropomyosin| myofilament| neuronal postsynaptic density| podosome| site of polarized growth| striated muscle thin filament| synapse part structural constituent of cytoskeleton G-protein coupled glutamate receptor signaling pathway| actin filament-based movement| actin-myosin filament sliding| behavioral response to cocaine| chemical homeostasis within a tissue| chordate embryonic development| glutamate receptor signaling pathway| in utero embryonic development| multicellular organismal movement| muscle cell development| muscle cell differentiation| muscle contraction| muscle organ development| muscle system process| muscle tissue development| positive regulation of ion transport| regulation of calcium ion transport| regulation of metal ion transport| response to alkaloid| response to ammonium ion| response to cocaine| striated muscle cell differentiation| striated muscle tissue development| tissue homeostasis
187 PF10023 Predicted aminopeptidase (DUF2265) No Pfam Clan 162 (26) 338 339 (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (49-337)
(1) Zincin-like [d.92]
NO PREDICTION d.92.1(49-337) NO PREDICTION NO PREDICTION d.92.1(163-202) 2 No information Bacteria|Viruses 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 cortical granule glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing
188 PF09664 Protein of unknown function C-terminus (DUF2399) Toprim-like (CL0413) 184 (17) 152 155 (1) DNA topoisomerase IV, alpha subunit [e.12.1] (5-144)
(1) DNA topoisomerase IV, alpha subunit [e.12]
e.12.1(5-144) NO PREDICTION NO PREDICTION NO PREDICTION e.12.1(24-148) 2 No information Eukaryota|Bacteria|Archaea No information No information No information DNA recombination| cellular process involved in reproduction| chromosome organization| chromosome organization involved in meiosis| meiosis| meiosis I| meiotic cell cycle| reciprocal meiotic recombination
189 PF02694 Uncharacterised BCR, YnfA/UPF0060 family DMT (CL0184) 1396 (4) 107 108 (1) Multidrug resistance efflux transporter EmrE [f.39.1] (6-106)
(1) Multidrug resistance efflux transporter EmrE [f.39]
NO PREDICTION f.39.1(6-106) f.39.1(7-106) NO PREDICTION NO PREDICTION 2 No information Eukaryota|Bacteria|Archaea No information No information No information No information
190 PF04570 Protein of unknown function (DUF581) TRASH (CL0175) 427 (42) 59 59 (1) Glucocorticoid receptor-like (DNA-binding domain) [g.39.1] (16-53)
(1) Glucocorticoid receptor-like (DNA-binding domain) [g.39]
g.39.1(19-55) g.39.1(16-53) NO PREDICTION NO PREDICTION NO PREDICTION 2 No information Eukaryota 2.7.1.21| 4.2.99.18 No information No information No information
191 PF11142 Protein of unknown function (DUF2917) No Pfam Clan 253 (40) 63 64 (1) RmlC-like cupins [b.82.1] (1-61)
(1) Double-stranded beta-helix [b.82]
b.82.1(2-53) b.82.1(1-61) NO PREDICTION NO PREDICTION NO PREDICTION 2 No information Bacteria 1.13.11.20| 1.13.11.24| 1.13.11.4| 1.13.11.5| 1.13.11.50| 1.13.11.53| 1.13.11.6| 1.2.3.4| 3.5.3.19| 4.1.1.2| 5.1.3.13| 5.3.1.15| 5.3.1.17| 5.3.1.8| 5.3.1.9 No information 3-hydroxyanthranilate 3,4-dioxygenase activity| auxin binding| dTDP-4-dehydrorhamnose 3,5-epimerase activity| dioxygenase activity| hormone binding| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporati| racemase and epimerase activity, acting on carbohydrates and derivatives L-methionine salvage| L-methionine salvage from methylthioadenosine| amino acid salvage| aspartate family amino acid biosynthetic process| cellular carbohydrate biosynthetic process| cellular metabolic compound salvage| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| extracellular polysaccharide biosynthetic process| extracellular polysaccharide metabolic process| lipopolysaccharide metabolic process| methionine biosynthetic process| methionine metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| sulfur amino acid biosynthetic process| sulfur amino acid metabolic process
192 PF07800 Protein of unknown function (DUF1644) No Pfam Clan 198 (18) 162 140 (1) RING/U-box [g.44.1] (1-103)
(2) beta-beta-alpha zinc fingers [g.37.1] (87-110)
(1) beta-beta-alpha zinc fingers [g.37]
(2) RING/U-box [g.44]
NO PREDICTION g.44.1(1-103) NO PREDICTION NO PREDICTION g.44.1(1-82)| g.37.1(87-110) 2 No information Eukaryota No information nuclear body| nuclear ubiquitin ligase complex| ubiquitin ligase complex acid-amino acid ligase activity| chromatin binding| small conjugating protein ligase activity activation of cysteine-type endopeptidase activity| anatomical structure homeostasis| inflammatory response to antigenic stimulus| intrinsic apoptotic signaling pathway in response to oxidative stress| mesenchyme development| modification-dependent macromolecule catabolic process| modification-dependent protein catabolic process| negative regulation of T-helper 2 cell differentiation| negative regulation of T-helper cell differentiation| negative regulation of type 2 immune response| palate development| positive regulation of gene expression| positive regulation of nucleobase-containing compound metabolic process| protein catabolic process| protein modification by small protein conjugation| protein modification by small protein conjugation or removal| regulation of T cell differentiation| regulation of T-helper 2 cell differentiation| regulation of T-helper cell differentiation| regulation of alpha-beta T cell activation| regulation of cell cycle phase transition| regulation of cysteine-type endopeptidase activity| regulation of endopeptidase activity| regulation of leukocyte activation| regulation of leukocyte differentiation| regulation of lymphocyte activation| regulation of lymphocyte differentiation| regulation of peptidase activity| regulation of type 2 immune response| tongue development
193 PF12031 Domain of unknown function (DUF3518) No Pfam Clan 191 (6) 257 257 (1) ARM repeat [a.118.1] (3-244)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(3-244) a.118.1(13-49)| a.118.1(82-231) NO PREDICTION NO PREDICTION 2 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
194 PF04842 Plant protein of unknown function (DUF639) No Pfam Clan 126 (4) 683 692 (1) ARM repeat [a.118.1] (18-670)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(18-670) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
195 PF06250 Protein of unknown function (DUF1016) PDDEXK (CL0236) 1895 (7) 320 324 (1) Restriction endonuclease-like [c.52.1] (1-319)
(1) Restriction endonuclease-like [c.52]
NO PREDICTION c.52.1(1-319) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 No information endonuclease activity| nuclease activity DNA repair| nucleotide-excision repair
196 PF11460 Protein of unknown function (DUF3007) No Pfam Clan 109 (30) 104 97 (1) MFS general substrate transporter [f.38.1] (7-84)
(1) MFS general substrate transporter [f.38]
NO PREDICTION NO PREDICTION f.38.1(7-84) NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
197 PF09895 RecB-family nuclease (DUF2122) SPOUT (CL0098) 59 (18) 106 104 (1) alpha/beta knot [c.116.1] (9-104)
(1) alpha/beta knot [c.116]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION c.116.1(9-104) 1 No information Archaea 2.1.1.31| 2.1.1.34| 2.1.1.66 No information RNA methyltransferase activity| methyltransferase activity| rRNA (pseudouridine) methyltransferase activity| rRNA methyltransferase activity| transferase activity, transferring one-carbon groups RNA methylation| RNA modification| macromolecule methylation| methylation| ncRNA processing| rRNA modification| ribonucleoprotein complex biogenesis| ribosome biogenesis
198 PF02720 Domain of unknown function (DUF222) No Pfam Clan 2037 (29) 301 326 (1) Bacterial muramidases [a.118.5] (67-198)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION NO PREDICTION a.118.5(67-198) NO PREDICTION NO PREDICTION 1 YES Bacteria No information No information No information No information
199 PF11271 Protein of unknown function (DUF3068) No Pfam Clan 301 (22) 301 311 (1) C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase [b.70.2] (INDIRECT)
(1) 8-bladed beta-propeller [b.70]
NO PREDICTION b.70.2(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 YES Bacteria|Archaea No information No information No information No information
200 PF05689 Salmonella repeat of unknown function (DUF823) No Pfam Clan 1826 (30) 184 181 (1) Fibronectin type III [b.1.2] (10-176)
(1) Immunoglobulin-like beta-sandwich [b.1]
b.1.2(10-176) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria 2.1.1.191| 2.1.1.43| 2.7.7.4| 3.5.1.23 No information cytokine receptor activity| molecular transducer activity| receptor activity| signaling receptor activity| transmembrane signaling receptor activity JAK-STAT cascade| cellular response to cytokine stimulus| cytokine-mediated signaling pathway| developmental growth| growth| intracellular protein kinase cascade| lactation| mammary gland alveolus development| mammary gland epithelial cell differentiation| mammary gland epithelium development| mammary gland lobule development| prolactin signaling pathway| prostate gland development| regulation of body fluid levels| regulation of cell adhesion| response to cytokine stimulus
201 PF08578 Protein of unknown function (DUF1765) No Pfam Clan 180 (31) 126 138 (1) Hypothetical protein ST1625 [a.118.20] (4-100)
(1) alpha-alpha superhelix [a.118]
a.118.20(4-100) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information No information No information
202 PF11259 Protein of unknown function (DUF3060) No Pfam Clan 317 (29) 61 62 (1) beta-Roll [b.80.7] (16-61)
(1) Single-stranded right-handed beta-helix [b.80]
b.80.7(16-61) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea No information No information No information No information
203 PF07374 Protein of unknown function (DUF1492) HTH (CL0123) 341 (6) 100 104 (1) Homeodomain-like [a.4.1] (66-100)
(1) DNA/RNA-binding 3-helical bundle [a.4]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION a.4.1(66-100) 1 No information Bacteria|Viruses No information transcription factor complex chromatin binding| nucleic acid binding transcription factor activity| transposase activity activin receptor signaling pathway| cell fate commitment| cell fate specification| chordate embryonic development| diencephalon development| embryonic morphogenesis| endoderm development| eye photoreceptor cell differentiation| negative regulation of developmental process| neural tube development| neuron fate commitment| nodal signaling pathway| pancreas development| pattern specification process| positive regulation of neuron differentiation| regulation of cell fate commitment| regulation of epithelial cell differentiation| regulation of gastrulation| retina development in camera-type eye| sensory organ development| somitogenesis| transmembrane receptor protein serine/threonine kinase signaling pathway| transposition| transposition, DNA-mediated| trophectodermal cell differentiation
204 PF06197 Protein of unknown function (DUF998) Frag1-like (CL0412) 925 (111) 184 183 (1) MFS general substrate transporter [f.38.1] (1-183)
(1) MFS general substrate transporter [f.38]
NO PREDICTION f.38.1(1-183) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
205 PF11847 Domain of unknown function (DUF3367) No Pfam Clan 220 (14) 680 667 (1) MFS general substrate transporter [f.38.1] (INDIRECT)
(1) MFS general substrate transporter [f.38]
NO PREDICTION f.38.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
206 PF13904 Domain of unknown function (DUF4207) No Pfam Clan 192 (19) 264 243 (1) MW0975(SA0943)-like [a.24.27] (68-237)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(68-237) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information No information No information No information
207 PF03690 Uncharacterised protein family (UPF0160) No Pfam Clan 570 (69) 318 324 (1) DHH phosphoesterases [c.107.1] (1-317)
(1) DHH phosphoesterases [c.107]
NO PREDICTION c.107.1(1-317) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 3.6.1.1| 3.6.1.11 No information No information No information
208 PF04028 Domain of unknown function (DUF374) Acyltransferase (CL0228) 649 (79) 74 90 (1) YVTN repeat-like/Quinoprotein amine dehydrogenase [b.69.2] (21-70)
(1) 7-bladed beta-propeller [b.69]
b.69.2(21-70) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 YES Eukaryota|Bacteria 2.3.2.5 No information No information No information
209 PF05212 Protein of unknown function (DUF707) No Pfam Clan 266 (9) 294 267 (1) Nucleotide-diphospho-sugar transferases [c.68.1] (40-290)
(1) Nucleotide-diphospho-sugar transferases [c.68]
NO PREDICTION c.68.1(40-290) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 2.4.1.101| 2.4.1.131| 2.4.1.135| 2.4.1.186| 2.4.1.217| 2.4.1.222| 2.4.1.223| 2.4.1.37| 2.4.1.41| 2.4.1.44| 2.4.1.87| 2.7.7.13| 2.7.7.23| 2.7.7.24| 2.7.7.27| 2.7.7.33| 2.7.7.38| 2.7.7.43| 2.7.7.60| 2.7.7.64| 2.7.7.9 Golgi apparatus| Golgi apparatus part| Golgi membrane| cis-Golgi network| mannosyltransferase complex UDP-glycosyltransferase activity| acetylgalactosaminyltransferase activity| ceramide glucosyltransferase activity| cytidylyltransferase activity| galactosyltransferase activity| glucose-1-phosphate thymidylyltransferase activity| guanylyltransferase activity| magnesium ion binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups aminoglycan biosynthetic process| aminoglycan metabolic process| cell wall biogenesis| cell wall mannoprotein biosynthetic process| cell wall organization or biogenesis| cellular carbohydrate biosynthetic process| cellular component macromolecule biosynthetic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| chondroitin sulfate biosynthetic process| chondroitin sulfate metabolic process| chondroitin sulfate proteoglycan biosynthetic process| chondroitin sulfate proteoglycan metabolic process| dolichol metabolic process| extracellular fibril organization| extracellular matrix organization| extracellular structure organization| fibril organization| galactose metabolic process| gametophyte development| glycolipid metabolic process| glycoprotein biosynthetic process| glycoprotein metabolic process| glycosaminoglycan biosynthetic process| glycosphingolipid biosynthetic process| glycosylation| heparan sulfate proteoglycan biosynthetic process| heparan sulfate proteoglycan metabolic process| lipopolysaccharide metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| negative regulation of fibroblast proliferation| nucleotide-sugar metabolic process| peptidyl-asparagine modification| phosphatidylinositol biosynthetic process| phosphatidylinositol metabolic process| pollen development| polyprenol metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein O-linked glycosylation| protein glycosylation| regulation of Notch signaling pathway| regulation of fibroblast proliferation| sphingolipid biosynthetic process| sphingolipid metabolic process
210 PF09980 Predicted membrane protein (DUF2214) No Pfam Clan 200 (26) 150 150 (1) Transmembrane di-heme cytochromes [f.21.1] (3-149)
(1) Heme-binding four-helical bundle [f.21]
NO PREDICTION f.21.1(3-149) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 1.10.2.2 No information electron carrier activity cellular respiration
211 PF07878 Protein of unknown function (DUF1662) Met_repress (CL0057) 70 (27) 55 50 (1) Ribbon-helix-helix [a.43.1] (5-45)
(1) Ribbon-helix-helix [a.43]
NO PREDICTION NO PREDICTION a.43.1(5-45) NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information positive regulation of growth
212 PF11145 Protein of unknown function (DUF2921) No Pfam Clan 137 (7) 909 955 (1) Anthrax protective antigen [f.11.1] (INDIRECT)
(2) Soluble quinoprotein glucose dehydrogenase [b.68.2] (INDIRECT)
(1) 6-bladed beta-propeller [b.68]
(2) Anthrax protective antigen [f.11]
NO PREDICTION f.11.1(INDIRECT)| b.68.2(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota 1.1.5.2 No information No information No information
213 PF14265 Domain of unknown function (DUF4355) No Pfam Clan 633 (85) 125 131 (1) MW0975(SA0943)-like [a.24.27] (1-124)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(1-124) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses No information No information No information No information
214 PF10060 Uncharacterized membrane protein (DUF2298) No Pfam Clan 117 (18) 473 553 (1) Respiratory nitrate reductase 1 gamma chain [f.21.3] (131-338)
(1) Heme-binding four-helical bundle [f.21]
NO PREDICTION f.21.3(131-338) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information No information No information No information
215 PF12072 Domain of unknown function (DUF3552) No Pfam Clan 2218 (58) 201 194 (1) MW0975(SA0943)-like [a.24.27] (23-200)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(23-200) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea No information No information No information No information
216 PF10086 Putative membrane peptidase family (DUF2324) Peptidase_U (CL0472) 607 (28) 223 220 (1) MFS general substrate transporter [f.38.1] (1-222)
(1) MFS general substrate transporter [f.38]
NO PREDICTION f.38.1(1-222) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
217 PF10909 Protein of unknown function (DUF2682) No Pfam Clan 13 (7) 77 79 (1) BAG domain [a.7.7] (3-70)
(1) Spectrin repeat-like [a.7]
a.7.7(3-70) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Viruses No information No information No information No information
218 PF10030 Uncharacterized protein conserved in bacteria (DUF2272) Peptidase_CA (CL0125) 136 (13) 183 188 (1) Cysteine proteinases [d.3.1] (5-170)
(1) Cysteine proteinases [d.3]
NO PREDICTION d.3.1(5-170) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses 2.3.1.118| 2.3.1.5| 2.3.2.13| 2.3.2.15| 3.1.1.4| 3.4.14.1| 3.4.18.1| 3.4.19.12| 3.4.22.1| 3.4.22.10| 3.4.22.14| 3.4.22.15| 3.4.22.16| 3.4.22.2| 3.4.22.25| 3.4.22.27| 3.4.22.30| 3.4.22.38| 3.4.22.39| 3.4.22.40| 3.4.22.41| 3.4.22.43| 3.4.22.48| 3.4.22.51| 3.4.22.52| 3.4.22.53| 3.4.22.6| 3.4.22.65| 3.4.22.68| 3.5.1.52| 6.3.1.9 alveolar lamellar body| endosome lumen| lamellar body| lytic vacuole| vacuolar lumen MHC class I receptor activity| N-acyltransferase activity| acetyltransferase activity| arylamine N-acetyltransferase activity| cysteine-type carboxypeptidase activity| cysteine-type endopeptidase activity| cysteine-type endopeptidase regulator activity involved in apoptotic process| cysteine-type peptidase activity| hormone binding| peptidase activator activity| peptidase activator activity involved in apoptotic process| peptidase activity| peptidase regulator activity| small conjugating protein binding| thiolester hydrolase activity| thyroid hormone binding| ubiquitin thiolesterase activity ERK1 and ERK2 cascade| T cell mediated cytotoxicity| T cell mediated immunity| adaptive immune response| anatomical structure maturation| bradykinin catabolic process| catagen| cell killing| cellular response to thyroid hormone stimulus| chemical homeostasis within a tissue| collagen metabolic process| decidualization| dichotomous subdivision of an epithelial terminal unit| dichotomous subdivision of terminal units involved in lung branching| epidermis morphogenesis| epithelial tube branching involved in lung morphogenesis| extracellular matrix disassembly| female pregnancy| hair cycle| hair cycle process| hair follicle development| hair follicle maturation| hair follicle morphogenesis| immune response-regulating signaling pathway| leukocyte mediated cytotoxicity| leukocyte mediated immunity| lung development| lung morphogenesis| lymphocyte mediated immunity| maternal placenta development| maternal process involved in female pregnancy| metanephros development| molting cycle process| multicellular organismal catabolic process| multicellular organismal homeostasis| negative regulation of epithelial cell proliferation| negative regulation of keratinocyte proliferation| neuropeptide catabolic process| peptide catabolic process| peptide metabolic process| placenta development| positive regulation of angiogenesis| positive regulation of apoptotic signaling pathway| positive regulation of developmental process| positive regulation of epithelial cell migration| positive regulation of peptidase activity| posttranscriptional regulation of gene expression| protein destabilization| protein maturation| protein modification by small protein conjugation or removal| protein modification by small protein removal| protein processing| proteolysis| regulation of actin cytoskeleton reorganization| regulation of epithelial cell migration| regulation of keratinocyte proliferation| regulation of peptidase activity| regulation of protein stability| respiratory tube development| response to retinoic acid| response to thyroid hormone stimulus| skin morphogenesis| surfactant homeostasis| tissue homeostasis
219 PF14988 Domain of unknown function (DUF4515) No Pfam Clan 151 (11) 206 206 (1) MW0975(SA0943)-like [a.24.27] (2-189)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(2-189) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information No information No information No information
220 PF04465 Protein of unknown function (DUF499) No Pfam Clan 220 (5) 1036 1016 (1) ARM repeat [a.118.1] (1-989)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(1-989) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
221 PF06532 Protein of unknown function (DUF1109) No Pfam Clan 293 (54) 204 204 (1) Acid phosphatase/Vanadium-dependent haloperoxidase [a.111.1] (9-170)
(1) Acid phosphatase/Vanadium-dependent haloperoxidase [a.111]
NO PREDICTION a.111.1(9-170) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 1.11.1.10| 1.11.1.18| 3.1.3.2 intrinsic to organelle membrane inositol phosphoceramide synthase activity| lipid phosphatase activity| phosphatase activity| phosphatidate phosphatase activity| sphingosine-1-phosphate phosphatase activity| sugar-phosphatase activity| sugar-terminal-phosphatase activity dephosphorylation| germ cell migration| membrane lipid biosynthetic process| membrane lipid metabolic process| phospholipid metabolic process| sphingolipid biosynthetic process| sphingolipid metabolic process
222 PF04240 Protein of unknown function (DUF422) No Pfam Clan 245 (13) 215 214 (1) Family A G protein-coupled receptor-like [f.13.1] (INDIRECT)
(1) Family A G protein-coupled receptor-like [f.13]
NO PREDICTION f.13.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information cilium| cilium membrane| cilium part| early endosome| integral to plasma membrane| intrinsic to plasma membrane| photoreceptor inner segment| photoreceptor inner segment membrane| photoreceptor outer segment| photoreceptor outer segment membrane| primary cilium G-protein coupled receptor activity| amide binding| catecholamine binding| chemokine receptor activity| molecular transducer activity| neuropeptide binding| odorant binding| peptide binding| pheromone binding| receptor activity| retinal binding| signaling receptor activity G-protein coupled receptor signaling pathway| calcium ion homeostasis| cellular calcium ion homeostasis| cellular divalent inorganic cation homeostasis| cellular response to cytokine stimulus| cellular response to disaccharide stimulus| cellular response to sucrose stimulus| chemokine-mediated signaling pathway| complement receptor mediated signaling pathway| detection of chemical stimulus| detection of chemical stimulus involved in sensory perception| detection of light stimulus| detection of stimulus| detection of stimulus involved in sensory perception| diet induced thermogenesis| divalent inorganic cation homeostasis| germ cell migration| histamine secretion| histamine transport| hormone secretion| inflammatory response| mRNA transcription| mRNA transcription from RNA polymerase II promoter| negative regulation of nucleotide biosynthetic process| negative regulation of nucleotide metabolic process| negative regulation of purine nucleotide metabolic process| nonassociative learning| platelet activation| positive regulation of MAPK cascade| positive regulation of cyclase activity| positive regulation of cyclic nucleotide biosynthetic process| positive regulation of cytokinesis| positive regulation of intracellular protein kinase cascade| positive regulation of leukocyte degranulation| positive regulation of lyase activity| positive regulation of mast cell activation| positive regulation of mast cell activation involved in immune response| positive regulation of mucus secretion| positive regulation of multicellular organismal metabolic process| positive regulation of nucleotide biosynthetic process| positive regulation of nucleotide metabolic process| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of purine nucleotide metabolic process| purinergic receptor signaling pathway| regulation of ERK1 and ERK2 cascade| regulation of MAPK cascade| regulation of cAMP biosynthetic process| regulation of cAMP metabolic process| regulation of cyclase activity| regulation of cyclic nucleotide biosynthetic process| regulation of cyclic nucleotide metabolic process| regulation of interleukin-8 secretion| regulation of intracellular protein kinase cascade| regulation of leukocyte degranulation| regulation of lyase activity| regulation of mast cell activation| regulation of mast cell activation involved in immune response| regulation of mucus secretion| regulation of multicellular organismal metabolic process| regulation of myeloid leukocyte mediated immunity| regulation of nucleotide biosynthetic process| regulation of nucleotide metabolic process| regulation of purine nucleotide biosynthetic process| regulation of purine nucleotide metabolic process| regulation of systemic arterial blood pressure by norepinephrine-epinephrine| regulation of vasoconstriction| response to pheromone| sensory perception| sensory perception of chemical stimulus
223 PF13252 Protein of unknown function (DUF4043) No Pfam Clan 188 (33) 341 332 (1) Major capsid protein gp5 [d.183.1] (INDIRECT)
(1) Major capsid protein gp5 [d.183]
NO PREDICTION d.183.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses No information No information No information No information
224 PF10097 Predicted membrane protein (DUF2335) No Pfam Clan 168 (15) 50 50 (1) TPR-like [a.118.8] (19-50)
(1) alpha-alpha superhelix [a.118]
a.118.8(19-50) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
225 PF07037 Putative transcription regulator (DUF1323) HTH (CL0123) 925 (10) 122 113 (1) Putative DNA-binding domain [a.6.1] (1-45)
(1) Putative DNA-binding domain [a.6]
NO PREDICTION NO PREDICTION a.6.1(1-45) NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information nucleic acid binding transcription factor activity| sequence-specific DNA binding transcription factor activity No information
226 PF13312 Domain of unknown function (DUF4081) No Pfam Clan 307 (49) 107 107 (1) Acyl-CoA N-acyltransferases (Nat) [d.108.1] (1-107)
(1) Acyl-CoA N-acyltransferases (Nat) [d.108]
d.108.1(1-107) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria 2.3.1.1| 2.3.1.128| 2.3.1.178| 2.3.1.4| 2.3.1.48| 2.3.1.57| 2.3.1.82| 2.3.1.87| 2.3.1.88| 2.3.1.97| 2.3.2.10| 2.3.2.6 N-terminal protein acetyltransferase complex| perinuclear region of cytoplasm| protein acetyltransferase complex N-acetyltransferase activity| N-acyltransferase activity| acetyltransferase activity| ornithine decarboxylase inhibitor activity| ornithine decarboxylase regulator activity| transferase activity, transferring acyl groups other than amino-acyl groups DNA packaging| N-terminal protein amino acid acetylation| N-terminal protein amino acid modification| UDP-N-acetylglucosamine biosynthetic process| UDP-N-acetylglucosamine metabolic process| amide biosynthetic process| amino sugar biosynthetic process| amino sugar metabolic process| cellular hormone metabolic process| cellular response to cAMP| cellular response to nitrogen compound| cellular response to organic cyclic compound| cellular response to organonitrogen compound| chromatin assembly| chromatin organization| chromosome organization| chromosome segregation| circadian rhythm| covalent chromatin modification| gastrulation with mouth forming second| histone acetylation| histone modification| hormone biosynthetic process| hormone metabolic process| indole-containing compound biosynthetic process| indole-containing compound metabolic process| melatonin biosynthetic process| melatonin metabolic process| mitotic sister chromatid cohesion| mitotic sister chromatid segregation| nucleotide-sugar biosynthetic process| nucleotide-sugar metabolic process| peptidyl-lysine modification| peptidyl-methionine modification| polyamine metabolic process| protein acetylation| protein acylation| protein-DNA complex assembly| protein-DNA complex subunit organization| regulation of hormone levels| response to cAMP| response to organophosphorus| response to purine-containing compound| response to toxic substance| rhythmic process
227 PF05284 Protein of unknown function (DUF736) No Pfam Clan 445 (66) 107 105 (1) TPR-like [a.118.8] (2-101)
(1) alpha-alpha superhelix [a.118]
a.118.8(2-101) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
228 PF10884 Protein of unknown function (DUF2683) No Pfam Clan 17 (7) 80 81 (1) TPR-like [a.118.8] (3-57)
(1) alpha-alpha superhelix [a.118]
a.118.8(3-57) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
229 PF10022 Uncharacterized protein conserved in bacteria (DUF2264) No Pfam Clan 781 (52) 361 368 (1) Chondroitin AC/alginate lyase [a.102.3] (41-304)
(1) alpha/alpha toroid [a.102]
NO PREDICTION a.102.3(41-304) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea 4.2.2.1| 4.2.2.12| 4.2.2.20| 4.2.2.21| 4.2.2.3| 4.2.2.5 No information No information No information
230 PF15090 Domain of unknown function (DUF4553) No Pfam Clan 61 (7) 463 459 (1) Rap30/74 interaction domains [b.65.1] (INDIRECT)
(2) "Winged helix" DNA-binding domain [a.4.5] (INDIRECT)
(1) DNA/RNA-binding 3-helical bundle [a.4]
(2) triple barrel [b.65]
NO PREDICTION b.65.1(INDIRECT)| a.4.5(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
231 PF06786 Uncharacterised protein family (UPF0253) No Pfam Clan 619 (8) 66 68 (1) ARM repeat [a.118.1] (4-66)
(1) alpha-alpha superhelix [a.118]
a.118.1(4-66) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
232 PF14133 Domain of unknown function (DUF4300) No Pfam Clan 333 (36) 250 250 (1) Cysteine proteinases [d.3.1] (1-248)
(1) Cysteine proteinases [d.3]
NO PREDICTION d.3.1(1-248) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria 2.3.1.118| 2.3.1.5| 2.3.2.13| 2.3.2.15| 3.1.1.4| 3.4.14.1| 3.4.18.1| 3.4.19.12| 3.4.22.1| 3.4.22.10| 3.4.22.14| 3.4.22.15| 3.4.22.16| 3.4.22.2| 3.4.22.25| 3.4.22.27| 3.4.22.30| 3.4.22.38| 3.4.22.39| 3.4.22.40| 3.4.22.41| 3.4.22.43| 3.4.22.48| 3.4.22.51| 3.4.22.52| 3.4.22.53| 3.4.22.6| 3.4.22.65| 3.4.22.68| 3.5.1.52| 6.3.1.9 alveolar lamellar body| endosome lumen| lamellar body| lytic vacuole| vacuolar lumen MHC class I receptor activity| N-acyltransferase activity| acetyltransferase activity| arylamine N-acetyltransferase activity| cysteine-type carboxypeptidase activity| cysteine-type endopeptidase activity| cysteine-type endopeptidase regulator activity involved in apoptotic process| cysteine-type peptidase activity| hormone binding| peptidase activator activity| peptidase activator activity involved in apoptotic process| peptidase activity| peptidase regulator activity| small conjugating protein binding| thiolester hydrolase activity| thyroid hormone binding| ubiquitin thiolesterase activity ERK1 and ERK2 cascade| T cell mediated cytotoxicity| T cell mediated immunity| adaptive immune response| anatomical structure maturation| bradykinin catabolic process| catagen| cell killing| cellular response to thyroid hormone stimulus| chemical homeostasis within a tissue| collagen metabolic process| decidualization| dichotomous subdivision of an epithelial terminal unit| dichotomous subdivision of terminal units involved in lung branching| epidermis morphogenesis| epithelial tube branching involved in lung morphogenesis| extracellular matrix disassembly| female pregnancy| hair cycle| hair cycle process| hair follicle development| hair follicle maturation| hair follicle morphogenesis| immune response-regulating signaling pathway| leukocyte mediated cytotoxicity| leukocyte mediated immunity| lung development| lung morphogenesis| lymphocyte mediated immunity| maternal placenta development| maternal process involved in female pregnancy| metanephros development| molting cycle process| multicellular organismal catabolic process| multicellular organismal homeostasis| negative regulation of epithelial cell proliferation| negative regulation of keratinocyte proliferation| neuropeptide catabolic process| peptide catabolic process| peptide metabolic process| placenta development| positive regulation of angiogenesis| positive regulation of apoptotic signaling pathway| positive regulation of developmental process| positive regulation of epithelial cell migration| positive regulation of peptidase activity| posttranscriptional regulation of gene expression| protein destabilization| protein maturation| protein modification by small protein conjugation or removal| protein modification by small protein removal| protein processing| proteolysis| regulation of actin cytoskeleton reorganization| regulation of epithelial cell migration| regulation of keratinocyte proliferation| regulation of peptidase activity| regulation of protein stability| respiratory tube development| response to retinoic acid| response to thyroid hormone stimulus| skin morphogenesis| surfactant homeostasis| tissue homeostasis
233 PF05895 Siphovirus protein of unknown function (DUF859) No Pfam Clan 110 (11) 624 657 (1) Porins [f.4.3] (30-628)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION NO PREDICTION NO PREDICTION f.4.3(30-628) NO PREDICTION 1 No information Eukaryota|Bacteria|Viruses No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity fatty acid transport| lipid localization| long-chain fatty acid transport
234 PF06181 Protein of unknown function (DUF989) No Pfam Clan 485 (60) 301 299 (1) MFS general substrate transporter [f.38.1] (1-282)
(1) MFS general substrate transporter [f.38]
NO PREDICTION f.38.1(1-282) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
235 PF09878 Predicted membrane protein (DUF2105) No Pfam Clan 32 (10) 212 228 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (3-192)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(3-192) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Archaea No information No information No information No information
236 PF11154 Protein of unknown function (DUF2934) No Pfam Clan 414 (64) 40 40 (1) HSP20-like chaperones [b.15.1] (1-38)
(1) HSP20-like chaperones [b.15]
b.15.1(1-38) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Viruses No information contractile fiber| contractile fiber part unfolded protein binding protein folding| response to endoplasmic reticulum stress| response to heat| response to high light intensity| response to hydrogen peroxide| response to light intensity| response to reactive oxygen species| response to temperature stimulus
237 PF10100 Uncharacterized protein conserved in bacteria (DUF2338) No Pfam Clan 271 (6) 429 430 (1) NAD(P)-binding Rossmann-fold domains [c.2.1] (1-199)
(2) 6-phosphogluconate dehydrogenase C-terminal domain-like [a.100.1] (207-395)
(1) 6-phosphogluconate dehydrogenase C-terminal domain-like [a.100]
(2) NAD(P)-binding Rossmann-fold domains [c.2]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION c.2.1(1-199)| a.100.1(207-395) 1 No information Bacteria 1.1.1.1| 1.1.1.10| 1.1.1.100| 1.1.1.103| 1.1.1.118| 1.1.1.12| 1.1.1.125| 1.1.1.126| 1.1.1.132| 1.1.1.133| 1.1.1.138| 1.1.1.14| 1.1.1.141| 1.1.1.146| 1.1.1.153| 1.1.1.157| 1.1.1.159| 1.1.1.16| 1.1.1.169| 1.1.1.17| 1.1.1.18| 1.1.1.184| 1.1.1.195| 1.1.1.2| 1.1.1.206| 1.1.1.219| 1.1.1.22| 1.1.1.234| 1.1.1.236| 1.1.1.237| 1.1.1.24| 1.1.1.248| 1.1.1.25| 1.1.1.252| 1.1.1.26| 1.1.1.268| 1.1.1.27| 1.1.1.271| 1.1.1.275| 1.1.1.276| 1.1.1.28| 1.1.1.282| 1.1.1.289| 1.1.1.29| 1.1.1.290| 1.1.1.291| 1.1.1.292| 1.1.1.30| 1.1.1.304| 1.1.1.31| 1.1.1.35| 1.1.1.36| 1.1.1.37| 1.1.1.38| 1.1.1.40| 1.1.1.44| 1.1.1.45| 1.1.1.47| 1.1.1.50| 1.1.1.51| 1.1.1.53| 1.1.1.60| 1.1.1.62| 1.1.1.67| 1.1.1.69| 1.1.1.79| 1.1.1.8| 1.1.1.82| 1.1.1.86| 1.1.1.9| 1.1.1.90| 1.1.1.94| 1.1.1.95| 1.1.99.28| 1.12.98.2| 1.16.1.2| 1.17.1.3| 1.2.1.10| 1.2.1.12| 1.2.1.13| 1.2.1.2| 1.2.1.38| 1.2.1.43| 1.2.1.46| 1.2.1.5| 1.2.1.59| 1.2.1.72| 1.2.99.4| 1.3.1.10| 1.3.1.12| 1.3.1.24| 1.3.1.26| 1.3.1.28| 1.3.1.34| 1.3.1.38| 1.3.1.43| 1.3.1.48| 1.3.1.74| 1.3.1.76| 1.3.1.77| 1.3.1.9| 1.4.1.1| 1.4.1.18| 1.4.1.20| 1.4.1.21| 1.4.1.3| 1.5.1.10| 1.5.1.11| 1.5.1.15| 1.5.1.2| 1.5.1.33| 1.5.1.34| 1.5.1.5| 1.5.1.7| 1.6.1.2| 1.6.5.2| 1.6.5.5| 2.3.1.85| 2.3.1.94| 3.2.1.122| 3.2.1.139| 3.2.1.20| 3.2.1.49| 3.2.1.86| 3.3.1.1| 4.1.1.35| 4.2.1.119| 4.2.1.45| 4.2.1.46| 4.2.1.47| 4.3.1.12| 5.1.3.10| 5.1.3.18| 5.1.3.2| 5.1.3.20| 5.1.3.7| 5.5.1.4 microbody NAD binding| NAD+ binding| NADH binding| NADP binding| NADPH binding| UDP-glucose 4-epimerase activity| coenzyme binding| cofactor binding| dTDP-glucose 4,6-dehydratase activity| fatty acid synthase activity| icosanoid receptor activity| long-chain-fatty-acyl-CoA reductase activity| oxidoreductase activity, acting on CH-OH group of donors| oxidoreductase activity, acting on the CH-CH group of donors| oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor| oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor| oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor| prostaglandin E receptor activity| prostaglandin receptor activity| prostanoid receptor activity| racemase and epimerase activity| steroid dehydrogenase activity amide biosynthetic process| cellular hormone metabolic process| cellular ketone metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| diterpenoid metabolic process| drug metabolic process| ductus arteriosus closure| estrogen biosynthetic process| extracellular polysaccharide biosynthetic process| extracellular polysaccharide metabolic process| fatty acid biosynthetic process| fatty acid elongation| hormone metabolic process| nucleotide-sugar biosynthetic process| nucleotide-sugar metabolic process| organic heteropentacyclic compound metabolic process| ovulation| parturition| pentose metabolic process| phenol-containing compound biosynthetic process| phenol-containing compound metabolic process| polysaccharide biosynthetic process| protein oligomerization| protein tetramerization| pteridine-containing compound biosynthetic process| pteridine-containing compound metabolic process| regulation of hormone levels| retinal metabolic process| retinoic acid biosynthetic process| retinoid metabolic process| secondary metabolic process| steroid metabolic process| terpenoid metabolic process| tetrahydrobiopterin biosynthetic process| tetrahydrobiopterin metabolic process| thrombin receptor signaling pathway| vitamin K metabolic process| xanthone-containing compound biosynthetic process| xanthone-containing compound metabolic process
238 PF10871 Protein of unknown function (DUF2748) No Pfam Clan 44 (2) 447 440 (1) ARM repeat [a.118.1] (1-443)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(1-443) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
239 PF06533 Protein of unknown function (DUF1110) No Pfam Clan 38 (6) 188 156 (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (4-100)
(1) 8-bladed beta-propeller [b.70]
b.70.1(4-100) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota 1.1.2.7| 1.1.98.1 No information endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein
240 PF10670 Domain of unknown function (DUF4198) No Pfam Clan 1021 (108) 215 215 (1) Cna protein B-type domain [b.3.5] (152-213)
(1) Prealbumin-like [b.3]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION b.3.5(152-213) 1 YES Bacteria|Archaea No information No information No information No information
241 PF11899 Protein of unknown function (DUF3419) No Pfam Clan 261 (42) 380 387 (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (274-352)
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66]
NO PREDICTION NO PREDICTION c.66.1(274-352) NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 nuclear matrix glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process
242 PF14220 Domain of unknown function (DUF4329) No Pfam Clan 415 (20) 123 121 (1) JAB1/MPN domain [c.97.3] (3-115)
(1) Cytidine deaminase-like [c.97]
NO PREDICTION c.97.3(3-115) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria 3.1.2.15 No information No information No information
243 PF12059 Protein of unknown function (DUF3540) No Pfam Clan 188 (14) 202 204 (1) Nucleic acid-binding proteins [b.40.4] (3-61)
(1) OB-fold [b.40]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION b.40.4(3-61) 1 No information Bacteria 3.1.13.1| 3.1.26.12| 6.5.1.1 DNA replication factor A complex| DNA-directed RNA polymerase II, core complex| DNA-directed RNA polymerase II, holoenzyme| DNA-directed RNA polymerase complex| RNA polymerase complex| cytoplasmic exosome (RNase complex)| cytosolic small ribosomal subunit| exosome (RNase complex)| mitochondrial nucleoid| nuclear DNA-directed RNA polymerase complex| nucleoid| organellar ribosome| replisome RNA polymerase activity| chromatin binding| ribonucleoprotein complex binding| single-stranded DNA binding| structure-specific DNA binding regulation of DNA-dependent transcription, termination| regulation of RNA stability| regulation of mRNA stability| response to cold| ribonucleoprotein complex biogenesis| telomere maintenance| telomere organization| transcriptional attenuation| translational initiation
244 PF10222 Uncharacterized conserved protein (DUF2152) No Pfam Clan 150 (6) 604 508 (1) Putative isomerase YbhE [b.69.11] (87-569)
(1) 7-bladed beta-propeller [b.69]
NO PREDICTION b.69.11(87-569) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information No information No information
245 PF06279 Protein of unknown function (DUF1033) No Pfam Clan 683 (16) 120 120 (1) TPR-like [a.118.8] (11-115)
(1) alpha-alpha superhelix [a.118]
a.118.8(11-115) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
246 PF10179 Uncharacterised conserved protein (DUF2369) No Pfam Clan 148 (5) 300 297 (1) Fibronectin type III [b.1.2] (171-287)
(1) Immunoglobulin-like beta-sandwich [b.1]
NO PREDICTION NO PREDICTION b.1.2(171-287) NO PREDICTION NO PREDICTION 1 No information Eukaryota 2.1.1.191| 2.1.1.43| 2.7.7.4| 3.5.1.23 No information cytokine receptor activity| molecular transducer activity| receptor activity| signaling receptor activity| transmembrane signaling receptor activity JAK-STAT cascade| cellular response to cytokine stimulus| cytokine-mediated signaling pathway| developmental growth| growth| intracellular protein kinase cascade| lactation| mammary gland alveolus development| mammary gland epithelial cell differentiation| mammary gland epithelium development| mammary gland lobule development| prolactin signaling pathway| prostate gland development| regulation of body fluid levels| regulation of cell adhesion| response to cytokine stimulus
247 PF04474 Protein of unknown function (DUF554) No Pfam Clan 1327 (64) 226 224 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-220)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(1-220) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information No information No information No information
248 PF04238 Protein of unknown function (DUF420) No Pfam Clan 636 (60) 133 135 (1) Cytochrome c oxidase subunit III-like [f.25.1] (4-135)
(1) Cytochrome c oxidase subunit III-like [f.25]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION f.25.1(4-135) 1 No information Bacteria|Archaea No information respiratory chain| respiratory chain complex IV No information cellular protein complex assembly| cellular respiration| electron transport chain| energy derivation by oxidation of organic compounds| respiratory chain complex IV assembly| respiratory electron transport chain
249 PF08101 Domain of unknown function (DUF1708) GAP (CL0409) 144 (19) 420 393 (1) GTPase activation domain, GAP [a.116.1] (4-154)
(1) GTPase activation domain, GAP [a.116]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION a.116.1(4-154) 1 No information Eukaryota 3.1.3.36 No information GTPase regulator activity| Rho GTPase activator activity| nucleoside-triphosphatase regulator activity| small GTPase regulator activity positive regulation of GTPase activity| positive regulation of Ras GTPase activity| positive regulation of Rho GTPase activity| positive regulation of hydrolase activity| regulation of GTP catabolic process| regulation of GTPase activity| regulation of Ras GTPase activity| regulation of Rho GTPase activity| regulation of Rho protein signal transduction| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| regulation of small GTPase mediated signal transduction
250 PF11856 Protein of unknown function (DUF3376) No Pfam Clan 113 (23) 488 515 (1) ARM repeat [a.118.1] (5-455)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(5-455) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
251 PF12449 Protein of unknown function (DUF3684) No Pfam Clan 109 (22) 1093 1078 (1) ARM repeat [a.118.1] (13-1062)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(13-1062) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
252 PF12257 Protein of unknown function (DUF3608) No Pfam Clan 344 (9) 281 279 (1) vWA-like [c.62.1] (69-274)
(1) vWA-like [c.62]
NO PREDICTION c.62.1(69-274) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information extracellular matrix No information DNA repair| double-strand break repair| double-strand break repair via nonhomologous end joining| non-recombinational repair| response to ionizing radiation
253 PF09949 Uncharacterized conserved protein (DUF2183) No Pfam Clan 563 (76) 100 98 (1) HAD-like [c.108.1] (2-92)
(1) HAD-like [c.108]
c.108.1(2-92) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 2.7.7.43| 3.1.3.16| 3.1.3.18| 3.1.3.2| 3.1.3.23| 3.1.3.24| 3.1.3.29| 3.1.3.3| 3.1.3.41| 3.1.3.45| 3.1.3.48| 3.1.3.5| 3.1.3.70| 3.1.3.74| 3.1.8.2| 3.11.1.1| 3.6.1.1| 3.6.3.10| 3.6.3.4| 3.6.3.6| 3.6.3.8| 3.6.3.9| 3.8.1.2| 5.4.2.6| 5.4.2.8 Nem1-Spo7 phosphatase complex| nuclear envelope| nuclear membrane| protein serine/threonine phosphatase complex D,D-heptose 1,7-bisphosphate phosphatase activity| acireductone synthase activity| inorganic diphosphatase activity| intramolecular transferase activity| intramolecular transferase activity, phosphotransferases| magnesium ion binding| phosphatase activity L-methionine biosynthetic process| L-methionine salvage| L-methionine salvage from methylthioadenosine| L-serine metabolic process| amino acid salvage| cellular carbohydrate biosynthetic process| cellular membrane organization| cellular metabolic compound salvage| cofactor catabolic process| deoxyribonucleotide catabolic process| dephosphorylation| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| methionine metabolic process| nuclear envelope organization| nucleus organization| organophosphate catabolic process| positive regulation of lipid biosynthetic process| positive regulation of lipid metabolic process| positive regulation of triglyceride biosynthetic process| positive regulation of triglyceride metabolic process| regulation of lipid biosynthetic process| regulation of lipid metabolic process| regulation of triglyceride biosynthetic process| regulation of triglyceride metabolic process
254 PF13575 Domain of unknown function (DUF4135) No Pfam Clan 396 (79) 370 375 (1) Protein kinase-like (PK-like) [d.144.1] (2-353)
(1) Protein kinase-like (PK-like) [d.144]
NO PREDICTION d.144.1(2-353) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea 2.7.1.100| 2.7.1.137| 2.7.1.153| 2.7.1.163| 2.7.1.17| 2.7.1.32| 2.7.1.39| 2.7.1.95| 2.7.10.1| 2.7.10.2| 2.7.11.1| 2.7.11.11| 2.7.11.13| 2.7.11.14| 2.7.11.15| 2.7.11.16| 2.7.11.17| 2.7.11.19| 2.7.11.21| 2.7.11.22| 2.7.11.24| 2.7.11.25| 2.7.11.26| 2.7.11.30| 2.7.11.7| 2.7.12.1| 2.7.12.2 cAMP-dependent protein kinase complex| calcium- and calmodulin-dependent protein kinase complex| cell-substrate adherens junction| cyclin-dependent protein kinase holoenzyme complex| neuromuscular junction| protein kinase CK2 complex| spindle| spindle pole ATP binding| adenyl nucleotide binding| adenyl ribonucleotide binding| calmodulin binding| cyclin binding| kinase activator activity| kinase regulator activity| magnesium ion binding| molecular transducer activity| nucleoside binding| phosphoprotein binding| phosphotransferase activity, alcohol group as acceptor| phosphotyrosine binding| protein kinase activator activity| protein kinase activity| protein kinase regulator activity| purine nucleoside binding| purine nucleotide binding| purine ribonucleoside binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| receptor signaling protein activity| ribonucleoside binding| ribonucleotide binding CDP-choline pathway| DNA damage checkpoint| activation of innate immune response| cell cycle phase transition| cell division| cell morphogenesis| cellular component morphogenesis| cellular process involved in reproduction| cellular response to biotic stimulus| cellular response to unfolded protein| embryonic placenta development| enzyme linked receptor protein signaling pathway| ethanolamine-containing compound metabolic process| fruiting body development| germ cell development| glycerolipid biosynthetic process| glycerolipid metabolic process| glycerophospholipid biosynthetic process| heart contraction| heart process| hemostasis| innate immune response| innate immune response-activating signal transduction| intracellular protein kinase cascade| labyrinthine layer development| lens development in camera-type eye| lipopolysaccharide-mediated signaling pathway| microtubule cytoskeleton organization| mitotic cell cycle phase transition| negative regulation of cell cycle process| neurotrophin signaling pathway| oogenesis| organelle fission| organic hydroxy compound biosynthetic process| peptidyl-serine modification| peptidyl-threonine modification| phosphatidylcholine biosynthetic process| phosphatidylcholine metabolic process| phosphatidylinositol-3-phosphate biosynthetic process| phospholipid biosynthetic process| positive regulation of MAP kinase activity| positive regulation of cellular protein metabolic process| positive regulation of determination of dorsal identity| positive regulation of developmental growth| positive regulation of innate immune response| positive regulation of intracellular protein transport| positive regulation of myoblast fusion| positive regulation of myotube differentiation| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of phosphorylation| positive regulation of protein kinase activity| positive regulation of protein phosphorylation| positive regulation of skeletal muscle cell differentiation| positive regulation of syncytium formation by plasma membrane fusion| positive regulation of transferase activity| positive regulation of unidimensional cell growth| programmed necrotic cell death| protein phosphorylation| regulation of Golgi inheritance| regulation of MAPK cascade| regulation of Wnt receptor signaling pathway| regulation of adult chitin-containing cuticle pigmentation| regulation of cell size| regulation of cellular response to stress| regulation of chitin-based cuticle tanning| regulation of early endosome to late endosome transport| regulation of fibroblast apoptotic process| regulation of innate immune response| regulation of intracellular protein kinase cascade| regulation of kinase activity| regulation of muscle cell differentiation| regulation of muscle organ development| regulation of muscle tissue development| regulation of protein kinase activity| regulation of reproductive process| regulation of skeletal muscle fiber development| regulation of sodium ion transport| regulation of transferase activity| response to cadmium ion| response to exogenous dsRNA| response to growth factor stimulus| response to molecule of bacterial origin| response to osmotic stress| salicylic acid biosynthetic process| salicylic acid metabolic process| spindle assembly| spindle midzone assembly| stomatal complex development| stress-activated protein kinase signaling cascade| striated muscle contraction| toll-like receptor signaling pathway
255 PF12586 Protein of unknown function (DUF3760) No Pfam Clan 44 (15) 46 46 (1) L domain-like [c.10.2] (3-46)
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10]
c.10.2(3-46) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information U2 snRNP 3'-5' exonuclease activity| 3'-5'-exoribonuclease activity| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomon| exoribonuclease activity| exoribonuclease activity, producing 5'-phosphomonoesters| phosphatase inhibitor activity| phosphatase regulator activity| poly(A)-specific ribonuclease activity B cell activation| B cell proliferation| B cell proliferation involved in immune response| RNA phosphodiester bond hydrolysis, exonucleolytic| biological adhesion| nuclear transport| nuclear-transcribed mRNA catabolic process| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay| nucleocytoplasmic transport| post-embryonic morphogenesis| post-embryonic organ development| regulation of JNK cascade| regulation of axonogenesis| regulation of cell size| regulation of extent of cell growth
256 PF06097 Bacterial protein of unknown function (DUF945) No Pfam Clan 1334 (50) 460 446 (1) Porins [f.4.3] (INDIRECT)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION f.4.3(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 YES Bacteria|Viruses No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity fatty acid transport| lipid localization| long-chain fatty acid transport
257 PF12119 Protein of unknown function (DUF3581) No Pfam Clan 187 (22) 218 215 (1) Thioesterase/thiol ester dehydrase-isomerase [d.38.1] (12-82)
(1) Thioesterase/thiol ester dehydrase-isomerase [d.38]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION d.38.1(12-82) 1 No information Bacteria|Viruses 3.1.2.1| 3.1.2.14| 3.1.2.20| 3.1.2.23| 4.2.1.119| 4.2.1.17| 4.2.1.60 No information 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity| CoA hydrolase activity| hydro-lyase activity| thiolester hydrolase activity fatty acid biosynthetic process| ketone biosynthetic process| quinone biosynthetic process| quinone cofactor biosynthetic process| quinone metabolic process
258 PF10925 Protein of unknown function (DUF2680) No Pfam Clan 166 (14) 59 61 (1) TPR-like [a.118.8] (2-60)
(1) alpha-alpha superhelix [a.118]
a.118.8(2-60) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
259 PF10070 Uncharacterized protein conserved in bacteria (DUF2309) No Pfam Clan 634 (67) 788 749 (1) ARM repeat [a.118.1] (1-784)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(1-784) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses|Archaea No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
260 PF11681 Protein of unknown function (DUF3277) No Pfam Clan 159 (7) 146 146 (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (11-141)
(1) 8-bladed beta-propeller [b.70]
b.70.1(11-141) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses 1.1.2.7| 1.1.98.1 No information endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein
261 PF04535 Domain of unknown function (DUF588) Marvel-like (CL0396) 771 (84) 150 151 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (4-149)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(4-149) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information No information No information
262 PF15112 Domain of unknown function (DUF4559) No Pfam Clan 62 (8) 307 292 (1) Cullin repeat-like [a.118.17] (1-306)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.17(1-306) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information protein heterodimerization activity cellular protein catabolic process| modification-dependent macromolecule catabolic process| modification-dependent protein catabolic process| negative regulation of granulocyte differentiation| negative regulation of leukocyte differentiation| negative regulation of myeloid cell differentiation| negative regulation of myeloid leukocyte differentiation| positive regulation of G1/S transition of mitotic cell cycle| positive regulation of cell cycle phase transition| positive regulation of cell cycle process| positive regulation of mitotic cell cycle phase transition| protein catabolic process| proteolysis| proteolysis involved in cellular protein catabolic process| regulation of DNA damage checkpoint| regulation of DNA metabolic process| regulation of DNA repair| regulation of cell cycle checkpoint| regulation of granulocyte differentiation| regulation of leukocyte differentiation| regulation of myeloid cell differentiation| regulation of myeloid leukocyte differentiation| regulation of nucleotide-excision repair| regulation of response to DNA damage stimulus| somatic stem cell maintenance| stem cell maintenance| ubiquitin-dependent protein catabolic process
263 PF15483 Domain of unknown function (DUF4641) No Pfam Clan 39 (16) 445 461 (1) ssDNA viruses [b.121.5] (1-407)
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121]
NO PREDICTION NO PREDICTION NO PREDICTION b.121.5(1-407) NO PREDICTION 1 No information Eukaryota No information No information No information No information
264 PF13595 Domain of unknown function (DUF4138) No Pfam Clan 514 (30) 246 254 (1) TPR-like [a.118.8] (9-167)
(1) alpha-alpha superhelix [a.118]
a.118.8(9-167) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 YES Bacteria No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
265 PF04250 Protein of unknown function (DUF429) No Pfam Clan 405 (41) 209 224 (1) Ribonuclease H-like [c.55.3] (1-185)
(1) Ribonuclease H-like motif [c.55]
NO PREDICTION c.55.3(1-185) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea 2.7.7.7| 3.1.11.1| 3.1.13.1| 3.1.13.4| 3.1.13.5| 3.1.22.4| 3.1.26.4| 3.6.4.12 CCR4-NOT complex| DNA polymerase complex| cytoplasmic mRNA processing body| micro-ribonucleoprotein complex| nucleolus| ribonuclease H2 complex| ribonucleoprotein granule DNA polymerase activity| DNA-directed DNA polymerase activity| endoribonuclease activity, producing 5'-phosphomonoesters| exonuclease activity| nuclease activity| ribonuclease H activity| transposase activity DNA catabolic process| DNA replication| DNA replication, removal of RNA primer| DNA strand elongation| RNA 3'-end processing| RNA catabolic process| RNA phosphodiester bond hydrolysis| cytoplasmic mRNA processing body assembly| gene silencing| gene silencing by RNA| lagging strand elongation| mRNA 3'-end processing| mitochondrial genome maintenance| mitotic DNA integrity checkpoint| mitotic G2 DNA damage checkpoint| ncRNA 3'-end processing| negative regulation of DNA metabolic process| negative regulation of DNA recombination| negative regulation of mitotic recombination| negative regulation of translation| nuclear-transcribed mRNA poly(A) tail shortening| nucleic acid phosphodiester bond hydrolysis| positive regulation of catabolic process| positive regulation of cellular catabolic process| positive regulation of mRNA catabolic process| positive regulation of mRNA processing| regulation of DNA metabolic process| regulation of DNA recombination| regulation of mRNA 3'-end processing| regulation of mRNA catabolic process| regulation of mRNA processing| regulation of mitotic recombination| response to ionizing radiation| ribonucleoprotein complex biogenesis| ribonucleoprotein complex subunit organization| transposition| transposition, DNA-mediated
266 PF05957 Bacterial protein of unknown function (DUF883) YjbJ-CsbD-like (CL0406) 2283 (59) 94 94 (1) ARM repeat [a.118.1] (3-85)
(1) alpha-alpha superhelix [a.118]
a.118.1(3-85) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
267 PF06023 Archaeal protein of unknown function (DUF911) PDDEXK (CL0236) 70 (8) 290 281 (1) Restriction endonuclease-like [c.52.1] (INDIRECT)
(1) Restriction endonuclease-like [c.52]
NO PREDICTION c.52.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 No information endonuclease activity| nuclease activity DNA repair| nucleotide-excision repair
268 PF07028 Protein of unknown function (DUF1319) No Pfam Clan 50 (11) 126 145 (1) L domain-like [c.10.2] (2-107)
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10]
c.10.2(2-107) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Viruses No information U2 snRNP 3'-5' exonuclease activity| 3'-5'-exoribonuclease activity| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomon| exoribonuclease activity| exoribonuclease activity, producing 5'-phosphomonoesters| phosphatase inhibitor activity| phosphatase regulator activity| poly(A)-specific ribonuclease activity B cell activation| B cell proliferation| B cell proliferation involved in immune response| RNA phosphodiester bond hydrolysis, exonucleolytic| biological adhesion| nuclear transport| nuclear-transcribed mRNA catabolic process| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay| nucleocytoplasmic transport| post-embryonic morphogenesis| post-embryonic organ development| regulation of JNK cascade| regulation of axonogenesis| regulation of cell size| regulation of extent of cell growth
269 PF07617 Protein of unknown function (DUF1579) No Pfam Clan 94 (17) 159 165 (1) Lipocalins [b.60.1] (5-157)
(1) Lipocalins [b.60]
NO PREDICTION b.60.1(5-157) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 1.10.99.3| 5.3.99.2 cell body| dendrite| neuron projection| neuronal cell body| perinuclear region of cytoplasm| rough endoplasmic reticulum alcohol binding| carboxylic acid binding| cholesterol binding| insulin-activated receptor activity| intramolecular oxidoreductase activity| isoprenoid binding| lipid transporter activity| monocarboxylic acid binding| odorant binding| prostaglandin-D synthase activity| protein tyrosine kinase activity| retinoid binding| retinol transporter activity| steroid binding| sterol binding| transmembrane receptor protein kinase activity| transmembrane receptor protein tyrosine kinase activity| vitamin binding| vitamin transporter activity aerobic respiration| aging| axon development| axon regeneration| brain development| carbohydrate homeostasis| cell projection organization| cellular hormone metabolic process| cellular respiration| cellular response to lipid| cellular response to nitrogen compound| cellular response to organonitrogen compound| cellular response to peptide| cellular response to peptide hormone stimulus| central nervous system development| circadian behavior| circadian rhythm| detection of abiotic stimulus| detection of light stimulus| detection of visible light| developmental growth| diterpenoid metabolic process| energy reserve metabolic process| fatty acid biosynthetic process| fatty acid derivative biosynthetic process| fatty acid derivative metabolic process| glucose metabolic process| growth| heat generation| hormone metabolic process| icosanoid biosynthetic process| icosanoid metabolic process| insulin receptor signaling pathway| isoprenoid transport| lipid localization| lipid transport| locomotor rhythm| mitochondrion morphogenesis| mitochondrion organization| monocarboxylic acid biosynthetic process| monocarboxylic acid transport| multicellular organismal homeostasis| negative regulation of T cell migration| negative regulation of carbohydrate metabolic process| negative regulation of cell adhesion| negative regulation of cell communication| negative regulation of cell junction assembly| negative regulation of cell migration| negative regulation of cell motility| negative regulation of cell proliferation| negative regulation of cell-matrix adhesion| negative regulation of cell-substrate adhesion| negative regulation of cellular carbohydrate metabolic process| negative regulation of cellular component movement| negative regulation of cellular component organization| negative regulation of chemokine production| negative regulation of cytokine production| negative regulation of cytokine production involved in inflammatory response| negative regulation of focal adhesion assembly| negative regulation of gluconeogenesis| negative regulation of hormone secretion| negative regulation of immune system process| negative regulation of insulin secretion| negative regulation of insulin secretion involved in cellular response to glucose stimulus| negative regulation of intracellular protein transport| negative regulation of intracellular transport| negative regulation of leukocyte migration| negative regulation of lipid biosynthetic process| negative regulation of lipid metabolic process| negative regulation of lipid storage| negative regulation of lipoprotein lipid oxidation| negative regulation of lipoprotein metabolic process| negative regulation of lipoprotein oxidation| negative regulation of locomotion| negative regulation of lymphocyte migration| negative regulation of monocyte chemotactic protein-1 production| negative regulation of multicellular organismal process| negative regulation of nucleocytoplasmic transport| negative regulation of peptide hormone secretion| negative regulation of peptide secretion| negative regulation of platelet-derived growth factor receptor signaling pathway| negative regulation of protein import into nucleus| negative regulation of protein transport| negative regulation of response to stimulus| negative regulation of signaling| negative regulation of smooth muscle cell proliferation| negative regulation of smooth muscle cell-matrix adhesion| negative regulation of transport| neuron development| neuron differentiation| neuron projection development| neuron projection regeneration| peripheral nervous system axon regeneration| positive regulation of carbohydrate metabolic process| positive regulation of cellular carbohydrate metabolic process| positive regulation of glucose metabolic process| positive regulation of intracellular protein kinase cascade| positive regulation of lipid metabolic process| positive regulation of protein kinase B signaling cascade| prostaglandin biosynthetic process| prostanoid biosynthetic process| prostanoid metabolic process| regeneration| regulation of T cell migration| regulation of carbohydrate biosynthetic process| regulation of carbohydrate metabolic process| regulation of cell adhesion| regulation of cell junction assembly| regulation of cell migration| regulation of cell motility| regulation of cell-matrix adhesion| regulation of cell-substrate adhesion| regulation of cell-substrate junction assembly| regulation of cellular carbohydrate metabolic process| regulation of cellular component biogenesis| regulation of cellular component movement| regulation of cellular ketone metabolic process| regulation of chemokine production| regulation of circadian rhythm| regulation of circadian sleep/wake cycle| regulation of cytokine production| regulation of cytokine production involved in inflammatory response| regulation of defense response| regulation of establishment of protein localization| regulation of focal adhesion assembly| regulation of gluconeogenesis| regulation of glucose metabolic process| regulation of homeostatic process| regulation of hormone secretion| regulation of inflammatory response| regulation of insulin secretion| regulation of insulin secretion involved in cellular response to glucose stimulus| regulation of intracellular protein transport| regulation of intracellular transport| regulation of leukocyte migration| regulation of lipid biosynthetic process| regulation of lipid metabolic process| regulation of lipid storage| regulation of lipoprotein lipid oxidation| regulation of lipoprotein metabolic process| regulation of lipoprotein oxidation| regulation of locomotion| regulation of lymphocyte migration| regulation of monocyte chemotactic protein-1 production| regulation of nucleocytoplasmic transport| regulation of peptide hormone secretion| regulation of peptide secretion| regulation of peptide transport| regulation of platelet-derived growth factor receptor signaling pathway| regulation of protein import into nucleus| regulation of protein kinase B signaling cascade| regulation of protein localization| regulation of protein localization to nucleus| regulation of protein transport| regulation of smooth muscle cell proliferation| regulation of smooth muscle cell-matrix adhesion| response to axon injury| response to drug| response to hormone stimulus| response to lipid| response to organonitrogen compound| response to peptide hormone stimulus| response to reactive oxygen species| retinoid metabolic process| retinol metabolic process| rhythmic behavior| rhythmic process| single-organism behavior| temperature homeostasis| tissue regeneration| transmembrane receptor protein tyrosine kinase signaling pathway| unsaturated fatty acid biosynthetic process| unsaturated fatty acid metabolic process| wound healing
270 PF11254 Protein of unknown function (DUF3053) No Pfam Clan 635 (8) 229 228 (1) MW0975(SA0943)-like [a.24.27] (22-221)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(22-221) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information No information No information No information
271 PF09959 Uncharacterized protein conserved in archaea (DUF2193) No Pfam Clan 32 (9) 499 499 (1) ARM repeat [a.118.1] (1-495)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(1-495) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Archaea No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
272 PF13210 Domain of unknown function (DUF4018) No Pfam Clan 74 (6) 192 194 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (6-191)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(6-191) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information No information
273 PF11832 Protein of unknown function (DUF3352) No Pfam Clan 156 (32) 536 553 (1) WD40 repeat-like [b.69.4] (INDIRECT)
(1) 7-bladed beta-propeller [b.69]
NO PREDICTION b.69.4(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information Arp2/3 protein complex| CIA complex| Cdc73/Paf1 complex| Cul4-RING ubiquitin ligase complex| ER to Golgi transport vesicle| SMN complex| SMN-Sm protein complex| Ski complex| THO complex| TORC1 complex| chromosome, centromeric region| cullin-RING ubiquitin ligase complex| eukaryotic translation initiation factor 3 complex| extrinsic to internal side of plasma membrane| extrinsic to membrane| extrinsic to plasma membrane| female germ cell nucleus| germ cell nucleus| heterotrimeric G-protein complex| histone methyltransferase complex| immunological synapse| internal side of plasma membrane| kinetochore| methylosome| methyltransferase complex| nuclear envelope| nuclear pore| nuclear pore outer ring| pore complex| transcription export complex| transcriptionally active chromatin| ubiquitin ligase complex G-protein gamma-subunit binding| histone binding| peroxisome targeting sequence binding| phosphatidylinositol binding| phosphatidylinositol-3,5-bisphosphate binding| phosphatidylinositol-3-phosphate binding| phosphatidylinositol-5-phosphate binding| signal sequence binding| translation initiation factor activity RNA splicing, via transesterification reactions with bulged adenosine as nucleophile| T cell homeostasis| TOR signaling cascade| attachment of spindle microtubules to kinetochore| attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation| autophagy| cellular response to starvation| chromosome segregation| embryonic digit morphogenesis| establishment of RNA localization| establishment of chromosome localization| establishment of organelle localization| fruiting body development| histone H3-K4 methylation| histone methylation| histone modification| iron-sulfur cluster assembly| mRNA export from nucleus| membrane disassembly| metallo-sulfur cluster assembly| metaphase plate congression| methylation| microtubule-based process| mitotic metaphase plate congression| mitotic spindle assembly checkpoint| negative regulation of calcium ion transmembrane transporter activity| negative regulation of cation channel activity| negative regulation of cell cycle process| negative regulation of ion transmembrane transporter activity| negative regulation of transporter activity| negative regulation of voltage-gated calcium channel activity| nuclear envelope disassembly| nuclear pore organization| nucleic acid transport| nucleobase-containing compound transport| peptidyl-lysine modification| peptidyl-lysine trimethylation| peroxisomal transport| positive regulation of DNA-dependent transcription, elongation| positive regulation of histone H3-K79 methylation| positive regulation of histone methylation| positive regulation of histone modification| positive regulation of organelle organization| positive regulation of transcription elongation from RNA polymerase II promoter| protein alkylation| protein import| protein targeting| regulation of cell cycle process| regulation of histone H3-K79 methylation| regulation of histone methylation| regulation of histone modification| regulation of metaphase/anaphase transition of cell cycle| regulation of mitotic metaphase/anaphase transition| regulation of reproductive process| regulation of transcription elongation from RNA polymerase II promoter| regulation of voltage-gated calcium channel activity| response to starvation| spindle assembly checkpoint| spindle checkpoint| uropod organization
274 PF10027 Predicted integral membrane protein (DUF2269) CopD_like (CL0430) 382 (56) 150 150 (1) Transmembrane di-heme cytochromes [f.21.1] (INDIRECT)
(1) Heme-binding four-helical bundle [f.21]
NO PREDICTION f.21.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea 1.10.2.2 No information electron carrier activity cellular respiration
275 PF13282 Domain of unknown function (DUF4070) No Pfam Clan 231 (55) 146 145 (1) Radical SAM enzymes [c.1.28] (1-146)
(1) TIM beta/alpha-barrel [c.1]
c.1.28(1-146) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 1.3.99.22| 1.97.1.4| 2.8.1.6| 5.4.3.2 lipid particle 4 iron, 4 sulfur cluster binding| biotin synthase activity| intramolecular transferase activity| lipoate synthase activity| lipoate-protein ligase activity| metal cluster binding| oxidoreductase activity, acting on the CH-CH group of donors| protein self-association| radical SAM enzyme activity| sulfurtransferase activity| transferase activity, transferring sulfur-containing groups CD4-positive, alpha-beta T cell activation| CD4-positive, alpha-beta T cell differentiation| T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| defense response to virus| lipoate biosynthetic process| lipoate metabolic process| lymphocyte differentiation| molybdopterin cofactor biosynthetic process| molybdopterin cofactor metabolic process| monocarboxylic acid biosynthetic process| negative regulation of protein secretion| negative regulation of protein transport| negative regulation of secretion| positive regulation of T cell cytokine production| positive regulation of T cell mediated immunity| positive regulation of T-helper 2 cell cytokine production| positive regulation of adaptive immune response| positive regulation of adaptive immune response based on somatic recombination of immune receptors b| positive regulation of cytokine production| positive regulation of cytokine production involved in immune response| positive regulation of immune effector process| positive regulation of leukocyte mediated immunity| positive regulation of lymphocyte mediated immunity| positive regulation of production of molecular mediator of immune response| positive regulation of toll-like receptor 9 signaling pathway| positive regulation of toll-like receptor signaling pathway| prosthetic group metabolic process| regulation of T cell cytokine production| regulation of T cell mediated immunity| regulation of T-helper 2 cell cytokine production| regulation of adaptive immune response| regulation of cytokine production involved in immune response| regulation of leukocyte mediated immunity| regulation of lymphocyte mediated immunity| regulation of production of molecular mediator of immune response| regulation of protein secretion| regulation of toll-like receptor 7 signaling pathway| regulation of toll-like receptor 9 signaling pathway| regulation of toll-like receptor signaling pathway| regulation of type 2 immune response| response to virus| vitamin biosynthetic process
276 PF12077 Transmembrane protein of unknown function (DUF3556) No Pfam Clan 188 (14) 574 575 (1) MFS general substrate transporter [f.38.1] (24-483)
(1) MFS general substrate transporter [f.38]
NO PREDICTION f.38.1(24-483) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
277 PF05218 Protein of unknown function (DUF713) No Pfam Clan 53 (6) 182 190 (1) t-snare proteins [a.47.2] (42-142)
(1) STAT-like [a.47]
NO PREDICTION NO PREDICTION a.47.2(42-142) NO PREDICTION NO PREDICTION 1 No information Eukaryota No information Golgi apparatus No information No information
278 PF06551 Protein of unknown function (DUF1120) Adhesin (CL0204) 319 (7) 116 102 (1) Bacterial adhesins [b.2.3] (1-55)
(1) Common fold of diphtheria toxin/transcription factors/cytochrome f [b.2]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION b.2.3(1-55) 1 YES Eukaryota|Bacteria No information pilus No information biofilm formation| biological adhesion| cell adhesion| cell adhesion involved in biofilm formation| cell adhesion involved in single-species biofilm formation| multi-organism cellular process| single-species biofilm formation
279 PF15016 Domain of unknown function (DUF4520) No Pfam Clan 57 (13) 86 80 (1) Polo-box domain [d.223.1] (12-60)
(1) Polo-box domain [d.223]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION d.223.1(12-60) 1 No information Eukaryota No information No information No information No information
280 PF14643 Domain of unknown function (DUF4455) No Pfam Clan 121 (16) 474 473 (1) ARM repeat [a.118.1] (24-463)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(24-463) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
281 PF07758 Protein of unknown function (DUF1614) No Pfam Clan 186 (48) 176 170 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (24-175)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(24-175) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information No information No information No information
282 PF09745 Coiled-coil domain-containing protein 55 (DUF2040) No Pfam Clan 288 (30) 128 128 (1) MW0975(SA0943)-like [a.24.27] (1-125)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(1-125) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information No information No information
283 PF13161 Protein of unknown function (DUF3996) No Pfam Clan 146 (16) 153 169 (1) OMPA-like [f.4.1] (1-152)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION f.4.1(1-152) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane O-acyltransferase activity| O-palmitoyltransferase activity| palmitoyltransferase activity| transferase activity, transferring acyl groups other than amino-acyl groups glycolipid biosynthetic process| glycolipid metabolic process| lipid A biosynthetic process| lipid A metabolic process| lipooligosaccharide biosynthetic process| lipooligosaccharide metabolic process| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| phospholipid biosynthetic process| phospholipid metabolic process
284 PF14188 Domain of unknown function (DUF4311) No Pfam Clan 329 (9) 213 213 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (INDIRECT)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information No information
285 PF10730 Protein of unknown function (DUF2521) No Pfam Clan 131 (10) 147 142 (1) "Winged helix" DNA-binding domain [a.4.5] (2-136)
(1) DNA/RNA-binding 3-helical bundle [a.4]
a.4.5(2-136) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
286 PF10920 Protein of unknown function (DUF2705) No Pfam Clan 30 (2) 245 245 (1) Bacterial photosystem II reaction centre, L and M subunits [f.26.1] (INDIRECT)
(1) Bacterial photosystem II reaction centre, L and M subunits [f.26]
NO PREDICTION f.26.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information No information
287 PF15239 Domain of unknown function (DUF4586) No Pfam Clan 143 (41) 302 291 (1) ssDNA viruses [b.121.5] (1-291)
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121]
NO PREDICTION NO PREDICTION NO PREDICTION b.121.5(1-291) NO PREDICTION 1 No information Eukaryota No information No information No information No information
288 PF10881 Protein of unknown function (DUF2726) PDDEXK (CL0236) 880 (35) 126 127 (1) Restriction endonuclease-like [c.52.1] (INDIRECT)
(1) Restriction endonuclease-like [c.52]
NO PREDICTION c.52.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 YES Bacteria|Viruses 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 No information endonuclease activity| nuclease activity DNA repair| nucleotide-excision repair
289 PF13171 Protein of unknown function (DUF4004) No Pfam Clan 172 (9) 199 194 (1) Putative DNA-binding domain [a.6.1] (3-57)
(1) Putative DNA-binding domain [a.6]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION a.6.1(3-57) 1 No information Bacteria|Archaea No information No information nucleic acid binding transcription factor activity| sequence-specific DNA binding transcription factor activity No information
290 PF07214 Protein of unknown function (DUF1418) No Pfam Clan 515 (7) 96 95 (1) RNI-like [c.10.1] (9-88)
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10]
c.10.1(9-88) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 YES Bacteria No information ubiquitin ligase complex acid-amino acid ligase activity| small conjugating protein ligase activity| ubiquitin-protein ligase activity cellular protein catabolic process| entrainment of circadian clock| entrainment of circadian clock by photoperiod| modification-dependent macromolecule catabolic process| photoperiodism| protein catabolic process| protein ubiquitination| proteolysis| regulation of circadian rhythm| ubiquitin-dependent protein catabolic process
291 PF12021 Protein of unknown function (DUF3509) No Pfam Clan 201 (19) 94 116 (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (4-82)
(1) 8-bladed beta-propeller [b.70]
b.70.1(4-82) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria 1.1.2.7| 1.1.98.1 No information endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein
292 PF07585 Protein of unknown function (DUF1551) No Pfam Clan 57 (14) 339 354 (1) OMPT-like [f.4.4] (44-338)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION f.4.4(44-338) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria 3.4.23.48| 3.4.23.49 No information No information No information
293 PF07957 Protein of unknown function (DUF3294) No Pfam Clan 45 (10) 216 193 (1) MW0975(SA0943)-like [a.24.27] (1-200)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(1-200) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information No information No information
294 PF09365 Conserved hypothetical protein (DUF2461) No Pfam Clan 698 (99) 212 214 (1) YktB/PF0168-like [d.296.1] (8-211)
(1) YktB/PF0168-like [d.296]
NO PREDICTION d.296.1(8-211) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information No information No information No information
295 PF15488 Domain of unknown function (DUF4645) No Pfam Clan 21 (7) 294 294 (1) ssDNA viruses [b.121.5] (1-294)
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121]
NO PREDICTION NO PREDICTION NO PREDICTION b.121.5(1-294) NO PREDICTION 1 No information Eukaryota No information No information No information No information
296 PF11882 Domain of unknown function (DUF3402) No Pfam Clan 336 (22) 409 476 (1) ARM repeat [a.118.1] (90-408)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(90-408) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
297 PF04342 Protein of unknown function, DUF486 DMT (CL0184) 583 (4) 108 108 (1) Multidrug resistance efflux transporter EmrE [f.39.1] (4-107)
(1) Multidrug resistance efflux transporter EmrE [f.39]
NO PREDICTION f.39.1(4-107) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea No information No information No information No information
298 PF13870 Domain of unknown function (DUF4201) No Pfam Clan 290 (56) 177 177 (1) MW0975(SA0943)-like [a.24.27] (1-176)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(1-176) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information No information No information
299 PF11250 Protein of unknown function (DUF3049) No Pfam Clan 167 (24) 56 56 (1) Calcium-dependent phosphotriesterase [b.68.6] (7-51)
(1) 6-bladed beta-propeller [b.68]
b.68.6(7-51) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota 3.1.1.17| 3.1.1.25| 3.1.8.2| 4.3.3.2 No information aryldialkylphosphatase activity| arylesterase activity| calcium ion binding| carboxylic ester hydrolase activity| gluconolactonase activity| zinc ion binding L-ascorbic acid biosynthetic process| L-ascorbic acid metabolic process| calcium ion homeostasis| cellular calcium ion homeostasis| cellular cation homeostasis| cellular chemical homeostasis| cellular divalent inorganic cation homeostasis| cellular ion homeostasis| cellular metal ion homeostasis| divalent inorganic cation homeostasis| metal ion homeostasis| monosaccharide biosynthetic process| positive regulation of ATPase activity| positive regulation of hydrolase activity| regulation of ATPase activity| regulation of calcium-mediated signaling| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| vitamin biosynthetic process| water-soluble vitamin biosynthetic process| water-soluble vitamin metabolic process
300 PF11677 Protein of unknown function (DUF3273) No Pfam Clan 59 (9) 265 262 (1) MFS general substrate transporter [f.38.1] (4-254)
(1) MFS general substrate transporter [f.38]
NO PREDICTION f.38.1(4-254) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
301 PF04447 Protein of unknown function (DUF550) MazG (CL0231) 150 (10) 101 100 (1) all-alpha NTP pyrophosphatases [a.204.1] (18-82)
(1) all-alpha NTP pyrophosphatases [a.204]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION a.204.1(18-82) 1 No information Bacteria|Viruses 3.6.1.19| 3.6.1.23| 3.6.1.31 No information magnesium ion binding| nucleoside-triphosphate diphosphatase activity nucleoside triphosphate catabolic process| organophosphate catabolic process
302 PF10721 Protein of unknown function (DUF2514) EpsM (CL0331) 309 (17) 162 167 (1) MW0975(SA0943)-like [a.24.27] (21-161)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(21-161) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses No information No information No information No information
303 PF09941 Uncharacterized conserved protein (DUF2173) No Pfam Clan 47 (11) 108 108 (1) Roadblock/LC7 domain [d.110.7] (1-107)
(1) Profilin-like [d.110]
NO PREDICTION d.110.7(1-107) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information Ragulator complex| cytoplasmic dynein complex| dynein complex| endosomal part| endosome membrane| late endosome| late endosome membrane| lysosome| lytic vacuole| membrane raft| microtubule associated complex ATPase activity, coupled| GTPase regulator activity| guanyl-nucleotide exchange factor activity| nucleoside-triphosphatase regulator activity| protein complex scaffold ATP catabolic process| ATP metabolic process| cell growth| cellular response to acid| cellular response to amino acid stimulus| cellular response to nitrogen compound| cellular response to organonitrogen compound| glycosyl compound catabolic process| growth| microtubule-based movement| microtubule-based process| nucleoside catabolic process| nucleoside monophosphate catabolic process| nucleoside monophosphate metabolic process| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| organophosphate catabolic process| positive regulation of TOR signaling cascade| protein localization to lysosome| protein localization to vacuole| purine nucleoside catabolic process| purine nucleoside monophosphate catabolic process| purine nucleoside monophosphate metabolic process| purine nucleoside triphosphate catabolic process| purine nucleoside triphosphate metabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside monophosphate catabolic process| purine ribonucleoside monophosphate metabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleoside triphosphate metabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| regulation of GTP catabolic process| regulation of GTPase activity| regulation of TOR signaling cascade| regulation of anatomical structure size| regulation of cell size| regulation of cellular component size| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| response to acid| response to amino acid stimulus| response to organonitrogen compound| ribonucleoside catabolic process| ribonucleoside monophosphate catabolic process| ribonucleoside monophosphate metabolic process| ribonucleoside triphosphate catabolic process| ribonucleoside triphosphate metabolic process| ribonucleotide catabolic process
304 PF15072 Domain of unknown function (DUF4539) No Pfam Clan 116 (32) 86 86 (1) Nucleic acid-binding proteins [b.40.4] (21-63)
(1) OB-fold [b.40]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION b.40.4(21-63) 1 No information Eukaryota 3.1.13.1| 3.1.26.12| 6.5.1.1 DNA replication factor A complex| DNA-directed RNA polymerase II, core complex| DNA-directed RNA polymerase II, holoenzyme| DNA-directed RNA polymerase complex| RNA polymerase complex| cytoplasmic exosome (RNase complex)| cytosolic small ribosomal subunit| exosome (RNase complex)| mitochondrial nucleoid| nuclear DNA-directed RNA polymerase complex| nucleoid| organellar ribosome| replisome RNA polymerase activity| chromatin binding| ribonucleoprotein complex binding| single-stranded DNA binding| structure-specific DNA binding regulation of DNA-dependent transcription, termination| regulation of RNA stability| regulation of mRNA stability| response to cold| ribonucleoprotein complex biogenesis| telomere maintenance| telomere organization| transcriptional attenuation| translational initiation
305 PF12013 Protein of unknown function (DUF3505) No Pfam Clan 197 (16) 109 111 (1) TRAF domain-like [b.8.1] (9-47)
(1) TRAF domain-like [b.8]
NO PREDICTION NO PREDICTION b.8.1(9-47) NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information No information No information
306 PF09899 Putative amidoligase enzyme (DUF2126) GCS (CL0286) 471 (40) 819 838 (1) Cysteine proteinases [d.3.1] (20-111)
(1) Cysteine proteinases [d.3]
NO PREDICTION NO PREDICTION d.3.1(20-111) NO PREDICTION NO PREDICTION 1 No information Bacteria 2.3.1.118| 2.3.1.5| 2.3.2.13| 2.3.2.15| 3.1.1.4| 3.4.14.1| 3.4.18.1| 3.4.19.12| 3.4.22.1| 3.4.22.10| 3.4.22.14| 3.4.22.15| 3.4.22.16| 3.4.22.2| 3.4.22.25| 3.4.22.27| 3.4.22.30| 3.4.22.38| 3.4.22.39| 3.4.22.40| 3.4.22.41| 3.4.22.43| 3.4.22.48| 3.4.22.51| 3.4.22.52| 3.4.22.53| 3.4.22.6| 3.4.22.65| 3.4.22.68| 3.5.1.52| 6.3.1.9 alveolar lamellar body| endosome lumen| lamellar body| lytic vacuole| vacuolar lumen MHC class I receptor activity| N-acyltransferase activity| acetyltransferase activity| arylamine N-acetyltransferase activity| cysteine-type carboxypeptidase activity| cysteine-type endopeptidase activity| cysteine-type endopeptidase regulator activity involved in apoptotic process| cysteine-type peptidase activity| hormone binding| peptidase activator activity| peptidase activator activity involved in apoptotic process| peptidase activity| peptidase regulator activity| small conjugating protein binding| thiolester hydrolase activity| thyroid hormone binding| ubiquitin thiolesterase activity ERK1 and ERK2 cascade| T cell mediated cytotoxicity| T cell mediated immunity| adaptive immune response| anatomical structure maturation| bradykinin catabolic process| catagen| cell killing| cellular response to thyroid hormone stimulus| chemical homeostasis within a tissue| collagen metabolic process| decidualization| dichotomous subdivision of an epithelial terminal unit| dichotomous subdivision of terminal units involved in lung branching| epidermis morphogenesis| epithelial tube branching involved in lung morphogenesis| extracellular matrix disassembly| female pregnancy| hair cycle| hair cycle process| hair follicle development| hair follicle maturation| hair follicle morphogenesis| immune response-regulating signaling pathway| leukocyte mediated cytotoxicity| leukocyte mediated immunity| lung development| lung morphogenesis| lymphocyte mediated immunity| maternal placenta development| maternal process involved in female pregnancy| metanephros development| molting cycle process| multicellular organismal catabolic process| multicellular organismal homeostasis| negative regulation of epithelial cell proliferation| negative regulation of keratinocyte proliferation| neuropeptide catabolic process| peptide catabolic process| peptide metabolic process| placenta development| positive regulation of angiogenesis| positive regulation of apoptotic signaling pathway| positive regulation of developmental process| positive regulation of epithelial cell migration| positive regulation of peptidase activity| posttranscriptional regulation of gene expression| protein destabilization| protein maturation| protein modification by small protein conjugation or removal| protein modification by small protein removal| protein processing| proteolysis| regulation of actin cytoskeleton reorganization| regulation of epithelial cell migration| regulation of keratinocyte proliferation| regulation of peptidase activity| regulation of protein stability| respiratory tube development| response to retinoic acid| response to thyroid hormone stimulus| skin morphogenesis| surfactant homeostasis| tissue homeostasis
307 PF09889 Uncharacterized protein containing a Zn-ribbon (DUF2116) Zn_Beta_Ribbon (CL0167) 52 (9) 59 58 (1) Glucocorticoid receptor-like (DNA-binding domain) [g.39.1] (2-27)
(1) Glucocorticoid receptor-like (DNA-binding domain) [g.39]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION g.39.1(2-27) 1 No information Bacteria|Viruses|Archaea 2.7.1.21| 4.2.99.18 No information No information No information
308 PF12482 Phage integrase protein No Pfam Clan 151 (38) 96 94 (1) C-terminal domain of RNA polymerase alpha subunit [a.60.3] (21-78)
(1) SAM domain-like [a.60]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION a.60.3(21-78) 1 No information Bacteria No information No information No information No information
309 PF11139 Protein of unknown function (DUF2910) NicO_HupE_DsbD (CL0549) 566 (46) 214 212 (1) MFS general substrate transporter [f.38.1] (INDIRECT)
(1) MFS general substrate transporter [f.38]
NO PREDICTION f.38.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
310 PF02006 Protein of unknown function DUF137 No Pfam Clan 143 (37) 178 176 (1) DHS-like NAD/FAD-binding domain [c.31.1] (1-167)
(1) DHS-like NAD/FAD-binding domain [c.31]
NO PREDICTION c.31.1(1-167) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea 1.2.5.1| 1.6.1.2| 2.2.1.6| 2.5.1.46| 2.5.1.66| 4.1.1.47| 4.1.1.7| 4.1.1.8 No information NAD-dependent protein deacetylase activity| deacetylase activity| histone deacetylase activity| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides chromatin modification| chromatin organization| chromosome organization| covalent chromatin modification| histone H3 deacetylation| histone deacetylation| histone modification| protein deacylation
311 PF14230 Domain of unknown function (DUF4333) No Pfam Clan 334 (37) 80 81 (1) Multiheme cytochromes [a.138.1] (8-80)
(1) Multiheme cytochromes [a.138]
a.138.1(8-80) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria 1.7.2.2| 1.7.3.4 No information electron carrier activity| oxidoreductase activity, acting on other nitrogenous compounds as donors No information
312 PF09526 Probable metal-binding protein (DUF2387) Zn_Beta_Ribbon (CL0167) 844 (44) 71 61 (1) Zinc beta-ribbon [g.41.3] (5-45)
(1) Rubredoxin-like [g.41]
NO PREDICTION NO PREDICTION g.41.3(5-45) NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information No information
313 PF03665 Uncharacterised protein family (UPF0172) JAB (CL0366) 258 (22) 196 186 (1) JAB1/MPN domain [c.97.3] (1-119)
(1) Cytidine deaminase-like [c.97]
NO PREDICTION c.97.3(1-119) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota 3.1.2.15 No information No information No information
314 PF08876 Domain of unknown function (DUF1836) HTH (CL0123) 1171 (48) 105 97 (1) Putative DNA-binding domain [a.6.1] (30-86)
(1) Putative DNA-binding domain [a.6]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION a.6.1(30-86) 1 No information Eukaryota|Bacteria No information No information nucleic acid binding transcription factor activity| sequence-specific DNA binding transcription factor activity No information
315 PF09913 Predicted membrane protein (DUF2142) GT-C (CL0111) 382 (34) 389 404 (1) MFS general substrate transporter [f.38.1] (72-388)
(1) MFS general substrate transporter [f.38]
NO PREDICTION f.38.1(72-388) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
316 PF11954 Domain of unknown function (DUF3471) No Pfam Clan 608 (67) 100 119 (1) D-aminopeptidase, middle and C-terminal domains [b.61.3] (13-84)
(1) Streptavidin-like [b.61]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION b.61.3(13-84) 1 No information Eukaryota|Bacteria|Archaea No information No information No information No information
317 PF13099 Domain of unknown function (DUF3944) No Pfam Clan 557 (19) 35 35 (1) ARM repeat [a.118.1] (13-35)
(1) alpha-alpha superhelix [a.118]
a.118.1(13-35) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
318 PF10106 Uncharacterized protein conserved in bacteria (DUF2345) No Pfam Clan 1108 (93) 156 153 (1) Phage fibre proteins [b.108.1] (12-153)
(1) Triple-stranded beta-helix [b.108]
b.108.1(12-153) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea 4.2.2.1 No information No information No information
319 PF12281 Protein of unknown function (DUF3620) No Pfam Clan 119 (29) 217 212 (1) Nucleotidyltransferase [d.218.1] (1-198)
(1) Nucleotidyltransferase [d.218]
NO PREDICTION d.218.1(1-198) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 2.7.6.5| 2.7.7.19| 2.7.7.31| 2.7.7.42| 2.7.7.52| 2.7.7.7| 2.7.7.72 No information adenylyltransferase activity| double-stranded RNA binding No information
320 PF03235 Protein of unknown function DUF262 ParBc (CL0248) 2983 (194) 221 211 (1) ParB/Sulfiredoxin [d.268.1] (8-220)
(1) ParB/Sulfiredoxin [d.268]
NO PREDICTION d.268.1(8-220) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Viruses|Archaea 1.8.98.2 No information No information No information
321 PF11868 Protein of unknown function (DUF3388) No Pfam Clan 391 (8) 192 192 (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (42-116)
(1) P-loop containing nucleoside triphosphate hydrolases [c.37]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION c.37.1(42-116) 1 No information Bacteria 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
322 PF09842 Predicted membrane protein (DUF2069) No Pfam Clan 494 (61) 109 108 (1) Respiratory nitrate reductase 1 gamma chain [f.21.3] (1-106)
(1) Heme-binding four-helical bundle [f.21]
NO PREDICTION f.21.3(1-106) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information No information
323 PF06787 Uncharacterised protein family (UPF0254) No Pfam Clan 29 (11) 160 160 (1) CinA-like [c.51.5] (2-160)
(1) Anticodon-binding domain-like [c.51]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION c.51.5(2-160) 1 No information Bacteria|Archaea No information No information No information No information
324 PF07077 Protein of unknown function (DUF1345) No Pfam Clan 475 (56) 181 186 (1) Voltage-gated potassium channels [f.14.1] (60-180)
(1) Voltage-gated potassium channels [f.14]
NO PREDICTION f.14.1(60-180) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information cation channel activity| ion channel activity| ion gated channel activity| monovalent inorganic cation transmembrane transporter activity| passive transmembrane transporter activity| substrate-specific channel activity monovalent inorganic cation transport
325 PF07867 Protein of unknown function (DUF1654) No Pfam Clan 129 (12) 73 72 (1) Pseudo ankyrin repeat-like [a.118.24] (15-60)
(1) alpha-alpha superhelix [a.118]
a.118.24(15-60) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses No information No information No information No information
326 PF06163 Bacterial protein of unknown function (DUF977) HTH (CL0123) 656 (3) 127 115 (1) "Winged helix" DNA-binding domain [a.4.5] (7-83)
(1) DNA/RNA-binding 3-helical bundle [a.4]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION a.4.5(7-83) 1 No information Eukaryota|Bacteria No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
327 PF10759 Protein of unknown function (DUF2587) No Pfam Clan 199 (15) 169 170 (1) Outer membrane efflux proteins (OEP) [f.5.1] (5-168)
(1) Outer membrane efflux proteins (OEP) [f.5]
f.5.1(5-168) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 YES Bacteria No information No information efflux transmembrane transporter activity drug transport| response to drug
328 PF03699 Uncharacterised protein family (UPF0182) No Pfam Clan 654 (63) 774 791 (1) Calcium-dependent phosphotriesterase [b.68.6] (255-753)
(2) Fumarate reductase respiratory complex transmembrane subunits [f.21.2] (20-271)
(1) 6-bladed beta-propeller [b.68]
(2) Heme-binding four-helical bundle [f.21]
NO PREDICTION b.68.6(255-753)| f.21.2(20-271) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea 1.3.5.1| 3.1.1.17| 3.1.1.25| 3.1.8.2| 4.3.3.2 fumarate reductase complex| mitochondrial respiratory chain| mitochondrial respiratory chain complex II| plasma membrane respiratory chain| plasma membrane respiratory chain complex II| respiratory chain| respiratory chain complex II| succinate dehydrogenase complex aryldialkylphosphatase activity| arylesterase activity| calcium ion binding| carboxylic ester hydrolase activity| cofactor binding| electron carrier activity| gluconolactonase activity| heme binding| oxidoreductase activity, acting on the CH-CH group of donors| quinone binding| succinate dehydrogenase activity| tetrapyrrole binding| ubiquinone binding| zinc ion binding L-ascorbic acid biosynthetic process| L-ascorbic acid metabolic process| calcium ion homeostasis| cellular calcium ion homeostasis| cellular cation homeostasis| cellular chemical homeostasis| cellular divalent inorganic cation homeostasis| cellular ion homeostasis| cellular metal ion homeostasis| cellular respiration| divalent inorganic cation homeostasis| electron transport chain| energy derivation by oxidation of organic compounds| metal ion homeostasis| mitochondrial ATP synthesis coupled electron transport| mitochondrial electron transport, succinate to ubiquinone| monosaccharide biosynthetic process| oxidative phosphorylation| positive regulation of ATPase activity| positive regulation of hydrolase activity| regulation of ATPase activity| regulation of calcium-mediated signaling| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| tricarboxylic acid cycle| vitamin biosynthetic process| water-soluble vitamin biosynthetic process| water-soluble vitamin metabolic process
329 PF11364 Protein of unknown function (DUF3165) No Pfam Clan 341 (7) 82 82 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-75)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(1-75) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information No information
330 PF11878 Domain of unknown function (DUF3398) No Pfam Clan 472 (20) 98 111 (1) PH domain-like [b.55.1] (14-98)
(1) PH domain-like barrel [b.55]
b.55.1(14-98) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota 3.1.4.11 actin cap| apical part of cell| apical plasma membrane| cell cortex| cell cortex part| cell leading edge| cortical actin cytoskeleton| cortical cytoskeleton| extrinsic to membrane| extrinsic to plasma membrane| lamellipodium alpha-catenin binding| cell adhesion molecule binding| phosphatidylinositol binding| phospholipid binding| phosphotransferase activity, alcohol group as acceptor| protein kinase activity Schwann cell development| Schwann cell differentiation| actin cytoskeleton organization| cell junction organization| cell projection organization| cellular membrane organization| cellular protein complex localization| cellular response to hormone stimulus| cellular response to insulin stimulus| cellular response to nitrogen compound| cellular response to organonitrogen compound| cellular response to peptide| cellular response to peptide hormone stimulus| ensheathment of neurons| neural precursor cell proliferation| peripheral nervous system development| plasma membrane organization| positive regulation of cellular response to insulin stimulus| positive regulation of glucose import in response to insulin stimulus| positive regulation of polarized epithelial cell differentiation| protein phosphorylation| regulation of GTP catabolic process| regulation of GTPase activity| regulation of Ras GTPase activity| regulation of actin cytoskeleton organization| regulation of actin filament length| regulation of cellular response to insulin stimulus| regulation of cytoskeleton organization| regulation of glucose import in response to insulin stimulus| regulation of glucose transport| regulation of nucleoside metabolic process| regulation of polarized epithelial cell differentiation| regulation of protein polymerization| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| response to organonitrogen compound| response to peptide| response to peptide hormone stimulus| stem cell proliferation| transmembrane receptor protein tyrosine kinase signaling pathway
331 PF10732 Protein of unknown function (DUF2524) No Pfam Clan 132 (8) 84 84 (1) TPR-like [a.118.8] (11-66)
(1) alpha-alpha superhelix [a.118]
a.118.8(11-66) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
332 PF14114 Domain of unknown function (DUF4286) No Pfam Clan 171 (46) 98 96 (1) Dimeric alpha+beta barrel [d.58.4] (1-97)
(1) Ferredoxin-like [d.58]
NO PREDICTION d.58.4(1-97) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 1.13.11.49| 1.13.11.55| 1.14.99.3| 5.3.3.4| 5.4.99.14 No information No information No information
333 PF07900 Protein of unknown function (DUF1670) HTH (CL0123) 52 (6) 220 218 (1) "Winged helix" DNA-binding domain [a.4.5] (87-141)
(1) DNA/RNA-binding 3-helical bundle [a.4]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION a.4.5(87-141) 1 No information Bacteria|Archaea No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
334 PF14351 Domain of unknown function (DUF4401) No Pfam Clan 202 (44) 326 321 (1) MFS general substrate transporter [f.38.1] (3-325)
(1) MFS general substrate transporter [f.38]
NO PREDICTION f.38.1(3-325) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
335 PF11150 Protein of unknown function (DUF2927) No Pfam Clan 243 (65) 213 205 (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (27-194)
(1) Zincin-like [d.92]
NO PREDICTION d.92.1(27-194) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 cortical granule glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing
336 PF09870 Uncharacterized protein conserved in archaea (DUF2097) No Pfam Clan 32 (8) 86 86 (1) HCP-like [a.118.18] (4-82)
(1) alpha-alpha superhelix [a.118]
a.118.18(4-82) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Archaea No information No information No information No information
337 PF07760 Protein of unknown function (DUF1616) No Pfam Clan 205 (38) 287 281 (1) MFS general substrate transporter [f.38.1] (17-166)
(1) MFS general substrate transporter [f.38]
NO PREDICTION NO PREDICTION f.38.1(17-166) NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
338 PF06027 Eukaryotic protein of unknown function (DUF914) DMT (CL0184) 558 (5) 336 336 (1) Multidrug resistance efflux transporter EmrE [f.39.1] (75-152)
(1) Multidrug resistance efflux transporter EmrE [f.39]
NO PREDICTION NO PREDICTION f.39.1(75-152) NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information No information No information No information
339 PF10935 Protein of unknown function (DUF2637) No Pfam Clan 337 (35) 160 158 (1) MFS general substrate transporter [f.38.1] (6-125)
(1) MFS general substrate transporter [f.38]
NO PREDICTION NO PREDICTION f.38.1(6-125) NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses|Archaea No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
340 PF10571 Uncharacterised protein family UPF0547 Zn_Beta_Ribbon (CL0167) 219 (31) 26 26 (1) Zn-binding ribosomal proteins [g.41.8] (1-24)
(1) Rubredoxin-like [g.41]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION g.41.8(1-24) 1 No information Eukaryota|Bacteria|Viruses|Archaea No information mitochondrial large ribosomal subunit| mitochondrial ribosome| organellar ribosome No information macropinocytosis| pinocytosis
341 PF11143 Protein of unknown function (DUF2919) No Pfam Clan 662 (29) 149 150 (1) Respiratory nitrate reductase 1 gamma chain [f.21.3] (1-147)
(1) Heme-binding four-helical bundle [f.21]
NO PREDICTION f.21.3(1-147) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information No information
342 PF07870 Protein of unknown function (DUF1657) No Pfam Clan 523 (27) 50 50 (1) TPR-like [a.118.8] (1-49)
(1) alpha-alpha superhelix [a.118]
a.118.8(1-49) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
343 PF05537 Borrelia burgdorferi protein of unknown function (DUF759) No Pfam Clan 148 (2) 431 422 (1) ARM repeat [a.118.1] (14-421)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(14-421) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
344 PF13959 Domain of unknown function (DUF4217) No Pfam Clan 1332 (193) 65 73 (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (1-65)
(1) P-loop containing nucleoside triphosphate hydrolases [c.37]
c.37.1(1-65) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
345 PF14471 Domain of unknown function (DUF4428) No Pfam Clan 71 (24) 51 55 (1) Glucocorticoid receptor-like (DNA-binding domain) [g.39.1] (1-29)
(1) Glucocorticoid receptor-like (DNA-binding domain) [g.39]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION g.39.1(1-29) 1 No information Bacteria|Viruses 2.7.1.21| 4.2.99.18 No information No information No information
346 PF08011 Protein of unknown function (DUF1703) PDDEXK (CL0236) 1376 (45) 105 97 (1) Restriction endonuclease-like [c.52.1] (INDIRECT)
(1) Restriction endonuclease-like [c.52]
NO PREDICTION c.52.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea 3.1.11.3| 3.1.11.5| 3.1.21.2| 3.1.21.4| 3.1.22.4 No information endonuclease activity| nuclease activity DNA repair| nucleotide-excision repair
347 PF05300 Protein of unknown function (DUF737) No Pfam Clan 182 (21) 187 160 (1) MW0975(SA0943)-like [a.24.27] (45-186)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(45-186) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information No information No information
348 PF13148 Protein of unknown function (DUF3987) No Pfam Clan 899 (117) 378 376 (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (12-369)
(1) P-loop containing nucleoside triphosphate hydrolases [c.37]
NO PREDICTION c.37.1(12-369) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Viruses|Archaea 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
349 PF05055 Protein of unknown function (DUF677) AT14A-like (CL0133) 135 (7) 336 336 (1) Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [a.114.1] (60-335)
(1) Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain [a.114]
NO PREDICTION a.114.1(60-335) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information No information cellular response to cytokine stimulus| cellular response to interferon-gamma| immune response| innate immune response| response to cytokine stimulus| response to interferon-gamma
350 PF11898 Domain of unknown function (DUF3418) No Pfam Clan 1852 (105) 586 600 (1) ARM repeat [a.118.1] (27-561)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(27-561) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
351 PF10094 Uncharacterized protein conserved in bacteria (DUF2332) No Pfam Clan 294 (37) 343 343 (1) S-adenosyl-L-methionine-dependent methyltransferases [c.66.1] (51-291)
(1) S-adenosyl-L-methionine-dependent methyltransferases [c.66]
NO PREDICTION c.66.1(51-291) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea 2.1.1.1| 2.1.1.104| 2.1.1.113| 2.1.1.125| 2.1.1.132| 2.1.1.144| 2.1.1.145| 2.1.1.166| 2.1.1.171| 2.1.1.172| 2.1.1.182| 2.1.1.183| 2.1.1.184| 2.1.1.187| 2.1.1.190| 2.1.1.191| 2.1.1.199| 2.1.1.2| 2.1.1.20| 2.1.1.28| 2.1.1.32| 2.1.1.33| 2.1.1.35| 2.1.1.36| 2.1.1.37| 2.1.1.43| 2.1.1.46| 2.1.1.49| 2.1.1.56| 2.1.1.57| 2.1.1.6| 2.1.1.61| 2.1.1.67| 2.1.1.68| 2.1.1.72| 2.1.1.77| 2.1.1.79| 2.1.1.8| 2.1.1.80| 2.5.1.16| 2.5.1.22 nuclear matrix glycine binding| methyltransferase activity| spermidine synthase activity| transferase activity, transferring one-carbon groups Actinobacterium-type cell wall biogenesis| DNA alkylation| DNA methylation involved in embryo development| N-terminal peptidyl-proline methylation| N-terminal peptidyl-serine methylation| N-terminal protein amino acid methylation| N-terminal protein amino acid modification| NADH dehydrogenase complex assembly| RNA capping| RNA modification| S-adenosylhomocysteine metabolic process| S-adenosylmethionine metabolic process| amine biosynthetic process| amino-acid betaine biosynthetic process| amino-acid betaine metabolic process| antibiotic biosynthetic process| antibiotic metabolic process| cellular biogenic amine biosynthetic process| cellular modified amino acid biosynthetic process| changes to DNA methylation involved in embryo development| chromatin modification| chromosome organization| coumarin biosynthetic process| covalent chromatin modification| gene silencing| glycine betaine biosynthetic process| glycine betaine biosynthetic process from glycine| glycine betaine metabolic process| glycine metabolic process| histone arginine methylation| ketone biosynthetic process| macromolecule methylation| methylation| mitochondrial RNA metabolic process| mitochondrial respiratory chain complex I assembly| mitochondrial respiratory chain complex I biogenesis| mycolic acid biosynthetic process| mycolic acid metabolic process| ncRNA processing| peptidoglycan-based cell wall biogenesis| peptidyl-arginine modification| phenylpropanoid biosynthetic process| polyamine biosynthetic process| polyamine metabolic process| protein alkylation| quinone cofactor biosynthetic process| quinone cofactor metabolic process| quinone metabolic process| regulation of DNA methylation| regulation of gene expression, epigenetic| ribonucleoprotein complex biogenesis| tRNA methylation| terpene metabolic process| transcription from mitochondrial promoter| ubiquinone metabolic process
352 PF04830 Possible hemagglutinin (DUF637) No Pfam Clan 397 (30) 178 174 (1) ARM repeat [a.118.1] (38-148)
(1) alpha-alpha superhelix [a.118]
a.118.1(38-148) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
353 PF11365 Protein of unknown function (DUF3166) No Pfam Clan 340 (4) 97 101 (1) TPR-like [a.118.8] (17-95)
(1) alpha-alpha superhelix [a.118]
a.118.8(17-95) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
354 PF14187 Domain of unknown function (DUF4310) No Pfam Clan 318 (9) 210 210 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (9-208)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(9-208) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information No information
355 PF11994 Protein of unknown function (DUF3489) No Pfam Clan 127 (26) 72 72 (1) "Winged helix" DNA-binding domain [a.4.5] (15-69)
(1) DNA/RNA-binding 3-helical bundle [a.4]
a.4.5(15-69) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
356 PF10093 Uncharacterized protein conserved in bacteria (DUF2331) No Pfam Clan 370 (50) 374 378 (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (1-352)
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87]
NO PREDICTION c.87.1(1-352) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process
357 PF04284 Protein of unknown function (DUF441) No Pfam Clan 1132 (35) 140 140 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-139)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(1-139) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information No information No information No information
358 PF12266 Protein of unknown function (DUF3613) No Pfam Clan 138 (18) 67 68 (1) Multiheme cytochromes [a.138.1] (5-67)
(1) Multiheme cytochromes [a.138]
a.138.1(5-67) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 1.7.2.2| 1.7.3.4 No information electron carrier activity| oxidoreductase activity, acting on other nitrogenous compounds as donors No information
359 PF15057 Domain of unknown function (DUF4537) Tudor (CL0049) 111 (24) 124 119 (1) Tudor/PWWP/MBT [b.34.9] (1-52)
(1) SH3-like barrel [b.34]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION b.34.9(1-52) 1 No information Eukaryota No information No information No information No information
360 PF08490 Domain of unknown function (DUF1744) DNA_pol_B-like (CL0194) 355 (17) 396 390 (1) DNA/RNA polymerases [e.8.1] (141-390)
(1) DNA/RNA polymerases [e.8]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION e.8.1(141-390) 1 No information Eukaryota 2.7.7.48| 2.7.7.49| 2.7.7.6| 2.7.7.7 No information DNA polymerase activity DNA replication| RNA-dependent DNA replication
361 PF04920 Family of unknown function (DUF656) No Pfam Clan 39 (2) 126 126 (1) Bacterial muramidases [a.118.5] (13-116)
(1) alpha-alpha superhelix [a.118]
a.118.5(13-116) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Viruses No information No information No information No information
362 PF11996 Protein of unknown function (DUF3491) No Pfam Clan 259 (8) 936 945 (1) DPP6 N-terminal domain-like [b.70.3] (81-914)
(1) 8-bladed beta-propeller [b.70]
NO PREDICTION b.70.3(81-914) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information No information
363 PF12616 Protein of unknown function (DUF3775) No Pfam Clan 175 (44) 75 75 (1) TPR-like [a.118.8] (2-68)
(1) alpha-alpha superhelix [a.118]
a.118.8(2-68) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
364 PF01345 Domain of unknown function DUF11 E-set (CL0159) 6559 (35) 76 76 (1) Subtilisin-like [c.41.1] (13-76)
(1) Subtilisin-like [c.41]
c.41.1(13-76) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea 3.4.14.10| 3.4.14.9| 3.4.21.100| 3.4.21.110| 3.4.21.61| 3.4.21.62| 3.4.21.64| 3.4.21.66| 3.4.21.75 No information No information No information
365 PF09990 Predicted membrane protein (DUF2231) No Pfam Clan 367 (51) 104 116 (1) Transmembrane di-heme cytochromes [f.21.1] (1-100)
(1) Heme-binding four-helical bundle [f.21]
NO PREDICTION f.21.1(1-100) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 1.10.2.2 No information electron carrier activity cellular respiration
366 PF05254 Uncharacterised protein family (UPF0203) No Pfam Clan 246 (19) 68 69 (1) Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [f.28.1] (5-56)
(1) Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) [f.28]
NO PREDICTION NO PREDICTION f.28.1(5-56) NO PREDICTION NO PREDICTION 1 No information Eukaryota No information respiratory chain No information No information
367 PF09747 Coiled-coil domain containing protein (DUF2052) No Pfam Clan 236 (20) 181 175 (1) MW0975(SA0943)-like [a.24.27] (1-180)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(1-180) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information No information No information
368 PF10812 Protein of unknown function (DUF2561) No Pfam Clan 80 (7) 207 210 (1) MFS general substrate transporter [f.38.1] (12-206)
(1) MFS general substrate transporter [f.38]
NO PREDICTION f.38.1(12-206) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
369 PF08822 Protein of unknown function (DUF1804) HTH (CL0123) 154 (12) 165 165 (1) Homeodomain-like [a.4.1] (2-49)
(1) DNA/RNA-binding 3-helical bundle [a.4]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION a.4.1(2-49) 1 No information Bacteria|Viruses No information transcription factor complex chromatin binding| nucleic acid binding transcription factor activity| transposase activity activin receptor signaling pathway| cell fate commitment| cell fate specification| chordate embryonic development| diencephalon development| embryonic morphogenesis| endoderm development| eye photoreceptor cell differentiation| negative regulation of developmental process| neural tube development| neuron fate commitment| nodal signaling pathway| pancreas development| pattern specification process| positive regulation of neuron differentiation| regulation of cell fate commitment| regulation of epithelial cell differentiation| regulation of gastrulation| retina development in camera-type eye| sensory organ development| somitogenesis| transmembrane receptor protein serine/threonine kinase signaling pathway| transposition| transposition, DNA-mediated| trophectodermal cell differentiation
370 PF15366 Domain of unknown function (DUF4597) No Pfam Clan 25 (4) 62 63 (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (5-57)
(1) 8-bladed beta-propeller [b.70]
b.70.1(5-57) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota 1.1.2.7| 1.1.98.1 No information endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein
371 PF12027 Protein of unknown function (DUF3514) No Pfam Clan 49 (26) 255 243 (1) ARM repeat [a.118.1] (3-252)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(3-252) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
372 PF10790 Protein of Unknown function (DUF2604) No Pfam Clan 5 (3) 76 76 (1) Ubiquitin-like [d.15.1] (3-74)
(1) beta-Grasp (ubiquitin-like) [d.15]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION d.15.1(3-74) 1 No information Bacteria 3.1.2.15| 3.1.4.11 autophagic vacuole| nuclear body SUMO ligase activity| non-membrane spanning protein tyrosine phosphatase activity| phosphoprotein phosphatase activity| protein tag| protein tyrosine phosphatase activity| small conjugating protein ligase activity| small conjugating protein ligase binding autophagy| catechol-containing compound metabolic process| catecholamine metabolic process| catecholamine transport| catecholamine uptake| catecholamine uptake involved in synaptic transmission| dopamine metabolic process| dopamine transport| dopamine uptake| dopamine uptake involved in synaptic transmission| monoamine transport| neurotransmitter uptake| norepinephrine metabolic process| peptidyl-tyrosine dephosphorylation| positive regulation of protein ubiquitination| positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc| protein modification by small protein conjugation or removal| protein sumoylation| proteolysis involved in cellular protein catabolic process| regulation of neurotransmitter secretion| regulation of neurotransmitter transport| regulation of protein catabolic process| regulation of protein ubiquitination| regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process| regulation of proteolysis| response to transforming growth factor beta stimulus| startle response| synaptic transmission, dopaminergic| synaptic transmission, glutamatergic
373 PF12069 Protein of unknown function (DUF3549) No Pfam Clan 187 (29) 340 343 (1) ARM repeat [a.118.1] (1-338)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(1-338) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
374 PF06496 Protein of unknown function (DUF1097) No Pfam Clan 1004 (53) 144 140 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (INDIRECT)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 YES Bacteria|Archaea No information No information No information No information
375 PF11071 Protein of unknown function (DUF2872) No Pfam Clan 147 (31) 141 139 (1) N-(deoxy)ribosyltransferase-like [c.23.14] (1-108)
(1) Flavodoxin-like [c.23]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION c.23.14(1-108) 1 No information Eukaryota|Bacteria 2.4.2.6| 3.2.2.5 No information deoxyribonucleoside 5'-monophosphate N-glycosidase activity| hydrolase activity, hydrolyzing N-glycosyl compounds deoxyribonucleoside monophosphate catabolic process| deoxyribonucleoside monophosphate metabolic process| nucleoside monophosphate catabolic process| nucleoside monophosphate metabolic process| nucleoside phosphate catabolic process| organophosphate catabolic process| positive regulation of cell growth| positive regulation of growth| regulation of cell growth
376 PF04094 Protein of unknown function (DUF390) No Pfam Clan 813 (2) 828 828 (1) ARM repeat [a.118.1] (INDIRECT)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
377 PF07289 Protein of unknown function (DUF1448) PH (CL0266) 172 (13) 339 336 (1) PH domain-like [b.55.1] (146-207)
(1) PH domain-like barrel [b.55]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION b.55.1(146-207) 1 No information Eukaryota 3.1.4.11 actin cap| apical part of cell| apical plasma membrane| cell cortex| cell cortex part| cell leading edge| cortical actin cytoskeleton| cortical cytoskeleton| extrinsic to membrane| extrinsic to plasma membrane| lamellipodium alpha-catenin binding| cell adhesion molecule binding| phosphatidylinositol binding| phospholipid binding| phosphotransferase activity, alcohol group as acceptor| protein kinase activity Schwann cell development| Schwann cell differentiation| actin cytoskeleton organization| cell junction organization| cell projection organization| cellular membrane organization| cellular protein complex localization| cellular response to hormone stimulus| cellular response to insulin stimulus| cellular response to nitrogen compound| cellular response to organonitrogen compound| cellular response to peptide| cellular response to peptide hormone stimulus| ensheathment of neurons| neural precursor cell proliferation| peripheral nervous system development| plasma membrane organization| positive regulation of cellular response to insulin stimulus| positive regulation of glucose import in response to insulin stimulus| positive regulation of polarized epithelial cell differentiation| protein phosphorylation| regulation of GTP catabolic process| regulation of GTPase activity| regulation of Ras GTPase activity| regulation of actin cytoskeleton organization| regulation of actin filament length| regulation of cellular response to insulin stimulus| regulation of cytoskeleton organization| regulation of glucose import in response to insulin stimulus| regulation of glucose transport| regulation of nucleoside metabolic process| regulation of polarized epithelial cell differentiation| regulation of protein polymerization| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| response to organonitrogen compound| response to peptide| response to peptide hormone stimulus| stem cell proliferation| transmembrane receptor protein tyrosine kinase signaling pathway
378 PF13311 Protein of unknown function (DUF4080) No Pfam Clan 385 (54) 190 187 (1) Radical SAM enzymes [c.1.28] (1-184)
(1) TIM beta/alpha-barrel [c.1]
c.1.28(1-184) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 1.3.99.22| 1.97.1.4| 2.8.1.6| 5.4.3.2 lipid particle 4 iron, 4 sulfur cluster binding| biotin synthase activity| intramolecular transferase activity| lipoate synthase activity| lipoate-protein ligase activity| metal cluster binding| oxidoreductase activity, acting on the CH-CH group of donors| protein self-association| radical SAM enzyme activity| sulfurtransferase activity| transferase activity, transferring sulfur-containing groups CD4-positive, alpha-beta T cell activation| CD4-positive, alpha-beta T cell differentiation| T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| defense response to virus| lipoate biosynthetic process| lipoate metabolic process| lymphocyte differentiation| molybdopterin cofactor biosynthetic process| molybdopterin cofactor metabolic process| monocarboxylic acid biosynthetic process| negative regulation of protein secretion| negative regulation of protein transport| negative regulation of secretion| positive regulation of T cell cytokine production| positive regulation of T cell mediated immunity| positive regulation of T-helper 2 cell cytokine production| positive regulation of adaptive immune response| positive regulation of adaptive immune response based on somatic recombination of immune receptors b| positive regulation of cytokine production| positive regulation of cytokine production involved in immune response| positive regulation of immune effector process| positive regulation of leukocyte mediated immunity| positive regulation of lymphocyte mediated immunity| positive regulation of production of molecular mediator of immune response| positive regulation of toll-like receptor 9 signaling pathway| positive regulation of toll-like receptor signaling pathway| prosthetic group metabolic process| regulation of T cell cytokine production| regulation of T cell mediated immunity| regulation of T-helper 2 cell cytokine production| regulation of adaptive immune response| regulation of cytokine production involved in immune response| regulation of leukocyte mediated immunity| regulation of lymphocyte mediated immunity| regulation of production of molecular mediator of immune response| regulation of protein secretion| regulation of toll-like receptor 7 signaling pathway| regulation of toll-like receptor 9 signaling pathway| regulation of toll-like receptor signaling pathway| regulation of type 2 immune response| response to virus| vitamin biosynthetic process
379 PF10561 Uncharacterised protein family UPF0565 No Pfam Clan 182 (12) 303 309 (1) alpha/beta-Hydrolases [c.69.1] (18-302)
(1) alpha/beta-Hydrolases [c.69]
NO PREDICTION c.69.1(18-302) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota 1.11.1.10| 1.13.11.47| 1.13.11.48| 1.13.12.5| 2.3.1.175| 2.3.1.31| 2.3.1.94| 3.1.1.1| 3.1.1.2| 3.1.1.23| 3.1.1.24| 3.1.1.3| 3.1.1.41| 3.1.1.43| 3.1.1.45| 3.1.1.47| 3.1.1.6| 3.1.1.7| 3.1.1.72| 3.1.1.73| 3.1.1.74| 3.1.1.75| 3.1.1.78| 3.1.1.8| 3.1.2.12| 3.1.2.2| 3.1.2.22| 3.3.2.10| 3.3.2.9| 3.4.11.5| 3.4.14.11| 3.4.14.12| 3.4.14.2| 3.4.14.5| 3.4.16.2| 3.4.16.5| 3.4.16.6| 3.4.19.1| 3.4.21.26| 3.4.21.83| 3.7.1.8| 3.7.1.9| 3.8.1.3| 3.8.1.5| 4.1.2.11 trans-Golgi network transport vesicle CD4 receptor binding| acetylcholinesterase activity| acyl-CoA hydrolase activity| carboxylic ester hydrolase activity| epoxide hydrolase activity| homoserine O-acetyltransferase activity| hydrolase activity, acting on ether bonds| lipase activity| palmitoyl-(protein) hydrolase activity| protein phosphatase 2A binding| serine-type carboxypeptidase activity| serine-type exopeptidase activity acyl-CoA metabolic process| acylglycerol catabolic process| chlorophyll catabolic process| formaldehyde metabolic process| glycerolipid catabolic process| grooming behavior| lipoprotein catabolic process| lipoprotein metabolic process| long term synaptic depression| lysosomal lumen acidification| lysosome organization| mast cell activation| membrane raft organization| negative regulation of Golgi to plasma membrane protein transport| negative regulation of lipid storage| negative regulation of neurological system process| negative regulation of transmission of nerve impulse| neutral lipid catabolic process| neutral lipid metabolic process| phosphatidic acid biosynthetic process| phosphatidic acid metabolic process| pigment catabolic process| porphyrin-containing compound catabolic process| positive regulation of lipid catabolic process| positive regulation of pinocytosis| positive regulation of triglyceride catabolic process| positive regulation of triglyceride metabolic process| protein deacylation| protein depalmitoylation| regulation of Golgi to plasma membrane protein transport| regulation of lipase activity| regulation of lipid catabolic process| regulation of phospholipase A2 activity| regulation of pinocytosis| regulation of sequestering of triglyceride| regulation of triglyceride catabolic process| regulation of triglyceride metabolic process| tetrapyrrole catabolic process| thioester metabolic process
380 PF09860 Uncharacterized protein conserved in bacteria (DUF2087) No Pfam Clan 586 (55) 71 69 (1) "Winged helix" DNA-binding domain [a.4.5] (1-70)
(1) DNA/RNA-binding 3-helical bundle [a.4]
a.4.5(1-70) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information cytosolic small ribosomal subunit| small ribosomal subunit nucleic acid binding transcription factor activity| transcription regulatory region DNA binding CD8-positive, alpha-beta T cell activation| CD8-positive, alpha-beta T cell differentiation| alpha-beta T cell activation| alpha-beta T cell differentiation| immune system development| positive regulation of interleukin-12 biosynthetic process| regulation of interleukin-12 production
381 PF06156 Protein of unknown function (DUF972) No Pfam Clan 1035 (43) 107 114 (1) Myosin rod fragments [h.1.26] (8-73)
(1) Parallel coiled-coil [h.1]
NO PREDICTION NO PREDICTION h.1.26(8-73) NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information No information No information No information
382 PF07044 Protein of unknown function (DUF1329) No Pfam Clan 761 (104) 367 372 (1) Tricorn protease N-terminal domain [b.68.7] (28-361)
(1) 6-bladed beta-propeller [b.68]
NO PREDICTION b.68.7(28-361) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses No information No information No information No information
383 PF01732 Putative peptidase (DUF31) Peptidase_PA (CL0124) 325 (40) 374 351 (1) Trypsin-like serine proteases [b.47.1] (34-373)
(1) Trypsin-like serine proteases [b.47]
NO PREDICTION b.47.1(34-373) NO PREDICTION NO PREDICTION NO PREDICTION 1 YES Bacteria 3.4.19.12| 3.4.21.1| 3.4.21.104| 3.4.21.106| 3.4.21.108| 3.4.21.109| 3.4.21.114| 3.4.21.117| 3.4.21.119| 3.4.21.12| 3.4.21.19| 3.4.21.2| 3.4.21.20| 3.4.21.21| 3.4.21.22| 3.4.21.27| 3.4.21.32| 3.4.21.34| 3.4.21.35| 3.4.21.36| 3.4.21.37| 3.4.21.39| 3.4.21.4| 3.4.21.41| 3.4.21.42| 3.4.21.43| 3.4.21.46| 3.4.21.47| 3.4.21.49| 3.4.21.5| 3.4.21.50| 3.4.21.59| 3.4.21.6| 3.4.21.68| 3.4.21.69| 3.4.21.7| 3.4.21.71| 3.4.21.73| 3.4.21.74| 3.4.21.77| 3.4.21.78| 3.4.21.79| 3.4.21.81| 3.4.21.82| 3.4.21.9| 3.4.21.91| 3.4.21.98 No information endopeptidase activity| glycosaminoglycan binding| heparin binding| peptidase activity| serine hydrolase activity| serine-type endopeptidase activity| serine-type peptidase activity blood circulation| cell killing| cellular component disassembly| collagen catabolic process| collagen metabolic process| complement activation, alternative pathway| endocrine process| extracellular matrix disassembly| extracellular matrix organization| extracellular structure organization| immune response| kinin cascade| leukocyte mediated cytotoxicity| memory| multicellular organismal catabolic process| multicellular organismal metabolic process| positive regulation of G-protein coupled receptor protein signaling pathway| positive regulation of Toll signaling pathway| proteolysis| regulation of Toll signaling pathway| regulation of blood coagulation| regulation of blood pressure| regulation of coagulation| regulation of hemostasis| regulation of systemic arterial blood pressure| regulation of systemic arterial blood pressure by hormone| regulation of wound healing
384 PF05113 Protein of unknown function (DUF693) No Pfam Clan 142 (2) 314 314 (1) WD40 repeat-like [b.69.4] (1-312)
(1) 7-bladed beta-propeller [b.69]
NO PREDICTION b.69.4(1-312) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information Arp2/3 protein complex| CIA complex| Cdc73/Paf1 complex| Cul4-RING ubiquitin ligase complex| ER to Golgi transport vesicle| SMN complex| SMN-Sm protein complex| Ski complex| THO complex| TORC1 complex| chromosome, centromeric region| cullin-RING ubiquitin ligase complex| eukaryotic translation initiation factor 3 complex| extrinsic to internal side of plasma membrane| extrinsic to membrane| extrinsic to plasma membrane| female germ cell nucleus| germ cell nucleus| heterotrimeric G-protein complex| histone methyltransferase complex| immunological synapse| internal side of plasma membrane| kinetochore| methylosome| methyltransferase complex| nuclear envelope| nuclear pore| nuclear pore outer ring| pore complex| transcription export complex| transcriptionally active chromatin| ubiquitin ligase complex G-protein gamma-subunit binding| histone binding| peroxisome targeting sequence binding| phosphatidylinositol binding| phosphatidylinositol-3,5-bisphosphate binding| phosphatidylinositol-3-phosphate binding| phosphatidylinositol-5-phosphate binding| signal sequence binding| translation initiation factor activity RNA splicing, via transesterification reactions with bulged adenosine as nucleophile| T cell homeostasis| TOR signaling cascade| attachment of spindle microtubules to kinetochore| attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation| autophagy| cellular response to starvation| chromosome segregation| embryonic digit morphogenesis| establishment of RNA localization| establishment of chromosome localization| establishment of organelle localization| fruiting body development| histone H3-K4 methylation| histone methylation| histone modification| iron-sulfur cluster assembly| mRNA export from nucleus| membrane disassembly| metallo-sulfur cluster assembly| metaphase plate congression| methylation| microtubule-based process| mitotic metaphase plate congression| mitotic spindle assembly checkpoint| negative regulation of calcium ion transmembrane transporter activity| negative regulation of cation channel activity| negative regulation of cell cycle process| negative regulation of ion transmembrane transporter activity| negative regulation of transporter activity| negative regulation of voltage-gated calcium channel activity| nuclear envelope disassembly| nuclear pore organization| nucleic acid transport| nucleobase-containing compound transport| peptidyl-lysine modification| peptidyl-lysine trimethylation| peroxisomal transport| positive regulation of DNA-dependent transcription, elongation| positive regulation of histone H3-K79 methylation| positive regulation of histone methylation| positive regulation of histone modification| positive regulation of organelle organization| positive regulation of transcription elongation from RNA polymerase II promoter| protein alkylation| protein import| protein targeting| regulation of cell cycle process| regulation of histone H3-K79 methylation| regulation of histone methylation| regulation of histone modification| regulation of metaphase/anaphase transition of cell cycle| regulation of mitotic metaphase/anaphase transition| regulation of reproductive process| regulation of transcription elongation from RNA polymerase II promoter| regulation of voltage-gated calcium channel activity| response to starvation| spindle assembly checkpoint| spindle checkpoint| uropod organization
385 PF06048 Domain of unknown function (DUF927) P-loop_NTPase (CL0023) 800 (39) 286 281 (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (149-265)
(1) P-loop containing nucleoside triphosphate hydrolases [c.37]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION c.37.1(149-265) 1 No information Bacteria|Viruses|Archaea 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
386 PF12097 Protein of unknown function (DUF3573) No Pfam Clan 128 (5) 383 376 (1) Pectin lyase-like [b.80.1] (8-368)
(1) Single-stranded right-handed beta-helix [b.80]
NO PREDICTION b.80.1(8-368) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria 3.1.1.11| 3.2.1.11| 3.2.1.15| 3.2.1.157| 3.2.1.57| 3.2.1.58| 3.4.21.72| 4.2.2.10| 4.2.2.18| 4.2.2.19| 4.2.2.2| 4.2.2.7 anchored to membrane| plant-type cell wall carbon-oxygen lyase activity, acting on polysaccharides| carboxylic ester hydrolase activity| galacturan 1,4-alpha-galacturonidase activity| pectinesterase activity| polygalacturonase activity cell growth| cell wall organization or biogenesis| developmental cell growth| developmental growth| developmental growth involved in morphogenesis| external encapsulating structure organization| galacturonan metabolic process| pectin catabolic process| plant-type cell wall organization| plant-type cell wall organization or biogenesis| pollen tube development| pollen tube growth| pollination| polysaccharide catabolic process| polysaccharide metabolic process| unidimensional cell growth
387 PF10850 Protein of unknown function (DUF2653) No Pfam Clan 127 (4) 91 91 (1) ARM repeat [a.118.1] (1-90)
(1) alpha-alpha superhelix [a.118]
a.118.1(1-90) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
388 PF11990 Protein of unknown function (DUF3487) No Pfam Clan 230 (25) 122 127 (1) TPR-like [a.118.8] (29-117)
(1) alpha-alpha superhelix [a.118]
a.118.8(29-117) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Viruses No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
389 PF05852 Gammaherpesvirus protein of unknown function (DUF848) No Pfam Clan 27 (13) 146 144 (1) RNI-like [c.10.1] (28-139)
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10]
c.10.1(28-139) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Viruses No information ubiquitin ligase complex acid-amino acid ligase activity| small conjugating protein ligase activity| ubiquitin-protein ligase activity cellular protein catabolic process| entrainment of circadian clock| entrainment of circadian clock by photoperiod| modification-dependent macromolecule catabolic process| photoperiodism| protein catabolic process| protein ubiquitination| proteolysis| regulation of circadian rhythm| ubiquitin-dependent protein catabolic process
390 PF12004 Domain of unknown function (DUF3498) No Pfam Clan 291 (7) 495 506 (1) ssDNA viruses [b.121.5] (1-354)
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121]
NO PREDICTION NO PREDICTION NO PREDICTION b.121.5(1-354) NO PREDICTION 1 No information Eukaryota No information No information No information No information
391 PF15363 Domain of unknown function (DUF4596) No Pfam Clan 87 (10) 46 46 (1) Calcium-dependent phosphotriesterase [b.68.6] (8-38)
(1) 6-bladed beta-propeller [b.68]
b.68.6(8-38) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota 3.1.1.17| 3.1.1.25| 3.1.8.2| 4.3.3.2 No information aryldialkylphosphatase activity| arylesterase activity| calcium ion binding| carboxylic ester hydrolase activity| gluconolactonase activity| zinc ion binding L-ascorbic acid biosynthetic process| L-ascorbic acid metabolic process| calcium ion homeostasis| cellular calcium ion homeostasis| cellular cation homeostasis| cellular chemical homeostasis| cellular divalent inorganic cation homeostasis| cellular ion homeostasis| cellular metal ion homeostasis| divalent inorganic cation homeostasis| metal ion homeostasis| monosaccharide biosynthetic process| positive regulation of ATPase activity| positive regulation of hydrolase activity| regulation of ATPase activity| regulation of calcium-mediated signaling| regulation of nucleoside metabolic process| regulation of nucleotide catabolic process| regulation of nucleotide metabolic process| regulation of purine nucleotide catabolic process| regulation of purine nucleotide metabolic process| vitamin biosynthetic process| water-soluble vitamin biosynthetic process| water-soluble vitamin metabolic process
392 PF10039 Predicted integral membrane protein (DUF2275) No Pfam Clan 40 (7) 218 212 (1) Bacterial muramidases [a.118.5] (63-205)
(1) alpha-alpha superhelix [a.118]
a.118.5(63-205) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information No information
393 PF10350 Putative death-receptor fusion protein (DUF2428) No Pfam Clan 333 (33) 255 182 (1) ARM repeat [a.118.1] (1-246)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(1-246) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
394 PF13559 Domain of unknown function (DUF4129) No Pfam Clan 1189 (194) 72 80 (1) TPR-like [a.118.8] (2-49)
(1) alpha-alpha superhelix [a.118]
a.118.8(2-49) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
395 PF09321 Domain of unknown function (DUF1978) No Pfam Clan 49 (6) 241 243 (1) MW0975(SA0943)-like [a.24.27] (49-225)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(49-225) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information No information
396 PF04645 Protein of unknown function, DUF603 No Pfam Clan 189 (3) 181 186 (1) Homeodomain-like [a.4.1] (19-60)
(1) DNA/RNA-binding 3-helical bundle [a.4]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION a.4.1(19-60) 1 No information Bacteria No information transcription factor complex chromatin binding| nucleic acid binding transcription factor activity| transposase activity activin receptor signaling pathway| cell fate commitment| cell fate specification| chordate embryonic development| diencephalon development| embryonic morphogenesis| endoderm development| eye photoreceptor cell differentiation| negative regulation of developmental process| neural tube development| neuron fate commitment| nodal signaling pathway| pancreas development| pattern specification process| positive regulation of neuron differentiation| regulation of cell fate commitment| regulation of epithelial cell differentiation| regulation of gastrulation| retina development in camera-type eye| sensory organ development| somitogenesis| transmembrane receptor protein serine/threonine kinase signaling pathway| transposition| transposition, DNA-mediated| trophectodermal cell differentiation
397 PF12398 Receptor serine/threonine kinase No Pfam Clan 150 (34) 42 42 (1) Protein kinase-like (PK-like) [d.144.1] (6-42)
(1) Protein kinase-like (PK-like) [d.144]
d.144.1(6-42) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota 2.7.1.100| 2.7.1.137| 2.7.1.153| 2.7.1.163| 2.7.1.17| 2.7.1.32| 2.7.1.39| 2.7.1.95| 2.7.10.1| 2.7.10.2| 2.7.11.1| 2.7.11.11| 2.7.11.13| 2.7.11.14| 2.7.11.15| 2.7.11.16| 2.7.11.17| 2.7.11.19| 2.7.11.21| 2.7.11.22| 2.7.11.24| 2.7.11.25| 2.7.11.26| 2.7.11.30| 2.7.11.7| 2.7.12.1| 2.7.12.2 cAMP-dependent protein kinase complex| calcium- and calmodulin-dependent protein kinase complex| cell-substrate adherens junction| cyclin-dependent protein kinase holoenzyme complex| neuromuscular junction| protein kinase CK2 complex| spindle| spindle pole ATP binding| adenyl nucleotide binding| adenyl ribonucleotide binding| calmodulin binding| cyclin binding| kinase activator activity| kinase regulator activity| magnesium ion binding| molecular transducer activity| nucleoside binding| phosphoprotein binding| phosphotransferase activity, alcohol group as acceptor| phosphotyrosine binding| protein kinase activator activity| protein kinase activity| protein kinase regulator activity| purine nucleoside binding| purine nucleotide binding| purine ribonucleoside binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| receptor signaling protein activity| ribonucleoside binding| ribonucleotide binding CDP-choline pathway| DNA damage checkpoint| activation of innate immune response| cell cycle phase transition| cell division| cell morphogenesis| cellular component morphogenesis| cellular process involved in reproduction| cellular response to biotic stimulus| cellular response to unfolded protein| embryonic placenta development| enzyme linked receptor protein signaling pathway| ethanolamine-containing compound metabolic process| fruiting body development| germ cell development| glycerolipid biosynthetic process| glycerolipid metabolic process| glycerophospholipid biosynthetic process| heart contraction| heart process| hemostasis| innate immune response| innate immune response-activating signal transduction| intracellular protein kinase cascade| labyrinthine layer development| lens development in camera-type eye| lipopolysaccharide-mediated signaling pathway| microtubule cytoskeleton organization| mitotic cell cycle phase transition| negative regulation of cell cycle process| neurotrophin signaling pathway| oogenesis| organelle fission| organic hydroxy compound biosynthetic process| peptidyl-serine modification| peptidyl-threonine modification| phosphatidylcholine biosynthetic process| phosphatidylcholine metabolic process| phosphatidylinositol-3-phosphate biosynthetic process| phospholipid biosynthetic process| positive regulation of MAP kinase activity| positive regulation of cellular protein metabolic process| positive regulation of determination of dorsal identity| positive regulation of developmental growth| positive regulation of innate immune response| positive regulation of intracellular protein transport| positive regulation of myoblast fusion| positive regulation of myotube differentiation| positive regulation of phosphate metabolic process| positive regulation of phosphorus metabolic process| positive regulation of phosphorylation| positive regulation of protein kinase activity| positive regulation of protein phosphorylation| positive regulation of skeletal muscle cell differentiation| positive regulation of syncytium formation by plasma membrane fusion| positive regulation of transferase activity| positive regulation of unidimensional cell growth| programmed necrotic cell death| protein phosphorylation| regulation of Golgi inheritance| regulation of MAPK cascade| regulation of Wnt receptor signaling pathway| regulation of adult chitin-containing cuticle pigmentation| regulation of cell size| regulation of cellular response to stress| regulation of chitin-based cuticle tanning| regulation of early endosome to late endosome transport| regulation of fibroblast apoptotic process| regulation of innate immune response| regulation of intracellular protein kinase cascade| regulation of kinase activity| regulation of muscle cell differentiation| regulation of muscle organ development| regulation of muscle tissue development| regulation of protein kinase activity| regulation of reproductive process| regulation of skeletal muscle fiber development| regulation of sodium ion transport| regulation of transferase activity| response to cadmium ion| response to exogenous dsRNA| response to growth factor stimulus| response to molecule of bacterial origin| response to osmotic stress| salicylic acid biosynthetic process| salicylic acid metabolic process| spindle assembly| spindle midzone assembly| stomatal complex development| stress-activated protein kinase signaling cascade| striated muscle contraction| toll-like receptor signaling pathway
398 PF07295 Protein of unknown function (DUF1451) No Pfam Clan 784 (31) 146 147 (1) Microbial and mitochondrial ADK, insert "zinc finger" domain [g.41.2] (112-145)
(1) Rubredoxin-like [g.41]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION g.41.2(112-145) 1 No information Bacteria|Archaea No information No information No information No information
399 PF05128 Domain of unknown function (DUF697) No Pfam Clan 1824 (81) 162 161 (1) P-loop containing nucleoside triphosphate hydrolases [c.37.1] (1-159)
(1) P-loop containing nucleoside triphosphate hydrolases [c.37]
c.37.1(1-159) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 YES Eukaryota|Bacteria 1.18.6.1| 2.5.1.17| 2.5.1.27| 2.5.1.75| 2.7.1.113| 2.7.1.12| 2.7.1.145| 2.7.1.164| 2.7.1.19| 2.7.1.21| 2.7.1.24| 2.7.1.25| 2.7.1.33| 2.7.1.4| 2.7.1.48| 2.7.1.71| 2.7.1.74| 2.7.1.78| 2.7.10.2| 2.7.11.1| 2.7.4.10| 2.7.4.13| 2.7.4.14| 2.7.4.2| 2.7.4.3| 2.7.4.8| 2.7.4.9| 2.8.2.1| 2.8.2.14| 2.8.2.2| 2.8.2.23| 2.8.2.4| 2.8.2.8| 2.8.2.9| 3.1.11.5| 3.1.21.3| 3.1.5.1| 3.6.1.14| 3.6.1.15| 3.6.1.3| 3.6.3.14| 3.6.3.16| 3.6.3.19| 3.6.3.21| 3.6.3.30| 3.6.3.33| 3.6.3.34| 3.6.3.49| 3.6.4.1| 3.6.4.12| 3.6.4.13| 3.6.4.4| 3.6.5.1| 3.6.5.2| 3.6.5.3| 3.6.5.4| 3.6.5.5| 6.3.3.3| 6.3.4.2| 6.3.4.3| 6.3.4.4| 6.6.1.1 ATP-binding cassette (ABC) transporter complex| Cajal body| DNA recombinase mediator complex| Golgi apparatus| Rad51B-Rad51C-Rad51D-XRCC2 complex| axoneme| axoneme part| cell cortex| cell division site| cell division site part| cell plate| cell septum| cellular bud| cilium| cytoplasmic microtubule| endocytic vesicle| extrinsic to membrane| extrinsic to plasma membrane| host intracellular part| hyphal tip| incipient cellular bud site| insulin-responsive compartment| internal side of plasma membrane| intracellular region of host| intraflagellar transport particle| intraflagellar transport particle B| kinesin complex| lateral plasma membrane| microtubule| midbody| photoreceptor connecting cilium| recycling endosome| septin complex| septin cytoskeleton| site of polarized growth| spindle| spitzenkorper| symbiont-containing vacuole membrane| synaptic vesicle ADP dimethylallyltransferase activity| AMP dimethylallyltransferase activity| ATP dimethylallyltransferase activity| GDP binding| GTP binding| GTPase activating protein binding| GTPase activity| P-P-bond-hydrolysis-driven transmembrane transporter activity| active transmembrane transporter activity| adenylylsulfate kinase activity| branched-chain amino acid transmembrane transporter activity| cyclo-ligase activity| dephospho-CoA kinase activity| dethiobiotin synthase activity| gluconokinase activity| guanyl nucleotide binding| guanyl ribonucleotide binding| heme transporter activity| metal cluster binding| nucleobase-containing compound kinase activity| nucleoside binding| peptide transporter activity| phosphomevalonate kinase activity| phosphotransferase activity, phosphate group as acceptor| primary active transmembrane transporter activity| purine nucleotide binding| purine ribonucleoside triphosphate binding| purine ribonucleotide binding| ribonucleoside binding| ribonucleotide binding| shikimate kinase activity| sulfotransferase activity| transferase activity, transferring sulfur-containing groups| tubulin binding 3'-phosphoadenosine 5'-phosphosulfate metabolic process| DNA recombination| GTP catabolic process| GTP metabolic process| Golgi to plasma membrane protein transport| Golgi to plasma membrane transport| Golgi vesicle transport| activation of phospholipase D activity| adhesion to other organism involved in symbiotic interaction| adhesion to symbiont| apical junction assembly| asexual reproduction| asymmetric neuroblast division| cell division| cell growth mode switching, budding to filamentous| cell projection assembly| cell-cell junction organization| cellular component assembly involved in morphogenesis| cellular component maintenance| cellular membrane organization| cellular monovalent inorganic cation homeostasis| cellular pigmentation| cellular process involved in reproduction| cellularization| cilium morphogenesis| cilium organization| coenzyme A biosynthetic process| cortical actin cytoskeleton organization| cortical cytoskeleton organization| cytokinesis| cytokinin biosynthetic process| dTDP metabolic process| deoxyribonucleoside monophosphate biosynthetic process| deoxyribose phosphate biosynthetic process| detection of light stimulus involved in sensory perception| detection of light stimulus involved in visual perception| dorsal closure| dorsal closure, amnioserosa morphology change| double-strand break repair| double-strand break repair via homologous recombination| endocytic recycling| endosomal transport| establishment of Sertoli cell barrier| establishment or maintenance of apical/basal cell polarity| establishment or maintenance of cell polarity| estrogen metabolic process| eye pigment precursor transport| glycosyl compound catabolic process| guanosine-containing compound catabolic process| guanosine-containing compound metabolic process| hyphal growth| initiation of dorsal closure| iron-sulfur cluster assembly| meiosis I| monovalent inorganic cation homeostasis| morphogenesis of a polarized epithelium| nucleoside catabolic process| nucleoside diphosphate biosynthetic process| nucleoside diphosphate phosphorylation| nucleoside phosphate catabolic process| nucleoside triphosphate catabolic process| nucleoside triphosphate metabolic process| nucleotide catabolic process| nucleotide phosphorylation| ocellus pigment biosynthetic process| ocellus pigment metabolic process| ommochrome biosynthetic process| organelle assembly| organophosphate catabolic process| peptidyl-cysteine methylation| phagolysosome assembly| phagosome maturation| pigment granule transport| positive regulation of calcium ion import| positive regulation of transcription from RNA polymerase I promoter| protein ADP-ribosylation| protein kinase A signaling cascade| protein localization to Golgi apparatus| purine nucleoside catabolic process| purine nucleoside triphosphate catabolic process| purine nucleotide catabolic process| purine ribonucleoside catabolic process| purine ribonucleoside triphosphate catabolic process| purine ribonucleotide catabolic process| purine-containing compound catabolic process| pyrimidine-containing compound biosynthetic process| reciprocal meiotic recombination| recombinational repair| regulation of cell shape| regulation of cellular pH| regulation of exocyst localization| regulation of exocytosis| regulation of intracellular pH| regulation of lipase activity| regulation of mitochondrial translation| regulation of pH| regulation of receptor internalization| regulation of vacuole organization| regulation of vesicle-mediated transport| response to electrical stimulus| retrograde transport, endosome to Golgi| ribonucleoside catabolic process| ribonucleoside triphosphate catabolic process| ribonucleotide catabolic process| shikimate metabolic process| small GTPase mediated signal transduction| strand invasion| sulfate assimilation| sulfation
400 PF11329 Protein of unknown function (DUF3131) No Pfam Clan 249 (24) 367 367 (1) Six-hairpin glycosidases [a.102.1] (1-364)
(1) alpha/alpha toroid [a.102]
NO PREDICTION a.102.1(1-364) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea 2.4.1.20| 2.4.1.8| 3.2.1.132| 3.2.1.156| 3.2.1.28| 3.2.1.3| 3.2.1.4| 3.2.1.40| 3.2.1.63| 3.2.1.70| 3.2.1.8| 3.2.1.91| 5.1.3.8| 5.3.1.8 brush border N-acylglucosamine 2-epimerase activity| cellulase activity| hydrolase activity, hydrolyzing O-glycosyl compounds| racemase and epimerase activity| racemase and epimerase activity, acting on carbohydrates and derivatives cell wall organization or biogenesis| cellular carbohydrate catabolic process| cellular polysaccharide metabolic process| oligosaccharide catabolic process| oligosaccharide metabolic process| polysaccharide metabolic process
401 PF11853 Protein of unknown function (DUF3373) No Pfam Clan 144 (18) 489 575 (1) Porins [f.4.3] (60-488)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION f.4.3(60-488) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information cell envelope| cell outer membrane| external encapsulating structure part| outer membrane amide transmembrane transporter activity| macromolecule transmembrane transporter activity| porin activity| wide pore channel activity fatty acid transport| lipid localization| long-chain fatty acid transport
402 PF09910 Uncharacterized protein conserved in archaea (DUF2139) No Pfam Clan 35 (6) 339 336 (1) 3-carboxy-cis,cis-mucoante lactonizing enzyme [b.69.10] (37-259)
(1) 7-bladed beta-propeller [b.69]
NO PREDICTION NO PREDICTION b.69.10(37-259) NO PREDICTION NO PREDICTION 1 No information Archaea 5.5.1.5 No information No information No information
403 PF09973 Predicted membrane protein (DUF2208) No Pfam Clan 43 (13) 233 238 (1) ABC transporter transmembrane region [f.37.1] (1-151)
(1) ABC transporter transmembrane region [f.37]
NO PREDICTION f.37.1(1-151) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Archaea No information No information No information No information
404 PF14858 Domain of unknown function (DUF4486) No Pfam Clan 92 (5) 542 547 (1) ARM repeat [a.118.1] (1-504)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(1-504) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
405 PF12983 Protein of unknown function (DUF3867) No Pfam Clan 47 (10) 186 186 (1) (Trans)glycosidases [c.1.8] (3-182)
(1) TIM beta/alpha-barrel [c.1]
c.1.8(3-182) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria 2.4.1.18| 2.4.1.19| 2.4.1.25| 2.4.1.4| 2.4.1.5| 2.4.1.7| 2.7.1.31| 2.7.7.43| 3.1.3.16| 3.1.3.18| 3.1.3.2| 3.1.3.23| 3.1.3.24| 3.1.3.29| 3.1.3.3| 3.1.3.41| 3.1.3.45| 3.1.3.48| 3.1.3.5| 3.1.3.70| 3.1.3.71| 3.1.3.74| 3.1.8.2| 3.11.1.1| 3.2.1.1| 3.2.1.10| 3.2.1.105| 3.2.1.123| 3.2.1.133| 3.2.1.135| 3.2.1.136| 3.2.1.139| 3.2.1.14| 3.2.1.141| 3.2.1.147| 3.2.1.151| 3.2.1.165| 3.2.1.17| 3.2.1.2| 3.2.1.20| 3.2.1.21| 3.2.1.22| 3.2.1.23| 3.2.1.25| 3.2.1.31| 3.2.1.32| 3.2.1.35| 3.2.1.37| 3.2.1.39| 3.2.1.4| 3.2.1.41| 3.2.1.45| 3.2.1.48| 3.2.1.49| 3.2.1.51| 3.2.1.52| 3.2.1.54| 3.2.1.55| 3.2.1.58| 3.2.1.60| 3.2.1.68| 3.2.1.70| 3.2.1.73| 3.2.1.78| 3.2.1.8| 3.2.1.85| 3.2.1.86| 3.2.1.89| 3.2.1.96| 3.2.1.98| 3.6.1.1| 3.6.3.10| 3.6.3.4| 3.6.3.6| 3.6.3.8| 3.6.3.9| 3.8.1.2| 4.2.2.13| 5.4.2.6| 5.4.2.8| 5.4.99.11| 5.4.99.15 anchored to membrane| anchored to plasma membrane| cell wall| fungal-type cell wall| hyaluranon cable| lysosome beta-mannosidase activity| galactosidase activity| glucanosyltransferase activity| hyaluronan synthase activity| hydrolase activity, hydrolyzing O-glycosyl compounds| transferase activity, transferring glycosyl groups| virus receptor activity aminoglycan biosynthetic process| aminoglycan catabolic process| aminoglycan metabolic process| autolysis| cartilage development| cell wall beta-glucan metabolic process| cell wall macromolecule catabolic process| cell wall macromolecule metabolic process| cell wall organization or biogenesis| cellular carbohydrate catabolic process| cellular polysaccharide catabolic process| cellular polysaccharide metabolic process| cellular response to UV| cellular response to UV-B| cellular response to abiotic stimulus| cellular response to cytokine stimulus| cellular response to growth factor stimulus| cellular response to interleukin-1| cellular response to light stimulus| cellular response to pH| cellular response to platelet-derived growth factor stimulus| cellular response to radiation| ceramide catabolic process| ceramide metabolic process| connective tissue development| cytolysis| diaphragm contraction| external encapsulating structure organization| glucosamine-containing compound catabolic process| glucosamine-containing compound metabolic process| glycosaminoglycan catabolic process| glycosphingolipid catabolic process| glycosylceramide catabolic process| glycosylceramide metabolic process| hyaluronan biosynthetic process| hyaluronan catabolic process| hyaluronan metabolic process| inflammatory response| involuntary skeletal muscle contraction| lysosome organization| mannan metabolic process| membrane lipid catabolic process| multicellular organismal movement| negative regulation of cell growth| negative regulation of growth| neuromuscular process controlling balance| neuromuscular process controlling posture| peptidoglycan turnover| polysaccharide catabolic process| polysaccharide metabolic process| positive regulation of angiogenesis| positive regulation of cell adhesion| positive regulation of cell growth| positive regulation of epithelial cell migration| positive regulation of epithelial cell proliferation| positive regulation of hyaluranon cable assembly| regulation of angiogenesis| regulation of cell growth| regulation of cell migration| regulation of cell motility| regulation of cellular component movement| regulation of epithelial cell migration| regulation of hyaluranon cable assembly| regulation of locomotion| regulation of vasculature development| respiratory gaseous exchange| respiratory system process| response to UV| response to UV-B| response to antibiotic| response to cytokine stimulus| response to growth factor stimulus| response to interleukin-1| response to pH| response to platelet-derived growth factor stimulus| response to reactive oxygen species| response to toxic substance| response to virus| single-species biofilm formation| skeletal muscle contraction| skeletal system development| sphingolipid catabolic process| vacuole organization
406 PF07301 Protein of unknown function (DUF1453) No Pfam Clan 613 (20) 148 149 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-145)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(1-145) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information No information No information No information
407 PF09874 Predicted membrane protein (DUF2101) No Pfam Clan 26 (5) 206 206 (1) MFS general substrate transporter [f.38.1] (17-141)
(1) MFS general substrate transporter [f.38]
NO PREDICTION NO PREDICTION f.38.1(17-141) NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
408 PF11489 Protein of unknown function (DUF3210) No Pfam Clan 113 (15) 711 781 (1) ssDNA viruses [b.121.5] (175-633)
(1) Nucleoplasmin-like/VP (viral coat and capsid proteins) [b.121]
NO PREDICTION NO PREDICTION NO PREDICTION b.121.5(175-633) NO PREDICTION 1 No information Eukaryota No information No information No information No information
409 PF12239 Protein of unknown function (DUF3605) No Pfam Clan 242 (21) 159 129 (1) HIT-like [d.13.1] (21-158)
(1) HIT-like [d.13]
NO PREDICTION d.13.1(21-158) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Viruses 2.7.7.12| 3.6.1.26| 3.6.1.29 histone deacetylase complex hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides| nucleotide diphosphatase activity apoptotic process| apoptotic signaling pathway| intrinsic apoptotic signaling pathway| intrinsic apoptotic signaling pathway by p53 class mediator| signal transduction by p53 class mediator
410 PF09847 Predicted permease (DUF2074) No Pfam Clan 50 (10) 449 448 (1) MFS general substrate transporter [f.38.1] (1-448)
(1) MFS general substrate transporter [f.38]
NO PREDICTION f.38.1(1-448) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information acrosomal membrane| brush border| brush border membrane| clathrin-coated vesicle| coated vesicle| cytoplasmic vesicle membrane| cytoplasmic vesicle part| female pronucleus| insulin-responsive compartment| intrinsic to organelle membrane| intrinsic to plasma membrane| pronucleus| synapse part| vacuolar membrane| vacuolar part| vesicle membrane calcium-dependent protein binding| carbohydrate derivative transporter activity| carbohydrate transmembrane transporter activity| carbohydrate transporter activity| drug transmembrane transporter activity| drug transporter activity| glucose binding| monocarboxylic acid transmembrane transporter activity| salt transmembrane transporter activity| secondary active transmembrane transporter activity| sodium ion transmembrane transporter activity| sodium:phosphate symporter activity| solute:cation symporter activity| sugar transmembrane transporter activity| toxin transporter activity| urate transmembrane transporter activity| voltage-gated anion channel activity amyloid precursor protein catabolic process| amyloid precursor protein metabolic process| arginine transport| autophagic vacuole fusion| carbohydrate derivative transport| carbohydrate transport| disaccharide transport| drug transmembrane transport| drug transport| folic acid transport| galactolipid metabolic process| galactosylceramide metabolic process| globoside metabolic process| glucosylceramide metabolic process| glycosylceramide metabolic process| hexose phosphate transport| lactate transmembrane transport| lactate transport| lysosomal lumen acidification| lysosomal lumen pH elevation| lysosome organization| negative regulation of autophagy| negative regulation of macroautophagy| negative regulation of response to extracellular stimulus| negative regulation of response to nutrient levels| neurotransmitter metabolic process| organelle membrane fusion| organic acid transport| organic anion transport| organic hydroxy compound transport| phosphate ion transport| pyruvate transmembrane transport| regulation of lysosomal lumen pH| regulation of macroautophagy| regulation of neurotransmitter levels| regulation of pH| response to drug| response to nematode| sphingomyelin metabolic process| toxin transport| urate metabolic process| urate transport| vitamin transport
411 PF05553 Cotton fibre expressed protein No Pfam Clan 622 (85) 38 38 (1) WD40 repeat-like [b.69.4] (2-30)
(1) 7-bladed beta-propeller [b.69]
b.69.4(2-30) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information Arp2/3 protein complex| CIA complex| Cdc73/Paf1 complex| Cul4-RING ubiquitin ligase complex| ER to Golgi transport vesicle| SMN complex| SMN-Sm protein complex| Ski complex| THO complex| TORC1 complex| chromosome, centromeric region| cullin-RING ubiquitin ligase complex| eukaryotic translation initiation factor 3 complex| extrinsic to internal side of plasma membrane| extrinsic to membrane| extrinsic to plasma membrane| female germ cell nucleus| germ cell nucleus| heterotrimeric G-protein complex| histone methyltransferase complex| immunological synapse| internal side of plasma membrane| kinetochore| methylosome| methyltransferase complex| nuclear envelope| nuclear pore| nuclear pore outer ring| pore complex| transcription export complex| transcriptionally active chromatin| ubiquitin ligase complex G-protein gamma-subunit binding| histone binding| peroxisome targeting sequence binding| phosphatidylinositol binding| phosphatidylinositol-3,5-bisphosphate binding| phosphatidylinositol-3-phosphate binding| phosphatidylinositol-5-phosphate binding| signal sequence binding| translation initiation factor activity RNA splicing, via transesterification reactions with bulged adenosine as nucleophile| T cell homeostasis| TOR signaling cascade| attachment of spindle microtubules to kinetochore| attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation| autophagy| cellular response to starvation| chromosome segregation| embryonic digit morphogenesis| establishment of RNA localization| establishment of chromosome localization| establishment of organelle localization| fruiting body development| histone H3-K4 methylation| histone methylation| histone modification| iron-sulfur cluster assembly| mRNA export from nucleus| membrane disassembly| metallo-sulfur cluster assembly| metaphase plate congression| methylation| microtubule-based process| mitotic metaphase plate congression| mitotic spindle assembly checkpoint| negative regulation of calcium ion transmembrane transporter activity| negative regulation of cation channel activity| negative regulation of cell cycle process| negative regulation of ion transmembrane transporter activity| negative regulation of transporter activity| negative regulation of voltage-gated calcium channel activity| nuclear envelope disassembly| nuclear pore organization| nucleic acid transport| nucleobase-containing compound transport| peptidyl-lysine modification| peptidyl-lysine trimethylation| peroxisomal transport| positive regulation of DNA-dependent transcription, elongation| positive regulation of histone H3-K79 methylation| positive regulation of histone methylation| positive regulation of histone modification| positive regulation of organelle organization| positive regulation of transcription elongation from RNA polymerase II promoter| protein alkylation| protein import| protein targeting| regulation of cell cycle process| regulation of histone H3-K79 methylation| regulation of histone methylation| regulation of histone modification| regulation of metaphase/anaphase transition of cell cycle| regulation of mitotic metaphase/anaphase transition| regulation of reproductive process| regulation of transcription elongation from RNA polymerase II promoter| regulation of voltage-gated calcium channel activity| response to starvation| spindle assembly checkpoint| spindle checkpoint| uropod organization
412 PF15023 Protein of unknown function (DUF4523) No Pfam Clan 34 (4) 166 166 (1) RNA-binding domain, RBD [d.58.7] (96-148)
(1) Ferredoxin-like [d.58]
NO PREDICTION NO PREDICTION d.58.7(96-148) NO PREDICTION NO PREDICTION 1 No information Eukaryota No information RNA cap binding complex| nuclear body| spliceosomal complex No information RNA export from nucleus| RNA localization| RNA splicing| establishment of RNA localization| gamete generation| mRNA metabolic process| mRNA processing| nuclear export| nuclear transport| nucleic acid transport| nucleobase-containing compound transport| nucleocytoplasmic transport| positive regulation of RNA export from nucleus| positive regulation of intracellular transport| positive regulation of nucleobase-containing compound transport| posttranscriptional regulation of gene expression| regulation of RNA export from nucleus| regulation of nucleobase-containing compound transport| regulation of translation| response to cold| snRNA export from nucleus| snRNA transport
413 PF13664 Domain of unknown function (DUF4149) CopD_like (CL0430) 975 (178) 101 100 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-100)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(1-100) NO PREDICTION NO PREDICTION NO PREDICTION 1 YES Eukaryota|Bacteria|Archaea No information No information No information No information
414 PF12427 Branched-chain amino acid aminotransferase No Pfam Clan 14 (3) 23 35 (1) D-aminoacid aminotransferase-like PLP-dependent enzymes [e.17.1] (1-23)
(1) D-aminoacid aminotransferase-like PLP-dependent enzymes [e.17]
e.17.1(1-23) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria 2.6.1.21| 2.6.1.42| 4.1.3.38 No information D-alanine:2-oxoglutarate aminotransferase activity| branched-chain-amino-acid transaminase activity| cofactor binding| pyridoxal phosphate binding| transaminase activity| transferase activity, transferring nitrogenous groups D-amino acid biosynthetic process| D-amino acid catabolic process| D-amino acid metabolic process| branched-chain amino acid biosynthetic process| branched-chain amino acid catabolic process| branched-chain amino acid metabolic process| cellular amino acid catabolic process| isoleucine metabolic process| toxin metabolic process
415 PF12038 Domain of unknown function (DUF3524) No Pfam Clan 155 (31) 168 172 (1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87.1] (19-140)
(1) UDP-Glycosyltransferase/glycogen phosphorylase [c.87]
NO PREDICTION NO PREDICTION c.87.1(19-140) NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Viruses 2.4.1.1| 2.4.1.11| 2.4.1.115| 2.4.1.14| 2.4.1.141| 2.4.1.15| 2.4.1.152| 2.4.1.17| 2.4.1.21| 2.4.1.218| 2.4.1.227| 2.4.1.27| 2.4.1.57| 2.4.99.4| 2.7.8.12| 5.1.3.14 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) UDP-N-acetylglucosamine 2-epimerase activity| UDP-glycosyltransferase activity| carboxylic acid binding| isoprenoid binding| monocarboxylic acid binding| retinoic acid binding| retinoid binding| transferase activity, transferring glycosyl groups| transferase activity, transferring hexosyl groups L-fucose catabolic process| L-fucose metabolic process| N-acetylneuraminate metabolic process| anthocyanin-containing compound biosynthetic process| anthocyanin-containing compound metabolic process| cellular carbohydrate biosynthetic process| cellular hormone metabolic process| cellular oligosaccharide metabolic process| cellular polysaccharide biosynthetic process| cellular polysaccharide metabolic process| cellular response to alcohol| cellular response to corticosteroid stimulus| cellular response to ethanol| cellular response to glucocorticoid stimulus| cellular response to heat| cellular response to steroid hormone stimulus| cellular response to xenobiotic stimulus| coumarin metabolic process| disaccharide biosynthetic process| dolichol-linked oligosaccharide biosynthetic process| drug metabolic process| flavone metabolic process| flavonoid biosynthetic process| flavonoid metabolic process| fucose catabolic process| fucose metabolic process| fucosylation| glucuronate metabolic process| glycogen biosynthetic process| glycolipid biosynthetic process| glycolipid metabolic process| glycoprotein metabolic process| glycoside biosynthetic process| glycoside metabolic process| hormone metabolic process| lipopolysaccharide biosynthetic process| lipopolysaccharide metabolic process| lipoprotein metabolic process| macromolecule glycosylation| membrane lipid biosynthetic process| membrane lipid metabolic process| oligosaccharide biosynthetic process| oligosaccharide metabolic process| oligosaccharide-lipid intermediate biosynthetic process| peptidyl-asparagine modification| phenylpropanoid metabolic process| pigment metabolic process| polysaccharide biosynthetic process| polysaccharide metabolic process| post-translational protein modification| protein glycosylation| protein lipidation| regulation of hormone levels| response to cyclopentenone| response to decreased oxygen levels| response to hypoxia| response to xenobiotic stimulus| retinoid metabolic process| terpenoid metabolic process| toxin catabolic process| trehalose metabolic process| uronic acid metabolic process| xenobiotic glucuronidation| xenobiotic metabolic process
416 PF08217 Fungal domain of unknown function (DUF1712) No Pfam Clan 421 (14) 604 646 (1) ARM repeat [a.118.1] (INDIRECT)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
417 PF12566 Protein of unknown function (DUF3748) No Pfam Clan 511 (11) 122 119 (1) DPP6 N-terminal domain-like [b.70.3] (1-122)
(1) 8-bladed beta-propeller [b.70]
b.70.3(1-122) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information No information No information No information
418 PF12341 Protein of unknown function (DUF3639) No Pfam Clan 247 (35) 27 27 (1) DPP6 N-terminal domain-like [b.70.3] (1-27)
(1) 8-bladed beta-propeller [b.70]
b.70.3(1-27) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information No information No information
419 PF09427 Domain of unknown function (DUF2014) No Pfam Clan 72 (8) 261 264 (1) ARM repeat [a.118.1] (3-258)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(3-258) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
420 PF12525 Protein of unknown function (DUF3726) No Pfam Clan 82 (34) 80 60 (1) L-sulfolactate dehydrogenase-like [c.122.1] (1-52)
(1) L-sulfolactate dehydrogenase-like [c.122]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION c.122.1(1-52) 1 No information Eukaryota|Bacteria 1.1.1.130| 1.1.1.154| 1.1.1.27| 1.1.1.272| 1.1.1.37 No information No information No information
421 PF07793 Protein of unknown function (DUF1631) No Pfam Clan 372 (36) 730 738 (1) ARM repeat [a.118.1] (8-729)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(8-729) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Viruses No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
422 PF11824 Protein of unknown function (DUF3344) No Pfam Clan 118 (42) 271 267 (1) Quinoprotein alcohol dehydrogenase-like [b.70.1] (3-254)
(1) 8-bladed beta-propeller [b.70]
b.70.1(3-254) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea 1.1.2.7| 1.1.98.1 No information endonuclease activity| endoribonuclease activity| nuclease activity| ribonuclease activity ER-nucleus signaling pathway| RNA phosphodiester bond hydrolysis| RNA phosphodiester bond hydrolysis, endonucleolytic| cellular response to topologically incorrect protein| cellular response to unfolded protein| cilium assembly| cilium organization| intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress| response to endoplasmic reticulum stress| response to topologically incorrect protein| response to unfolded protein
423 PF12531 DNA-K related protein No Pfam Clan 220 (38) 249 249 (1) ARM repeat [a.118.1] (25-243)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(25-243) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
424 PF11846 Domain of unknown function (DUF3366) No Pfam Clan 415 (29) 193 203 (1) TPR-like [a.118.8] (46-183)
(1) alpha-alpha superhelix [a.118]
a.118.8(46-183) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
425 PF07248 Protein of unknown function (DUF1431) No Pfam Clan 156 (17) 161 163 (1) Growth factor receptor domain [g.3.9] (31-155)
(1) Knottins (small inhibitors, toxins, lectins) [g.3]
NO PREDICTION g.3.9(31-155) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information No information No information cell migration| cell motility| enzyme linked receptor protein signaling pathway| localization of cell| transmembrane receptor protein tyrosine kinase signaling pathway
426 PF10309 Protein of unknown function (DUF2414) No Pfam Clan 181 (19) 62 90 (1) RNA-binding domain, RBD [d.58.7] (61-88)
(1) Ferredoxin-like [d.58]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION d.58.7(61-88) 1 No information Eukaryota No information RNA cap binding complex| nuclear body| spliceosomal complex No information RNA export from nucleus| RNA localization| RNA splicing| establishment of RNA localization| gamete generation| mRNA metabolic process| mRNA processing| nuclear export| nuclear transport| nucleic acid transport| nucleobase-containing compound transport| nucleocytoplasmic transport| positive regulation of RNA export from nucleus| positive regulation of intracellular transport| positive regulation of nucleobase-containing compound transport| posttranscriptional regulation of gene expression| regulation of RNA export from nucleus| regulation of nucleobase-containing compound transport| regulation of translation| response to cold| snRNA export from nucleus| snRNA transport
427 PF11331 Protein of unknown function (DUF3133) No Pfam Clan 112 (13) 46 46 (1) L domain-like [c.10.2] (11-44)
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10]
c.10.2(11-44) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria No information U2 snRNP 3'-5' exonuclease activity| 3'-5'-exoribonuclease activity| exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomon| exoribonuclease activity| exoribonuclease activity, producing 5'-phosphomonoesters| phosphatase inhibitor activity| phosphatase regulator activity| poly(A)-specific ribonuclease activity B cell activation| B cell proliferation| B cell proliferation involved in immune response| RNA phosphodiester bond hydrolysis, exonucleolytic| biological adhesion| nuclear transport| nuclear-transcribed mRNA catabolic process| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay| nucleocytoplasmic transport| post-embryonic morphogenesis| post-embryonic organ development| regulation of JNK cascade| regulation of axonogenesis| regulation of cell size| regulation of extent of cell growth
428 PF13036 Protein of unknown function (DUF3897) TolB_N (CL0342) 1082 (74) 180 195 (1) TolB, N-terminal domain [c.51.2] (61-179)
(1) Anticodon-binding domain-like [c.51]
NO PREDICTION c.51.2(61-179) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information No information No information No information
429 PF10704 Protein of unknown function (DUF2508) No Pfam Clan 434 (23) 71 70 (1) TPR-like [a.118.8] (4-67)
(1) alpha-alpha superhelix [a.118]
a.118.8(4-67) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
430 PF11166 Protein of unknown function (DUF2951) No Pfam Clan 299 (6) 98 97 (1) TPR-like [a.118.8] (5-71)
(1) alpha-alpha superhelix [a.118]
a.118.8(5-71) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Viruses No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
431 PF14234 Domain of unknown function (DUF4336) No Pfam Clan 413 (47) 285 321 (1) Metallo-hydrolase/oxidoreductase [d.157.1] (1-284)
(1) Metallo-hydrolase/oxidoreductase [d.157]
NO PREDICTION d.157.1(1-284) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 3.1.1.81| 3.1.2.6| 3.1.26.11| 3.1.4.38| 3.1.8.1| 3.5.2.6 No information hydroxyacylglutathione hydrolase activity| thiolester hydrolase activity aldehyde catabolic process| amide biosynthetic process| cellular aldehyde metabolic process| cellular modified amino acid biosynthetic process| glutathione biosynthetic process| glutathione metabolic process| lactate metabolic process| methylglyoxal metabolic process| nonribosomal peptide biosynthetic process| peptide biosynthetic process| peptide metabolic process
432 PF04780 Protein of unknown function (DUF629) No Pfam Clan 139 (14) 466 462 (1) ARM repeat [a.118.1] (8-464)
(1) alpha-alpha superhelix [a.118]
NO PREDICTION a.118.1(8-464) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information anchoring junction| beta-catenin destruction complex| cell-cell adherens junction| lateral plasma membrane| microvillus membrane| mitotic spindle| nuclear pore| pore complex| proteasome accessory complex| protein phosphatase type 2A complex| protein serine/threonine phosphatase complex| spindle pole| spindle pole body| trans-Golgi network alpha-catenin binding| cadherin binding| cell adhesion molecule binding| deoxyhypusine monooxygenase activity| nuclear localization sequence binding| phosphatase regulator activity| protein phosphatase regulator activity| protein phosphatase type 2A regulator activity| protein transporter activity| signal sequence binding RNA catabolic process| T cell differentiation in thymus| bone resorption| cell fate commitment involved in formation of primary germ layer| central nervous system vasculogenesis| cerebral cortex radial glia guided migration| cerebral cortex radially oriented cell migration| ectodermal placode development| embryonic epithelial tube formation| embryonic foregut morphogenesis| embryonic forelimb morphogenesis| embryonic hindlimb morphogenesis| endoderm formation| endodermal cell differentiation| epithelial cell morphogenesis| epithelial tube formation| establishment of blood-brain barrier| establishment of endothelial barrier| establishment of endothelial blood-brain barrier| establishment of organelle localization| establishment or maintenance of cell polarity| eye morphogenesis| foregut morphogenesis| forelimb morphogenesis| fungiform papilla development| fungiform papilla formation| fungiform papilla morphogenesis| genitalia morphogenesis| glial cell fate commitment| hair follicle placode formation| hypusine metabolic process| intracellular protein transport| layer formation in cerebral cortex| lung cell differentiation| lung induction| lung-associated mesenchyme development| mesenchymal cell proliferation involved in lung development| metanephric nephron morphogenesis| negative regulation of chondrocyte differentiation| negative regulation of glial cell differentiation| negative regulation of gliogenesis| negative regulation of microtubule depolymerization| negative regulation of oligodendrocyte differentiation| neural plate development| neuroblast proliferation| nuclear import| nuclear transport| organ induction| oviduct development| peptidyl-lysine modification| peptidyl-lysine modification to hypusine| peptidyl-serine dephosphorylation| positive regulation of branching involved in lung morphogenesis| positive regulation of determination of dorsal identity| positive regulation of endothelial cell differentiation| positive regulation of epithelial cell proliferation involved in prostate gland development| positive regulation of extrinsic apoptotic signaling pathway| positive regulation of extrinsic apoptotic signaling pathway in absence of ligand| positive regulation of fibroblast growth factor receptor signaling pathway| positive regulation of neural precursor cell proliferation| positive regulation of neuroblast proliferation| positive regulation of reproductive process| protein import| protein import into nucleus| protein localization to nucleus| protein targeting| protein targeting to nucleus| proximal/distal pattern formation| regulation of branching involved in lung morphogenesis| regulation of cardioblast proliferation| regulation of cell proliferation involved in heart morphogenesis| regulation of determination of dorsal identity| regulation of endothelial cell differentiation| regulation of epithelial cell proliferation involved in prostate gland development| regulation of extrinsic apoptotic signaling pathway in absence of ligand| regulation of heart morphogenesis| regulation of intracellular protein transport| regulation of microtubule depolymerization| regulation of neural precursor cell proliferation| regulation of nucleocytoplasmic transport| regulation of oligodendrocyte differentiation| regulation of protein localization to nucleus| renal inner medulla development| renal outer medulla development| renal vesicle development| renal vesicle formation| renal vesicle morphogenesis| stem cell proliferation| thymus development| tongue morphogenesis| trachea formation| trachea morphogenesis| tube formation
433 PF12259 Protein of unknown function (DUF3609) No Pfam Clan 125 (7) 361 353 (1) Head and neck region of the ectodomain of NDV fusion glycoprotein [f.12.1] (1-243)
(1) Head and neck region of the ectodomain of NDV fusion glycoprotein [f.12]
NO PREDICTION f.12.1(1-243) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Viruses No information No information No information No information
434 PF12640 UPF0489 domain Arginase (CL0302) 190 (34) 162 160 (1) Arginase/deacetylase [c.42.1] (1-161)
(1) Arginase/deacetylase [c.42]
NO PREDICTION c.42.1(1-161) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea 3.5.1.98| 3.5.3.1| 3.5.3.11| 3.5.3.22| 3.5.3.8 histone deacetylase complex arginase activity| chromatin DNA binding| chromatin binding| deacetylase activity| histone deacetylase activity| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines| manganese ion binding| protein deacetylase activity| structure-specific DNA binding| transcription factor binding arginine metabolic process| cellular amino acid catabolic process| chromatin modification| chromosome organization| glutamine family amino acid catabolic process| glutamine family amino acid metabolic process| histone deacetylation| histone modification| negative regulation of transcription from RNA polymerase II promoter| nitrogen cycle metabolic process| ornithine metabolic process| polyamine metabolic process| protein deacetylation| protein deacylation| urea metabolic process
435 PF03382 Mycoplasma protein of unknown function, DUF285 LRR (CL0022) 2904 (147) 120 123 (1) RNI-like [c.10.1] (1-113)
(1) Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) [c.10]
c.10.1(1-113) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Viruses|Archaea No information ubiquitin ligase complex acid-amino acid ligase activity| small conjugating protein ligase activity| ubiquitin-protein ligase activity cellular protein catabolic process| entrainment of circadian clock| entrainment of circadian clock by photoperiod| modification-dependent macromolecule catabolic process| photoperiodism| protein catabolic process| protein ubiquitination| proteolysis| regulation of circadian rhythm| ubiquitin-dependent protein catabolic process
436 PF13355 Protein of unknown function (DUF4101) No Pfam Clan 153 (63) 117 115 (1) NTF2-like [d.17.4] (1-116)
(1) Cystatin-like [d.17]
NO PREDICTION d.17.4(1-116) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 3.3.2.8| 4.2.1.94| 5.3.3.1 T-tubule| axon initial segment| axon part| cell-cell contact zone| main axon| neuromuscular junction| nuclear envelope| pore complex| sarcolemma Ran GTPase binding G1/S transition of mitotic cell cycle| RNA export from nucleus| RNA localization| antibiotic biosynthetic process| antibiotic metabolic process| blood circulation| calcium ion transport| cardiac muscle contraction| cell cycle phase| cell cycle phase transition| drug metabolic process| establishment of RNA localization| heart contraction| heart process| interphase| interphase of mitotic cell cycle| mitotic cell cycle phase transition| muscle contraction| muscle system process| nuclear transport| nucleobase-containing compound transport| nucleocytoplasmic transport| peptidyl-serine phosphorylation| poly(A)+ mRNA export from nucleus| positive regulation of antimicrobial peptide biosynthetic process| positive regulation of cellular amide metabolic process| protein autophosphorylation| regulation of antimicrobial humoral response| regulation of antimicrobial peptide biosynthetic process| regulation of antimicrobial peptide production| regulation of cellular amide metabolic process| regulation of humoral immune response| regulation of production of molecular mediator of immune response| regulation of sodium ion transport| striated muscle contraction
437 PF07187 Protein of unknown function (DUF1405) No Pfam Clan 478 (31) 164 163 (1) Multidrug efflux transporter AcrB transmembrane domain [f.35.1] (1-163)
(1) Multidrug efflux transporter AcrB transmembrane domain [f.35]
NO PREDICTION f.35.1(1-163) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Bacteria|Archaea No information No information No information No information
438 PF11889 Domain of unknown function (DUF3409) No Pfam Clan 239 (8) 56 56 (1) Ubiquitin-like [d.15.1] (2-39)
(1) beta-Grasp (ubiquitin-like) [d.15]
d.15.1(2-39) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Viruses 3.1.2.15| 3.1.4.11 autophagic vacuole| nuclear body SUMO ligase activity| non-membrane spanning protein tyrosine phosphatase activity| phosphoprotein phosphatase activity| protein tag| protein tyrosine phosphatase activity| small conjugating protein ligase activity| small conjugating protein ligase binding autophagy| catechol-containing compound metabolic process| catecholamine metabolic process| catecholamine transport| catecholamine uptake| catecholamine uptake involved in synaptic transmission| dopamine metabolic process| dopamine transport| dopamine uptake| dopamine uptake involved in synaptic transmission| monoamine transport| neurotransmitter uptake| norepinephrine metabolic process| peptidyl-tyrosine dephosphorylation| positive regulation of protein ubiquitination| positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc| protein modification by small protein conjugation or removal| protein sumoylation| proteolysis involved in cellular protein catabolic process| regulation of neurotransmitter secretion| regulation of neurotransmitter transport| regulation of protein catabolic process| regulation of protein ubiquitination| regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process| regulation of proteolysis| response to transforming growth factor beta stimulus| startle response| synaptic transmission, dopaminergic| synaptic transmission, glutamatergic
439 PF07786 Protein of unknown function (DUF1624) Acyl_transf_3 (CL0316) 1276 (49) 223 227 (1) Transmembrane di-heme cytochromes [f.21.1] (INDIRECT)
(2) Fumarate reductase respiratory complex transmembrane subunits [f.21.2] (INDIRECT)
(1) Heme-binding four-helical bundle [f.21]
NO PREDICTION f.21.1(INDIRECT)| f.21.2(INDIRECT) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea 1.10.2.2| 1.3.5.1 fumarate reductase complex| mitochondrial respiratory chain| mitochondrial respiratory chain complex II| plasma membrane respiratory chain| plasma membrane respiratory chain complex II| respiratory chain| respiratory chain complex II| succinate dehydrogenase complex cofactor binding| electron carrier activity| heme binding| oxidoreductase activity, acting on the CH-CH group of donors| quinone binding| succinate dehydrogenase activity| tetrapyrrole binding| ubiquinone binding cellular respiration| electron transport chain| energy derivation by oxidation of organic compounds| mitochondrial ATP synthesis coupled electron transport| mitochondrial electron transport, succinate to ubiquinone| oxidative phosphorylation| tricarboxylic acid cycle
440 PF13293 Domain of unknown function (DUF4074) No Pfam Clan 230 (14) 64 76 (1) TPR-like [a.118.8] (19-75)
(1) alpha-alpha superhelix [a.118]
a.118.8(19-75) NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota No information COPI-coated vesicle| ER membrane protein complex| Golgi-associated vesicle| SNARE complex| axoneme| axoneme part| integral to mitochondrial outer membrane| integral to organelle membrane| intraflagellar transport particle| intraflagellar transport particle B| intrinsic to organelle membrane| microtubule basal body| mitochondrial outer membrane| mitochondrial outer membrane translocase complex| organelle outer membrane| outer membrane heat shock protein binding| macromolecule transmembrane transporter activity| soluble NSF attachment protein activity SNARE complex disassembly| cell projection organization| cytoskeleton-dependent intracellular transport| intra-Golgi vesicle-mediated transport| negative regulation of cell morphogenesis involved in differentiation| negative regulation of neuron differentiation| organelle fission| peroxisome fission| peroxisome organization| pilus organization| positive regulation of mitochondrial fission| positive regulation of organelle organization| protein O-linked glycosylation| protein folding| regulation of mitochondrial fission
441 PF12315 Protein of unknown function (DUF3633) Peptidase_MA (CL0126) 151 (17) 212 212 (1) Metalloproteases ("zincins"), catalytic domain [d.92.1] (15-211)
(1) Zincin-like [d.92]
NO PREDICTION d.92.1(15-211) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria 3.3.2.6| 3.4.11.2| 3.4.15.1| 3.4.15.5| 3.4.17.19| 3.4.17.23| 3.4.24.11| 3.4.24.15| 3.4.24.16| 3.4.24.17| 3.4.24.19| 3.4.24.20| 3.4.24.21| 3.4.24.22| 3.4.24.23| 3.4.24.24| 3.4.24.25| 3.4.24.26| 3.4.24.27| 3.4.24.28| 3.4.24.29| 3.4.24.34| 3.4.24.35| 3.4.24.36| 3.4.24.39| 3.4.24.40| 3.4.24.42| 3.4.24.44| 3.4.24.46| 3.4.24.49| 3.4.24.53| 3.4.24.58| 3.4.24.65| 3.4.24.66| 3.4.24.68| 3.4.24.69| 3.4.24.7| 3.4.24.71| 3.4.24.74| 3.4.24.77| 3.4.24.80| 3.4.24.82| 3.4.24.83| 3.4.24.86 cortical granule glutamic-type peptidase activity| metalloendopeptidase activity| metallopeptidase activity| peptidase activity biological adhesion| cell adhesion| egg activation| fertilization| negative regulation of binding of sperm to zona pellucida| negative regulation of fertilization| negative regulation of reproductive process| positive regulation of protein processing| prevention of polyspermy| proteolysis| regulation of binding of sperm to zona pellucida| regulation of protein processing
442 PF05335 Protein of unknown function (DUF745) No Pfam Clan 190 (14) 188 187 (1) MW0975(SA0943)-like [a.24.27] (8-187)
(1) Four-helical up-and-down bundle [a.24]
NO PREDICTION a.24.27(8-187) NO PREDICTION NO PREDICTION NO PREDICTION 1 No information Eukaryota|Bacteria|Archaea No information No information No information No information
443 PF11686 Protein of unknown function (DUF3283) No Pfam Clan 120 (10) 61 61 (1) DNA polymerase III theta subunit-like [a.237.1] (1-60)
(1) DNA polymerase III theta subunit-like [a.237]
NO PREDICTION NO PREDICTION NO PREDICTION NO PREDICTION a.237.1(1-60) 1 No information Bacteria No information No information No information No information
444 PF04357 Family of unknown function (DUF490) AsmA-like (CL0401) 2461 (151) 379 385 (1) Porins [f.4.3] (INDIRECT)
(1) Transmembrane beta-barrels [f.4]
NO PREDICTION