Rv3566c

Tuberculist information
Gene namenat
Protein functionArylamine N-acetyltransferase Nat (arylamine acetylase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4007.33
Molecular mass(da)31029.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 283
	  		  	1    MALDLTAYFDRINYRGATDPTLDVLQDLVTVHSRTIPFENLDPLLGVPVDDLSPQALADK   60
			  	61   LVLRRRGGYCFEHNGLMGYVLAELGYRVRRFAARVVWKLAPDAPLPPQTHTLLGVTFPGS  120
			  	121  GGCYLVDVGFGGQTPTSPLRLETGAVQPTTHEPYRLEDRVDGFVLQAMVRDTWQTLYEFT  180
			  	181  TQTRPQIDLKVASWYASTHPASKFVTGLTAAVITDDARWNLSGRDLAVHRAGGTEKIRLA  240
			  	241  DAAAVVDTLSERFGINVADIGERGALETRIDELLARQPGADAP

Known structures in the PDB
PDB ID4BGF
Total residue count2264
Number of chains8
MethodX-RAY
Resolution2.1
1 29 57 85 113 141 169 197 225 253 281 Range: 21 to 260  |  Coverage: 84% Acetyltransf_2 Range: 3 to 274  |  Coverage: 95% 1 Range: 1 to 280  |  Coverage: 98% 1
Number of amino acids : 283
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acetyltransf_2PF0079721-260
Mtb Structural Proteome models
Model Number1
Model nameRv3566c
Template1W5R    APDBCREDO
Template coverage3_273
Template Identity(%)60.5
Model coverage(%)95.8
Normalized DOPE score-1.294

Structure Models from Chopin
Model Number1
Profiled.3.1.5
Click for model details
zscore53.72
Residue begin1
Residue end280
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3566cGene nameConfidence Score
Rv3566ARv3566A0.976
Rv3569chsaD0.916
Rv3568chsaC0.911
Rv3567chsaB0.905
Rv3570chsaA0.901
Rv3570chsaA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
coenzyme APubChem0.978767.534
Co-APubChem0.971767.534
acetyl-CoAPubChem0.97809.571
para-aminosalicylic acidPubChem0.967153.135
p-aminobenzoic acidPubChem0.964137.136
AcCoAPubChem0.955809.571
isoniazidPubChem0.943137.139
N-hydroxy-4-aminobiphenylPubChem0.938185.222
5-acetylamino-6-formylamino-3-methyluracilPubChem0.938226.189
acetyl coenzyme-APubChem0.917809.571
paraxanthinePubChem0.916180.164
acetylisoniazidPubChem0.913179.176
sulfonamidePubChem0.904172.205
2,4-diamino-6-nitrotoluenePubChem0.9167.165
N-acetoxy-4-aminobiphenylPubChem0.9227.259
hydralazinePubChem0.757160.176
anilinePubChem0.73393.1265
2-aminofluorenePubChem0.73181.233