Rv2232

Tuberculist information
Gene nameptkA
Protein functionProtein tyrosine kinase transcriptional regulatory protein PtkA
Functional category(tuberculist)regulatory proteins
Gene location(kb)2506.28
Molecular mass(da)30662.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 291
	  		  	1    VSSPRERRPASQAPRLSRRPPAHQTSRSSPDTTAPTGSGLSNRFVNDNGIVTDTTASGTN   60
			  	61   CPPPPRAAARRASSPGESPQLVIFDLDGTLTDSARGIVSSFRHALNHIGAPVPEGDLATH  120
			  	121  IVGPPMHETLRAMGLGESAEEAIVAYRADYSARGWAMNSLFDGIGPLLADLRTAGVRLAV  180
			  	181  ATSKAEPTARRILRHFGIEQHFEVIAGASTDGSRGSKVDVLAHALAQLRPLPERLVMVGD  240
			  	241  RSHDVDGAAAHGIDTVVVGWGYGRADFIDKTSTTVVTHAATIDELREALGV

Known structures in the PDB
No Known structures
1 30 59 88 117 146 175 204 233 262 291 Range: 82 to 276  |  Coverage: 66% HAD_2 Range: 77 to 278  |  Coverage: 69% 1 Range: 1 to 156  |  Coverage: 53% 1
Number of amino acids : 291
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HAD_2PF1341982-276
Mtb Structural Proteome models
Model Number1
Model nameRv2232
Template2AH5    APDBCREDO
Template coverage2_200
Template Identity(%)29.6
Model coverage(%)69.1
Normalized DOPE score-0.959

Structure Models from Chopin
Model Number1
Profilec.108.1.13
Click for model details
zscore12.17
Residue begin1
Residue end156
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2232Gene nameConfidence Score
Rv2234ptpA0.977
Rv2231ccobC0.914
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
SeMetPubChem0.796196.106
selenomethioninePubChem0.795196.106
chloridePubChem0.70835.453