SInCRe - Rv2234

Tuberculist information

Gene name	ptpA
Protein function	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)
Functional category(tuberculist)	regulatory proteins
Gene location(kb)	2507.15
Molecular mass(da)	17860
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 163

	  		  	1    VSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAG   60
			  	61   VLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTH  120
			  	121  ALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS

Known structures in the PDB

	PDB ID	1U2P
	Total residue count	163
	Number of chains	1
	Method	X-RAY
	Resolution	1.9

	PDB ID	1U2Q
	Total residue count	163
	Number of chains	1
	Method	X-RAY
	Resolution	2.5

	PDB ID	2LUO
	Total residue count	164
	Number of chains	1
	Method	NMR
	Resolution	N/A

Number of amino acids : 163

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
LMWPc	PF01451	7-150

Mtb Structural Proteome models

Model Number	1
Model name	Rv2234_1u2p_A
Template	1U2P APDB CREDO
Template coverage	4_159
Template Identity(%)	100.0
Model coverage(%)	95.1
Normalized DOPE score	-2.135

Model Number	2
Model name	Rv2234
Template	1U2P APDB CREDO
Template coverage	4_159
Template Identity(%)	100.0
Model coverage(%)	95.1
Normalized DOPE score	-1.936

Structure Models from Chopin

Model Number	1
Profile	3.40.50.270 Click for model details
zscore	29.14
Residue begin	1
Residue end	163

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2234	Gene name	Confidence Score
Rv2232	ptkA	0.977
Rv2235	Rv2235	0.977
Rv2465c	rpiB	0.939
Rv0365c	Rv0365c	0.912

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv2234_1u2p_A	2	3s23_CER_A_359 PDB CREDO	0.634	0.140	0.556	0.004

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

View results in TIBLE page

Name	Affinity	Assay description	DOI
CHEMBL1075689	Ki = 92.3 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1075731	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1075838	Ki = 54.8 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1075857	Ki = 22.7 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1075905	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1075973	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1079478	Ki = 6 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1079479	Ki = 4.9 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1079495	Ki = 65.5 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1079660	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1079661	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1079662	Ki = 84.4 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1079663	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1079845	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1079988	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1079989	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1080016	Ki = 43.1 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1080017	Ki = 33 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1080018	Ki = 24 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1080200	Ki = 44.6 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1080201	Ki = 41.8 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1080202	Ki = 34.9 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1080311	Ki = 18.2 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1080488	Ki = 10.7 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1080494	Ki = 18.5 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1080495	Ki = 16.8 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1080496	Ki = 10.3 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1080667	Ki = 11.4 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1081059	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1081060	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1081578	Ki = 3.3 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1081579	Ki = 1.4 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1081583	Ki = 75.4 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1081748	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1081935	Ki = 72.4 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1081936	Ki = 61.6 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1081937	Ki = 49.7 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1081955	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1081956	Ki = 3.1 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1082128	ND(Insoluble)	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1082129	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1082130	Ki = 68 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1096286	Inhibition = 12 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1096287	Inhibition = 18 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1098610	Inhibition = 39 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1098610	IC50 = 93 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1288972	Inhibition = 38 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1288972	IC50 = 117 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1289338	Kb = 3.41 10'4/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by fluorescence quenching assay	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289338	Kb = 3.6 10'4/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by circular dichroism spectral analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289338	Ki = 140.2 uM	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by Lineweaver-Burke plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289456	Ki = 36.3 uM	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by Lineweaver-Burke plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289456	Kb = 8.89 10'4/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by fluorescence quenching assay	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289456	Kb = 8.5 10'4/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by circular dichroism spectral analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289457	Ki = 85.5 uM	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by Lineweaver-Burke plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289457	Kb = 4.7 10'4/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by circular dichroism spectral analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289457	Kb = 4.87 10'4/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by fluorescence quenching assay	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289563	Ki = 215.4 uM	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by Lineweaver-Burke plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289563	Kb = 2.95 10'4/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by circular dichroism spectral analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289563	Kb = 2.99 10'4/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by fluorescence quenching assay	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289564	Kb = 1 10'4/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by fluorescence quenching assay	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289564	Kb = 1.1 10'4/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by circular dichroism spectral analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289564	Ki = 220.2 uM	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by Lineweaver-Burke plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289670	Kb = 1.2 10'5/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by circular dichroism spectral analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289670	Ki = 8 uM	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by Lineweaver-Burke plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289670	Kb = 1.5 10'5/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by fluorescence quenching assay	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289671	Kb = 3.3 10'4/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by circular dichroism spectral analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289671	Kb = 3.27 10'4/M	Binding affinity to Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by fluorescence quenching assay	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1289671	Ki = 199.1 uM	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase A by Lineweaver-Burke plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/21050767
CHEMBL1358982	Inhibition = 10 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL139856	Activity = 80 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL1431701	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1499057	Inhibition = 5 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL151848	Ki > 100 uM	Inhibition of Mycobacterium tuberculosis PtpA	http://www.ncbi.nlm.nih.gov/pubmed/19889539
CHEMBL1572512	Inhibition = 4 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL160111	Inhibition = 10 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1631408	Inhibition = 7 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL17200	Inhibition = 4 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1765359	IC50 = 0.9 uM	Inhibition of Mycobacterium tuberculosis ptpA	http://www.ncbi.nlm.nih.gov/pubmed/21420867
CHEMBL1765360	Ki = 1.6 uM	Inhibition of Mycobacterium tuberculosis ptpA	http://www.ncbi.nlm.nih.gov/pubmed/21420867
CHEMBL1773168	IC50 > 50 uM	Inhibition of Mycobacterium tuberculosis PTPA expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis	http://www.ncbi.nlm.nih.gov/pubmed/21116447
CHEMBL1773180	IC50 > 50 uM	Inhibition of Mycobacterium tuberculosis PTPA expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis	http://www.ncbi.nlm.nih.gov/pubmed/21116447
CHEMBL1773181	IC50 > 50 uM	Inhibition of Mycobacterium tuberculosis PTPA expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis	http://www.ncbi.nlm.nih.gov/pubmed/21116447
CHEMBL1784316	IC50 = 110.2 uM	Non-competitive inhibition of Mycobacterium tuberculosis PTPA using p-nitrophenyl phosphate as substrate by Lineweaver-Burk plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/21530278
CHEMBL1784316	Ki = 22.5 uM	Non-competitive inhibition of Mycobacterium tuberculosis PTPA using p-nitrophenyl phosphate as substrate by Lineweaver-Burk plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/21530278
CHEMBL1784317	Ki = 101.4 uM	Non-competitive inhibition of Mycobacterium tuberculosis PTPA using p-nitrophenyl phosphate as substrate by Lineweaver-Burk plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/21530278
CHEMBL1784317	IC50 = 235.6 uM	Non-competitive inhibition of Mycobacterium tuberculosis PTPA using p-nitrophenyl phosphate as substrate by Lineweaver-Burk plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/21530278
CHEMBL1851809	IC50 = 24.5 uM	Inhibition of Mycobacterium tuberculosis PTPA	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL1945174	Inhibition = 22 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945175	Inhibition = 5 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945176	Inhibition = 24 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945177	Inhibition = 13 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945178	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945179	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945180	Inhibition = 22 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945181	Inhibition = 22 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945182	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945183	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945184	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945185	Inhibition = 10 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945186	Ki = 12 uM	Competitive inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by Lineweaver-Burk plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945186	Inhibition = 40 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945186	Ratio = 1.3 None	Ratio of IC50 to Ki for Mycobacterium tuberculosis protein tyrosine phosphatase-A	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945186	IC50 = 15 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945187	Inhibition = 38 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945187	IC50 = 102 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945188	Inhibition = 12 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945189	IC50 = 8.8 uM	Inhibition of Mycobacterium tuberculosis PTP-A	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945543	Inhibition = 19 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945544	Inhibition = 14 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945545	Inhibition = 12 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945546	Inhibition = 4 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945547	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945548	Inhibition = 5 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945549	Inhibition = 7 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945550	Inhibition = 7 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945551	Inhibition = 14 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945552	IC50 = 93 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945552	Inhibition = 29 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945553	Inhibition = 19 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945702	IC50 = 101 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945702	Inhibition = 42 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945987	Inhibition = 13 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945988	Inhibition = 16 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945989	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945990	Inhibition = 8 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945991	Inhibition = 10 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945992	Inhibition = 7 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945993	Inhibition = 13 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945994	Inhibition = 8 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945995	Inhibition = 15 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945996	IC50 = 1023 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945996	Inhibition = 30 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945997	Inhibition = 49 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945997	IC50 = 1659 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945998	Inhibition = 19 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945999	Inhibition = 43 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1945999	IC50 = 331 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946000	Inhibition = 21 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946001	Inhibition = 10 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946002	Inhibition = 9 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946003	Inhibition = 9 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946279	IC50 = 100 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946279	Inhibition = 40 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946280	Inhibition = 16 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946281	Ki = 23 uM	Competitive inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by Lineweaver-Burk plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946281	IC50 = 32 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946281	Inhibition = 31 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946281	Ratio = 1.4 None	Ratio of IC50 to Ki for Mycobacterium tuberculosis protein tyrosine phosphatase-A	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946282	IC50 = 302 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946282	Inhibition = 63 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946283	Inhibition = 5 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946284	Inhibition = 23 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946285	Inhibition = 35 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946285	IC50 = 151 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946286	Inhibition = 23 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946287	Inhibition = 17 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946288	Inhibition = 5 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946289	Inhibition = 6 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946436	Inhibition = 8 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946437	Inhibition = 11 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946438	Inhibition = 9 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946439	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946440	Inhibition = 40 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946440	IC50 = 169 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946441	Inhibition = 12 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946980	Inhibition = 13 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946981	Inhibition = 35 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946981	IC50 = 74 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946982	IC50 = 66 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946982	Inhibition = 37 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946983	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946984	IC50 = 155 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946984	Inhibition = 41 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946985	Inhibition = 27 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946985	IC50 = 407 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946986	IC50 = 174 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946986	Inhibition = 36 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946987	Inhibition = 19 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946988	Inhibition = 26 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946988	IC50 = 83 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946989	Inhibition = 8 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946990	Inhibition = 10 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946991	Inhibition = 11 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946992	Inhibition = 35 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946992	IC50 = 93 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946993	IC50 = 214 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946993	Inhibition = 40 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946994	Inhibition = 8 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946995	Inhibition = 23 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946996	Inhibition = 13 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946997	Inhibition = 43 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946997	IC50 = 93 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946998	IC50 > 100 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL1946998	Inhibition = 9 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL200386	IC50 > 100 uM	Inhibitory activity against MPTPA	http://www.ncbi.nlm.nih.gov/pubmed/16236508
CHEMBL200475	IC50 = 74.9 uM	Inhibitory activity against MPTPA	http://www.ncbi.nlm.nih.gov/pubmed/16236508
CHEMBL200830	IC50 > 100 uM	Inhibitory activity against MPTPA	http://www.ncbi.nlm.nih.gov/pubmed/16236508
CHEMBL217931	Ki = 4.9 uM	Inhibition of Mycobacterium tuberculosis PTPA-mediated pNPP hydrolysis	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL217931	IC50 = 23.1 uM	Inhibition of Mycobacterium tuberculosis PTPA after 20 mins by ELISA	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL217931	IC50 = 23.1 uM	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL217931	Active	Competitive inhibition of Mycobacterium tuberculosis PTPA by Lineweaver-Burke plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL217931	Activity = 31.5 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL220818	Activity = 109 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL220930	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL221741	Activity = 82.4 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL227400	Activity = 103 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL238634	Activity = 91.3 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL244458	Activity = 103 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL270117	Activity = 99 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL272001	Activity = 98 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL275787	IC50 = 8.8 uM	Inhibition of Mycobacterium tuberculosis PTP-A	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL276600	Activity = 82.4 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL32856	Activity = 100 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL32896	Activity = 104 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL371922	IC50 > 100 uM	Inhibitory activity against MPTPA	http://www.ncbi.nlm.nih.gov/pubmed/16236508
CHEMBL372159	IC50 > 100 uM	Inhibitory activity against MPTPA	http://www.ncbi.nlm.nih.gov/pubmed/16236508
CHEMBL374279	Activity = 54 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL374279	Ki = 21.3 uM	Inhibition of Mycobacterium tuberculosis PTPA-mediated pNPP hydrolysis	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL374279	IC50 = 39.5 uM	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL374279	IC50 = 39.5 uM	Inhibition of Mycobacterium tuberculosis PTPA after 20 mins by ELISA	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL374279	Active	Competitive inhibition of Mycobacterium tuberculosis PTPA by Lineweaver-Burke plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL377360	IC50 > 100 uM	Inhibition of Mycobacterium tuberculosis ptpA	http://www.ncbi.nlm.nih.gov/pubmed/16884299
CHEMBL381633	IC50 > 100 uM	Inhibitory activity against MPTPA	http://www.ncbi.nlm.nih.gov/pubmed/16236508
CHEMBL394397	Activity = 80 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL404603	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL409618	IC50 > 100 uM	Inhibition of Mycobacterium tuberculosis ptpA	http://www.ncbi.nlm.nih.gov/pubmed/16884299
CHEMBL426212	Activity = 102 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL427374	IC50 > 100 uM	Inhibitory activity against MPTPA	http://www.ncbi.nlm.nih.gov/pubmed/16236508
CHEMBL430187	Inhibition = 0 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL439324	IC50 > 100 uM	Inhibition of Mycobacterium tuberculosis ptpA	http://www.ncbi.nlm.nih.gov/pubmed/16884299
CHEMBL441861	IC50 = 8.4 uM	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL441861	IC50 = 8.4 uM	Inhibition of Mycobacterium tuberculosis PTPA after 20 mins by ELISA	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL441861	Activity = 42.5 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL441861	Ki = 5.4 uM	Inhibition of Mycobacterium tuberculosis PTPA-mediated pNPP hydrolysis	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL441861	Active	Competitive inhibition of Mycobacterium tuberculosis PTPA by Lineweaver-Burke plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL447611	Activity = 92 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL449857	Activity = 89 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL455453	Activity = 80.5 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL455453	IC50 = 62 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL455453	Inhibition = 33 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL455469	Ki = 29 uM	Competitive inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by Lineweaver-Burk plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL455469	Ratio = 1.5 None	Ratio of IC50 to Ki for Mycobacterium tuberculosis protein tyrosine phosphatase-A	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL455469	Inhibition = 26 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL455469	Activity = 74 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL455469	IC50 = 45 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL484145	IC50 = 53.7 uM	Inhibition of Mycobacterium tuberculosis PTPA after 20 mins by ELISA	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL484145	Active	Competitive inhibition of Mycobacterium tuberculosis PTPA by Lineweaver-Burke plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL484145	Ki = 17.9 uM	Inhibition of Mycobacterium tuberculosis PTPA-mediated pNPP hydrolysis	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL487051	Dose-dependent effect	Inhibition of Mycobacterium tuberculosis PTPA-mediated dephosphorylation of VPS33B assessed as increase in phosphorylated VPS33B level after 15 mins by scintillation counting	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL487051	Ki = 9.1 uM	Inhibition of Mycobacterium tuberculosis PTPA-mediated pNPP hydrolysis	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL487051	Activity = 24 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL487051	Active	Competitive inhibition of Mycobacterium tuberculosis PTPA by Lineweaver-Burke plot analysis	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL487051	IC50 = 50.7 uM	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL487051	IC50 = 50.2 uM	Inhibition of Mycobacterium tuberculosis PTPA after 20 mins by ELISA	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL487052	Activity = 82 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL487073	Activity = 88 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL487217	Activity = 62.7 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL487231	Activity = 84.4 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL487232	Activity = 84 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL487233	Activity = 79.5 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL488058	Activity = 88 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL499801	Activity = 94 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL506032	Activity = 87 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL50626	IC50 = 28 uM	Inhibition of Mycobacterium tuberculosis PTPA	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CHEMBL507837	Activity = 86 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL509013	Activity = 99 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL510834	Activity = 74.6 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL512571	Inhibition = 19 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL519069	Activity = 89.2 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL519069	Inhibition = 11 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL519069	IC50 > 50 uM	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL520060	Activity = 81.5 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL520906	IC50 = 53.7 uM	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL520906	Activity = 61 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL521380	Activity = 75 %	Inhibition of Mycobacterium tuberculosis recombinant protein tyrosine phosphatase assessed as enzyme activity at 25 uM	http://www.ncbi.nlm.nih.gov/pubmed/18930396
CHEMBL595779	Inhibition = 5 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL609286	Inhibition = 10 %	Inhibition of Mycobacterium tuberculosis PTP-A using p-nitrophenyl phosphate as substrate at 25 uM measured for 10 mins by spectrofluorimetry	http://www.ncbi.nlm.nih.gov/pubmed/22136336
CHEMBL85943	IC50 = 30.8 uM	Inhibition of Mycobacterium tuberculosis PTPA	http://www.ncbi.nlm.nih.gov/pubmed/20462762
CDD-344419	None	None	None
CDD-344447	None	None	None
CDD-344562	None	None	None
CDD-344619	None	None	None
CDD-344747	None	None	None

Off-target activity - ligand based from TIBLE

View results in TIBLE page

Predicted off-target	Method	Summary	Full results
Proto-oncogene tyrosine-protein kinase LCK 2OG8	PharmMapper	5 hydroph + 5 HB + 1 pos/neg + 0 arom	Link
Proto-oncogene tyrosine-protein kinase LCK 2OFV	PharmMapper	5 hydroph + 4 HB + 0 pos/neg + 0 arom	Link
Angiopoietin-1 receptor 2P4I	PharmMapper	7 hydroph + 2 HB + 0 pos/neg + 0 arom	Link
Cellular retinoic acid-binding protein 2 1CBS	PharmMapper	7 hydroph + 2 HB + 1 pos/neg + 0 arom	Link
Aldose reductase 2IKI	PharmMapper	5 hydroph + 0 HB + 1 pos/neg + 0 arom	Link
Protein-tyrosine phosphatase 1B	PASS	Pa = 0.858 & SM = CHEMBL1081579	Link
JAK2 expression	PASS	Pa = 0.848 & SM = CHEMBL487051	Link
formyl peptide receptor; N-formyl-Met-Leu-Phe receptor [-]	SEA	E_value = 4.06e-35 & MaxTC = 0.6	Link
nitric-oxide synthase; inducible [-]	SEA	E_value = 3.82e-34 & MaxTC = 0.65	Link
cysteinyl leukotriene receptor 1; leukotriene D4 receptor	SEA	E_value = 1.86e-31 & MaxTC = 0.52	Link
histone deacetylase 1A [-]	SEA	E_value = 8.51e-26 & MaxTC = 0.55	Link
histone deacetylase 1B [-]	SEA	E_value = 8.51e-26 & MaxTC = 0.55	Link
Nuclear factor NF-kappa-B p100/p49 subunits	SEA	E_value = 1.23e-18 & MaxTC = 0.53	Link
superoxide dismutase [-]	SEA	E_value = 1.57e-16 & MaxTC = 0.82	Link
Nuclear factor NF-kappa-B p105 subunit	SEA	E_value = 6.49e-16 & MaxTC = 0.53	Link
Protein kinase Pfmrk	SEA	E_value = 2.97e-15 & MaxTC = 0.64	Link
prostaglandin H2 synthase [-]	SEA	E_value = 1.82e-13 & MaxTC = 0.75	Link
Glucuronidase (beta) Inhibitor	SEA	E_value = 2.73e-13 & MaxTC = 0.67	Link
histone deacetylase 2 [-]	SEA	E_value = 1.64e-12 & MaxTC = 0.55	Link
Proto-oncogene c-JUN	SEA	E_value = 9.07e-12 & MaxTC = 0.53	Link

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
phosphatePubChem	0.985	96.9872
chloridePubChem	0.97	35.453
glycerolPubChem	0.97	92.0938
adeninePubChem	0.942	135.127
p-nitrophenyl phosphatePubChem	0.934	219.089
hydroxyl radicalsPubChem	0.9	17.0073
HEPESPubChem	0.833	238.305
2-(N-methyl-N-nitroso)hydroquinonePubChem	0.826	168.15
sulfatePubChem	0.75	96.0626
hydron diphosphatePubChem	0.74	391.981
hydron sulfatePubChem	0.734	196.157
magnesiumPubChem	0.733	24.305