Rv2181

Tuberculist information
Gene nameRv2181
Protein functionAlpha(1->2)mannosyltransferase
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2443.3
Molecular mass(da)47143.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 427
	  		  	1    MSAWRAPEVGSRLGRRVLWCLLWLLAGVALGYVAWRLFGHTPYRIDIDIYQMGARAWLDG   60
			  	61   RPLYGGGVLFHTPIGLNLPFTYPPLAAVLFSPFAWLQMPAASVAITVLTLVLLIASTAIV  120
			  	121  LTGLDAWPTSRLVPAPARLRRLWLAVLIVAPATIWLEPISSNFAFGQINVVLMTLVIVDC  180
			  	181  FPRRTPWPRGLMLGLGIALKLTPAVFLLYFLLRRDGRAALTALASFAVATLLGFVLAWRD  240
			  	241  SWEYWTHTLHHTDRIGAAALNTDQNIAGALARLTIGDDERFALWVAGSLLVLAATIWAMR  300
			  	301  RVLRAGEPTLAVICVALFGLVVSPVSWSHHWVWMLPAVLVIGLLGWRRRNVALAMLSLAG  360
			  	361  VVLMRWTPIDLLPQHRETTAVWWRQLAGMSYVWWALAVIVVAGLTVTARMTPQRSLTRGL  420
			  	421  TPAPTAS

Known structures in the PDB
No Known structures
1 43 85 127 169 211 253 295 337 379 421 Range: 80 to 324  |  Coverage: 57% DUF2029 Range: 105 to 396  |  Coverage: 68% 1
Number of amino acids : 427
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
DUF2029PF0959480-324
Mtb Structural Proteome models
Model Number1
Model nameRv2181
Template1L7V    APDBCREDO
Template coverage15_322
Template Identity(%)18.8
Model coverage(%)68.1
Normalized DOPE score0.8

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2181Gene nameConfidence Score
Rv1635cRv1635c0.907
Rv2673aftC0.906
Rv2174mptA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions