Rv1859

Tuberculist information
Gene namemodC
Protein functionProbable molybdenum-transport ATP-binding protein ABC transporter ModC
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2106.57
Molecular mass(da)38610.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 369
	  		  	1    MSKLQLRAVVADRRLDVEFSVSAGEVLAVLGPNGAGKSTALHVIAGLLRPDAGLVRLGDR   60
			  	61   VLTDTEAGVNVATHDRRVGLLLQDPLLFPHLSVAKNVAFGPQCRRGMFGSGRARTRASAL  120
			  	121  RWLREVNAEQFADRKPRQLSGGQAQRVAIARALAAEPDVLLLDEPLTGLDVAAAAGIRSV  180
			  	181  LRSVVARSGCAVVLTTHDLLDVFTLADRVLVLESGTIAEIGPVADVLTAPRSRFGARIAG  240
			  	241  VNLVNGTIGPDGSLRTQSGAHWYGTPVQDLPTGHEAIAVFPPTAVAVYPEPPHGSPRNIV  300
			  	301  GLTVAEVDTRGPTVLVRGHDQPGGAPGLAACITVDAATELRVAPGSRVWFSVKAQEVALH  360
			  	361  PAPHQHASS

Known structures in the PDB
No Known structures
1 37 73 109 145 181 217 253 289 325 361 Range: 15 to 167  |  Coverage: 41% ABC_tran Range: 294 to 359  |  Coverage: 17% TOBE Range: 6 to 360  |  Coverage: 95% 1 Range: 1 to 369  |  Coverage: 99% 1 Range: 1 to 284  |  Coverage: 76% 2 Range: 294 to 359  |  Coverage: 17% 3 Range: 238 to 369  |  Coverage: 35% 4
Number of amino acids : 369
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ABC_tranPF0000515-167
TOBEPF03459294-359
Mtb Structural Proteome models
Model Number1
Model nameRv1859
Template1OXX    KPDBCREDO
Template coverage13_350
Template Identity(%)26.6
Model coverage(%)95.9
Normalized DOPE score0.18

Structure Models from Chopin
Model Number1
Profileb.40.6.3, c.37.1.12 - 2.40.50.100, 2.40.50.140, 3.40.50.300
Click for model details
zscore52.11
Residue begin1
Residue end369
Model Number2
Profilec.37.1.12
Click for model details
zscore28.39
Residue begin1
Residue end284
Model Number3
Profileb.40.6.2
Click for model details
zscore10.44
Residue begin294
Residue end359
Model Number4
Profileb.40.6.3
Click for model details
zscore9.48
Residue begin238
Residue end369
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1859Gene nameConfidence Score
Rv1858modB0.997
Rv1857modA0.993
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine triphosphatePubChem0.907507.181
molybdatePubChem0.905159.938
adenosine diphosphatePubChem0.903427.201
hydroxyl radicalsPubChem0.917.0073
phosphatePubChem0.996.9872