Rv1858

Tuberculist information
Gene namemodB
Protein functionProbable molybdenum-transport integral membrane protein ABC transporter ModB
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2105.77
Molecular mass(da)27676.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 264
	  		  	1    MHPPTDLPRWVYLPAIAGIVFVAMPLVAIAIRVDWPRFWALITTPSSQTALLLSVKTAAA   60
			  	61   STVLCVLLGVPMALVLARSRGRLVRSLRPLILLPLVLPPVVGGIALLYAFGRLGLIGRYL  120
			  	121  EAAGISIAFSTAAVVLAQTFVSLPYLVISLEGAARTAGADYEVVAATLGARPGTVWWRVT  180
			  	181  LPLLLPGVVSGSVLAFARSLGEFGATLTFAGSRQGVTRTLPLEIYLQRVTDPDAAVALSL  240
			  	241  LLVVVAALVVLGVGARTPIGTDTR

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 65 to 256  |  Coverage: 72% BPD_transp_1 Range: 38 to 249  |  Coverage: 79% 1 Range: to   |  Coverage: 0% 1 Range: 1 to 264  |  Coverage: 99% 2
Number of amino acids : 264
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
BPD_transp_1PF0052865-256
Mtb Structural Proteome models
Model Number1
Model nameRv1858
Template4DCG    APDBCREDO
Template coverage12_217
Template Identity(%)6.5
Model coverage(%)79.9
Normalized DOPE score1.678

Structure Models from Chopin
Model Number1
Profilef.58.1.1 - 1.10.3720.10
Click for model details
zscore17.03
Residue begin
Residue end
Model Number2
Profiled.128.1.2
Click for model details
zscore4.66
Residue begin1
Residue end264
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1858Gene nameConfidence Score
Rv1857modA0.999
Rv1859modC0.997
Rv1859modC0.997
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
molybdatePubChem0.958159.938
phosphatePubChem0.91996.9872
adenosine diphosphatePubChem0.9427.201
hydroxyl radicalsPubChem0.917.0073
adenosine triphosphatePubChem0.9507.181