Rv1458c

Tuberculist information
Gene nameRv1458c
Protein functionProbable unidentified antibiotic-transport ATP-binding protein ABC transporter
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)1643.32
Molecular mass(da)33726.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 313
	  		  	1    VNRAPDTPEVVLRLRGVCKRYGSITAVSNLDLDVHDAEVMALLGPNGAGKTTTVEMCEGF   60
			  	61   VRPDAGSIEVLGLDPITDNARLRARIGVMLQGGGGYPAARAGEMLDLVASYAANPLDPHW  120
			  	121  LLDTLGLTEAARTTYRRLSGGQQQRLALACALVGRPQLVFLDEPTAGMDAHARVLVWELI  180
			  	181  DALRRDGVTVVLTTHHLKEAEELADRLVIIDHGVTVAAGTPAELMRSGAKDQLRFTAPPR  240
			  	241  LDLSLLASALPEGYQATELTPGEYLVEGPVDPQVLATVTAWCAQIDVLATDMRVEQRSLE  300
			  	301  DVFLDLTGRKLRQ

Known structures in the PDB
No Known structures
1 32 63 94 125 156 187 218 249 280 311 Range: 27 to 166  |  Coverage: 44% ABC_tran Range: 8 to 312  |  Coverage: 97% 1 Range: 1 to 312  |  Coverage: 99% 1
Number of amino acids : 313
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ABC_tranPF0000527-166
Mtb Structural Proteome models
Model Number1
Model nameRv1458c
Template1Z47    APDBCREDO
Template coverage11_309
Template Identity(%)26.8
Model coverage(%)97.1
Normalized DOPE score0.376

Structure Models from Chopin
Model Number1
Profilec.37.1.12 - 3.40.50.300
Click for model details
zscore25.06
Residue begin1
Residue end312
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1458cGene nameConfidence Score
Rv1457cRv1457c0.999
Rv1456cRv1456c0.93
Rv1459cRv1459c0.929
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine triphosphatePubChem0.902507.181
phosphatePubChem0.996.9872
adenosine diphosphatePubChem0.9427.201
hydroxyl radicalsPubChem0.917.0073