Rv1457c

Tuberculist information
Gene nameRv1457c
Protein functionProbable unidentified antibiotic-transport integral membrane ABC transporter
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)1642.54
Molecular mass(da)27338.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 261
	  		  	1    VTQTNRPAFPAGTFSPDPRPNAVPLMLAAQFSLELKLLLRNGEQLLLTMFIPITLLVGLT   60
			  	61   LLPMGSFGHNRAATFVPVIMALAVISTAFTGQAIAVAFDRRYGALKRLGATPLPVWGIIA  120
			  	121  GKSLAVVAVVFLQAIILGAIGFALGWRPALTALTLGAGIIALGTAGFAALGLLLGGTLRA  180
			  	181  EIVLAVANLMWFVFAGFGALTLESNVIPTAFKWVARVTPSGALTEALSQAMTVSVDWFGI  240
			  	241  VVLAVWGALAALAALRWFRFT

Known structures in the PDB
No Known structures
1 27 53 79 105 131 157 183 209 235 261 Range: 44 to 256  |  Coverage: 81% ABC2_membrane_3 Range: 71 to 253  |  Coverage: 69% 1
Number of amino acids : 261
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ABC2_membrane_3PF1269844-256
Mtb Structural Proteome models
Model Number1
Model nameRv1457c
Template1XME    APDBCREDO
Template coverage66_251
Template Identity(%)12.6
Model coverage(%)69.7
Normalized DOPE score0.984

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1457cGene nameConfidence Score
Rv1458cRv1458c0.999
Rv1459cRv1459c0.933
Rv1456cRv1456c0.928
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine triphosphatePubChem0.9507.181
phosphatePubChem0.996.9872
adenosine diphosphatePubChem0.9427.201
hydroxyl radicalsPubChem0.917.0073