Rv1349

Tuberculist information
Gene nameirtB
Protein functionIron-regulated transporter IrtB
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)1515.62
Molecular mass(da)60954.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 579
	  		  	1    MIRTWIALVPNDHRARLIGFALLAFCSVVARAVGTVLLVPLMAALFGEAPQRAWLWLGWL   60
			  	61   SAATVAGWVLDAVTARIGIELGFAVLNHTQHDVADRLPVVRLDWFTAENTATARQAIAAT  120
			  	121  GPELVGLVVNLVTPLTSAILLPAVIALALLPISWQLGVAALAGVPLLLGALWASAAFARR  180
			  	181  ADTAADKANTALTERIIEFARTQQALRAARRVEPARSLVGNALASQHTATMRLLGMQIPG  240
			  	241  QLLFSIASQLALIVLAGTTAALTITGTLTVPEAIALIVVMVRYLEPFTAVSELAPALEST  300
			  	301  RATLGRIGSVLTAPVMVAGSGTWRDGAVVPRIEFDDVAFGYDGGSGPVLDGVSFCLQPGT  360
			  	361  TTAIVGPSGCGKSTILALIAGLHQPTRGRVLIDGTDVATLDARAQQAVCSVVFQHPYLFH  420
			  	421  GTIRDNVFAADPGASDDQFAQAVRLARVDELIARLPDGANTIVGEAGSALSGGERQRVSI  480
			  	481  ARALLKAAPVLLVDEATSALDAENEAAVVDALAADPRSRTRVIVAHRLASIRHADRVLFV  540
			  	541  DDGRVVEDGSISELLTAGGRFSQFWRQQHEAAEWQILAE

Known structures in the PDB
No Known structures
1 58 115 172 229 286 343 400 457 514 571 Range: 373 to 498  |  Coverage: 21% ABC_tran Range: 3 to 551  |  Coverage: 94% 1 Range: 315 to 579  |  Coverage: 45% 1 Range: to   |  Coverage: 0% 2 Range: 1 to 579  |  Coverage: 99% 3
Number of amino acids : 579
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ABC_tranPF00005373-498
Mtb Structural Proteome models
Model Number1
Model nameRv1349
Template1Z2R    APDBCREDO
Template coverage15_562
Template Identity(%)25.5
Model coverage(%)94.6
Normalized DOPE score1.718

Structure Models from Chopin
Model Number1
Profilec.37.1.12
Click for model details
zscore39.07
Residue begin315
Residue end579
Model Number2
Profilef.37.1.1
Click for model details
zscore27.2
Residue begin
Residue end
Model Number3
Profilec.37.1.12 - 3.40.50.300
Click for model details
zscore11.11
Residue begin1
Residue end579
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1349Gene nameConfidence Score
Rv1348irtA0.995
Rv1348irtA0.995
Rv1348irtA0.995
Rv1348irtA0.995
Rv2383cmbtB0.935
Rv2383cmbtB0.935
Rv2383cmbtB0.935
Rv2383cmbtB0.935
Rv2383cmbtB0.935
Rv2383cmbtB0.935
Rv2895cviuB0.934
Rv2895cviuB0.934
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions