SInCRe - Rv1348

Tuberculist information

Gene name	irtA
Protein function	Iron-regulated transporter IrtA
Functional category(tuberculist)	cell wall and cell processes
Gene location(kb)	1513.05
Molecular mass(da)	92965.9
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 859

	  		  	1    MARGLQGVMLRSFGARDHTATVIETISIAPHFVRVRMVSPTLFQDAEAEPAAWLRFWFPD   60
			  	61   PNGSNTEFQRAYTISEADPAAGRFAVDVVLHDPAGPASSWARTVKPGATIAVMSLMGSSR  120
			  	121  FDVPEEQPAGYLLIGDSASIPGMNGIIETVPNDVPIEMYLEQHDDNDTLIPLAKHPRLRV  180
			  	181  RWVMRRDEKSLAEAIENRDWSDWYAWATPEAAALKCVRVRLRDEFGFPKSEIHAQAYWNA  240
			  	241  GRAMGTHRATEPAATEPEVGAAPQPESAVPAPARGSWRAQAASRLLAPLKLPLVLSGVLA  300
			  	301  ALVTLAQLAPFVLLVELSRLLVSGAGAHRLFTVGFAAVGLLGTGALLAAALTLWLHVIDA  360
			  	361  RFARALRLRLLSKLSRLPLGWFTSRGSGSIKKLVTDDTLALHYLVTHAVPDAVAAVVAPV  420
			  	421  GVLVYLFVVDWRVALVLFGPVLVYLTITSSLTIQSGPRIVQAQRWAEKMNGEAGSYLEGQ  480
			  	481  PVIRVFGAASSSFRRRLDEYIGFLVAWQRPLAGKKTLMDLATRPATFLWLIAATGTLLVA  540
			  	541  THRMDPVNLLPFMFLGTTFGARLLGIAYGLGGLRTGLLAARHLQVTLDETELAVREHPRE  600
			  	601  PLDGEAPATVVFDHVTFGYRPGVPVIQDVSLTLRPGTVTALVGPSGSGKSTLATLLARFH  660
			  	661  DVERGAIRVGGQDIRSLAADELYTRVGFVLQEAQLVHGTAAENIALAVPDAPAEQVQVAA  720
			  	721  REAQIHDRVLRLPDGYDTVLGANSGLSGGERQRLTIARAILGDTPVLILDEATAFADPES  780
			  	781  EYLVQQALNRLTRDRTVLVIAHRLHTITRADQIVVLDHGRIVERGTHEELLAAGGRYCRL  840
			  	841  WDTGQGSRVAVAAAQDGTR

Known structures in the PDB

No Known structures

Number of amino acids : 859

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
FAD_binding_9	PF08021	21-119
SIP	PF04954	128-241
ABC_membrane	PF00664	293-563
ABC_tran	PF00005	626-774

Mtb Structural Proteome models

Model Number	1
Model name	Rv1348
Template	2GHI APDB CREDO
Template coverage	2_256
Template Identity(%)	38.8
Model coverage(%)	30.2
Normalized DOPE score	-0.916

Model Number	2
Model name	Rv1348.1
Template	2GPJ APDB CREDO
Template coverage	5_244
Template Identity(%)	24.2
Model coverage(%)	28.1
Normalized DOPE score	-0.445

Structure Models from Chopin

Model Number	1
Profile	c.37.1.12, f.37.1.1 Click for model details
zscore	56.06
Residue begin	276
Residue end	846

Model Number	2
Profile	c.37.1.12 Click for model details
zscore	34.59
Residue begin	593
Residue end	859

Model Number	3
Profile	f.37.1.1 Click for model details
zscore	24.93
Residue begin	293
Residue end	563

Model Number	4
Profile	3.40.50.80 Click for model details
zscore	10.66
Residue begin	128
Residue end	241

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1348	Gene name	Confidence Score
Rv1349	irtB	0.995
Rv2895c	viuB	0.913
Rv2895c	viuB	0.913
Rv2383c	mbtB	0.906
Rv2383c	mbtB	0.906
Rv2383c	mbtB	0.906
Rv2383c	mbtB	0.906
Rv2383c	mbtB	0.906
Rv2383c	mbtB	0.906

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv1348.1	4	3bjw_SVR_E_503 PDB CREDO	0.670	0.106	0.652	0.001
Rv1348.1	4	3b0w_DGX_B_1 PDB CREDO	0.654	0.121	0.619	0.001
Rv1348.1	4	3kk6_CEL_B_1701 PDB CREDO	0.619	0.157	0.619	0.001
Rv1348.1	4	3bjw_SVR_B_501 PDB CREDO	0.683	0.094	0.614	0.002
Rv1348.1	4	3bjw_SVR_F_502 PDB CREDO	0.678	0.099	0.609	0.002
Rv1348.1	4	3bjw_SVR_H_504 PDB CREDO	0.676	0.100	0.608	0.002
Rv1348.1	4	1uwj_BAX_A_1723 PDB CREDO	0.656	0.119	0.603	0.002
Rv1348.1	4	3frq_ERY_A_195 PDB CREDO	0.681	0.096	0.592	0.002
Rv1348.1	4	3kk6_CEL_A_701 PDB CREDO	0.648	0.127	0.582	0.003
Rv1348.1	4	2xkw_P1B_A_1478 PDB CREDO	0.655	0.120	0.574	0.003
Rv1348.1	4	1skx_RFP_A_1 PDB CREDO	0.573	0.212	0.573	0.003
Rv1348.1	4	1z2b_VLB_C_800 PDB CREDO	0.689	0.090	0.564	0.004
Rv1348.1	4	1y0x_T44_X_500 PDB CREDO	0.710	0.074	0.563	0.004
Rv1348.1	4	1uob_PNN_A_1311 PDB CREDO	0.685	0.093	0.561	0.004
Rv1348.1	4	3b0w_DGX_A_1 PDB CREDO	0.664	0.111	0.560	0.004
Rv1348.1	4	1t46_STI_A_3 PDB CREDO	0.589	0.192	0.558	0.004
Rv1348.1	1	3fuu_ADN_A_0 PDB CREDO	0.629	0.146	0.558	0.004
Rv1348.1	4	1hwk_117_B_1 PDB CREDO	0.620	0.156	0.554	0.005
Rv1348.1	4	3frq_ERY_B_195 PDB CREDO	0.742	0.052	0.554	0.005
Rv1348.1	4	1xkk_FMM_A_91 PDB CREDO	0.616	0.161	0.554	0.005
Rv1348.1	4	1uwj_BAX_B_1723 PDB CREDO	0.656	0.119	0.553	0.005
Rv1348.1	4	1xzx_T3_X_500 PDB CREDO	0.758	0.043	0.548	0.005
Rv1348.1	4	3uvv_T3_A_501 PDB CREDO	0.758	0.043	0.548	0.005
Rv1348.1	4	1bsx_T3_A_1 PDB CREDO	0.774	0.036	0.542	0.006
Rv1348.1	4	1bsx_T3_B_2 PDB CREDO	0.774	0.036	0.542	0.006
Rv1348.1	4	3gws_T3_X_500 PDB CREDO	0.770	0.037	0.539	0.006
Rv1348.1	4	3h52_486_B_1 PDB CREDO	0.657	0.117	0.538	0.006
Rv1348.1	4	2hw2_RFP_A_1200 PDB CREDO	0.719	0.067	0.537	0.006
Rv1348.1	4	2v0z_C41_O_1327 PDB CREDO	0.580	0.204	0.535	0.006
Rv1348.1	4	3d91_REM_A_350 PDB CREDO	0.633	0.141	0.534	0.006
Rv1348.1	4	3d91_REM_B_350 PDB CREDO	0.633	0.142	0.534	0.006
Rv1348.1	4	2oax_SNL_D_4001 PDB CREDO	0.652	0.123	0.534	0.007
Rv1348.1	4	2oax_SNL_F_6001 PDB CREDO	0.648	0.126	0.531	0.007
Rv1348.1	4	2oax_SNL_E_5001 PDB CREDO	0.648	0.127	0.530	0.007
Rv1348.1	4	2oax_SNL_A_1001 PDB CREDO	0.645	0.129	0.528	0.007
Rv1348.1	4	3h52_486_D_2 PDB CREDO	0.664	0.111	0.528	0.007
Rv1348.1	1	3sxr_1N1_B_2 PDB CREDO	0.549	0.245	0.527	0.007
Rv1348.1	4	3nxu_RIT_A_600 PDB CREDO	0.525	0.280	0.525	0.007
Rv1348.1	1	2itz_IRE_A_2021 PDB CREDO	0.547	0.249	0.525	0.007
Rv1348.1	4	1uwh_BAX_B_1723 PDB CREDO	0.661	0.114	0.525	0.007
Rv1348.1	4	1uwh_BAX_A_1723 PDB CREDO	0.660	0.115	0.524	0.008
Rv1348.1	4	2h79_T3_A_1 PDB CREDO	0.773	0.036	0.524	0.008
Rv1348.1	1	1ie4_T44_A_128 PDB CREDO	0.523	0.283	0.523	0.008
Rv1348.1	4	1fm6_BRL_X_504 PDB CREDO	0.721	0.065	0.522	0.008
Rv1348.1	4	3nxu_RIT_B_600 PDB CREDO	0.521	0.286	0.521	0.008
Rv1348.1	4	2ab2_SNL_A_502 PDB CREDO	0.697	0.083	0.520	0.008
Rv1348.1	1	2uxo_TAC_B_1211 PDB CREDO	0.542	0.256	0.520	0.008
Rv1348.1	4	3sm2_478_A_126 PDB CREDO	0.608	0.169	0.520	0.008
Rv1348.1	4	3jwq_VIA_D_901 PDB CREDO	0.821	0.018	0.520	0.008
Rv1348.1	4	3vn2_TLS_A_501 PDB CREDO	0.674	0.102	0.519	0.008
Rv1348.1	4	2ab2_SNL_B_503 PDB CREDO	0.694	0.085	0.518	0.008
Rv1348.1	4	2qxs_RAL_B_600 PDB CREDO	0.518	0.291	0.518	0.008
Rv1348.1	4	2qxs_RAL_A_600 PDB CREDO	0.516	0.293	0.516	0.008
Rv1348.1	1	1v8b_ADN_D_3502 PDB CREDO	0.538	0.261	0.516	0.009
Rv1348.1	4	2oax_SNL_B_2001 PDB CREDO	0.691	0.087	0.516	0.009
Rv1348.1	1	3ubo_ADN_A_353 PDB CREDO	0.561	0.229	0.515	0.009
Rv1348.1	1	1v8b_ADN_C_2502 PDB CREDO	0.559	0.232	0.515	0.009
Rv1348.1	1	3kw2_ADN_B_300 PDB CREDO	0.558	0.233	0.515	0.009
Rv1348.1	1	1m17_AQ4_A_999 PDB CREDO	0.514	0.296	0.514	0.009
Rv1348.1	4	2h77_T3_A_1 PDB CREDO	0.784	0.031	0.514	0.009
Rv1348.1	1	3ubo_ADN_B_353 PDB CREDO	0.558	0.233	0.513	0.009
Rv1348.1	1	4e3a_ADN_A_500 PDB CREDO	0.513	0.299	0.513	0.009
Rv1348.1	4	1hwk_117_A_2 PDB CREDO	0.608	0.170	0.512	0.009
Rv1348.1	1	1jg3_ADN_B_550 PDB CREDO	0.577	0.207	0.512	0.009
Rv1348.1	4	3ln1_CEL_C_682 PDB CREDO	0.731	0.059	0.512	0.009
Rv1348.1	1	3kw2_ADN_A_300 PDB CREDO	0.622	0.153	0.512	0.009
Rv1348.1	4	1hwk_117_C_4 PDB CREDO	0.606	0.172	0.511	0.009
Rv1348.1	4	1sa1_POD_B_700 PDB CREDO	0.606	0.172	0.511	0.009
Rv1348.1	4	3ln1_CEL_B_682 PDB CREDO	0.730	0.059	0.511	0.009
Rv1348.1	4	3ln1_CEL_A_682 PDB CREDO	0.730	0.060	0.511	0.009
Rv1348.1	1	3g5d_1N1_B_1 PDB CREDO	0.576	0.209	0.511	0.009
Rv1348.1	1	3qlg_1N1_B_601 PDB CREDO	0.576	0.209	0.511	0.009
Rv1348.1	4	1hwl_FBI_B_1 PDB CREDO	0.623	0.152	0.510	0.009
Rv1348.1	4	1hwl_FBI_D_3 PDB CREDO	0.623	0.153	0.510	0.009
Rv1348.1	4	2nni_MTK_A_501 PDB CREDO	0.587	0.195	0.510	0.009
Rv1348.1	4	2v0z_C41_C_1328 PDB CREDO	0.596	0.184	0.509	0.009
Rv1348.1	1	4agd_B49_A_2000 PDB CREDO	0.529	0.274	0.508	0.010
Rv1348.1	4	3mnp_DEX_A_784 PDB CREDO	0.659	0.116	0.508	0.010
Rv1348.1	1	1d4f_ADN_A_601 PDB CREDO	0.550	0.244	0.507	0.010
Rv1348.1	4	3vhu_SNL_A_1001 PDB CREDO	0.680	0.097	0.507	0.010
Rv1348.1	4	2oax_SNL_C_3001 PDB CREDO	0.679	0.098	0.507	0.010
Rv1348.1	1	3g5d_1N1_A_1 PDB CREDO	0.571	0.215	0.507	0.010
Rv1348.1	1	3g0e_B49_A_9000 PDB CREDO	0.527	0.277	0.506	0.010
Rv1348.1	4	3mno_DEX_A_784 PDB CREDO	0.657	0.117	0.506	0.010
Rv1348.1	1	1v8b_ADN_B_1502 PDB CREDO	0.527	0.278	0.505	0.010
Rv1348.1	1	3sxr_1N1_A_1 PDB CREDO	0.548	0.247	0.505	0.010
Rv1348.1	1	2ity_IRE_A_2020 PDB CREDO	0.547	0.249	0.504	0.010
Rv1348.1	4	3ut5_LOC_B_502 PDB CREDO	0.635	0.140	0.504	0.010
Rv1348.1	4	1hwl_FBI_C_4 PDB CREDO	0.616	0.161	0.504	0.010
Rv1348.1	1	1fmo_ADN_E_351 PDB CREDO	0.525	0.281	0.504	0.010
Rv1348.1	4	3bjw_SVR_C_505 PDB CREDO	0.517	0.292	0.503	0.010
Rv1348.1	4	1hwl_FBI_A_2 PDB CREDO	0.614	0.162	0.503	0.010
Rv1348.1	1	3qlg_1N1_A_601 PDB CREDO	0.565	0.223	0.502	0.011
Rv1348.1	4	3bjw_SVR_G_506 PDB CREDO	0.528	0.276	0.500	0.011
Rv1348.1	14	3ua1_08Y_A_600 PDB CREDO	0.634	0.140	0.500	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

No high confidence interactions