Rv1188

Tuberculist information
Gene nameRv1188
Protein functionProbable proline dehydrogenase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1331.02
Molecular mass(da)36237.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 329
	  		  	1    MAGWFAHTLRPAMLAAGRSDRLGRIVERSPLTRGVVRRFVPGDTLDDVVDIVTALRDSGR   60
			  	61   YLSIDYLGENVTDADDAAAAVRAYLGLLDVLGRRGDIACDGVRPLEVSLKLSALGQALDR  120
			  	121  DGQKIALDNARAICERAERVGAWVTVDAEDHTTTDSTLSISGDLRVDFPWLGTVVQAYLR  180
			  	181  RTLADCAELAAVGARVRLCKGAYDEPASVAYRDAAQVTDSYLRCLRVLTAGRGYPMVATH  240
			  	241  DPVIIAAVPGITRESGRSQGDFEYQMLYGVRDDEQRRLTGAGNHVRVYVPFGTRWYGYFL  300
			  	301  RRLAERPANLAFFLRALTDRRRARGCAER

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 8 to 320  |  Coverage: 94% Pro_dh Range: 2 to 315  |  Coverage: 95% 1 Range: 42 to 329  |  Coverage: 87% 1
Number of amino acids : 329
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Pro_dhPF016198-320
Mtb Structural Proteome models
Model Number1
Model nameRv1188
Template1K87    APDBCREDO
Template coverage209_569
Template Identity(%)27.7
Model coverage(%)95.1
Normalized DOPE score-0.073

Structure Models from Chopin
Model Number1
Profilec.1.23.2
Click for model details
zscore30.3
Residue begin42
Residue end329
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1188Gene nameConfidence Score
Rv1187rocA0.997
Rv0500proC0.937
Rv0500proC0.937
Rv0840cpip0.931
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
pyrroline-5-carboxylatePubChem0.9113.115
glutamate gamma-semialdehydePubChem0.9131.13
hydroxyglutamic acidPubChem0.9163.129
C05947PubChem0.9163.129
NAD+PubChem0.9663.425
(2R)-4-hydroxypyrrolidin-1-ium-2-carboxylatePubChem0.9131.13
hydroxyl radicalsPubChem0.917.0073
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
L-prolinePubChem0.9115.13
C04281PubChem0.9129.114
L-hydroxyprolinePubChem0.9131.13
4-hydroxyprolinePubChem0.9131.13
1-pyrroline-5-carboxylatePubChem0.9113.115
glutamate semialdehydePubChem0.9131.13
protiumPubChem0.92.01576
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
H(+)PubChem0.92.01588
glutamatePubChem0.9147.129
molecular oxygenPubChem0.931.9988
AR-1L2874PubChem0.9129.114
deuteriumPubChem0.92.01588