Rv0840c

Tuberculist information
Gene namepip
Protein functionProbable proline iminopeptidase Pip (prolyl aminopeptidase) (pap)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)936.457
Molecular mass(da)31893.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 286
	  		  	1    VEGTIAVPGGRVWFQRIGGGPGRPLLVVHGGPGLPHNYLAPLRRLSDEREVIFWDQLGCG   60
			  	61   NSACPSDVDLWTMNRSVAEMATVAEALALTRFHIFSHSWGGMLAQQYVLDKAPDAVSLTI  120
			  	121  ANSTASIPEFSASLVSLKSCLDVATRSAIDRHEAAGTTHSAEYQAAIRTWNETYLCRTRP  180
			  	181  WPRELTEAFANMGTEIFETMFGPSDFRIVGNVRDWDVVDRLADIAVPTLLVVGRFDECSP  240
			  	241  EHMREMQGRIAGSRLEFFESSSHMPFIEEPARFDRVMREFLRLHDI

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 25 to 276  |  Coverage: 87% Abhydrolase_6 Range: 25 to 284  |  Coverage: 90% 1 Range: 1 to 286  |  Coverage: 99% 1
Number of amino acids : 286
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Abhydrolase_6PF1269725-276
Mtb Structural Proteome models
Model Number1
Model nameRv0840c
Template1MTZ    APDBCREDO
Template coverage31_292
Template Identity(%)32.7
Model coverage(%)90.6
Normalized DOPE score-1.389

Structure Models from Chopin
Model Number1
Profilec.69.1.7 - 3.40.50.1820
Click for model details
zscore33.74
Residue begin1
Residue end286
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0840cGene nameConfidence Score
Rv1188Rv11880.931
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-prolinePubChem0.967115.13
selenomethioninePubChem0.728196.106
SeMetPubChem0.728196.106
L-phenylalanine-beta-naphthylamidePubChem0.715290.359
glycerolPubChem0.70492.0938