Rv0735

Tuberculist information
Gene namesigL
Protein functionProbable alternative RNA polymerase sigma factor SigL
Functional category(tuberculist)information pathways
Gene location(kb)827.543
Molecular mass(da)19506
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 177
	  		  	1    VARVSGAAAAEAALMRALYDEHAAVLWRYALRLTGDAAQAEDVVQETLLRAWQHPEVIGD   60
			  	61   TARPARAWLFTVARNMIIDERRSARFRNVVGSTDQSGTPEQSTPDEVNAALDRLLIADAL  120
			  	121  AQLSAEHRAVIQRSYYRGWSTAQIATDLGIAEGTVKSRLHYAVRALRLTLQELGVTR

Known structures in the PDB
PDB ID3HUG
Total residue count2000
Number of chains20
MethodX-RAY
Resolution2.35
1 18 35 52 69 86 103 120 137 154 171 Range: 18 to 87  |  Coverage: 38% Sigma70_r2 Range: 119 to 168  |  Coverage: 27% Sigma70_r4 Range: 2 to 172  |  Coverage: 96% 1 Range: 1 to 175  |  Coverage: 98% 1 Range: 7 to 82  |  Coverage: 42% 2 Range: 1 to 106  |  Coverage: 59% 3 Range: 101 to 177  |  Coverage: 42% 4
Number of amino acids : 177
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Sigma70_r2PF0454218-87
Sigma70_r4PF04545119-168
Mtb Structural Proteome models
Model Number1
Model nameRv0735
Template1OR7    APDBCREDO
Template coverage9_187
Template Identity(%)18.7
Model coverage(%)96.0
Normalized DOPE score0.271

Structure Models from Chopin
Model Number1
Profilea.177.1.1, a.4.13.2 - 1.10.10.10, 1.10.1740.10
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zscore19.83
Residue begin1
Residue end175
Model Number2
Profilea.177.1.1 - 1.10.1740.10
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zscore16.11
Residue begin7
Residue end82
Model Number3
Profilea.177.1.1
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zscore11.36
Residue begin1
Residue end106
Model Number4
Profilea.4.13.2 - 1.10.10.10
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zscore9.47
Residue begin101
Residue end177
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0735Gene nameConfidence Score
Rv0736rslA0.992
Rv3286csigF0.911
Rv3286csigF0.911
Rv3286csigF0.911
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
zincPubChem0.90865.409
hydron sulfatePubChem0.905196.157
sulfatePubChem0.90596.0626