Rv0636

Tuberculist information
Gene namehadB
Protein function(3R)-hydroxyacyl-ACP dehydratase subunit HadB
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)732.393
Molecular mass(da)14934
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 142
	  		  	1    MALREFSSVKVGDQLPEKTYPLTRQDLVNYAGVSGDLNPIHWDDEIAKVVGLDTAIAHGM   60
			  	61   LTMGIGGGYVTSWVGDPGAVTEYNVRFTAVVPVPNDGKGAELVFNGRVKSVDPESKSVTI  120
			  	121  ALTATTGGKKIFGRAIASAKLA

Known structures in the PDB
No Known structures
1 15 29 43 57 71 85 99 113 127 141 Range: 5 to 128  |  Coverage: 86% MaoC_dehydratas Range: 6 to 139  |  Coverage: 93% 1 Range: 1 to 142  |  Coverage: 99% 1
Number of amino acids : 142
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MaoC_dehydratasPF015755-128
Mtb Structural Proteome models
Model Number1
Model nameRv0636
Template2B3N    APDBCREDO
Template coverage32_156
Template Identity(%)28.0
Model coverage(%)93.7
Normalized DOPE score-0.738

Structure Models from Chopin
Model Number1
Profiled.38.1.4 - 3.10.129.10
Click for model details
zscore10.49
Residue begin1
Residue end142
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0636Gene nameConfidence Score
Rv0635hadA0.998
Rv0637hadC0.998
Rv0504cRv0504c0.989
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions