Rv0637

Tuberculist information
Gene namehadC
Protein function(3R)-hydroxyacyl-ACP dehydratase subunit HadC
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)732.825
Molecular mass(da)18929.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 166
	  		  	1    MALKTDIRGMIWRYPDYFIVGREQCREFARAVKCDHPAFFSEEAAADLGYDALVAPLTFV   60
			  	61   TILAKYVQLDFFRHVDVGMETMQIVQVDQRFVFHKPVLAGDKLWARMDIHSVDERFGADI  120
			  	121  VVTRNLCTNDDGELVMEAYTTLMGQQGDGSARLKWDKESGQVIRTA

Known structures in the PDB
No Known structures
1 17 33 49 65 81 97 113 129 145 161 Range: 12 to 138  |  Coverage: 75% zf-MaoC Range: 3 to 144  |  Coverage: 84% 1 Range: 1 to 166  |  Coverage: 99% 1
Number of amino acids : 166
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
zf-MaoCPF1345212-138
Mtb Structural Proteome models
Model Number1
Model nameRv0637
Template2B3N    APDBCREDO
Template coverage33_158
Template Identity(%)16.7
Model coverage(%)84.9
Normalized DOPE score-0.089

Structure Models from Chopin
Model Number1
Profiled.38.1.4 - 3.10.129.10
Click for model details
zscore10.3
Residue begin1
Residue end166
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0637Gene nameConfidence Score
Rv0636hadB0.998
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions