Rv3433c

Tuberculist information
Gene nameRv3433c
Protein functionConserved protein
Functional category(tuberculist)conserved hypotheticals
Gene location(kb)3851.79
Molecular mass(da)46857.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 473
	  		  	1    MRHYYSVDTIRAAEAPLLASLPDGALMRRAAFGLATEIGRELTARTGGVVGRRVCAVVGS   60
			  	61   GDNGGDALWAATFLRRRGAAADAVLLNPDRTHRKALAAFTKSGGRLVESVSAATDLVIDG  120
			  	121  VVGISGSGPLRPAAAQVFAAVQAAAIPVVAVDIPSGIDVATGAITGPAVHAALTVTFGGL  180
			  	181  KPVHALADCGRVVLVDIGLDLAHTDVLGFEATDVAARWPVPGPRDDKYTQGVTGVLAGSS  240
			  	241  TYPGAAVLCTGAAVAATSGMVRYAGTAHAEVLAHWPEVIASPTPAAAGRVQAWVVGPGLG  300
			  	301  TDEAGAAALWFALDTDLPVLVDADGLTMLADHPDLVAGRNAPTVLTPHAGEFARLAGAPP  360
			  	361  GDDRVGACRQLADALGATVLLKGNVTVIADPGGPVYLNPAGQSWAATAGSGDVLSGMIGA  420
			  	421  LLASGLPSGEAAAAAAFVHARASAAAAADPGPGDAPTSASRISGHIRAALAAL

Known structures in the PDB
No Known structures
1 48 95 142 189 236 283 330 377 424 471 Range: 19 to 183  |  Coverage: 34% YjeF_N Range: 233 to 465  |  Coverage: 49% Carb_kinase Range: 10 to 473  |  Coverage: 97% 1 Range: 8 to 473  |  Coverage: 98% 1 Range: 205 to 473  |  Coverage: 56% 2 Range: 19 to 183  |  Coverage: 34% 3 Range: 1 to 224  |  Coverage: 47% 4
Number of amino acids : 473
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
YjeF_NPF0385319-183
Carb_kinasePF01256233-465
Mtb Structural Proteome models
Model Number1
Model nameRv3433c
Template2AX3    APDBCREDO
Template coverage1_488
Template Identity(%)28.7
Model coverage(%)97.9
Normalized DOPE score0.143

Structure Models from Chopin
Model Number1
Profilec.104.1.1, c.72.1.4 - 3.40.1190.20, 3.40.50.10260
Click for model details
zscore64.97
Residue begin8
Residue end473
Model Number2
Profilec.72.1.4 - 3.40.1190.20
Click for model details
zscore46.47
Residue begin205
Residue end473
Model Number3
Profilec.104.1.1 - 3.40.50.10260
Click for model details
zscore32.65
Residue begin19
Residue end183
Model Number4
Profilec.104.1.1 - 3.40.50.10260
Click for model details
zscore30.44
Residue begin1
Residue end224
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3433cGene nameConfidence Score
Rv3422cRv3422c0.927
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
selenomethioninePubChem0.719196.106
SeMetPubChem0.719196.106