SInCRe - Rv3290c

Tuberculist information

Gene name	lat
Protein function	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	3670.45
Molecular mass(da)	49012.1
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 449

	  		  	1    MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMF   60
			  	61   TFVASSALGMNPPALVDDREFHAELMQAALNKPSNSDVYSVAMARFVETFARVLGDPALP  120
			  	121  HLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNT  180
			  	181  KPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPI  240
			  	241  QGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGK  300
			  	301  KTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQH  360
			  	361  GKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQLWQRAVIVLPAGADT  420
			  	421  VRFRPPLTVSTAEIDAAIAAVRSALPVVT

Known structures in the PDB

	PDB ID	2CIN
	Total residue count	449
	Number of chains	1
	Method	X-RAY
	Resolution	1.98

	PDB ID	2CJD
	Total residue count	449
	Number of chains	1
	Method	X-RAY
	Resolution	2

	PDB ID	2CJG
	Total residue count	449
	Number of chains	1
	Method	X-RAY
	Resolution	1.95

	PDB ID	2CJH
	Total residue count	449
	Number of chains	1
	Method	X-RAY
	Resolution	2

	PDB ID	2JJE
	Total residue count	449
	Number of chains	1
	Method	X-RAY
	Resolution	2.2

	PDB ID	2JJF
	Total residue count	449
	Number of chains	1
	Method	X-RAY
	Resolution	1.95

	PDB ID	2JJG
	Total residue count	449
	Number of chains	1
	Method	X-RAY
	Resolution	2.4

	PDB ID	2JJH
	Total residue count	449
	Number of chains	1
	Method	X-RAY
	Resolution	2.7

Number of amino acids : 449

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Aminotran_3	PF00202	38-395

Mtb Structural Proteome models

Model Number	1
Model name	Rv3290c_2cjg_A
Template	2CJG APDB CREDO
Template coverage	15_449
Template Identity(%)	100.0
Model coverage(%)	96.7
Normalized DOPE score	-1.479

Model Number	2
Model name	Rv3290c
Template	1SFF APDB CREDO
Template coverage	9_423
Template Identity(%)	28.7
Model coverage(%)	95.5
Normalized DOPE score	0.067

Structure Models from Chopin

Model Number	1
Profile	c.67.1.4 Click for model details
zscore	27.27
Residue begin	1
Residue end	449

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3290c	Gene name	Confidence Score
Rv1293	lysA	0.904
Rv1293	lysA	0.904

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
alpha-ketoglutaratePubChem	0.995	146.098
L-lysinePubChem	0.994	146.188
pyridoxal phosphatePubChem	0.98	247.142
glutamatePubChem	0.952	147.129
pyridoxamine 5'-phosphatePubChem	0.924	248.173
poly-L-lysine hydrobromidePubChem	0.9	146.188
protiumPubChem	0.9	2.01576
alpha-aminoadipic-delta-semialdehydePubChem	0.9	145.156
deuteriumPubChem	0.9	2.01588
H(+)PubChem	0.9	2.01588
alpha-aminoadipic semialdehydePubChem	0.9	145.156
DB08071PubChem	0.8	259.43