Rv2869c

Tuberculist information
Gene namerip
Protein functionMembrane bound metalloprotease
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)3180.55
Molecular mass(da)42834.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 404
	  		  	1    MMFVTGIVLFALAILISVALHECGHMWVARRTGMKVRRYFVGFGPTLWSTRRGETEYGVK   60
			  	61   AVPLGGFCDIAGMTPVEELDPDERDRAMYKQATWKRVAVLFAGPGMNLAICLVLIYAIAL  120
			  	121  VWGLPNLHPPTRAVIGETGCVAQEVSQGKLEQCTGPGPAALAGIRSGDVVVKVGDTPVSS  180
			  	181  FDEMAAAVRKSHGSVPIVVERDGTAIVTYVDIESTQRWIPNGQGGELQPATVGAIGVGAA  240
			  	241  RVGPVRYGVFSAMPATFAVTGDLTVEVGKALAALPTKVGALVRAIGGGQRDPQTPISVVG  300
			  	301  ASIIGGDTVDHGLWVAFWFFLAQLNLILAAINLLPLLPFDGGHIAVAVFERIRNMVRSAR  360
			  	361  GKVAAAPVNYLKLLPATYVVLVLVVGYMLLTVTADLVNPIRLFQ

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 9 to 395  |  Coverage: 95% Peptidase_M50 Range: 149 to 200  |  Coverage: 12% 1 Range: 128 to 212  |  Coverage: 20% 1 Range: 71 to 233  |  Coverage: 40% 2
Number of amino acids : 404
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Peptidase_M50PF021639-395
Mtb Structural Proteome models
Model Number1
Model nameRv2869c
Template1G9O    APDBCREDO
Template coverage38_91
Template Identity(%)23.1
Model coverage(%)12.6
Normalized DOPE score-0.335

Structure Models from Chopin
Model Number1
Profileb.36.1.5
Click for model details
zscore13.44
Residue begin128
Residue end212
Model Number2
Profileb.36.1.1 - 2.30.42.10
Click for model details
zscore9.33
Residue begin71
Residue end233
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2869cGene nameConfidence Score
Rv2870cdxr0.981
Rv2870cdxr0.981
Rv2870cdxr0.981
Rv2868cgcpE0.969
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions