Rv2857c

Tuberculist information
Gene nameRv2857c
Protein functionProbable short-chain type dehydrogenase/reductase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3168.58
Molecular mass(da)26772.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 258
	  		  	1    VMDLSQRLAGRVAVITGGGSGIGLAAGRRMRAEGATIVVGDVDVEAGGAAADELSGLFVP   60
			  	61   TDVCDEDAVNGLFDGAAETYGRIDIAFNNAGISPPEDNLIENTELAAWQRVQDVNLKSVY  120
			  	121  LCCRAALRHMVLAGKGSIVNTASFVAVMGSATSQISYTASKGGVLAMSRELGVQFARQGI  180
			  	181  RVNALCPGPVNTPLLQELFAKNPERAARRMVHVPLGRFAEPDEIAAAVAFLASDDASFIT  240
			  	241  ASTFLVDGGISSAYVTPL

Known structures in the PDB
No Known structures
1 26 51 76 101 126 151 176 201 226 251 Range: 17 to 251  |  Coverage: 90% adh_short_C2 Range: 7 to 254  |  Coverage: 95% 1 Range: 1 to 258  |  Coverage: 99% 1
Number of amino acids : 258
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
adh_short_C2PF1356117-251
Mtb Structural Proteome models
Model Number1
Model nameRv2857c
Template1IY8    APDBCREDO
Template coverage10_267
Template Identity(%)42.7
Model coverage(%)95.7
Normalized DOPE score-0.538

Structure Models from Chopin
Model Number1
Profilec.2.1.2 - 3.40.50.720
Click for model details
zscore24.92
Residue begin1
Residue end258
Binding pockets
STRING
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Protein interacting with Rv2857cGene nameConfidence Score
Rv2860cglnA40.965
Rv2860cglnA40.965
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions