Rv2435c

Tuberculist information
Gene nameRv2435c
Protein functionProbable cyclase (adenylyl- or guanylyl-)(adenylate- or guanylate-)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2730.56
Molecular mass(da)80245.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 730
	  		  	1    LTSGEALDSVAESESTPAKKRHKNVLRRRPRFRASIQSKLMVLLLLTSIVSVAAIAAIVY   60
			  	61   QSGRTSLRAAAYERLTQLRESQKRAVETLFSDLTNSLVIYERGLTVVDAVVRFTAGFDQL  120
			  	121  ADATISPAQQQAIVNYYNNEFITPVERTTGDKLDITALLPTSPAQRYLQAYYTAPFTSDQ  180
			  	181  DAMRLDDAGDGSAWSAANAQFNSYFREIVTRFDYDDAVLLDTRGNIVYTLSKDPDLGTNI  240
			  	241  LTGPYRESNLRDAYLKALGANAVDFTWITDFKPYQPQLGVPTAWLVAPVEAGGKTQGVLA  300
			  	301  LPLPIDKINKIMTADRQWQAAGMGSGTETYLAGPDSLMRSDSRLFLQDPEEYRKQVVAAG  360
			  	361  TSLDVVNRAIQFGGTTLLQPVATEGLRAAQRGQTGTVTSTDYTGSRELEAYAPLNVPDSD  420
			  	421  LHWSILATRNDSEAFAAVASFSRALVLVTVGIIVVICVASMLIAHAMVRPIRRLEVGTQK  480
			  	481  ISAGDYEVNIPVKSRDEIGDLTAAFNEMSRNLQTKEELLNEQRKENDRLLLSMMPEPVVE  540
			  	541  RYRLGEQTIAQEHQDVTVLFADILGVDEISSGLSGNELVKIVDELVRQFDSAAEHLGVER  600
			  	601  IRTLHNGYLAGCGVTTPRLDNIPRTVDFALEMRRIVDRFNCQTGNDLHLRVGINTGDVIS  660
			  	661  GLVGRSSVVYDMWGAAVSLAYQMHSGSPQPGIYVTSQVYEAMRDVWQFTAAGTISVGGLE  720
			  	721  EPIYRLSERS

Known structures in the PDB
No Known structures
1 74 147 220 293 366 439 512 585 658 731 Range: 445 to 514  |  Coverage: 9% HAMP Range: 548 to 727  |  Coverage: 24% Guanylate_cyc Range: 543 to 710  |  Coverage: 22% 1 Range: 548 to 727  |  Coverage: 24% 1
Number of amino acids : 730
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
HAMPPF00672445-514
Guanylate_cycPF00211548-727
Mtb Structural Proteome models
Model Number1
Model nameRv2435c
Template1AZS    APDBCREDO
Template coverage377_544
Template Identity(%)27.4
Model coverage(%)22.9
Normalized DOPE score-1.136

Structure Models from Chopin
Model Number1
Profiled.58.29.1 - 3.30.70.1230
Click for model details
zscore22.94
Residue begin548
Residue end727
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2435cGene nameConfidence Score
Rv2434cRv2434c0.997
Rv2434cRv2434c0.997
Rv1625ccya0.95
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Target nameCHEMBL IDSMILES
Adenylyl CyclaseC[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)COS(=O)(=O)c5ccc(Br)cc5
Adenylyl CyclaseOC(=O)c1cc2C3C(C4C(c2cc1S(=O)(=O)O)C5(Cl)C(=C(Cl)C4(Cl)C5(Cl)Cl)Cl)C6(Cl)C(=C(Cl)C3(Cl)C6(Cl)Cl)Cl
Adenylyl CyclaseCC(=O)O[C@H]1[C@@H](O)[C@H]2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]2(O)C(=O)C[C@@](C)(O[C@]12C)C=C
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
cyclic AMPPubChem0.9329.206
pyrophosphatePubChem0.9177.975
adenosine triphosphatePubChem0.9507.181
magnesiumPubChem0.924.305