Rv2434c

Tuberculist information
Gene nameRv2434c
Protein functionProbable conserved transmembrane protein
Functional category(tuberculist)cell wall and cell processes
Gene location(kb)2729.11
Molecular mass(da)52272.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 481
	  		  	1    MNLLDSTWFYWAVGIAIGLPAGLIVLTELHNILVRRNSHLARQASLLRNYLLPLGAVLLL   60
			  	61   LVKASEVPAEDPTVRVLTTAFGFLVLVLLLSLLNATLFQGAPQQSWRKRLPAIFVDVARF  120
			  	121  ALIGIGLAVILSYIWGVRVGGLFAALGVTSVVIGLMLQNSVGQIVSGLFMLFEQPFRIDD  180
			  	181  WLETPTARGRVVEVNWRAVHIDTGSGLQIMPNSMLATTAFTNLSRPAGAHECSITTTFST  240
			  	241  SDPPDKVCAMLNRAASALPHVKPGVVPATIARGAAEYRTTVRLTSPADEGPTQATFLRWV  300
			  	301  WYAARREGLHLDEADDEFSTAERVESALRTVVGPELRLSSSDQQSLARYARLVRYGTDEI  360
			  	361  VQHAGVVPMGITFVIAGSVRLTVTTDDGSVVAIATLKKGTFLGLTALTRQPDPAGAVALE  420
			  	421  EVTALQIGREHLEQVVMNKPMLLQELGRVIDERQRKAQQAIRRDLHQSPAAAGEHRGPAR  480
			  	481  R

Known structures in the PDB
No Known structures
1 49 97 145 193 241 289 337 385 433 481 Range: 115 to 311  |  Coverage: 40% MS_channel Range: 352 to 441  |  Coverage: 18% cNMP_binding Range: 339 to 476  |  Coverage: 28% 1 Range: 70 to 324  |  Coverage: 52% 1 Range: 159 to 224  |  Coverage: 13% 2 Range: 329 to 467  |  Coverage: 28% 3 Range: 226 to 323  |  Coverage: 20% 4 Range: 175 to 223  |  Coverage: 9% 5
Number of amino acids : 481
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MS_channelPF00924115-311
cNMP_bindingPF00027352-441
Mtb Structural Proteome models
Model Number1
Model nameRv2434c
Template1HW5    APDBCREDO
Template coverage7_146
Template Identity(%)14.5
Model coverage(%)28.5
Normalized DOPE score-0.627

Structure Models from Chopin
Model Number1
Profileb.38.1.3, d.58.43.1, f.34.1.1 - 2.30.30.60, 3.30.70.100
Click for model details
zscore22.03
Residue begin70
Residue end324
Model Number2
Profileb.38.1.3
Click for model details
zscore17.52
Residue begin159
Residue end224
Model Number3
Profileb.82.3.1
Click for model details
zscore15.89
Residue begin329
Residue end467
Model Number4
Profiled.58.43.1
Click for model details
zscore15.26
Residue begin226
Residue end323
Model Number5
Profile2.30.30.60
Click for model details
zscore12.53
Residue begin175
Residue end223
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2434cGene nameConfidence Score
Rv2435cRv2435c0.997
Rv2435cRv2435c0.997
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions