SInCRe - Rv2006

Tuberculist information

Gene name	otsB1
Protein function	Probable trehalose-6-phosphate phosphatase OtsB1 (trehalose-phosphatase) (TPP)
Functional category(tuberculist)	virulence,detoxification and adaptaion
Gene location(kb)	2252
Molecular mass(da)	145752
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 1327

	  		  	1    VRCGIVVNVTGPPPTIDRRYHDAVIVGLDNVVDKATRVHAAAWTKFLDDYLTRRPQRTGE   60
			  	61   DHCPLTHDDYRRFLAGKPDGVADFLAARGIRLPPGSPTDLTDDTVYGLQNLERQTFLQLL  120
			  	121  NTGVPEGKSIASFARRLQVAGVRVAAHTSHRNYGHTLDATGLAEVFAVFVDGAVTAELGL  180
			  	181  PAEPNPAGLIETAKRLGANPGRCVVIDSCQTGLRAGRNGGFALVIAVDAHGDAENLLSSG  240
			  	241  ADAVVADLAAVTVGSGDAAISTIPDALQVYSQLKRLLTGRRPAVFLDFDGTLSDIVERPE  300
			  	301  AATLVDGAAEALRALAAQCPVAVISGRDLADVRNRVKVDGLWLAGSHGFELVAPDGSHHQ  360
			  	361  NAAATAAIDGLAEAAAQLADALREIAGAVVEHKRFAVAVHYRNVADDSVDNLIAAVRRLG  420
			  	421  HAAGLRVTTGRKVVELRPDIAWDKGKALDWIGERLGPAEVGPDLRLPIYIGDDLTDEDAF  480
			  	481  DAVRFTGVGIVVRHNEHGDRRSAATFRLECPYTVCQFLSQLACDLQEAVQHDDPWTLVFH  540
			  	541  GYDPGQERLREALCAVGNGYLGSRGCAPESAESEAHYPGTYVAGVYNQLTDHIEGCTVDN  600
			  	601  ESLVNLPNWLSLTFRIDGGAWFNVDTVELLSYRQTFDLRRATLTRSLRFRDAGGRVTTMT  660
			  	661  QERFASMNRPNLVALQTRIESENWSGTVDFRSLVDGGVHNTLVDRYRQLSSQHLTTAEIE  720
			  	721  VLADSVLLRTQTSQSGIAIAVAARSTLWRDGQRVDAQYRVARDTNRGGHDIQVTLSAGQS  780
			  	781  VTLEKVATIFTSRDAATLTAAISAQRCLGEAGRYAELCQQHVRAWARLWERCAIDLTGNT  840
			  	841  EELRLVRLHLLHLLQTISPHTAELDAGVPARGLNGEAYRGHVFWDALFVAPVLSLRMPKV  900
			  	901  ARSLLDYRYRRLPAARRAAHRAGHLGAMYPWQSGSDGSEVSQQLHLNPRSGRWTPDPSDR  960
			  	961  AHHVGLAVAYNAWHYYQVTGDRQYLVDCGAELLVEIARFWVGLAKLDDSRGRYLIRGVIG 1020
			  	1021 PDEFHSGYPGNEYDGIDNNAYTNVMAVWVILRAMEALDLLPLTDRRHLIEKLGLTTQERD 1080
			  	1081 QWDDVSRRMFVPFHDGVISQFEGYSELAELDWDHYRHRYGNIQRLDRILEAEGDSVNNYQ 1140
			  	1141 ASKQADALMLLYLLSSDELIGLLARLGYRFAPTQIPGTVDYYLARTSDGSTLSAVVHAWV 1200
			  	1201 LARANRSNAMEYFRQVLRSDIADVQGGTTQEGIHLAAMAGSIDLLQRCYSGLELRDDRLV 1260
			  	1261 LSPQWPEALGPLEFPFVYRRHQLSLRISGRSATLTAESGDAEPIEVECRGHVQRLRCGHT 1320
			  	1321 IEVGCSR

Known structures in the PDB

No Known structures

Number of amino acids : 1327

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Hydrolase	PF00702	38-220
Trehalose_PPase	PF02358	285-512
Glyco_hydro_65N	PF03636	536-795
Glyco_hydro_65m	PF03632	847-1259
Glyco_hydro_65C	PF03633	1263-1317

Mtb Structural Proteome models

Model Number	1
Model name	Rv2006.1
Template	1O08 APDB CREDO
Template coverage	1002_1193
Template Identity(%)	14.6
Model coverage(%)	15.8
Normalized DOPE score	-0.574

Model Number	2
Model name	Rv2006
Template	1H54 APDB CREDO
Template coverage	6_753
Template Identity(%)	24.2
Model coverage(%)	59.3
Normalized DOPE score	-0.383

Model Number	3
Model name	Rv2006.3
Template	1Y8A APDB CREDO
Template coverage	-2_308
Template Identity(%)	18.0
Model coverage(%)	21.3
Normalized DOPE score	0.426

Model Number	4
Model name	Rv2006.2
Template	1L6R APDB CREDO
Template coverage	0_224
Template Identity(%)	16.0
Model coverage(%)	18.5
Normalized DOPE score	0.52

Structure Models from Chopin

Model Number	1
Profile	a.102.1.4, b.30.5.3 - 1.50.10.10, 2.60.420.10, 2.70.98.40 Click for model details
zscore	85.96
Residue begin	526
Residue end	1319

Model Number	2
Profile	a.102.1.4 Click for model details
zscore	41.36
Residue begin	792
Residue end	1321

Model Number	3
Profile	2.70.98.40 Click for model details
zscore	32.62
Residue begin	526
Residue end	796

Model Number	4
Profile	c.108.1.15 Click for model details
zscore	28.29
Residue begin	282
Residue end	529

Model Number	5
Profile	c.108.1.6 Click for model details
zscore	17.53
Residue begin	13
Residue end	266

Model Number	6
Profile	c.108.1.10 Click for model details
zscore	12.91
Residue begin	175
Residue end	538

Model Number	7
Profile	2.60.420.10 Click for model details
zscore	11.91
Residue begin	1243
Residue end	1318

Model Number	8
Profile	c.108.1.2, c.69.1.11 - 3.40.50.1000, 3.40.50.1820 Click for model details
zscore	11.16
Residue begin	78
Residue end	548

Model Number	9
Profile	c.108.1.9, c.37.1.1 - 3.40.50.1000, 3.40.50.300 Click for model details
zscore	10.05
Residue begin	128
Residue end	407

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2006	Gene name	Confidence Score
Rv3372	otsB2	0.971

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv2006.3	5	1pcg_EST_B_2 PDB CREDO	0.688	0.090	0.688	0.000
Rv2006.3	5	1ere_EST_E_600 PDB CREDO	0.680	0.097	0.680	0.000
Rv2006.3	5	1ere_EST_B_600 PDB CREDO	0.678	0.099	0.678	0.000
Rv2006.3	5	1g50_EST_B_1600 PDB CREDO	0.677	0.100	0.677	0.000
Rv2006.3	5	1ere_EST_A_600 PDB CREDO	0.675	0.101	0.675	0.000
Rv2006.3	5	1gwr_EST_A_600 PDB CREDO	0.674	0.102	0.674	0.000
Rv2006.3	5	1qku_EST_B_600 PDB CREDO	0.674	0.102	0.674	0.000
Rv2006.3	5	1qku_EST_A_600 PDB CREDO	0.673	0.103	0.673	0.000
Rv2006.3	5	1qku_EST_C_600 PDB CREDO	0.672	0.104	0.672	0.000
Rv2006.3	5	1gwr_EST_B_600 PDB CREDO	0.671	0.105	0.671	0.000
Rv2006.3	5	1pcg_EST_A_1 PDB CREDO	0.732	0.059	0.640	0.001
Rv2006.3	5	3hm1_J3Z_B_1 PDB CREDO	0.732	0.059	0.640	0.001
Rv2006.3	5	2j7x_EST_A_1454 PDB CREDO	0.730	0.059	0.639	0.001
Rv2006.3	5	1ere_EST_C_600 PDB CREDO	0.728	0.061	0.637	0.001
Rv2006.3	5	1ere_EST_D_600 PDB CREDO	0.727	0.061	0.636	0.001
Rv2006.3	5	1ere_EST_F_600 PDB CREDO	0.727	0.061	0.636	0.001
Rv2006.3	5	2ocf_EST_A_596 PDB CREDO	0.727	0.061	0.636	0.001
Rv2006.3	5	1g50_EST_C_2600 PDB CREDO	0.726	0.062	0.636	0.001
Rv2006.3	5	1qkt_EST_A_600 PDB CREDO	0.726	0.062	0.636	0.001
Rv2006.3	5	3oll_EST_B_600 PDB CREDO	0.726	0.062	0.636	0.001
Rv2006.3	5	3oll_EST_A_600 PDB CREDO	0.725	0.063	0.635	0.001
Rv2006.3	5	1a52_EST_B_2 PDB CREDO	0.721	0.066	0.631	0.001
Rv2006.3	5	1a52_EST_A_1 PDB CREDO	0.716	0.069	0.626	0.001
Rv2006.3	5	3hm1_J3Z_A_2 PDB CREDO	0.610	0.167	0.610	0.002
Rv2006.3	5	1cqp_803_A_311 PDB CREDO	0.604	0.175	0.604	0.002
Rv2006.3	3	3k4v_ROC_D_201 PDB CREDO	0.615	0.162	0.601	0.002
Rv2006.3	3	2nnk_ROC_A_401 PDB CREDO	0.638	0.137	0.594	0.002
Rv2006.3	3	3ndt_ROC_D_100 PDB CREDO	0.637	0.138	0.593	0.002
Rv2006.3	3	2avv_MK1_A_901 PDB CREDO	0.618	0.158	0.589	0.003
Rv2006.3	3	2o4k_DR7_A_301 PDB CREDO	0.589	0.193	0.589	0.003
Rv2006.3	3	3ndu_ROC_D_100 PDB CREDO	0.602	0.177	0.588	0.003
Rv2006.3	3	2avv_MK1_E_902 PDB CREDO	0.615	0.162	0.587	0.003
Rv2006.3	5	2y7j_B49_A_1294 PDB CREDO	0.585	0.198	0.585	0.003
Rv2006.3	3	3cs9_NIL_C_600 PDB CREDO	0.764	0.040	0.582	0.003
Rv2006.3	3	3cs9_NIL_D_600 PDB CREDO	0.762	0.042	0.580	0.003
Rv2006.3	3	2nmy_ROC_A_401 PDB CREDO	0.606	0.172	0.579	0.003
Rv2006.3	3	3gp0_NIL_A_1 PDB CREDO	0.736	0.056	0.576	0.003
Rv2006.3	5	3ols_EST_A_600 PDB CREDO	0.744	0.051	0.575	0.003
Rv2006.3	5	3ols_EST_B_600 PDB CREDO	0.744	0.051	0.575	0.003
Rv2006.3	3	2fxd_DR7_A_102 PDB CREDO	0.768	0.038	0.570	0.004
Rv2006.3	5	1g50_EST_A_600 PDB CREDO	0.736	0.056	0.568	0.004
Rv2006.3	5	2yja_EST_B_1550 PDB CREDO	0.733	0.058	0.566	0.004
Rv2006.3	5	2y7j_B49_D_1294 PDB CREDO	0.591	0.190	0.565	0.004
Rv2006.3	5	3uud_EST_B_600 PDB CREDO	0.728	0.061	0.562	0.004
Rv2006.3	3	1sdt_MK1_B_902 PDB CREDO	0.618	0.158	0.562	0.004
Rv2006.3	3	1k6c_MK1_B_902 PDB CREDO	0.588	0.193	0.561	0.004
Rv2006.3	5	3lfa_1N1_A_361 PDB CREDO	0.668	0.107	0.560	0.004
Rv2006.3	3	3cyx_ROC_A_201 PDB CREDO	0.572	0.214	0.559	0.004
Rv2006.3	5	3uud_EST_A_600 PDB CREDO	0.721	0.066	0.557	0.004
Rv2006.3	3	1c6z_ROC_B_505 PDB CREDO	0.642	0.132	0.556	0.005
Rv2006.3	3	3tkg_ROC_C_901 PDB CREDO	0.556	0.236	0.556	0.005
Rv2006.3	3	3ucb_017_A_201 PDB CREDO	0.595	0.185	0.555	0.005
Rv2006.3	3	1rl8_RIT_A_9001 PDB CREDO	0.624	0.152	0.554	0.005
Rv2006.3	3	3pwr_ROC_A_401 PDB CREDO	0.608	0.170	0.553	0.005
Rv2006.3	3	3el4_ROC_A_100 PDB CREDO	0.579	0.205	0.553	0.005
Rv2006.3	3	3oxx_DR7_C_100 PDB CREDO	0.622	0.153	0.553	0.005
Rv2006.3	5	1cqp_803_B_311 PDB CREDO	0.552	0.241	0.552	0.005
Rv2006.3	3	3oxc_ROC_A_401 PDB CREDO	0.630	0.145	0.551	0.005
Rv2006.3	3	1opj_STI_A_3 PDB CREDO	0.782	0.032	0.549	0.005
Rv2006.3	3	2aqu_DR7_B_300 PDB CREDO	0.648	0.126	0.547	0.005
Rv2006.3	3	3oxx_DR7_A_100 PDB CREDO	0.647	0.128	0.546	0.005
Rv2006.3	5	3rem_SAL_B_301 PDB CREDO	0.662	0.113	0.545	0.005
Rv2006.3	3	1opj_STI_B_4 PDB CREDO	0.776	0.035	0.545	0.005
Rv2006.3	3	1hxb_ROC_A_100 PDB CREDO	0.626	0.149	0.542	0.006
Rv2006.3	3	3eky_DR7_A_100 PDB CREDO	0.675	0.101	0.542	0.006
Rv2006.3	3	3cs9_NIL_B_600 PDB CREDO	0.750	0.048	0.541	0.006
Rv2006.3	3	3k4v_ROC_B_201 PDB CREDO	0.659	0.116	0.541	0.006
Rv2006.3	5	2j7y_E3O_A_1454 PDB CREDO	0.788	0.030	0.541	0.006
Rv2006.3	5	2uxp_CLM_B_1211 PDB CREDO	0.540	0.258	0.540	0.006
Rv2006.3	3	2fxe_DR7_A_102 PDB CREDO	0.672	0.104	0.539	0.006
Rv2006.3	3	3d1y_ROC_A_201 PDB CREDO	0.607	0.170	0.539	0.006
Rv2006.3	3	3em4_DR7_V_100 PDB CREDO	0.672	0.104	0.539	0.006
Rv2006.3	3	3cs9_NIL_A_600 PDB CREDO	0.767	0.039	0.539	0.006
Rv2006.3	5	1pg2_ADN_A_552 PDB CREDO	0.564	0.225	0.538	0.006
Rv2006.3	3	1hxw_RIT_B_301 PDB CREDO	0.668	0.107	0.536	0.006
Rv2006.3	3	2r5p_MK1_B_902 PDB CREDO	0.667	0.108	0.536	0.006
Rv2006.3	3	1t7i_017_A_200 PDB CREDO	0.561	0.229	0.535	0.006
Rv2006.3	5	1s9p_DES_B_459 PDB CREDO	0.721	0.066	0.535	0.006
Rv2006.3	3	2r5p_MK1_D_902 PDB CREDO	0.666	0.109	0.535	0.006
Rv2006.3	5	1s9p_DES_C_500 PDB CREDO	0.720	0.066	0.534	0.006
Rv2006.3	3	3el9_DR7_A_100 PDB CREDO	0.719	0.067	0.533	0.007
Rv2006.3	3	3ndt_ROC_A_101 PDB CREDO	0.663	0.112	0.533	0.007
Rv2006.3	3	3ogq_AB1_A_200 PDB CREDO	0.647	0.128	0.533	0.007
Rv2006.1	16	4dta_ADN_B_401 PDB CREDO	0.532	0.270	0.532	0.007
Rv2006.3	5	1uay_ADN_A_1001 PDB CREDO	0.531	0.272	0.531	0.007
Rv2006.3	3	1sdv_MK1_B_902 PDB CREDO	0.696	0.084	0.530	0.007
Rv2006.1	4	3n58_ADN_A_500 PDB CREDO	0.585	0.197	0.528	0.007
Rv2006.3	3	2ieo_017_A_402 PDB CREDO	0.540	0.258	0.527	0.007
Rv2006.3	3	3ndw_RIT_A_100 PDB CREDO	0.594	0.186	0.527	0.007
Rv2006.3	3	3d20_017_A_201 PDB CREDO	0.527	0.278	0.527	0.007
Rv2006.3	3	3tkg_ROC_B_801 PDB CREDO	0.627	0.148	0.525	0.007
Rv2006.3	3	2qxs_RAL_A_600 PDB CREDO	0.726	0.062	0.524	0.008
Rv2006.3	3	3rgf_BAX_A_465 PDB CREDO	0.788	0.029	0.523	0.008
Rv2006.3	5	1r9o_FLP_A_501 PDB CREDO	0.523	0.283	0.523	0.008
Rv2006.3	3	2qxs_RAL_B_600 PDB CREDO	0.724	0.064	0.523	0.008
Rv2006.3	3	2xkw_P1B_A_1478 PDB CREDO	0.635	0.140	0.523	0.008
Rv2006.3	5	3rem_SAL_A_301 PDB CREDO	0.633	0.141	0.522	0.008
Rv2006.3	3	3d1z_017_B_201 PDB CREDO	0.559	0.231	0.521	0.008
Rv2006.3	3	1hsh_MK1_C_402 PDB CREDO	0.702	0.079	0.521	0.008
Rv2006.3	3	3k5v_STI_A_2 PDB CREDO	0.762	0.041	0.521	0.008
Rv2006.3	3	1hsh_MK1_A_401 PDB CREDO	0.702	0.080	0.520	0.008
Rv2006.3	3	2hs2_017_A_201 PDB CREDO	0.559	0.232	0.520	0.008
Rv2006.3	3	2avo_MK1_B_902 PDB CREDO	0.599	0.180	0.519	0.008
Rv2006.3	3	3ndx_RIT_A_100 PDB CREDO	0.543	0.254	0.518	0.008
Rv2006.3	3	2q64_1UN_B_1001 PDB CREDO	0.597	0.183	0.517	0.008
Rv2006.3	3	1sh9_RIT_B_301 PDB CREDO	0.696	0.084	0.516	0.009
Rv2006.3	3	2q63_1UN_A_1001 PDB CREDO	0.595	0.185	0.515	0.009
Rv2006.3	3	2pym_1UN_A_1001 PDB CREDO	0.595	0.185	0.515	0.009
Rv2006.3	3	2qak_1UN_A_1001 PDB CREDO	0.594	0.186	0.515	0.009
Rv2006.3	3	3tl9_ROC_A_401 PDB CREDO	0.563	0.226	0.515	0.009
Rv2006.3	3	2pyn_1UN_A_1001 PDB CREDO	0.594	0.187	0.514	0.009
Rv2006.3	3	3s56_ROC_A_201 PDB CREDO	0.693	0.086	0.514	0.009
Rv2006.3	3	3jvy_017_B_401 PDB CREDO	0.550	0.245	0.513	0.009
Rv2006.3	5	2uxp_CLM_A_1211 PDB CREDO	0.513	0.299	0.513	0.009
Rv2006.3	3	1xkk_FMM_A_91 PDB CREDO	0.638	0.137	0.512	0.009
Rv2006.3	3	2b60_RIT_B_100 PDB CREDO	0.655	0.120	0.512	0.009
Rv2006.3	3	3ekw_DR7_B_100 PDB CREDO	0.620	0.156	0.510	0.009
Rv2006.3	3	2nnp_ROC_A_401 PDB CREDO	0.534	0.266	0.510	0.009
Rv2006.2	3	3ilt_TRU_E_800 PDB CREDO	0.536	0.264	0.510	0.009
Rv2006.3	3	3qoz_017_A_201 PDB CREDO	0.534	0.267	0.510	0.009
Rv2006.3	5	3hgx_SAL_B_104 PDB CREDO	0.724	0.064	0.510	0.009
Rv2006.3	3	3oez_STI_A_601 PDB CREDO	0.789	0.029	0.509	0.009
Rv2006.3	3	3em4_DR7_A_100 PDB CREDO	0.686	0.091	0.509	0.009
Rv2006.1	4	1d4f_ADN_C_603 PDB CREDO	0.565	0.224	0.509	0.009
Rv2006.3	3	2hyy_STI_C_600 PDB CREDO	0.788	0.030	0.508	0.010
Rv2006.3	3	2avs_MK1_B_902 PDB CREDO	0.586	0.196	0.508	0.010
Rv2006.3	3	3jw2_017_A_401 PDB CREDO	0.545	0.251	0.508	0.010
Rv2006.3	3	3mss_STI_B_1 PDB CREDO	0.786	0.030	0.507	0.010
Rv2006.3	3	2hyy_STI_D_600 PDB CREDO	0.786	0.030	0.507	0.010
Rv2006.3	3	3gvu_STI_A_1001 PDB CREDO	0.786	0.030	0.507	0.010
Rv2006.3	3	3pyy_STI_B_4 PDB CREDO	0.785	0.031	0.507	0.010
Rv2006.3	3	2o4l_TPV_A_403 PDB CREDO	0.518	0.291	0.506	0.010
Rv2006.3	3	2hyy_STI_A_600 PDB CREDO	0.783	0.032	0.505	0.010
Rv2006.3	3	3el1_DR7_A_100 PDB CREDO	0.614	0.163	0.505	0.010
Rv2006.3	5	3ret_SAL_B_201 PDB CREDO	0.718	0.068	0.505	0.010
Rv2006.3	3	1iep_STI_B_202 PDB CREDO	0.783	0.032	0.505	0.010
Rv2006.3	3	3k5v_STI_B_2 PDB CREDO	0.783	0.032	0.505	0.010
Rv2006.3	5	1mx1_THA_B_2 PDB CREDO	0.628	0.147	0.505	0.010
Rv2006.3	3	1iep_STI_A_201 PDB CREDO	0.782	0.032	0.505	0.010
Rv2006.3	3	1sdu_MK1_B_902 PDB CREDO	0.612	0.164	0.504	0.010
Rv2006.3	3	3ggu_017_B_201 PDB CREDO	0.628	0.147	0.504	0.010
Rv2006.3	3	2ien_017_B_402 PDB CREDO	0.539	0.259	0.504	0.010
Rv2006.3	5	2zva_1N1_A_513 PDB CREDO	0.679	0.098	0.504	0.010
Rv2006.3	3	3mss_STI_C_1 PDB CREDO	0.779	0.033	0.503	0.010
Rv2006.2	3	3rf4_FUN_C_203 PDB CREDO	0.503	0.314	0.503	0.010
Rv2006.3	3	3ms9_STI_A_1 PDB CREDO	0.778	0.034	0.503	0.010
Rv2006.3	3	3ms9_STI_B_1 PDB CREDO	0.778	0.034	0.503	0.010
Rv2006.3	3	3mss_STI_A_1 PDB CREDO	0.778	0.034	0.502	0.011
Rv2006.3	3	3mss_STI_D_1 PDB CREDO	0.778	0.034	0.502	0.011
Rv2006.3	3	3d1x_ROC_A_201 PDB CREDO	0.574	0.212	0.502	0.011
Rv2006.3	3	3pyy_STI_A_3 PDB CREDO	0.777	0.034	0.501	0.011
Rv2006.1	16	1pwy_AC2_E_290 PDB CREDO	0.574	0.212	0.501	0.011
Rv2006.3	3	1t46_STI_A_3 PDB CREDO	0.657	0.118	0.500	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
trehalosePubChem	0.959	342.296
trehalose-6-phosphatePubChem	0.728	422.276