SInCRe - Rv1901

Tuberculist information

Gene name	cinA
Protein function	Probable CinA-like protein CinA
Functional category(tuberculist)	virulence,detoxification and adaptaion
Gene location(kb)	2147.66
Molecular mass(da)	45512
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 430

	  		  	1    MAVSARAGIVITGTEVLTGRVQDRNGPWIADRLLELGVELAHITICGDRPADIEAQLRFM   60
			  	61   AEQGVDLIVTSGGLGPTADDMTVEVVARYCGRELVLDDELENRIANILKKLMGRNPAIEP  120
			  	121  ANFDSIRAANRKQAMIPAGSQVIDPVGTAPGLVVPGRPAVMVLPGPPRELQPIWSKAIQT  180
			  	181  APVQDAIAGRTTYRQETIRIFGLPESSLADTLRDAEAAIPGFDLVEITTCLRRGEIEMVT  240
			  	241  RFEPNAAQVYTQLARLLRDRHGHQVYSEDGASVDELVAKLLTGRRIATAESCTAGLLAAR  300
			  	301  LTDRPGSSKYVAGAVVAYSNEAKAQLLGVDPALIEAHGAVSEPVAQAMAAGALQGFGADT  360
			  	361  ATAITGIAGPSGGTPEKPVGTVCFTVLLDDGRTTTRTVRLPGNRSDIRERSTTVAMHLLR  420
			  	421  RTLSGIPGSP

Known structures in the PDB

No Known structures

Number of amino acids : 430

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
MoCF_biosynth	PF00994	8-184
CinA	PF02464	270-423

Mtb Structural Proteome models

Model Number	1
Model name	Rv1901
Template	2A9S APDB CREDO
Template coverage	8_160
Template Identity(%)	41.5
Model coverage(%)	34.0
Normalized DOPE score	-1.272

Model Number	2
Model name	Rv1901.1
Template	1UUY APDB CREDO
Template coverage	7_156
Template Identity(%)	22.7
Model coverage(%)	40.9
Normalized DOPE score	-0.852

Structure Models from Chopin

Model Number	1
Profile	c.51.5.1 - 3.90.950.20 Click for model details
zscore	39.29
Residue begin	270
Residue end	423

Model Number	2
Profile	c.57.1.2 Click for model details
zscore	13.76
Residue begin	3
Residue end	159

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1901	Gene name	Confidence Score
Rv2737c	recA	0.903
Rv2737c	recA	0.903

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv1901.1	1	3q70_RIT_A_2001 PDB CREDO	0.637	0.137	0.618	0.001
Rv1901.1	1	3tne_RIT_A_401 PDB CREDO	0.616	0.160	0.579	0.003
Rv1901.1	1	3tne_RIT_B_401 PDB CREDO	0.612	0.165	0.575	0.003
Rv1901.1	1	3tkd_CYZ_B_267 PDB CREDO	0.569	0.218	0.569	0.004
Rv1901.1	1	1lhv_NOG_A_301 PDB CREDO	0.616	0.160	0.561	0.004
Rv1901.1	1	3d91_REM_A_350 PDB CREDO	0.587	0.195	0.553	0.005
Rv1901.1	1	3d91_REM_B_350 PDB CREDO	0.586	0.196	0.552	0.005
Rv1901.1	1	3tkd_CYZ_A_266 PDB CREDO	0.576	0.209	0.541	0.006
Rv1901.1	1	2nni_MTK_A_501 PDB CREDO	0.585	0.197	0.535	0.006
Rv1901.1	1	1uwh_BAX_A_1723 PDB CREDO	0.520	0.287	0.520	0.008
Rv1901.1	1	1uwh_BAX_B_1723 PDB CREDO	0.520	0.288	0.520	0.008
Rv1901.1	1	1etr_MIT_H_1 PDB CREDO	0.580	0.204	0.511	0.009
Rv1901.1	1	3pww_ROC_A_1001 PDB CREDO	0.670	0.106	0.504	0.010
Rv1901.1	1	1z2b_VLB_C_800 PDB CREDO	0.517	0.293	0.501	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

No high confidence interactions