SInCRe - Rv1882c

Tuberculist information

Gene name	Rv1882c
Protein function	Probable short-chain type dehydrogenase/reductase
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	2132.37
Molecular mass(da)	30010.4
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 277

	  		  	1    MKAIFITGAGSGMGREGATLFHANGWRVGAIDRNEDGLAALRVQLGAERLWARAVDVTDK   60
			  	61   AALEGALADFCAGNVGGGLDMMWNNAGIGEGGWFEDVPYEAAVRVVDVNFKAVLTGAYAA  120
			  	121  LPYLKKAPGSLMFSTSSSSGTYGMPRIAVYSATKHAVKGLTEALSVEWQRHGVRVADVLP  180
			  	181  GLIDTAILTSTRQHSDEGPYTISAEQIRAAAPKKGMFRLMPSSSVAEAAWRAYQHPTRLH  240
			  	241  WYVPRSIRWIDRLKGVSPEFVRRHIAKSLATLEPKRK

Known structures in the PDB

No Known structures

Number of amino acids : 277

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
adh_short	PF00106	2-169

Mtb Structural Proteome models

Model Number	1
Model name	Rv1882c
Template	1GEG APDB CREDO
Template coverage	3_253
Template Identity(%)	26.7
Model coverage(%)	91.0
Normalized DOPE score	-0.101

Structure Models from Chopin

Model Number	1
Profile	c.2.1.2 - 3.40.50.720 Click for model details
zscore	19.5
Residue begin	1
Residue end	277

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv1882c	Gene name	Confidence Score
Rv1883c	Rv1883c	0.957
Rv1881c	lppE	0.952
Rv1885c	Rv1885c	0.934
Rv1884c	rpfC	0.933

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
(1R)-(-)-myrtenalPubChem	0.9	150.218
C09825PubChem	0.9	907.671
2-hydroxy-1,4-benzoquinonePubChem	0.9	124.094
C11948PubChem	0.9	933.751
c0887PubChem	0.9	935.767
benzoquinonePubChem	0.9	108.095
1,2-bis(4-hydroxyphenyl)-2-propanolPubChem	0.9	244.286
1,2,4-benzenetriolPubChem	0.9	126.11
C16205PubChem	0.9	212.244
trans-pinocarveolPubChem	0.9	152.233
C11947PubChem	0.9	935.767
c0232PubChem	0.9	907.671
C14119PubChem	0.9	1021.77
c0888PubChem	0.9	933.751
myrtenolPubChem	0.9	152.233
c1113PubChem	0.9	1021.77