Rv1750c

Tuberculist information
Gene namefadD1
Protein functionPossible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1977.97
Molecular mass(da)57413.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 532
	  		  	1    MTDTIQSLLRQHVSDPTIAVKYGGLQWTWSQYLAESAARAAALITIADPQRPTHIGSLLG   60
			  	61   NTPEMLAQLAAAGLGGYVLCGLNTTRRGDALAADVRRADCQIVVTDADHRALLDGLDLAG  120
			  	121  ARILDTSTPRWAELVAGDGAFVPYREVDTMDPFMMIFTSGTSGNPKAVPVSHLMATFAGR  180
			  	181  SLTERFGLTEQDTCYVSMPLFHSNAVVAGWAPAVVSGAAIAPATFSATGFLDDVRRYHAT  240
			  	241  YMNYVGKPLAYILATPERDDDADNPLRVAFGNEANDKDIEEFSRRFGVQVEDGFGSTENA  300
			  	301  VIVIREPGTPPGSIGRGAHGVAVYNGETVTECAVARFDAHGALTNADEAIGELVNTTGSG  360
			  	361  FFTGYYNDPEANAERMRHGMYWSGDLAYRDSEGWIYLAGRTADWMRVDGENLTAAPIERI  420
			  	421  LLRYKAINRVAVYAVPDEYVGDQVMAALVLRAGDTFDPDAFEAFLDAQPDLSTKARPRYI  480
			  	481  RIAADLPSTATHKVLKRQLIDEGTAVGKADTLWVREPRGSAYHHASGPAKAI

Known structures in the PDB
PDB ID3R44
Total residue count517
Number of chains1
MethodX-RAY
Resolution1.8
PDB ID3T5B
Total residue count396
Number of chains1
MethodX-RAY
Resolution2.35
PDB ID3T5C
Total residue count792
Number of chains2
MethodX-RAY
Resolution2.09
1 54 107 160 213 266 319 372 425 478 531 Range: 9 to 408  |  Coverage: 75% AMP-binding Range: 416 to 493  |  Coverage: 14% AMP-binding_C Range: 1 to 502  |  Coverage: 94% 1 Range: 1 to 522  |  Coverage: 97% 1 Range: 326 to 400  |  Coverage: 13% 2 Range: 399 to 510  |  Coverage: 20% 3
Number of amino acids : 532
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AMP-bindingPF005019-408
AMP-binding_CPF13193416-493
Mtb Structural Proteome models
Model Number1
Model nameRv1750c
Template1T5H    XPDBCREDO
Template coverage4_501
Template Identity(%)22.9
Model coverage(%)94.2
Normalized DOPE score-0.14

Structure Models from Chopin
Model Number1
Profilee.23.1.1
Click for model details
zscore45.88
Residue begin1
Residue end522
Model Number2
Profile2.30.38.10
Click for model details
zscore15.26
Residue begin326
Residue end400
Model Number3
Profile3.30.300.30
Click for model details
zscore11.88
Residue begin399
Residue end510
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1750cGene nameConfidence Score
Rv1206fadD60.944
Rv1206fadD60.944
Rv1683Rv16830.941
Rv1683Rv16830.941
Rv3506fadD170.906
Rv3506fadD170.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions