Rv1206

Tuberculist information
Gene namefadD6
Protein functionProbable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1349.33
Molecular mass(da)64305
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 597
	  		  	1    VSDYYGGAHTTVRLIDLATRMPRVLADTPVIVRGAMTGLLARPNSKASIGTVFQDRAARY   60
			  	61   GDRVFLKFGDQQLTYRDANATANRYAAVLAARGVGPGDVVGIMLRNSPSTVLAMLATVKC  120
			  	121  GAIAGMLNYHQRGEVLAHSLGLLDAKVLIAESDLVSAVAECGASRGRVAGDVLTVEDVER  180
			  	181  FATTAPATNPASASAVQAKDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGGMGLRLKG  240
			  	241  SDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWDEVIANRATAFVYIGEIC  300
			  	301  RYLLNQPAKPTDRAHQVRVICGNGLRPEIWDEFTTRFGVARVCEFYAASEGNSAFINIFN  360
			  	361  VPRTAGVSPMPLAFVEYDLDTGDPLRDASGRVRRVPDGEPGLLLSRVNRLQPFDGYTDPV  420
			  	421  ASEKKLVRNAFRDGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALAS  480
			  	481  DQTVEECTVYGVQIPRTGGRAGMAAITLRAGAEFDGQALARTVYGHLPGYALPLFVRVVG  540
			  	541  SLAHTTTFKSRKVELRNQAYGADIEDPLYVLAGPDEGYVPYYAEYPEEVSLGRRPQG

Known structures in the PDB
No Known structures
1 60 119 178 237 296 355 414 473 532 591 Range: 53 to 465  |  Coverage: 69% AMP-binding Range: 473 to 549  |  Coverage: 12% AMP-binding_C Range: 2 to 577  |  Coverage: 96% 1 Range: 1 to 578  |  Coverage: 96% 1 Range: 382 to 457  |  Coverage: 12% 2
Number of amino acids : 597
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AMP-bindingPF0050153-465
AMP-binding_CPF13193473-549
Mtb Structural Proteome models
Model Number1
Model nameRv1206
Template1PG4    APDBCREDO
Template coverage36_647
Template Identity(%)18.2
Model coverage(%)96.3
Normalized DOPE score0.12

Structure Models from Chopin
Model Number1
Profilee.23.1.1
Click for model details
zscore33.35
Residue begin1
Residue end578
Model Number2
Profile2.30.38.10
Click for model details
zscore11.39
Residue begin382
Residue end457
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1206Gene nameConfidence Score
Rv1750cfadD10.944
Rv1750cfadD10.944
Rv1683Rv16830.932
Rv1683Rv16830.932
Rv3506fadD170.926
Rv3506fadD170.926
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
coenzyme APubChem0.946767.534
choloyl-CoAPubChem0.9251158.09
cholic acidPubChem0.917408.571
bile acidPubChem0.914408.571
chenodeoxycholic acidPubChem0.909392.572
trihydroxycoprostanoyl-CoAPubChem0.9081200.17
ursodeoxycholic acidPubChem0.906392.572
phytanoyl-CoAPubChem0.9051062.05
phytanic acidPubChem0.905312.53
pristanic acidPubChem0.904298.504
cholyl-coenzyme APubChem0.9021158.09
CHEBI:51341PubChem0.91048.02
CHEBI:37642PubChem0.91200.17
Trihydroxycholestanoic AcidPubChem0.9450.651
C04644PubChem0.91184.17
CHEBI:27403PubChem0.91200.17
pyrophosphatePubChem0.9177.975
C05448PubChem0.91200.17
adenosine monophosphatePubChem0.9347.221
CHEBI:16577PubChem0.9434.652
chenodeoxycholoyl-CoAPubChem0.91142.09
trihydroxycoprostanic acidPubChem0.9450.651
CHEBI:28701PubChem0.91142.09
Co-APubChem0.9767.534
C04554PubChem0.9434.652
CHEBI:15494PubChem0.91184.17
hydroxyl radicalsPubChem0.917.0073
2,6,10,14-tetramethylpentadecanoic acidPubChem0.9298.504
CHEBI:27458PubChem0.91216.17
C05450PubChem0.91216.17
adenosine triphosphatePubChem0.9507.181
CHEBI:15538PubChem0.91062.05
propionatePubChem0.74774.0785